Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Stearoyl-CoA desaturase219 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A17406 | 27801862 | Nutrients | Liver Fatty Acid Composition and Inflammation in Mice Fed with High-Carbohydrate Diet or High-Fat Diet. | 2016 | Details |
| A17488 | 27768909 | J Nutr Biochem | High-fructose corn syrup-55 consumption alters hepatic lipid metabolism and promotes triglyceride accumulation. | 2016 | Details |
| A17542 | 27752492 | Prev Nutr Food Sci | Carrot Juice Administration Decreases Liver Stearoyl-CoA Desaturase 1 and Improves Docosahexaenoic Acid Levels, but Not Steatosis in High Fructose Diet-Fed Weanling Wistar Rats. | 2016 | Details |
| A17635 | 27697525 | Biochem Biophys Res Commun | Long-term fructose consumption prolongs hepatic stearoyl-CoA desaturase 1 activity independent of upstream regulation in rats. | 2016 | Details |
| A17918 | 27477676 | Biochim Biophys Acta | SCD1 deficiency protects mice against ethanol-induced liver injury. | 2016 | Details |
| A17971 | 27445343 | Am J Physiol Gastrointest Liver Physiol | A return to ad libitum feeding following caloric restriction promotes hepatic steatosis in hyperphagic OLETF rats. | 2016 | Details |
| A18508 | 27085774 | Metabolism | Fatty acid metabolism is altered in non-alcoholic steatohepatitis independent of obesity. | 2016 | Details |
| A18860 | 26895665 | J Nutr Biochem | Liver-specific deletion of the signal transducer and activator of transcription 5 gene aggravates fatty liver in response to a high-fat diet in mice. | 2015 | Details |
| A18964 | 26846206 | Sci Rep | Targeting arginase-II protects mice from high-fat-diet-induced hepatic steatosis through suppression of macrophage inflammation. | 2016 | Details |
| A19213 | 26698881 | J Biol Chem | The Hepatitis C Virus-induced NLRP3 Inflammasome Activates the Sterol Regulatory Element-binding Protein (SREBP) and Regulates Lipid Metabolism. | 2015 | Details |
| A19249 | 26674248 | BBA Clin | Mechanism of the development of nonalcoholic steatohepatitis after pancreaticoduodenectomy. | 2015 | Details |
| A19323 | 26629547 | EBioMedicine | Circulating Unsaturated Fatty Acids Delineate the Metabolic Status of Obese Individuals. | 2015 | Details |
| A19383 | 26597784 | Biochim Biophys Acta | Vitamin A deficiency suppresses high fructose-induced triglyceride synthesis and elevates resolvin D1 levels. | 2015 | Details |
| A19390 | 26593707 | Eur J Pharmacol | Betaine prevented fructose-induced NAFLD by regulating LXRα/PPARα pathway and alleviating ER stress in rats. | 2015 | Details |
| A19499 | 26519296 | BMC Gastroenterol | Western diet-induced hepatic steatosis and alterations in the liver transcriptome in adult Brown-Norway rats. | 2015 | Details |
| A19662 | 26429665 | Nutrition | ω-3 Fatty acids reverse lipotoxity through induction of autophagy in nonalcoholic fatty liver disease. | 2015 | Details |
| A19724 | 26394261 | Appl Physiol Nutr Metab | Combining metformin therapy with caloric restriction for the management of type 2 diabetes and nonalcoholic fatty liver disease in obese rats. | 2015 | Details |
| A19859 | 26300958 | Chin Med | Crude triterpenoid saponins from Ilex latifolia (Da Ye Dong Qing) ameliorate lipid accumulation by inhibiting SREBP expression via activation of AMPK in a non-alcoholic fatty liver disease model. | 2015 | Details |
| A20050 | 26190559 | Food Funct | Modulation of tissue fatty acids by L-carnitine attenuates metabolic syndrome in diet-induced obese rats. | 2015 | Details |
| A20195 | 26090419 | Biomed Res Int | Individual CLA Isomers, c9t11 and t10c12, Prevent Excess Liver Glycogen Storage and Inhibit Lipogenic Genes Expression Induced by High-Fructose Diet in Rats. | 2015 | Details |
| A20311 | 26035386 | Dis Model Mech | Chronic administration of recombinant IL-6 upregulates lipogenic enzyme expression and aggravates high-fat-diet-induced steatosis in IL-6-deficient mice. | 2015 | Details |
| A20453 | 25952508 | Lipids Health Dis | Mechanism of the effect of glycosyltransferase GLT8D2 on fatty liver. | 2015 | Details |
| A20491 | 25925967 | Phytomedicine | [6]-gingerol dampens hepatic steatosis and inflammation in experimental nonalcoholic steatohepatitis. | 2015 | Details |
| A20510 | 25915743 | Nutr Diabetes | Effect of multiple binge alcohol on diet-induced liver injury in a mouse model of obesity. | 2015 | Details |
