Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A04677 | 33545051 | Cell Metab | Metabolic stress drives sympathetic neuropathy within the liver. | 2021 | Details |
| A04689 | 33541789 | Obes Res Clin Pract | Roles and mechanisms of NRG1 in modulating the pathogenesis of NAFLD through ErbB3 signaling in hepatocytes (NRG1 modulates NAFLD through ErbB3 signaling). | 2021 | Details |
| A04725 | 33526807 | Lab Invest | NLRP3 deficiency did not attenuate NASH development under high fat calorie diet plus high fructose and glucose in drinking water. | 2021 | Details |
| A04752 | 33515562 | Life Sci | miR-125b promotes the NF-κB-mediated inflammatory response in NAFLD via directly targeting TNFAIP3. | 2021 | Details |
| A04766 | 33512269 | J Med Food | Zingerone Administered Neonatally Prevents the Subsequent Development of High Dietary Fructose-Induced Fatty Liver in Sprague Dawley Rats. | 2021 | Details |
| A04799 | 33501889 | Am J Physiol Gastrointest Liver Physiol | A dietary ketone ester mitigates histological outcomes of NAFLD and markers of fibrosis in high-fat diet fed mice. | 2021 | Details |
| A04822 | 33493657 | Pharmacol Res | Baicalin and the liver-gut system: Pharmacological bases explaining its therapeutic effects. | 2021 | Details |
| A04826 | 33492571 | Mol Biol Rep | Association of xenobiotic-metabolizing enzymes (GSTM1 and GSTT 1), and pro-inflammatory cytokines (TNF-α and IL-6) genetic polymorphisms with non-alcoholic fatty liver disease. | 2021 | Details |
| A04988 | 33424294 | Saudi J Biol Sci | The protective effect of shrimp cooked in different methods on high-cholesterol- induced fatty liver in rats. | 2020 | Details |
| A04997 | 33421258 | J Biochem Mol Toxicol | The protective effects of trelagliptin on high-fat diet-induced nonalcoholic fatty liver disease in mice. | 2021 | Details |
| A05000 | 33419084 | Antioxidants (Basel) | Antioxidant and Anti-Inflammatory Effects of Korean Black Ginseng Extract through ER Stress Pathway. | 2021 | Details |
| A05003 | 33417955 | Life Sci | Sacran, a sulfated polysaccharide, suppresses the absorption of lipids and modulates the intestinal flora in non-alcoholic steatohepatitis model rats. | 2021 | Details |
| A05012 | 33410857 | Food Funct | Aloin protects mice from diet-induced non-alcoholic steatohepatitis via activation of Nrf2/HO-1 signaling. | 2021 | Details |
| A05155 | 33352229 | Pharmacol Res | Cryptotanshinone specifically suppresses NLRP3 inflammasome activation and protects against inflammasome-mediated diseases. | 2020 | Details |
| A05180 | 33345314 | J Cell Physiol | Ghrelin ameliorates nonalcoholic steatohepatitis induced by chronic low-grade inflammation via blockade of Kupffer cell M1 polarization. | 2020 | Details |
| A05187 | 33343352 | Front Pharmacol | Hepatoprotective Effect and Molecular Mechanisms of Hengshun Aromatic Vinegar on Non-Alcoholic Fatty Liver Disease. | 2020 | Details |
| A05239 | 33327816 | J Int Med Res | Using intestinal flora to distinguish non-alcoholic steatohepatitis from non-alcoholic fatty liver. | 2020 | Details |
| A05276 | 33317065 | Biomedicines | Dietary-Induced Low-Grade Inflammation in the Liver. | 2020 | Details |
| A05323 | 33302736 | Exp Biol Med (Maywood) | Characterizing disease progression of nonalcoholic steatohepatitis in Leptin-deficient rats by integrated transcriptome analysis. | 2020 | Details |
| A05336 | 33298885 | Cell Death Dis | Hepatocyte cannabinoid 1 receptor nullification alleviates toxin-induced liver damage via NF-κB signaling. | 2020 | Details |
| A05383 | 33275637 | PLoS One | The endothelial dysfunction blocker CU06-1004 ameliorates choline-deficient L-amino acid diet-induced non-alcoholic steatohepatitis in mice. | 2020 | Details |
