Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A21060 | 28356818 | J Med Biochem | Epidemiology and Natural History of NAFLD. | 2014 | Details |
| A21063 | 27508191 | J Hepatocell Carcinoma | A clinical perspective of the link between metabolic syndrome and hepatocellular carcinoma. | 2015 | Details |
| A21076 | 25548491 | World J Gastroenterol | Lean-non-alcoholic fatty liver disease increases risk for metabolic disorders in a normal weight Chinese population. | 2014 | Details |
| A21079 | 25548472 | World J Gastroenterol | Intestinal microbiota and type 2 diabetes: from mechanism insights to therapeutic perspective. | 2014 | Details |
| A21096 | 25537957 | J Gastrointest Surg | Bariatric surgery improves histological features of nonalcoholic fatty liver disease and liver fibrosis. | 2014 | Details |
| A21100 | 25536573 | Probl Radiac Med Radiobiol | Peculiarities of viruses Herpesviridae family persistence in patients with non-alcoholic fatty liver disease who had been exposed to the factors of Chornobyl NPP accident. | 2014 | Details |
| A21102 | 25535951 | PLoS One | Establishment of a general NAFLD scoring system for rodent models and comparison to human liver pathology. | 2014 | Details |
| A21131 | 25524812 | Liver Int | Application of hepatocellular carcinoma surveillance in a European setting. What can we learn from clinical practice? | 2015 | Details |
| A21180 | 25496394 | BMC Gastroenterol | Non-alcoholic fatty liver disease associated with gallstones in females rather than males: a longitudinal cohort study in Chinese urban population. | 2014 | Details |
| A21183 | 25495373 | Liver Int | ELF score ≥9.8 indicates advanced hepatic fibrosis and is influenced by age, steatosis and histological activity. | 2015 | Details |
| A21187 | 25492998 | World J Gastroenterol | Focus on emerging drugs for the treatment of patients with non-alcoholic fatty liver disease. | 2014 | Details |
| A21188 | 25492997 | World J Gastroenterol | Alimentary regimen in non-alcoholic fatty liver disease: Mediterranean diet. | 2014 | Details |
| A21189 | 25492996 | World J Gastroenterol | Non-invasive diagnosis of advanced fibrosis and cirrhosis. | 2014 | Details |
| A21218 | 25470667 | Expert Opin Ther Pat | Acyltransferase inhibitors: a patent review (2010-present). | 2014 | Details |
| A21227 | 25469015 | World J Gastroenterol | Pathology of alcoholic liver disease, can it be differentiated from nonalcoholic steatohepatitis? | 2014 | Details |
| A21235 | 25468160 | Lancet | Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial. | 2014 | Details |
| A21245 | 25457209 | J Hepatol | Circulating triacylglycerol signatures and insulin sensitivity in NAFLD associated with the E167K variant in TM6SF2. | 2014 | Details |
| A21250 | 25456097 | Metabolism | Leptin in nonalcoholic fatty liver disease: a narrative review. | 2014 | Details |
| A21263 | 25450212 | J Hepatol | Circulating phospholipid profiling identifies portal contribution to NASH signature in obesity. | 2014 | Details |
| A21290 | 25429984 | Hepatol Res | Serum alanine aminotransferase predicts the histological course of non-alcoholic steatohepatitis in Japanese patients. | 2014 | Details |
| A21299 | 25426570 | J Hypertens | The association of nonalcoholic fatty liver disease with central and peripheral blood pressure in adolescence: findings from a cross-sectional study. | 2015 | Details |
| A21300 | 25422863 | Biochem J | Steatosis inhibits liver cell store-operated Ca²⁺ entry and reduces ER Ca²⁺ through a protein kinase C-dependent mechanism. | 2015 | Details |
| A21323 | 25405502 | J Clin Endocrinol Metab | Liver fat content and hepatic insulin sensitivity in overweight patients with type 1 diabetes. | 2014 | Details |
| A21334 | 25399407 | Ital J Pediatr | Chemerin as a novel non-invasive serum marker of intrahepatic lipid content in obese children. | 2014 | Details |
| A21343 | 25388536 | Curr Top Med Chem | Knocking on FXR's door: the "hammerhead"-structure series of FXR agonists - amphiphilic isoxazoles with potent in vitro and in vivo activities. | 2014 | Details |
| A21349 | 25385252 | J Clin Lab Anal | AdipoQ T45 G and G276 T Polymorphisms and Susceptibility to Nonalcoholic Fatty Liver Disease Among Asian Populations: A Meta-Analysis and Meta-Regression. | 2014 | Details |
