Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A02693 | 34280397 | Eur J Pharmacol | Thymosin beta 4 alleviates non-alcoholic fatty liver by inhibiting ferroptosis via up-regulation of GPX4. | 2021 | Details |
| A02708 | 34277236 | Cureus | The Significance of the Mediterranean Diet in the Management of Non-Alcoholic Fatty Liver Disease: A Systematic Review. | 2021 | Details |
| A02710 | 34276360 | Front Pharmacol | Network Pharmacological Analysis and Experimental Validation of the Mechanisms of Action of Si-Ni-San Against Liver Fibrosis. | 2021 | Details |
| A02745 | 34262330 | Int J Gen Med | Identification of Autophagy-Related Genes in the Progression from Non-Alcoholic Fatty Liver to Non-Alcoholic Steatohepatitis. | 2021 | Details |
| A02777 | 34245170 | J Food Biochem | Ziziphus spina-christi (L.) fortified with Camellia sinensis mediates apoptosis, Notch-1 signaling, and mitigates obesity-induced non-alcoholic fatty liver. | 2021 | Details |
| A02783 | 34242696 | J Hepatol | The multifaceted role of cathepsins in liver disease. | 2021 | Details |
| A02787 | 34240649 | Int J Immunopathol Pharmacol | Allopurinol ameliorates liver injury in type 1 diabetic rats through activating Nrf2. | 2022 | Details |
| A02794 | 34238176 | Curr Mol Pharmacol | The Protective Role of Etoricoxib Against Diethylnitrosamine/2-acetylaminofluorene- Induced Hepatocarcinogenesis in Wistar Rats: The Impact of NF-κB/COX-2/PGE2 Signaling. | 2022 | Details |
| A02823 | 34229251 | Biomed Pharmacother | Bicyclol ameliorates nonalcoholic fatty liver disease in mice via inhibiting MAPKs and NF-κB signaling pathways. | 2021 | Details |
| A02887 | 34204987 | Antioxidants (Basel) | Aqueous Extract of Pepino Leaves Ameliorates Palmitic Acid-Induced Hepatocellular Lipotoxicity via Inhibition of Endoplasmic Reticulum Stress and Apoptosis. | 2021 | Details |
| A02891 | 34204343 | Metabolites | Fructose Causes Liver Damage, Polyploidy, and Dysplasia in the Setting of Short Telomeres and p53 Loss. | 2021 | Details |
| A02901 | 34202537 | Int J Mol Sci | Liver Disease: Induction, Progression, Immunological Mechanisms, and Therapeutic Interventions. | 2021 | Details |
| A02908 | 34200939 | Foods | Effects of Flutriafol Fungicide on the Lipid Accumulation in Human Liver Cells and Rat Liver. | 2021 | Details |
| A02919 | 34199098 | Int J Mol Sci | Western Diet Decreases the Liver Mitochondrial Oxidative Flux of Succinate: Insight from a Murine NAFLD Model. | 2021 | Details |
| A02980 | 34175381 | Toxicology | Hepatotoxic potentials of methotrexate: Understanding the possible toxicological molecular mechanisms. | 2021 | Details |
| A02994 | 34171418 | Food Chem Toxicol | Palmitoyl-CoA effect on cytochrome c release, a key process of apoptosis, from liver mitochondria of rat with sucrose diet-induced obesity. | 2021 | Details |
| A03019 | 34161185 | Autophagy | Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective. | 2021 | Details |
| A03067 | 34144391 | Redox Biol | Proteasome dysfunction under compromised redox metabolism dictates liver injury in NASH through ASK1/PPARγ binodal complementary modules. | 2021 | Details |
| A03116 | 34124059 | Front Cell Dev Biol | Pathological Crosstalk Between Oxidized LDL and ER Stress in Human Diseases: A Comprehensive Review. | 2021 | Details |
| A03125 | 34119957 | Stem Cell Res | Restorative effect of adipose tissue-derived stem cells on impaired hepatocytes through Notch signaling in non-alcoholic steatohepatitis mice. | 2021 | Details |