| A05426 | 33260679 | Nutrients | The Dietary Replacement of Soybean Oil by Canola Oil Does Not Prevent Liver Fatty Acid Accumulation and Liver Inflammation in Mice. | 2020 | Details |
| A05481 | 33240906 | Front Med (Lausanne) | CML/RAGE Signal Bridges a Common Pathogenesis Between Atherosclerosis and Non-alcoholic Fatty Liver. | 2020 | Details |
| A05608 | 33190588 | Autophagy | TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation. | 2020 | Details |
| A05650 | 33173107 | Sci Rep | Dipeptidyl peptidase-4 inhibitor protects against non-alcoholic steatohepatitis in mice by targeting TRAIL receptor-mediated lipoapoptosis via modulating hepatic dipeptidyl peptidase-4 expression. | 2020 | Details |
| A05691 | 33155659 | Int J Mol Med | Role of Asxl2 in non‑alcoholic steatohepatitis‑related hepatocellular carcinoma developed from diabetes. | 2020 | Details |
| A05715 | 33144092 | Peptides | Chemerin/CMKLR1 ameliorates nonalcoholic steatohepatitis by promoting autophagy and alleviating oxidative stress through the JAK2-STAT3 pathway. | 2020 | Details |
| A05779 | 33122078 | Gene | TCTP participates in hepatic metabolism by regulating gene expression involved in insulin resistance. | 2020 | Details |
| A05795 | 33114564 | Nutrients | Protective Effects of (E)-β-Caryophyllene (BCP) in Chronic Inflammation. | 2020 | Details |
| A05848 | 33102399 | Can J Gastroenterol Hepatol | Characteristics of NAFLD Based on Hypopituitarism. | 2020 | Details |
| A05916 | 33076582 | Life (Basel) | Quercitrin Ameliorates Hyperlipidemia and Hepatic Steatosis in Ovariectomized Mice. | 2020 | Details |
| A05946 | 33067533 | Sci Rep | HFD-induced hepatic lipid accumulation and inflammation are decreased in Factor D deficient mouse. | 2020 | Details |
| A05988 | 33050067 | Biomolecules | Pharmaceutical Efficacy of Gypenoside LXXV on Non-Alcoholic Steatohepatitis (NASH). | 2020 | Details |
| A05989 | 33050035 | Cells | Kupffer Cells Sense Free Fatty Acids and Regulate Hepatic Lipid Metabolism in High-Fat Diet and Inflammation. | 2020 | Details |
| A05997 | 33045675 | J Trace Elem Med Biol | A pilot study of the effects of chromium picolinate supplementation on serum fetuin-A, metabolic and inflammatory factors in patients with nonalcoholic fatty liver disease: A double-blind, placebo-controlled trial. | 2020 | Details |
| A06056 | 33026380 | Food Funct | Gut inflammation exacerbates hepatic injury in C57BL/6J mice via gut-vascular barrier dysfunction with high-fat-incorporated meat protein diets. | 2020 | Details |
| A06076 | 33015093 | Front Med (Lausanne) | Association Between Leukocyte Mitochondrial DNA Copy Number and Non-alcoholic Fatty Liver Disease in a Chinese Population Is Mediated by 8-Oxo-2'-Deoxyguanosine. | 2020 | Details |
| A06180 | 32978261 | J Biol Chem | ERAD deficiency promotes mitochondrial dysfunction and transcriptional rewiring in human hepatic cells. | 2020 | Details |
| A06251 | 32952340 | World J Gastroenterol | Tumor necrosis factor alpha receptor 1 deficiency in hepatocytes does not protect from non-alcoholic steatohepatitis, but attenuates insulin resistance in mice. | 2020 | Details |
| A06327 | 32927776 | Nutrients | New Insights into the Pathogenesis of Non-Alcoholic Fatty Liver Disease: Gut-Derived Lipopolysaccharides and Oxidative Stress. | 2020 | Details |
| A06357 | 32916992 | Molecules | LRRK2 Regulates CPT1A to Promote β-Oxidation in HepG2 Cells. | 2020 | Details |
| A06487 | 32859881 | Chin J Physiol | Administration of low-dose resveratrol attenuated hepatic inflammation and lipid accumulation in high cholesterol-fructose diet-induced rat model of nonalcoholic fatty liver disease. | 2020 | Details |
