Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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PPAR2265 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A46963 | 32206109 | Theranostics | NIK links inflammation to hepatic steatosis by suppressing PPARα in alcoholic liver disease. | 2020 | Details |
| A46975 | 31612718 | J Proteome Res | Proteomic Investigations of Transcription Factors Critical in Geniposide-Mediated Suppression of Alcoholic Steatosis and in Overdose-Induced Hepatotoxicity on Liver in Rats. | 2019 | Details |
| A46980 | 31463983 | Lipids | Vitamin D Deficiency Attenuates Acute Alcohol-Induced Hepatic Lipid Accumulation in Mice. | 2019 | Details |
| A46997 | 30803859 | Dig Liver Dis | FXR deficiency alters bile acid pool composition and exacerbates chronic alcohol induced liver injury. | 2019 | Details |
| A47010 | 30150688 | Sci Rep | Ethanol and C2 ceramide activate fatty acid oxidation in human hepatoma cells. | 2018 | Details |
| A47031 | 28882574 | Toxicology | Kupffer cells activation promoted binge drinking-induced fatty liver by activating lipolysis in white adipose tissues. | 2017 | Details |
| A47035 | 28689299 | J Mol Med (Berl) | 4-O'-methylhonokiol protects from alcohol/carbon tetrachloride-induced liver injury in mice. | 2017 | Details |
| A47050 | 27861855 | Int J Cancer | Effect of statin on hepatocellular carcinoma in patients with type 2 diabetes: A nationwide nested case-control study. | 2016 | Details |
| A47051 | 27837167 | Toxicol Sci | Nrf2 Activation Is Required for Ligustrazine to Inhibit Hepatic Steatosis in Alcohol-Preferring Mice and Hepatocytes. | 2016 | Details |
| A47061 | 27404390 | Sci Rep | Suppression of PPARγ-mediated monoacylglycerol O-acyltransferase 1 expression ameliorates alcoholic hepatic steatosis. | 2016 | Details |
| A47067 | 27044810 | Biomed Pharmacother | Diallyl trisulfide attenuates ethanol-induced hepatic steatosis by inhibiting oxidative stress and apoptosis. | 2016 | Details |
| A47068 | 26968209 | Am J Physiol Gastrointest Liver Physiol | Enhanced ethanol catabolism in orphan nuclear receptor SHP-null mice. | 2016 | Details |
| A47073 | 26854922 | Food Chem Toxicol | Ethanol and fatty acids impair lipid homeostasis in an in vitro model of hepatic steatosis. | 2016 | Details |
| A47077 | 26637972 | Biofactors | Endogenously elevated n-3 polyunsaturated fatty acids alleviate acute ethanol-induced liver steatosis. | 2015 | Details |
| A47093 | 26099526 | Gastroenterology | Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans. | 2015 | Details |
| A47118 | 25622859 | J Nutr Biochem | Enhanced AMPK phosphorylation contributes to the beneficial effects of Lactobacillus rhamnosus GG supernatant on chronic-alcohol-induced fatty liver disease. | 2014 | Details |
| A47120 | 25592162 | Arch Biochem Biophys | Dietary tomato powder inhibits alcohol-induced hepatic injury by suppressing cytochrome p450 2E1 induction in rodent models. | 2015 | Details |
| A47122 | 25561792 | World J Gastroenterol | Delayed ethanol elimination and enhanced susceptibility to ethanol-induced hepatosteatosis after liver resection. | 2014 | Details |
| A47131 | 25409421 | J Phys Chem B | Kinetics and thermodynamics of 1-hydroxyethyl radical reaction with unsaturated lipids and prenylflavonoids. | 2014 | Details |
| A47139 | 25228362 | Pharmacology | Emodin ameliorates ethanol-induced fatty liver injury in mice. | 2014 | Details |
| A47147 | 24859453 | J Hepatol | Inhibition of heat shock protein 90 alleviates steatosis and macrophage activation in murine alcoholic liver injury. | 2014 | Details |
| A47154 | 24797033 | Alcohol Clin Exp Res | Involvement of insulin resistance in the protective effect of metformin against alcoholic liver injury. | 2014 | Details |
| A47158 | 24730561 | Alcohol Clin Exp Res | Methylation and gene expression responses to ethanol feeding and betaine supplementation in the cystathionine beta synthase-deficient mouse. | 2014 | Details |