| A21362 | 25375228 | PLoS One | Weight loss in nonalcoholic Fatty liver disease patients in an ambulatory care setting is largely unsuccessful but correlates with frequency of clinic visits. | 2014 | Details |
| A21375 | 25363574 | Clin Exp Pharmacol Physiol | Serum vitamin D levels are inversely related with non-alcoholic fatty liver disease independent of visceral obesity in Chinese postmenopausal women. | 2015 | Details |
| A21385 | 25356042 | World J Gastroenterol | Effects of glucagon-like peptide-1 receptor agonists on non-alcoholic fatty liver disease and inflammation. | 2014 | Details |
| A21408 | 25344588 | J Lipid Res | Lipoprotein subclass metabolism in nonalcoholic steatohepatitis. | 2014 | Details |
| A21416 | 25339805 | World J Gastroenterol | Review of nonalcoholic fatty liver disease in women with polycystic ovary syndrome. | 2014 | Details |
| A21453 | 25309705 | Korean J Fam Med | The impact of weight changes on nonalcoholic Fatty liver disease in adult men with normal weight. | 2014 | Details |
| A21467 | 25299043 | PLoS One | Complement alternative pathway activation in human nonalcoholic steatohepatitis. | 2014 | Details |
| A21473 | 25296075 | Arq Gastroenterol | Age and gender may influence the results of Roux-en-Y gastric bypass? Metabolic syndrome parameters. | 2015 | Details |
| A21476 | 25294377 | J Zhejiang Univ Sci B | Association between non-alcoholic fatty liver disease and arterial stiffness in the non-obese, non-hypertensive, and non-diabetic young and middle-aged Chinese population. | 2014 | Details |
| A21478 | 25293867 | Eur J Clin Invest | Nonalcoholic fatty liver disease vs. obesity on the risk of erosive oesophagitis. | 2014 | Details |
| A21480 | 25291138 | J Clin Gastroenterol | Coffee and liver health. | 2015 | Details |
| A21493 | 25281430 | Diabetes | WISP1 is a novel adipokine linked to inflammation in obesity. | 2014 | Details |
| A21502 | 25270373 | Acta Radiol | High resolution in vivo 31P-MRS of the liver: potential advantages in the assessment of non-alcoholic fatty liver disease. | 2014 | Details |
| A21505 | 25268068 | Am J Clin Oncol | Hepatocellular Carcinoma Management in Nonalcoholic Fatty Liver Disease Patients: Applicability of the BCLC Staging System. | 2016 | Details |
| A21518 | 25259621 | Scand J Gastroenterol | A comparison of FibroMeter™ NAFLD Score, NAFLD fibrosis score, and transient elastography as noninvasive diagnostic tools for hepatic fibrosis in patients with biopsy-proven non-alcoholic fatty liver disease. | 2014 | Details |
| A21521 | 25256357 | J Nutr Biochem | Interstrain differences in the progression of nonalcoholic steatohepatitis to fibrosis in mice are associated with altered hepatic iron metabolism. | 2014 | Details |
| A21529 | 25252033 | J Clin Lab Anal | Elevation of Serum Levels of Advanced Glycation End Products in Patients With Non-B or Non-C Hepatocellular Carcinoma. | 2014 | Details |
| A21534 | 25247408 | Radiology | Accuracy of MR imaging-estimated proton density fat fraction for classification of dichotomized histologic steatosis grades in nonalcoholic fatty liver disease. | 2014 | Details |
| A21541 | 25242225 | Cell Metab | Thiazolidinediones and the promise of insulin sensitization in type 2 diabetes. | 2014 | Details |
| A21550 | 25238605 | J Gastroenterol Hepatol | Modest alcohol consumption reduces the incidence of fatty liver in men: a population-based large-scale cohort study. | 2015 | Details |
| A21581 | 25211791 | Practitioner | Improving outcomes for patients with obesity. | 2014 | Details |
| A21596 | 25195551 | J Hepatol | Relationship of vitamin D with insulin resistance and disease severity in non-alcoholic steatohepatitis. | 2014 | Details |
| A21620 | 25182422 | Arch Toxicol | Pregnane X receptor activation and silencing promote steatosis of human hepatic cells by distinct lipogenic mechanisms. | 2014 | Details |
| A21624 | 25175670 | J Med Case Rep | Oliguric acute kidney injury as a main symptom of bradycardia and arteriosclerosis resolved by pacemaker implantation: a case report. | 2014 | Details |
| A21635 | 25164277 | Expert Opin Investig Drugs | GFT505 for the treatment of nonalcoholic steatohepatitis and type 2 diabetes. | 2014 | Details |