| A06488 | 32859329 | Clin Nutr ESPEN | The effects of Bacillus coagulans supplementation in patients with non-alcoholic fatty liver disease: A randomized, placebo-controlled, clinical trial. | 2020 | Details |
| A06559 | 32825154 | Nutrients | The Protective Effect of Myristica fragrans Houtt. Extracts Against Obesity and Inflammation by Regulating Free Fatty Acids Metabolism in Nonalcoholic Fatty Liver Disease. | 2020 | Details |
| A06592 | 32815965 | Food Funct | A multi-targeting strategy to ameliorate high-fat-diet- and fructose-induced (western diet-induced) non-alcoholic fatty liver disease (NAFLD) with supplementation of a mixture of legume ethanol extracts. | 2020 | Details |
| A06639 | 32798261 | Phytother Res | The effect of saffron supplementation on some inflammatory and oxidative markers, leptin, adiponectin, and body composition in patients with nonalcoholic fatty liver disease: A double-blind randomized clinical trial. | 2020 | Details |
| A06665 | 32789148 | Clin Nutr Res | Association between Inflammatory Biomarkers and Nutritional Status in Fatty Liver. | 2020 | Details |
| A06822 | 32734012 | Porto Biomed J | An albino mouse model of nonalcoholic fatty liver disease induced using high-fat liquid "Lieber-DeCarli" diet: a preliminary investigation. | 2020 | Details |
| A06831 | 32731119 | Cytokine | Osteocalcin and osteoprotegerin levels and their relationship with adipokines and proinflammatory cytokines in children with nonalcoholic fatty liver disease. | 2020 | Details |
| A06839 | 32728632 | Clin Exp Hepatol | Glutathione S-transferase T1 and M1 null genotype distribution among non-alcoholic fatty liver disease patients and its association with cytokine and adipokine profiles. | 2020 | Details |
| A06851 | 32724031 | Minerva Gastroenterol Dietol | Helicobacter pylori and non-alcoholic fatty liver disease. | 2020 | Details |
| A06912 | 32699301 | Sci Rep | Hyperglycemia-stimulating diet induces liver steatosis in sheep. | 2020 | Details |
| A06913 | 32699233 | Sci Rep | MCD diet-induced steatohepatitis generates a diurnal rhythm of associated biomarkers and worsens liver injury in Klf10 deficient mice. | 2020 | Details |
| A06924 | 32696189 | Metab Brain Dis | Melatonin regulates neurodegenerative complications associated with NAFLD via enhanced neurotransmission and cellular integrity: a correlational study. | 2020 | Details |
| A07093 | 32626560 | Middle East J Dig Dis | Assessment of Genetic Aspects of Non-alcoholic Fatty Liver and Premature Cardiovascular Events. | 2020 | Details |
| A07110 | 32619269 | FEBS Lett | SHP-1 ameliorates nonalcoholic steatohepatitis by inhibiting proinflammatory cytokine production. | 2020 | Details |
| A07150 | 32599319 | Int Immunopharmacol | Potential anti-inflammatory effect of dapagliflozin in HCHF diet- induced fatty liver degeneration through inhibition of TNF-α, IL-1β, and IL-18 in rat liver. | 2020 | Details |
| A07198 | 32585734 | Scand J Med Sci Sports | The impact of high-intensity interval training on inflammatory markers in metabolic disorders: A meta-analysis. | 2020 | Details |
| A07210 | 32581811 | Front Pharmacol | Untargeted Metabolomic Analysis of the Effects and Mechanism of Nuciferine Treatment on Rats With Nonalcoholic Fatty Liver Disease. | 2020 | Details |
| A07310 | 32545215 | Diagnostics (Basel) | Could SCGF-Beta Levels Be Associated with Inflammation Markers and Insulin Resistance in Male Patients Suffering from Obesity-Related NAFLD? | 2020 | Details |
| A07328 | 32535386 | Biomed Pharmacother | HCBP6 deficiency exacerbates glucose and lipid metabolism disorders in non-alcoholic fatty liver mice. | 2020 | Details |