| A20959 | 25617503 | J Hepatol | Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity. | 2015 | Details |
| A21125 | 25527748 | Am J Clin Nutr | Palmitoleic acid is elevated in fatty liver disease and reflects hepatic lipogenesis. | 2014 | Details |
| A21401 | 25348739 | J Sci Food Agric | Carnosic acid attenuates obesity-induced glucose intolerance and hepatic fat accumulation by modulating genes of lipid metabolism in C57BL/6J-ob/ob mice. | 2014 | Details |
| A21451 | 25310357 | Mol Med Rep | Ezetimibe prevents the development of non‑alcoholic fatty liver disease induced by high‑fat diet in C57BL/6J mice. | 2014 | Details |
| A21514 | 25261688 | J Ethnopharmacol | Magnolia officinalis attenuates free fatty acid-induced lipogenesis via AMPK phosphorylation in hepatocytes. | 2014 | Details |
| A21571 | 25219574 | Liver Int | Characteristics of hepatic fatty acid compositions in patients with nonalcoholic steatohepatitis. | 2014 | Details |
| A21645 | 25156247 | Liver Int | Protective effects of farnesoid X receptor (FXR) on hepatic lipid accumulation are mediated by hepatic FXR and independent of intestinal FGF15 signal. | 2014 | Details |
| A21697 | 25111690 | Lab Invest | Uric acid induces fat accumulation via generation of endoplasmic reticulum stress and SREBP-1c activation in hepatocytes. | 2014 | Details |
| A21706 | 25105012 | Cell Biosci | Regulation of fatty acid composition and lipid storage by thyroid hormone in mouse liver. | 2014 | Details |
| A21724 | 25090711 | Zhong Yao Cai | [Effects of soothing liver and invigorating spleen recipes on SREBP-1c, SCD-1 mRNA and proteins expression in hepatocytes of NAFLD rats]. | 2014 | Details |
| A21772 | 25057104 | Nutrients | Pinus densiflora Sieb. et Zucc. alleviates lipogenesis and oxidative stress during oleic acid-induced steatosis in HepG2 cells. | 2014 | Details |
| A22571 | 24456353 | J Med Food | Cooked rice inhibits hepatic fat accumulation by regulating lipid metabolism-related gene expression in mice fed a high-fat diet. | 2014 | Details |
| A22584 | 24445047 | J Nutr Biochem | Role of immunodeficient animal models in the development of fructose induced NAFLD. | 2013 | Details |
| A23002 | 24121055 | Toxicol Appl Pharmacol | Accumulation of lipids and oxidatively damaged DNA in hepatocytes exposed to particles. | 2013 | Details |
| A23029 | 24098813 | PLoS One | Fatty liver is associated with transcriptional downregulation of stearoyl-CoA desaturase and impaired protein dimerization. | 2013 | Details |
| A23163 | 23994574 | Free Radic Biol Med | Free radical biology for medicine: learning from nonalcoholic fatty liver disease. | 2013 | Details |
| A23595 | 23651738 | Toxicol Appl Pharmacol | Resveratrol inhibits LXRα-dependent hepatic lipogenesis through novel antioxidant Sestrin2 gene induction. | 2013 | Details |
| A23888 | 23401753 | J Obes | Altered hepatic lipid metabolism contributes to nonalcoholic fatty liver disease in leptin-deficient Ob/Ob mice. | 2013 | Details |
| A23924 | 23385644 | J Mol Med (Berl) | Lack of kinin B₁ receptor potentiates leptin action in the liver. | 2013 | Details |
| A23939 | 23370355 | Biol Pharm Bull | A novel inhibitor of stearoyl-CoA desaturase-1 attenuates hepatic lipid accumulation, liver injury and inflammation in model of nonalcoholic steatohepatitis. | 2013 | Details |
| A24001 | 23313470 | Prostaglandins Leukot Essent Fatty Acids | Lipidomics of hepatic lipogenesis inhibition by omega 3 fatty acids. | 2013 | Details |
| A24205 | 23124044 | Gene | cDNA cloning and the response to overfeeding in the expression of stearoyl-CoA desaturase 1 gene in Landes goose. | 2012 | Details |
| A24473 | 22858825 | Mol Med Rep | Polydatin alleviates non-alcoholic fatty liver disease in rats by inhibiting the expression of TNF-α and SREBP-1c. | 2012 | Details |
| A24668 | 22633099 | Transl Res | Silibinin modulates lipid homeostasis and inhibits nuclear factor kappa B activation in experimental nonalcoholic steatohepatitis. | 2012 | Details |
| A24736 | 22546860 | J Clin Invest | The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans. | 2012 | Details |
| A24861 | 22425624 | J Hepatol | Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis. | 2012 | Details |