| A03173 | 34101924 | Biofactors | alpha-Tocopherol supplementation reduces inflammation and apoptosis in high cholesterol mediated nonalcoholic steatohepatitis. | 2021 | Details |
| A03178 | 34099068 | Hum Genomics | Mitochondrial genome copy number measured by DNA sequencing in human blood is strongly associated with metabolic traits via cell-type composition differences. | 2021 | Details |
| A03185 | 34096005 | Methods Mol Biol | Protocols for Mitochondria as the Target of Pharmacological Therapy in the Context of Nonalcoholic Fatty Liver Disease (NAFLD). | 2021 | Details |
| A03291 | 34058224 | Metabolism | Regulation of hepatic fibrosis by carcinoembryonic antigen-related cell adhesion molecule 1. | 2021 | Details |
| A03301 | 34052855 | Diabetologia | Non-alcoholic fatty liver disease in mice with hepatocyte-specific deletion of mitochondrial fission factor. | 2021 | Details |
| A03309 | 34050551 | J Gastroenterol Hepatol | Role of the inflammasome, gasdermin D, and pyroptosis in non-alcoholic fatty liver disease. | 2021 | Details |
| A03332 | 34040583 | Front Endocrinol (Lausanne) | Gene-Environmental Interactions as Metabolic Drivers of Nonalcoholic Steatohepatitis. | 2021 | Details |
| A03406 | 34013366 | Int J Mol Med | Histone deacetylase‑2: A potential regulator and therapeutic target in liver disease (Review). | 2021 | Details |
| A03447 | 33995543 | Evid Based Complement Alternat Med | Network Pharmacology-Based Investigation of the Therapeutic Mechanisms of Action of Danning Tablets in Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A03452 | 33994867 | Int J Biol Sci | MicroRNAs in the Pathogenesis of Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A03456 | 33994069 | Cytokine | Changes in liver steatosis in HIV-positive women are associated with the BMI, but not with biomarkers. | 2021 | Details |
| A03474 | 33990765 | Acta Pharmacol Sin | Blueberry-derived exosomes-like nanoparticles ameliorate nonalcoholic fatty liver disease by attenuating mitochondrial oxidative stress. | 2021 | Details |
| A03518 | 33973136 | Obes Surg | Role of Indole-3-Acetic Acid in NAFLD Amelioration After Sleeve Gastrectomy. | 2021 | Details |
| A03532 | 33966599 | Autophagy | Lipotoxicity reduces DDX58/Rig-1 expression and activity leading to impaired autophagy and cell death. | 2021 | Details |
| A03544 | 33961941 | J Hepatol | Glutaminolysis-induced mTORC1 activation drives non-alcoholic steatohepatitis progression. | 2021 | Details |
| A03560 | 33953830 | Oxid Med Cell Longev | Epigallocatechin-3-Gallate Alleviates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease via Inhibition of Apoptosis and Promotion of Autophagy through the ROS/MAPK Signaling Pathway. | 2021 | Details |
| A03562 | 33953586 | Diabetes Metab Syndr Obes | Astragaloside IV Alleviates Liver Inflammation, Oxidative Stress and Apoptosis to Protect Against Experimental Non-Alcoholic Fatty Liver Disease. | 2021 | Details |
| A03585 | 33941551 | BMJ Open Diabetes Res Care | Insulin resistance and liver histopathology in metabolically unhealthy subjects do not correlate with the hepatic abundance of NLRP3 inflammasome nor circulating IL-1β levels. | 2021 | Details |
| A03593 | 33939118 | Drugs | Targeting AMPK by Statins: A Potential Therapeutic Approach. | 2021 | Details |
| A03614 | 33930596 | Mol Metab | Hepatocyte miR-34a is a key regulator in the development and progression of non-alcoholic fatty liver disease. | 2021 | Details |
| A03650 | 33920670 | Int J Mol Sci | Remodeling of Mitochondrial Plasticity: The Key Switch from NAFLD/NASH to HCC. | 2021 | Details |