| A21646 | 25155259 | Aliment Pharmacol Ther | Nonalcoholic fatty liver disease (NAFLD) in the Veterans Administration population: development and validation of an algorithm for NAFLD using automated data. | 2014 | Details |
| A21655 | 25145976 | Hepatol Res | Non-alcoholic fatty liver disease fibrosis score and FIB-4 scoring system could identify patients at risk of systemic complications. | 2014 | Details |
| A21657 | 25145475 | Hepatology | The role of liver fat and insulin resistance as determinants of plasma aminotransferase elevation in nonalcoholic fatty liver disease. | 2014 | Details |
| A21665 | 25138963 | Endocrine | Adipogenic changes of hepatocytes in a high-fat diet-induced fatty liver mice model and non-alcoholic fatty liver disease patients. | 2014 | Details |
| A21673 | 25130427 | Hepatology | Genetic ablation of solute carrier family 7a3a leads to hepatic steatosis in zebrafish during fasting. | 2014 | Details |
| A21682 | 25123088 | Toxicology | Genotoxic, epigenetic, and transcriptomic effects of tamoxifen in mouse liver. | 2014 | Details |
| A21686 | 25120595 | Exp Ther Med | Elevated levels of alanine transaminase and triglycerides within normal limits are associated with fatty liver. | 2014 | Details |
| A21707 | 25104497 | Am J Physiol Gastrointest Liver Physiol | Effects of acute glucocorticoid blockade on metabolic dysfunction in patients with Type 2 diabetes with and without fatty liver. | 2014 | Details |
| A21744 | 25074471 | Clin Sci (Lond) | CXCR4 dysfunction in non-alcoholic steatohepatitis in mice and patients. | 2015 | Details |
| A21758 | 25066281 | Liver Int | Blockade of interleukin 6 signalling ameliorates systemic insulin resistance through upregulation of glucose uptake in skeletal muscle and improves hepatic steatosis in high-fat diet fed mice. | 2014 | Details |
| A21763 | 25063232 | Int J Biochem Cell Biol | Exercise alters liver mitochondria phospholipidomic profile and mitochondrial activity in non-alcoholic steatohepatitis. | 2014 | Details |
| A21771 | 25057109 | J Mol Endocrinol | oxLDL induces injury and defenestration of human liver sinusoidal endothelial cells via LOX1. | 2014 | Details |
| A21785 | 25045618 | Curr Hepatol Rep | Mechanisms of Liver Injury in Non-Alcoholic Steatohepatitis. | 2014 | Details |
| A21798 | 25038727 | Metabolism | Metabolically healthy obesity from childhood to adulthood - Does weight status alone matter? | 2014 | Details |
| A21804 | 25034287 | Dig Dis | The pathogenesis of hepatocellular carcinoma. | 2014 | Details |
| A21816 | 25024624 | World J Gastroenterol | Pro-atherosclerotic markers and cardiovascular risk factors one year after liver transplantation. | 2014 | Details |
| A21822 | 25024594 | World J Gastroenterol | Nonalcoholic fatty liver disease and polycystic ovary syndrome. | 2014 | Details |
| A21858 | 24994581 | Panminerva Med | Serum adipokine levels in overweight patients and their relationship with non-alcoholic fatty liver disease. | 2014 | Details |
| A21867 | 24990270 | BMC Gastroenterol | Characterization and prognosis of patients with hepatocellular carcinoma (HCC) in the non-cirrhotic liver. | 2014 | Details |
| A21884 | 24978432 | Cancers (Basel) | Fibrogenesis and Carcinogenesis in Nonalcoholic Steatohepatitis (NASH): Involvement of Matrix Metalloproteinases (MMPs) and Tissue Inhibitors of Metalloproteinase (TIMPs). | 2014 | Details |
| A21889 | 24976563 | Hepatol Res | Influence of lifestyle-related diseases and age on the development and progression of non-alcoholic fatty liver disease. | 2014 | Details |
| A21899 | 24974489 | J Assoc Physicians India | Hepatocyte growth factor, adiponectin and hepatic histopathology in non-alcoholic steatohepatitis. | 2013 | Details |
| A21900 | 30310479 | Eur Cardiol | The Role of Non-alcoholic Fatty Liver Disease in Cardiovascular Disease. | 2014 | Details |
| A21917 | 24966603 | World J Gastroenterol | Role of autophagy in the pathophysiology of nonalcoholic fatty liver disease: a controversial issue. | 2014 | Details |
| A21918 | 24966598 | World J Gastroenterol | Gallstones in patients with liver cirrhosis: incidence, etiology, clinical and therapeutical aspects. | 2014 | Details |
| A21919 | 24966597 | World J Gastroenterol | Cellular and molecular mechanisms in the pathogenesis of liver fibrosis: An update. | 2014 | Details |