| A07410 | 32512072 | Toxicol Appl Pharmacol | Diosmin ameliorates inflammation, insulin resistance, and fibrosis in an experimental model of non-alcoholic steatohepatitis in rats. | 2020 | Details |
| A07461 | 32486073 | Cancers (Basel) | Exercise Attenuates the Transition from Fatty Liver to Steatohepatitis and Reduces Tumor Formation in Mice. | 2020 | Details |
| A07471 | 32483129 | Sci Rep | Gut metabolites and inflammation factors in non-alcoholic fatty liver disease: A systematic review and meta-analysis. | 2020 | Details |
| A07508 | 32466275 | Nutrients | Blackcurrant (Ribes nigrum) Extract Prevents Dyslipidemia and Hepatic Steatosis in Ovariectomized Rats. | 2020 | Details |
| A07525 | 32455208 | ACS Omega | Ginsenoside Rg1 Regulates Liver Lipid Factor Metabolism in NAFLD Model Rats. | 2020 | Details |
| A07549 | 32446022 | Semin Arthritis Rheum | Safety of TNF inhibitors in rheumatic disease in case of NAFLD and cirrhosis. | 2020 | Details |
| A07576 | 32438122 | J Nutr Biochem | Resveratrol prevents liver damage in MCD-induced steatohepatitis mice by promoting SIGIRR gene transcription. | 2020 | Details |
| A07577 | 32437795 | Life Sci | TLR4 knockout upregulates the expression of Mfn2 and PGC-1α in a high-fat diet and ischemia-reperfusion mice model of liver injury. | 2020 | Details |
| A07651 | 32408667 | Int J Environ Res Public Health | The Bisphenol A Induced Oxidative Stress in Non-Alcoholic Fatty Liver Disease Male Patients: A Clinical Strategy to Antagonize the Progression of the Disease. | 2020 | Details |
| A07666 | 32403887 | Zhonghua Gan Zang Bing Za Zhi | [Discussion on the curative effect and mechanisms of berberine in rats with non-alcoholic fatty liver]. | 2020 | Details |
| A07669 | 32401929 | Braz J Med Biol Res | A Brazilian regional basic diet-induced chronic malnutrition drives liver inflammation with higher ApoA-I activity in C57BL6J mice. | 2020 | Details |
| A07680 | 32392802 | Int J Mol Sci | Short-Term Western Diet Aggravates Non-Alcoholic Fatty Liver Disease (NAFLD) With Portal Hypertension in TGR(mREN2)27 Rats. | 2020 | Details |
| A07694 | 32389170 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | [Inulin increases the proportion of monocytic myeloid-derived suppressor cells in peripheral blood, liver, spleen and regulates the secretion of plasma inflammatory cytokines in mice with non-alcoholic fatty liver disease]. | 2020 | Details |
| A07718 | 32377366 | BMJ Open Gastroenterol | Antitumour necrosis factor-α agents and development of new-onset cirrhosis or non-alcoholic fatty liver disease: a retrospective cohort. | 2020 | Details |
| A07771 | 32360132 | Dig Liver Dis | Mitochondrial DNA from hepatocytes induces upregulation of interleukin-33 expression of macrophages in nonalcoholic steatohepatitis. | 2020 | Details |
| A07814 | 32348835 | Life Sci | Exenatide ameliorates experimental non-alcoholic fatty liver in rats via suppression of toll-like receptor 4/NFκB signaling: Comparison to metformin. | 2020 | Details |
| A07880 | 32325178 | J Ethnopharmacol | Qiang-Gan formula extract improves non-alcoholic steatohepatitis via regulating bile acid metabolism and gut microbiota in mice. | 2020 | Details |
| A07945 | 32303004 | Aging (Albany NY) | Ultraconserved element uc.333 increases insulin sensitivity by binding to miR-223. | 2020 | Details |
| A08050 | 32268115 | Cell Metab | TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation. | 2020 | Details |
| A08077 | 32256346 | Front Pharmacol | Hepatoprotective Effect of Cranberry Nutraceutical Extract in Non-alcoholic Fatty Liver Model in Rats: Impact on Insulin Resistance and Nrf-2 Expression. | 2020 | Details |