| A03656 | 33918059 | J Pers Med | Animal Evidence for Synergistic Induction of Hepatic Injury by Dietary Fat and Alcohol Consumption and Its Potential Mechanisms. | 2021 | Details |
| A03684 | 33902605 | Lipids Health Dis | Elucidation of SIRT-1/PGC-1α-associated mitochondrial dysfunction and autophagy in nonalcoholic fatty liver disease. | 2021 | Details |
| A03714 | 33894425 | Cell Mol Gastroenterol Hepatol | Caspase-11-Mediated Hepatocytic Pyroptosis Promotes the Progression of Nonalcoholic Steatohepatitis. | 2021 | Details |
| A03926 | 33815655 | Oxid Med Cell Longev | Effect of Different Exercise Intensities on Hepatocyte Apoptosis in HFD-Induced NAFLD in Rats: The Possible Role of Endoplasmic Reticulum Stress through the Regulation of the IRE1/JNK and eIF2α/CHOP Signal Pathways. | 2021 | Details |
| A03930 | 33813878 | Am J Physiol Endocrinol Metab | Enoyl coenzyme A hydratase 1 alleviates nonalcoholic steatohepatitis in mice by suppressing hepatic ferroptosis. | 2021 | Details |
| A03945 | 33810882 | Clin Investig Arterioscler | Alleviation of non-alcoholic fatty liver disease by Huazhi Fugan Granules is associated with suppression of TLR4/NF-κB signaling pathway. | 2021 | Details |
| A03951 | 33809676 | J Clin Med | Caspase-Cleaved Keratin 18 Measurements Identified Ongoing Liver Injury after Bariatric Surgery. | 2021 | Details |
| A03972 | 33805795 | Nutrients | The Role of Resveratrol in Liver Disease: A Comprehensive Review from In Vitro to Clinical Trials. | 2021 | Details |
| A04006 | 33791907 | Mol Biol Rep | Bioactive dipeptide from potato protein hydrolysate combined with swimming exercise prevents high fat diet induced hepatocyte apoptosis by activating PI3K/Akt in SAMP8 mouse. | 2021 | Details |
| A04008 | 33790913 | Front Immunol | Group 3 Innate Lymphoid Cells Protect Steatohepatitis From High-Fat Diet Induced Toxicity. | 2021 | Details |
| A04049 | 33776490 | J Exp Pharmacol | Experimental and Investigational Targeted Therapies for the Management of Fibrosis in NASH: An Update. | 2021 | Details |
| A04073 | 33769609 | FASEB J | CDKN2A deregulation in fatty liver disease and its accelerative role in the process of lipogenesis. | 2021 | Details |
| A04095 | 33762390 | Clin Med (Lond) | Hydrogen treatment: a novel option in liver diseases. | 2021 | Details |
| A04109 | 33754067 | Theranostics | NAD+-boosting therapy alleviates nonalcoholic fatty liver disease via stimulating a novel exerkine Fndc5/irisin. | 2021 | Details |
| A04174 | 33728021 | Oxid Med Cell Longev | Plant-Based Foods and Their Bioactive Compounds on Fatty Liver Disease: Effects, Mechanisms, and Clinical Application. | 2021 | Details |
| A04193 | 33720620 | Ter Arkh | [Hepatocellular damage and inflammation in various forms of alcoholic liver disease]. | 2021 | Details |
| A04207 | 33713358 | Hepatology | TNF-α-Induce Protein 8-Like 1 Inhibits Hepatic Steatosis, Inflammation, and Fibrosis by Suppressing Polyubiquitination of Apoptosis Signal-Regulating Kinase 1. | 2021 | Details |
| A04251 | 33689215 | J Cell Mol Med | Inhibition of miR-188-5p alleviates hepatic fibrosis by significantly reducing the activation and proliferation of HSCs through PTEN/PI3K/AKT pathway. | 2021 | Details |
| A04275 | 33680282 | Oxid Med Cell Longev | Hepatoprotection of Lycii Fructus Polysaccharide against Oxidative Stress in Hepatocytes and Larval Zebrafish. | 2021 | Details |
| A04310 | 33670839 | Antioxidants (Basel) | Changes in Glutathione Content in Liver Diseases: An Update. | 2021 | Details |
| A04330 | 33664289 | Sci Rep | Clodronate, an inhibitor of the vesicular nucleotide transporter, ameliorates steatohepatitis and acute liver injury. | 2021 | Details |