| A25351 | 21936721 | Scand J Gastroenterol | Short-term inhibition of SREBP-1c expression reverses diet-induced non-alcoholic fatty liver disease in mice. | 2011 | Details |
| A25448 | 21821952 | Biosci Biotechnol Biochem | Isolation and anti-fatty liver activity of a novel cerebroside from the sea cucumber Acaudina molpadioides. | 2011 | Details |
| A25919 | 21327921 | Dig Dis Sci | Correlation analysis between gene expression profile of rat liver tissues and high-fat emulsion-induced nonalcoholic fatty liver. | 2011 | Details |
| A26191 | 20936724 | Zhejiang Da Xue Xue Bao Yi Xue Ban | [Effect of sea cucumber cerebroside on lipid metabolism in fatty liver rats]. | 2010 | Details |
| A26275 | 20801631 | J Nutr Biochem | An increase in liver PPARγ2 is an initial event to induce fatty liver in response to a diet high in butter: PPARγ2 knockdown improves fatty liver induced by high-saturated fat. | 2010 | Details |
| A26305 | 20673376 | Br J Nutr | A polyphenol extract modifies quantity but not quality of liver fatty acid content in high-fat-high-sucrose diet-fed rats: possible implication of the sirtuin pathway. | 2010 | Details |
| A27104 | 19166967 | Biochim Biophys Acta | Stearoyl-CoA desaturase and its relation to high-carbohydrate diets and obesity. | 2009 | Details |
| A27126 | 19119140 | J Biol Chem | Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase. | 2009 | Details |
| A27205 | 18989145 | Eur J Gastroenterol Hepatol | Treatment of preestablished diet-induced fatty liver by oral fatty acid-bile acid conjugates in rodents. | 2008 | Details |
| A27338 | 18617560 | J Physiol | Cessation of daily exercise dramatically alters precursors of hepatic steatosis in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. | 2008 | Details |
| A27459 | 18346305 | Br J Nutr | Dietary single cell protein reduces fatty liver in obese Zucker rats. | 2008 | Details |
| A27477 | 18317565 | J Clin Invest | Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. | 2008 | Details |
| A28089 | 16466828 | J Hepatol | Early diet-induced non-alcoholic steatohepatitis in APOE2 knock-in mice and its prevention by fibrates. | 2005 | Details |
| A28120 | 16374859 | Hepatology | Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice. | 2006 | Details |
| A28495 | 12538076 | Prostaglandins Leukot Essent Fatty Acids | Stearoyl-CoA desaturase, a short-lived protein of endoplasmic reticulum with multiple control mechanisms. | 2003 | Details |
| A29976 | 33178326 | Evid Based Complement Alternat Med | Efficacy and Mechanism of a Chinese Classic Prescription of Yueju in Treating Nonalcoholic Steatohepatitis and Protecting Hepatocytes from Apoptosis. | 2020 | Details |
| A32308 | 28740538 | Evid Based Complement Alternat Med | Linarin Enriched Extract Attenuates Liver Injury and Inflammation Induced by High-Fat High-Cholesterol Diet in Rats. | 2017 | Details |
| A32923 | 27083546 | Poult Sci | Expression and methylation of microsomal triglyceride transfer protein and acetyl-CoA carboxylase are associated with fatty liver syndrome in chicken. | 2016 | Details |
| A33261 | 26344107 | Chem Phys Lipids | Recent progress in the discovery and development of stearoyl CoA desaturase inhibitors. | 2015 | Details |
| A34247 | 23974795 | Mol Pharmacol | Ursodeoxycholyl lysophosphatidylethanolamide inhibits lipoapoptosis by shifting fatty acid pools toward monosaturated and polyunsaturated fatty acids in mouse hepatocytes. | 2013 | Details |
| A35552 | 20376096 | Gene Ther | PPARgamma is essential for protection against nonalcoholic steatohepatitis. | 2010 | Details |
| A42406 | 34621322 | Evid Based Complement Alternat Med | YiQi YangYin Decoction Attenuates Nonalcoholic Fatty Liver Disease in Type 2 Diabetes Rats. | 2021 | Details |
| A43663 | 31160717 | Cell Death Differ | SIRT3 promotes lipophagy and chaperon-mediated autophagy to protect hepatocytes against lipotoxicity. | 2019 | Details |
| A43671 | 31142011 | Int J Mol Sci | Involvement of G-Protein-Coupled Receptor 40 in the Inhibitory Effects of Docosahexaenoic Acid on SREBP1-Mediated Lipogenic Enzyme Expression in Primary Hepatocytes. | 2019 | Details |
| A44059 | 30014902 | Redox Biol | Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1/Nrf2 pathway. | 2018 | Details |