| A47164 | 24513924 | Food Funct | Polyphenol-rich extract of Nelumbo nucifera leaves inhibits alcohol-induced steatohepatitis via reducing hepatic lipid accumulation and anti-inflammation in C57BL/6J mice. | 2014 | Details |
| A47165 | 24456360 | J Med Food | Schisandra chinensis prevents alcohol-induced fatty liver disease in rats. | 2014 | Details |
| A47168 | 24396389 | Clin Dev Immunol | Anti-IL-17 antibody improves hepatic steatosis by suppressing interleukin-17-related fatty acid synthesis and metabolism. | 2013 | Details |
| A47170 | 24269941 | Cell Signal | β-Lapachone alleviates alcoholic fatty liver disease in rats. | 2013 | Details |
| A47191 | 23682678 | Liver Int | Circulating MicroRNAs as potential biomarkers for alcoholic steatohepatitis. | 2013 | Details |
| A47199 | 23206305 | Zhonghua Gan Zang Bing Za Zhi | [Changes in the intestinal microenvironment during development of alcoholic fatty liver disease and related effects of probiotic therapy]. | 2012 | Details |
| A47204 | 22988930 | J Gastroenterol Hepatol | Chronic alcohol-induced hepatic insulin resistance and endoplasmic reticulum stress ameliorated by peroxisome-proliferator activated receptor-δ agonist treatment. | 2013 | Details |
| A47206 | 22905112 | PLoS One | Reduced susceptibility of DNA methyltransferase 1 hypomorphic (Dnmt1N/+) mice to hepatic steatosis upon feeding liquid alcohol diet. | 2012 | Details |
| A47209 | 22841822 | Am J Pathol | Leptin deficiency contributes to the pathogenesis of alcoholic fatty liver disease in mice. | 2012 | Details |
| A47228 | 22208561 | Lipids Health Dis | Activation of peroxisome proliferator activated receptor alpha ameliorates ethanol induced steatohepatitis in mice. | 2011 | Details |
| A47242 | 21673994 | PLoS One | Catechin suppresses an array of signalling molecules and modulates alcohol-induced endotoxin mediated liver injury in a rat model. | 2011 | Details |
| A47256 | 21087523 | J Transl Med | Exploring the molecular mechanisms underlying the potentiation of exogenous growth hormone on alcohol-induced fatty liver diseases in mice. | 2010 | Details |
| A47265 | 20042322 | Phytomedicine | Osthol regulates hepatic PPAR alpha-mediated lipogenic gene expression in alcoholic fatty liver murine. | 2009 | Details |
| A47274 | 19637192 | Hepatology | Zinc supplementation reverses alcohol-induced steatosis in mice through reactivating hepatocyte nuclear factor-4alpha and peroxisome proliferator-activated receptor-alpha. | 2009 | Details |
| A47276 | 19606259 | J Biomed Biotechnol | Curcumin decreased oxidative stress, inhibited NF-kappaB activation, and improved liver pathology in ethanol-induced liver injury in rats. | 2009 | Details |
| A47277 | 19588123 | Arch Toxicol | Ethanol and liver: recent advances in the mechanisms of ethanol-induced hepatosteatosis. | 2009 | Details |
| A47293 | 18693172 | Hepatobiliary Pancreat Dis Int | Epidemiology of fatty liver in an islander population of China: a population-based case-control study. | 2008 | Details |
| A47306 | 18337117 | Cytokine | Evaluation of the transforming growth factor beta1 codon 25 (Arg-->Pro) polymorphism in alcoholic liver disease. | 2008 | Details |
| A47327 | 16958658 | J Gastroenterol Hepatol | Anti-adipogenic regulation underlies hepatic stellate cell transdifferentiation. | 2006 | Details |
| A47362 | 12512042 | Gastroenterology | Peroxisome proliferator-activated receptor-beta signaling contributes to enhanced proliferation of hepatic stellate cells. | 2003 | Details |
| A47437 | 8176892 | Lab Invest | Covalent protein adducts in the liver as a result of ethanol metabolism and lipid peroxidation. | 1994 | Details |
| A47439 | 8119681 | Hepatology | "Inapparent" hepatitis B virus infection and hepatitis C virus replication in alcoholic subjects with and without liver disease. | 1994 | Details |
| A47448 | 8286481 | Minerva Gastroenterol Dietol | [Changes in lipoglycoprotein metabolism in toxic fatty liver]. | 1993 | Details |
| A47483 | 2295475 | Hepatology | The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years. | 1990 | Details |
| A47523 | 3023474 | J Clin Gastroenterol | Alcoholic liver disease in Japan. | 1986 | Details |