| A04337 | 33659827 | Vavilovskii Zhurnal Genet Selektsii | Apoptosis in the liver of male db/db mice during the development of obesity and type 2 diabetes. | 2020 | Details |
| A04453 | 33610041 | Biochem Biophys Res Commun | Inhibition of Notch1 signaling reduces hepatocyte injury in nonalcoholic fatty liver disease via autophagy. | 2021 | Details |
| A04563 | 33579000 | Int J Mol Sci | IL-6 Reduces Mitochondrial Replication, and IL-6 Receptors Reduce Chronic Inflammation in NAFLD and Type 2 Diabetes. | 2021 | Details |
| A04568 | 33578292 | Biochem Biophys Res Commun | Mesenchymal stem cell-conditioned medium improved mitochondrial function and alleviated inflammation and apoptosis in non-alcoholic fatty liver disease by regulating SIRT1. | 2021 | Details |
| A04690 | 33541129 | Exp Biol Med (Maywood) | Effect of vitamin D3 supplementation on hepatic lipid dysregulation associated with autophagy regulatory AMPK/Akt-mTOR signaling in type 2 diabetic mice. | 2021 | Details |
| A04734 | 33522200 | J Tradit Chin Med | Efficacy of Cigu Xiaozhi pill on non-alcoholic steatohepatitis-associated lipoapoptosis through stress-activated c-Jun N-terminal kinase signalling pathway. | 2021 | Details |
| A04764 | 33513383 | J Steroid Biochem Mol Biol | Long-term androgen excess induces insulin resistance and non-alcoholic fatty liver disease in PCOS-like rats. | 2021 | Details |
| A04775 | 33510844 | Oxid Med Cell Longev | Phloroglucinol Strengthens the Antioxidant Barrier and Reduces Oxidative/Nitrosative Stress in Nonalcoholic Fatty Liver Disease (NAFLD). | 2021 | Details |
| A04776 | 33510172 | Nat Commun | CD4 derived double negative T cells prevent the development and progression of nonalcoholic steatohepatitis. | 2021 | Details |
| A04787 | 33505505 | Evid Based Complement Alternat Med | A Study on the Therapeutic Efficacy of San Zi Yang Qin Decoction for Non-Alcoholic Fatty Liver Disease and the Underlying Mechanism Based on Network Pharmacology. | 2021 | Details |
| A04799 | 33501889 | Am J Physiol Gastrointest Liver Physiol | A dietary ketone ester mitigates histological outcomes of NAFLD and markers of fibrosis in high-fat diet fed mice. | 2021 | Details |
| A04817 | 33495844 | Mol Med Rep | Effects of renalase deficiency on liver fibrosis markers in a nonalcoholic steatohepatitis mouse model. | 2021 | Details |
| A04822 | 33493657 | Pharmacol Res | Baicalin and the liver-gut system: Pharmacological bases explaining its therapeutic effects. | 2021 | Details |
| A04884 | 33467546 | Int J Mol Sci | Empagliflozin Attenuates Non-Alcoholic Fatty Liver Disease (NAFLD) in High Fat Diet Fed ApoE(-/-) Mice by Activating Autophagy and Reducing ER Stress and Apoptosis. | 2021 | Details |
| A04893 | 33464700 | Kaohsiung J Med Sci | Herp knockout protects against nonalcoholic fatty liver disease in mice on a high fat diet. | 2021 | Details |
| A04894 | 33464677 | Diabetes Obes Metab | Nonalcoholic fatty liver disease as a metabolic disease in humans: A literature review. | 2021 | Details |
| A04951 | 33439102 | Am J Physiol Gastrointest Liver Physiol | Hydrogen-rich water protects against liver injury in nonalcoholic steatohepatitis through HO-1 enhancement via IL-10 and Sirt 1 signaling. | 2021 | Details |
| A05012 | 33410857 | Food Funct | Aloin protects mice from diet-induced non-alcoholic steatohepatitis via activation of Nrf2/HO-1 signaling. | 2021 | Details |
| A05043 | 33396939 | Int J Mol Sci | Deletion of KLF10 Leads to Stress-Induced Liver Fibrosis upon High Sucrose Feeding. | 2020 | Details |