| A08098 | 32245940 | Med Sci Monit | Ganoderma Lucidum Polysaccharides Ameliorates Hepatic Steatosis and Oxidative Stress in db/db Mice via Targeting Nuclear Factor E2 (Erythroid-Derived 2)-Related Factor-2/Heme Oxygenase-1 (HO-1) Pathway. | 2020 | Details |
| A08126 | 32238704 | Biol Pharm Bull | Reduced Serum Cholesterol and Triglyceride Levels in a Choline-Deficient L-Amino Acid-Defined High-Fat Diet (CDAHFD)-Induced Mouse Model of Non-alcoholic Steatohepatitis (NASH). | 2020 | Details |
| A08133 | 32235497 | Nutrients | Oral Supplementation of Sodium Butyrate Attenuates the Progression of Non-Alcoholic Steatohepatitis. | 2020 | Details |
| A08176 | 32217808 | J Endocrinol | Hepatic inflammation precedes steatosis and is mediated by visceral fat accumulation. | 2020 | Details |
| A08206 | 32205419 | Gut | Intestinal gluconeogenesis prevents obesity-linked liver steatosis and non-alcoholic fatty liver disease. | 2020 | Details |
| A08222 | 32194416 | Front Pharmacol | Berberine Inhibits Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation and Pyroptosis in Nonalcoholic Steatohepatitis via the ROS/TXNIP Axis. | 2020 | Details |
| A08308 | 32158249 | Clin Exp Gastroenterol | Effect of Ginger Powder Supplementation in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial. | 2020 | Details |
| A08346 | 32147075 | Complement Ther Med | Effects of curcuminoids on inflammatory status in patients with non-alcoholic fatty liver disease: A randomized controlled trial. | 2020 | Details |
| A08399 | 32124935 | Int J Mol Med | CYP4A11 is involved in the development of nonalcoholic fatty liver disease via ROS‑induced lipid peroxidation and inflammation. | 2020 | Details |
| A08475 | 32096475 | Eur Cytokine Netw | Effect of folate supplementation on immunological and autophagy markers in experimental nonalcoholic fatty liver disease. | 2019 | Details |
| A08499 | 32085637 | Nutrients | A Diterpenoid, 14-Deoxy-11, 12-Didehydroandrographolide, in Andrographis paniculata Reduces Steatohepatitis and Liver Injury in Mice Fed a High-Fat and High-Cholesterol Diet. | 2020 | Details |
| A08502 | 32083947 | Can J Physiol Pharmacol | Combined treatments with metformin and phosphodiesterase inhibitors alleviate nonalcoholic fatty liver disease in high-fat diet fed rats: a comparative study. | 2020 | Details |
| A08655 | 32031871 | Am J Physiol Heart Circ Physiol | Gut microbiome of a porcine model of metabolic syndrome and HF-pEF. | 2020 | Details |
| A08656 | 32031683 | Hepatology | Hepatic Deficiency of Augmenter of Liver Regeneration Predisposes to Nonalcoholic Steatohepatitis and Fibrosis. | 2020 | Details |
| A08672 | 32026851 | Med Sci Monit | The Effects of RKI-1447 in a Mouse Model of Nonalcoholic Fatty Liver Disease Induced by a High-Fat Diet and in HepG2 Human Hepatocellular Carcinoma Cells Treated with Oleic Acid. | 2020 | Details |
| A08678 | 32025166 | J Clin Exp Hepatol | 2019 Update of Indian National Association for Study of the Liver Consensus on Prevention, Diagnosis, and Management of Hepatocellular Carcinoma in India: The Puri II Recommendations. | 2019 | Details |
| A08681 | 32024509 | BMC Complement Med Ther | Structural modulation of gut microbiota during alleviation of non-alcoholic fatty liver disease with Gynostemma pentaphyllum in rats. | 2020 | Details |
| A08764 | 31993306 | Acta Pharm Sin B | Cytochrome P450 endoplasmic reticulum-associated degradation (ERAD): therapeutic and pathophysiological implications. | 2019 | Details |
| A08852 | 31965894 | Gut Microbes | Lactobacillus and Pediococcus ameliorate progression of non-alcoholic fatty liver disease through modulation of the gut microbiome. | 2020 | Details |