| A47556 | 6378350 | Can Med Assoc J | Invasive aspergillosis in a "healthy" patient. | 1984 | Details |
| A47571 | 6143671 | Eur J Clin Pharmacol | Assessment of drug metabolism in hepatic disease: comparison of plasma kinetics of oral cyclobarbital and the intravenous aminopyrine breath test. | 1984 | Details |
| A47580 | 6688340 | Arch Pathol Lab Med | The role of the Ito cell in perivenular and intralobular fibrosis in alcoholic hepatitis. | 1983 | Details |
| A47595 | 6634852 | Pharmacol Biochem Behav | Low Km ALDH isozyme and alcoholic liver injury. | 1983 | Details |
| A47601 | 35235191 | Clin Pharmacokinet | Population Pharmacokinetics of Cotadutide in Subjects with Type 2 Diabetes. | 2022 | Details |
| A47654 | 34192554 | Toxicol Lett | NFATc4 mediates ethanol-triggered hepatocyte senescence. | 2021 | Details |
| A47746 | 32597707 | Am J Physiol Gastrointest Liver Physiol | Obeticholic acid improves fetal bile acid profile in a mouse model of gestational hypercholanemia. | 2020 | Details |
| A47783 | 31988864 | Euroasian J Hepatogastroenterol | Hepatocellular Carcinoma in Asia: A Challenging Situation. | 2020 | Details |
| A47904 | 29607946 | Intern Med | Clinical Characteristics, Phenotype of Lipodystrophy and a Genetic Analysis of Six Diabetic Japanese Women with Familial Partial Lipodystrophy in a Diabetic Outpatient Clinic. | 2018 | Details |
| A47918 | 29404444 | Hepatol Commun | Hairy and enhancer of split 6 prevents hepatic lipid accumulation through inhibition of Pparg2 expression. | 2017 | Details |
| A47950 | 28513320 | Cancer Biol Ther | CRISPR/Cas9-based Pten knock-out and Sleeping Beauty Transposon-mediated Nras knock-in induces hepatocellular carcinoma and hepatic lipid accumulation in mice. | 2017 | Details |
| A47957 | 28236037 | Inflammopharmacology | PPARα/γ antagonists reverse the ameliorative effects of osthole on hepatic lipid metabolism and inflammatory response in steatohepatitic rats. | 2017 | Details |
| A47960 | 28098353 | J Cell Physiol | The role of various peroxisome proliferator-activated receptors and their ligands in clinical practice. | 2017 | Details |
| A48006 | 26781175 | Mol Med Rep | TLR4‑dependent signaling pathway modulation: A novel mechanism by which pioglitazone protects against nutritional fibrotic steatohepatitis in mice. | 2016 | Details |
| A48088 | 24445078 | J Nutr Biochem | Sesame oil attenuates nutritional fibrosing steatohepatitis by modulating matrix metalloproteinases-2, 9 and PPAR-γ. | 2013 | Details |
| A48089 | 24424044 | Endocrinology | Liver-enriched transcription factor CREBH interacts with peroxisome proliferator-activated receptor α to regulate metabolic hormone FGF21. | 2014 | Details |
| A48117 | 22699820 | Cell Mol Life Sci | Peroxisome proliferator-activated receptor-γ as a therapeutic target for hepatic fibrosis: from bench to bedside. | 2012 | Details |
| A48176 | 20660066 | Endocrinology | Curcumin protects hepatic stellate cells against leptin-induced activation in vitro by accumulating intracellular lipids. | 2010 | Details |
| A48205 | 19808779 | Endocrinology | Curcumin inhibits srebp-2 expression in activated hepatic stellate cells in vitro by reducing the activity of specificity protein-1. | 2009 | Details |
| A48238 | 19013165 | Gastroenterology | Rosiglitazone for nonalcoholic steatohepatitis. | 2008 | Details |
| A48276 | 17661403 | Hepatology | Divergent effects of peroxisome proliferator-activated receptor-gamma ligands in human and mouse nonalcoholic steatohepatitis. | 2007 | Details |
| A48297 | 17038787 | Nihon Yakurigaku Zasshi | [PPAR gamma ligand pioglitazone as a therapeutic strategy in nonalcoholic steatohepatitis (NASH)]. | 2006 | Details |
| A48326 | 16494792 | Zhonghua Gan Zang Bing Za Zhi | [Role of peroxisome proliferator activated receptor alpha in the pathogenesis of nonalcoholic steatohepatitis]. | 2006 | Details |
| A48363 | 15199412 | J Clin Invest | Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. | 2004 | Details |
| A48392 | 12663460 | Diabetes | Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-gamma. | 2003 | Details |