| A21922 | 24965234 | J Surg Oncol | Nonalcoholic fatty liver disease after pancreatoduodenectomy is closely associated with postoperative pancreatic exocrine insufficiency. | 2014 | Details |
| A21924 | 24962805 | Diabetes Obes Metab | Abdominal subcutaneous adipose tissue insulin resistance and lipolysis in patients with non-alcoholic steatohepatitis. | 2014 | Details |
| A21927 | 24961607 | Liver Transpl | Recurrent or de novo nonalcoholic fatty liver disease after liver transplantation: natural history based on liver biopsy analysis. | 2014 | Details |
| A21935 | 24953607 | Life Sci | Testosterone suppresses the expression of regulatory enzymes of fatty acid synthesis and protects against hepatic steatosis in cholesterol-fed androgen deficient mice. | 2014 | Details |
| A21961 | 24929638 | J Gastroenterol | Clinical characteristics, treatment, and prognosis of non-B, non-C hepatocellular carcinoma: a large retrospective multicenter cohort study. | 2014 | Details |
| A21972 | 24923363 | Hepatol Res | Hepatocellular carcinoma based on cryptogenic liver disease: The most common non-viral hepatocellular carcinoma in patients aged over 80 years. | 2014 | Details |
| A21982 | 24916329 | J Magn Reson Imaging | Phagocytic function of Kupffer cells in mouse nonalcoholic fatty liver disease models: Evaluation with superparamagnetic iron oxide. | 2014 | Details |
| A22007 | 24895809 | Hepatogastroenterology | Expression of intestinal tight junction proteins in patients with non-alcoholic fatty liver disease. | 2014 | Details |
| A22023 | 24870301 | Korean J Gastroenterol | [Clinical features of non-alcoholic fatty liver disease in cryptogenic hepatocellular carcinoma]. | 2014 | Details |
| A22032 | 24864249 | Biomed Res Int | Endocannabinoid receptors gene expression in morbidly obese women with nonalcoholic fatty liver disease. | 2014 | Details |
| A22037 | 24858947 | PLoS One | The hepatoselective glucokinase activator PF-04991532 ameliorates hyperglycemia without causing hepatic steatosis in diabetic rats. | 2014 | Details |
| A22045 | 24853141 | PLoS One | HCC development is associated to peripheral insulin resistance in a mouse model of NASH. | 2014 | Details |
| A22046 | 24851525 | Trop Gastroenterol | Risk of development of hepatocellular carcinoma in patients with NASH-related cirrhosis. | 2014 | Details |
| A22071 | 24841950 | Obes Surg | The diagnostic accuracy of transient elastography for the diagnosis of liver fibrosis in bariatric surgery candidates with suspected NAFLD. | 2014 | Details |
| A22073 | 24838722 | BMJ Open | Clinical outcomes and resource utilisation in Medicare patients with chronic liver disease: a historical cohort study. | 2014 | Details |
| A22082 | 24830603 | Exp Mol Pathol | Lipidomic analysis of the liver from high-fat diet induced obese mice identifies changes in multiple lipid classes. | 2014 | Details |
| A22098 | 24824077 | J Hepatobiliary Pancreat Sci | Paradoxical impact of the remnant pancreatic volume and infectious complications on the development of nonalcoholic fatty liver disease after pancreaticoduodenectomy. | 2014 | Details |
| A22101 | 24821109 | Biochem Pharmacol | Cyanidin-3-O-β-glucoside protects primary mouse hepatocytes against high glucose-induced apoptosis by modulating mitochondrial dysfunction and the PI3K/Akt pathway. | 2014 | Details |
| A22115 | 24806753 | Hepatology | FAM3A activates PI3K p110α/Akt signaling to ameliorate hepatic gluconeogenesis and lipogenesis. | 2014 | Details |
| A22123 | 24799987 | World J Hepatol | Effects of resveratrol in experimental and clinical non-alcoholic fatty liver disease. | 2014 | Details |
| A22125 | 24799031 | Clin Imaging | Is diffusion-weighted imaging a significant indicator of the development of vascularization in hypovascular hepatocellular lesions? | 2014 | Details |
| A22126 | 24798049 | Liver Int | The combination of liver stiffness measurement and NAFLD fibrosis score improves the noninvasive diagnostic accuracy for severe liver fibrosis in patients with nonalcoholic fatty liver disease. | 2014 | Details |
| A22132 | 24796231 | Hepatol Res | Pilot study of liraglutide effects in non-alcoholic steatohepatitis and non-alcoholic fatty liver disease with glucose intolerance in Japanese patients (LEAN-J). | 2014 | Details |