| A44245 | 29254285 | Clin Mol Hepatol | Picroside II attenuates fatty acid accumulation in HepG2 cells via modulation of fatty acid uptake and synthesis. | 2017 | Details |
| A44330 | 28980402 | Mol Nutr Food Res | Is Palmitoleic Acid a Plausible Nonpharmacological Strategy to Prevent or Control Chronic Metabolic and Inflammatory Disorders? | 2017 | Details |
| A44353 | 28866102 | Life Sci | Liver steatosis in hypothalamic obese rats improves after duodeno-jejunal bypass by reduction in de novo lipogenesis pathway. | 2017 | Details |
| A45214 | 25644347 | J Nutr | Lycopene and apo-10'-lycopenoic acid have differential mechanisms of protection against hepatic steatosis in β-carotene-9',10'-oxygenase knockout male mice. | 2014 | Details |
| A45509 | 24223615 | Evid Based Complement Alternat Med | Zerumbone, a Natural Cyclic Sesquiterpene of Zingiber zerumbet Smith, Attenuates Nonalcoholic Fatty Liver Disease in Hamsters Fed on High-Fat Diet. | 2013 | Details |
| A45709 | 23161873 | Endocrinology | The role of the carbohydrate response element-binding protein in male fructose-fed rats. | 2012 | Details |
| A46244 | 20060143 | Metabolism | Dietary fat intake promotes the development of hepatic steatosis independently from excess caloric consumption in a murine model. | 2010 | Details |
| A46283 | 19783528 | J Lipid Res | A subset of dysregulated metabolic and survival genes is associated with severity of hepatic steatosis in obese Zucker rats. | 2009 | Details |
| A46407 | 19027012 | Gastroenterology | Tissue inhibitor of metalloproteinase 3 deficiency causes hepatic steatosis and adipose tissue inflammation in mice. | 2008 | Details |
| A46995 | 30935969 | Metabolism | Chitinase-3-like-1 deficiency attenuates ethanol-induced liver injury by inhibition of sterol regulatory element binding protein 1-dependent triglyceride synthesis. | 2019 | Details |
| A47118 | 25622859 | J Nutr Biochem | Enhanced AMPK phosphorylation contributes to the beneficial effects of Lactobacillus rhamnosus GG supernatant on chronic-alcohol-induced fatty liver disease. | 2014 | Details |
| A47151 | 24828027 | J Nutr | Luteolin alleviates alcoholic liver disease induced by chronic and binge ethanol feeding in mice. | 2014 | Details |
| A47177 | 24146112 | Arch Toxicol | Protective effects of dioscin against alcohol-induced liver injury. | 2013 | Details |
| A47284 | 19170661 | Alcohol Clin Exp Res | Quantitative lipid metabolomic changes in alcoholic micropigs with fatty liver disease. | 2009 | Details |
| A47302 | 18395093 | Gastroenterology | Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury. | 2008 | Details |
| A47786 | 31936134 | Cells | Sterculic Acid: The Mechanisms of Action beyond Stearoyl-CoA Desaturase Inhibition and Therapeutic Opportunities in Human Diseases. | 2020 | Details |
| A48663 | 32010333 | Exp Ther Med | Prevention of arachidonic acid-induced liver injury by controlling oxidative stress-mediated transglutaminase activation with garlic extracts. | 2019 | Details |
| A48756 | 29597210 | Pharmacology | Euodia daniellii Hemsl. (Bee-Bee Tree) Oil Attenuates Palmitate-Induced Lipid Accumulation and Apoptosis in Hepatocytes. | 2018 | Details |
| A49125 | 16622296 | Endocrine | Modulation of fatty acid metabolism as a potential approach to the treatment of obesity and the metabolic syndrome. | 2006 | Details |
| A49805 | 35631319 | Nutrients | Reduction of De Novo Lipogenesis Mediates Beneficial Effects of Isoenergetic Diets on Fatty Liver: Mechanistic Insights from the MEDEA Randomized Clinical Trial. | 2022 | Details |
| A49944 | 35586049 | Front Pharmacol | Artemether Ameliorates Non-Alcoholic Steatohepatitis by Repressing Lipogenesis, Inflammation, and Fibrosis in Mice. | 2022 | Details |
| A50217 | 35469167 | JHEP Rep | Lipid alterations in chronic liver disease and liver cancer. | 2022 | Details |
| A50511 | 35358477 | Biochem Pharmacol | Valdecoxib attenuates lipid-induced hepatic steatosis through autophagy-mediated suppression of endoplasmic reticulum stress. | 2022 | Details |
| A50557 | 35341816 | Environ Pollut | Early-life exposure to bisphenol A induces dysregulation of lipid homeostasis by the upregulation of SCD1 in male mice. | 2022 | Details |
| A50733 | 35283810 | Front Microbiol | Alleviation of Hepatic Steatosis: Dithizone-Related Gut Microbiome Restoration During Paneth Cell Dysfunction. | 2022 | Details |