| A48411 | 12099000 | Nihon Shokakibyo Gakkai Zasshi | [Mechanism of the onset and development of nonalcoholic steatohepatitis and PPAR]. | 2002 | Details |
| A48412 | 12073774 | In Vivo | Prevention/reversal of choline deficiency-induced steatohepatitis by a peroxisome proliferator-activated receptor alpha ligand in rats. | 2003 | Details |
| A48421 | 11705737 | Am J Physiol Gastrointest Liver Physiol | Nonalcoholic steatosis and steatohepatitis. III. Peroxisomal beta-oxidation, PPAR alpha, and steatohepatitis. | 2001 | Details |
| A48433 | 11110619 | Can J Gastroenterol | Iron and liver diseases. | 2000 | Details |
| A48439 | 10945719 | Curr Opin Lipidol | Serum triglycerides, the liver and the pancreas. | 2000 | Details |
| A48471 | 7489979 | Hepatology | The natural history of nonalcoholic fatty liver: a follow-up study. | 1995 | Details |
| A48482 | 2227807 | Hepatology | Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors. | 1990 | Details |
| A48525 | 34846697 | Drugs | Chiglitazar: First Approval. | 2022 | Details |
| A48539 | 34483915 | Front Pharmacol | Anti-Adipogenic Effect of Alchemilla monticola is Mediated Via PI3K/AKT Signaling Inhibition in Human Adipocytes. | 2021 | Details |
| A48567 | 33917706 | Pharmaceutics | Effect of Curcumin Nanoemulsions Stabilized with MAG and DAG-MCFAs in a Fructose-Induced Hepatic Steatosis Rat Model. | 2021 | Details |
| A48618 | 32903449 | Front Pharmacol | Therapeutic Efficacy of Antioxidants in Ameliorating Obesity Phenotype and Associated Comorbidities. | 2020 | Details |
| A48625 | 32760397 | Front Immunol | Alox12/15 Deficiency Exacerbates, While Lipoxin A4 Ameliorates Hepatic Inflammation in Murine Alcoholic Hepatitis. | 2020 | Details |
| A48639 | 32592089 | J Physiol Biochem | Lactosylceramide induced by elastin-derived peptides decreases adipocyte differentiation. | 2020 | Details |
| A48656 | 32195457 | JHEP Rep | miR-22 inhibition reduces hepatic steatosis via FGF21 and FGFR1 induction. | 2020 | Details |
| A48710 | 31000363 | J Hepatol | Clinical utility of genomic analysis in adults with idiopathic liver disease. | 2019 | Details |
| A48725 | 30602573 | Clin Sci (Lond) | Elafibranor interrupts adipose dysfunction-mediated gut and liver injury in mice with alcoholic steatohepatitis. | 2019 | Details |
| A48736 | 30305645 | Sci Rep | Hesperidin and capsaicin, but not the combination, prevent hepatic steatosis and other metabolic syndrome-related alterations in western diet-fed rats. | 2018 | Details |
| A48778 | 28990365 | J Cell Mol Med | Endocannabinoid-related compounds in gastrointestinal diseases. | 2017 | Details |
| A48817 | 27709831 | J Cell Mol Med | GATA binding protein 3 is correlated with leptin regulation of PPARγ1 in hepatic stellate cells. | 2016 | Details |
| A48871 | 25954479 | World J Hepatol | Control of oxidative stress in hepatocellular carcinoma: Helpful or harmful? | 2015 | Details |
| A48880 | 25800177 | Pancreatology | Metabolic reprogramming and cell fate regulation in alcoholic liver disease. | 2015 | Details |
| A48891 | 25463480 | Biochim Biophys Acta | Decreased lipogenesis in white adipose tissue contributes to the resistance to high fat diet-induced obesity in phosphatidylethanolamine N-methyltransferase-deficient mice. | 2014 | Details |
| A48899 | 25230385 | Rozhl Chir | Bariatric metabolic surgery. | 2014 | Details |
| A48901 | 25103596 | Acta Clin Belg | The value of liver and spleen ADC measurements in the diagnosis and follow up of hepatic fibrosis in chronic liver disease. | 2014 | Details |
| A48902 | 25086218 | Biochim Biophys Acta | Lipocalin-2 (LCN2) regulates PLIN5 expression and intracellular lipid droplet formation in the liver. | 2014 | Details |
| A48910 | 24804175 | Liver Cancer | Hepatic iron overload and hepatocellular carcinoma. | 2014 | Details |
| A48919 | 24489787 | PLoS One | Model steatogenic compounds (amiodarone, valproic acid, and tetracycline) alter lipid metabolism by different mechanisms in mouse liver slices. | 2014 | Details |