| A05061 | 33390956 | Front Pharmacol | Hydrogen Sulfide Attenuates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease by Inhibiting Apoptosis and Promoting Autophagy via Reactive Oxygen Species/Phosphatidylinositol 3-Kinase/AKT/Mammalian Target of Rapamycin Signaling Pathway. | 2020 | Details |
| A05062 | 33390939 | Front Pharmacol | Inulin Exerts Beneficial Effects on Non-Alcoholic Fatty Liver Disease via Modulating gut Microbiome and Suppressing the Lipopolysaccharide-Toll-Like Receptor 4-Mψ-Nuclear Factor-κB-Nod-Like Receptor Protein 3 Pathway via gut-Liver Axis in Mice. | 2020 | Details |
| A05067 | 33388954 | Pediatr Surg Int | The administration of hepatocyte growth factor prevents total parenteral nutrition-induced hepatocellular injury in a rat model. | 2021 | Details |
| A05140 | 33358861 | Exp Cell Res | Src-mediated Tyr353 phosphorylation of IP3R1 promotes its stability and causes apoptosis in palmitic acid-treated hepatocytes. | 2021 | Details |
| A05144 | 33357707 | Poult Sci | Based on network pharmacology method to discovered the targets and therapeutic mechanism of Paederia scandens against nonalcoholic fatty liver disease in chicken. | 2020 | Details |
| A05151 | 33353156 | Int J Mol Sci | Cell Death in Liver Diseases: A Review. | 2020 | Details |
| A05188 | 33342543 | J Hepatol | Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis. | 2020 | Details |
| A05212 | 33337101 | Compr Rev Food Sci Food Saf | Phytosterols and their derivatives: Potential health-promoting uses against lipid metabolism and associated diseases, mechanism, and safety issues. | 2020 | Details |
| A05247 | 33325808 | Am J Physiol Gastrointest Liver Physiol | Hepatocyte-specific expression of human carboxylesterase 2 attenuates nonalcoholic steatohepatitis in mice. | 2020 | Details |
| A05272 | 33317575 | Lipids Health Dis | A trans fatty acid substitute enhanced development of liver proliferative lesions induced in mice by feeding a choline-deficient, methionine-lowered, L-amino acid-defined, high-fat diet. | 2020 | Details |
| A05336 | 33298885 | Cell Death Dis | Hepatocyte cannabinoid 1 receptor nullification alleviates toxin-induced liver damage via NF-κB signaling. | 2020 | Details |
| A05355 | 33284502 | Hepatology | Metabolic Landscape of the Mouse Liver by Quantitative 31 P Nuclear Magnetic Resonance Analysis of the Phosphorome. | 2021 | Details |
| A05362 | 33282271 | Food Sci Nutr | Protective effect of celastrol on type 2 diabetes mellitus with nonalcoholic fatty liver disease in mice. | 2020 | Details |
| A05444 | 33255318 | Int J Mol Sci | The Role of Histone Acetylation-/Methylation-Mediated Apoptotic Gene Regulation in Hepatocellular Carcinoma. | 2020 | Details |
| A05500 | 33228663 | J Transl Med | LncRNA NEAT1/microRNA-129-5p/SOCS2 axis regulates liver fibrosis in alcoholic steatohepatitis. | 2020 | Details |
| A05512 | 33221744 | Aging (Albany NY) | Hsa_circ_0048179 attenuates free fatty acid-induced steatosis via hsa_circ_0048179/miR-188-3p/GPX4 signaling. | 2020 | Details |
| A05516 | 33220425 | Free Radic Biol Med | Physiological evidence of mitochondrial permeability transition pore opening caused by lipid deposition leading to hepatic steatosis in db/db mice. | 2020 | Details |
| A05549 | 33211913 | Vopr Pitan | [Effect of carnosine and α-lipoic acid on hepatocyte apoptosis and the cytokine profile in induced fatty liver disease in Wistar rats]. | 2020 | Details |
| A05551 | 33208891 | Cell Death Differ | RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in macrophages. | 2020 | Details |