Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Lipid metabolism4743 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A14742 | 29263118 | Physiol Rep | In vitro cellular models of human hepatic fatty acid metabolism: differences between Huh7 and HepG2 cell lines in human and fetal bovine culturing serum. | 2017 | Details |
| A14743 | 29262266 | Appl Physiol Nutr Metab | Effect of a short-term physical activity intervention on liver fat content in obese children. | 2017 | Details |
| A14748 | 29258109 | Cell Physiol Biochem | Multiple MicroRNAs Ameliorate Hepatocyte Steatosis and Injury by Suppressing FABP1 Expression. | 2017 | Details |
| A14751 | 29255346 | Drug Des Devel Ther | Hepatoprotective effect of calculus bovis sativus on nonalcoholic fatty liver disease in mice by inhibiting oxidative stress and apoptosis of hepatocytes. | 2017 | Details |
| A14762 | 29249532 | Clin Nutr | Omega-3 PUFA modulate lipogenesis, ER stress, and mitochondrial dysfunction markers in NASH - Proteomic and lipidomic insight. | 2017 | Details |
| A14789 | 29232562 | Atherosclerosis | TM6SF2: A novel target for plasma lipid regulation. | 2017 | Details |
| A14805 | 29224098 | Adv Exp Med Biol | Role of Estrogens in the Regulation of Liver Lipid Metabolism. | 2017 | Details |
| A14816 | 29222051 | Biochem Biophys Res Commun | Long-term fermented soybean paste improves metabolic parameters associated with non-alcoholic fatty liver disease and insulin resistance in high-fat diet-induced obese mice. | 2017 | Details |
| A14818 | 29221790 | Metabolism | FAM3 gene family: A promising therapeutical target for NAFLD and type 2 diabetes. | 2017 | Details |
| A14820 | 29220698 | Redox Biol | Synergistic interaction of fatty acids and oxysterols impairs mitochondrial function and limits liver adaptation during nafld progression. | 2017 | Details |
| A14824 | 29217477 | Biochim Biophys Acta Mol Cell Biol Lipids | Activation of hepatic Nogo-B receptor expression-A new anti-liver steatosis mechanism of statins. | 2017 | Details |
| A14827 | 29216278 | PLoS One | Systematic integrative analysis of gene expression identifies HNF4A as the central gene in pathogenesis of non-alcoholic steatohepatitis. | 2017 | Details |
| A14834 | 29212576 | Gene Expr | The Effects of Physical Exercise on Fatty Liver Disease. | 2017 | Details |
| A14842 | 29209111 | World J Gastroenterol | Palmitate induces fat accumulation by activating C/EBPβ-mediated G0S2 expression in HepG2 cells. | 2017 | Details |
| A14845 | 29207650 | Oncotarget | Upregulation of miR-181a impairs hepatic glucose and lipid homeostasis. | 2017 | Details |
| A14852 | 29203511 | Diabetes | Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling. | 2017 | Details |
| A14861 | 29201200 | Exp Ther Med | Effect of a stilbene glycoside-rich extract from Polygoni Multiflori Radix on experimental non-alcoholic fatty liver disease based on principal component and orthogonal partial least squares discriminant analysis. | 2017 | Details |
| A14864 | 29201040 | PPAR Res | Caffeoylquinic Acid-Rich Extract of Aster glehni F. Schmidt Ameliorates Nonalcoholic Fatty Liver through the Regulation of PPARδ and Adiponectin in ApoE KO Mice. | 2017 | Details |
| A14866 | 29199584 | Int J Med Mushrooms | Anti-Inflammation and Lipogenic Inhibition of Taiwanofungus salmonea Mycelium and Grifola frondosa Fruiting Body. | 2017 | Details |
| A14870 | 29197664 | Biochim Biophys Acta Mol Basis Dis | Emerging metabolic risk factors in hepatocellular carcinoma and their influence on the liver microenvironment. | 2017 | Details |
| A14871 | 29197627 | Int J Biochem Cell Biol | MiR-34a regulates mitochondrial content and fat ectopic deposition induced by resistin through the AMPK/PPARα pathway in HepG2 cells. | 2017 | Details |
| A14875 | 29197188 | FEBS J | Genipin alleviates high-fat diet-induced hyperlipidemia and hepatic lipid accumulation in mice via miR-142a-5p/SREBP-1c axis. | 2017 | Details |
| A14896 | 29187142 | BMC Gastroenterol | Gut microbiota-mediated generation of saturated fatty acids elicits inflammation in the liver in murine high-fat diet-induced steatohepatitis. | 2017 | Details |
| A14902 | 29182572 | Int J Mol Sci | Aberrant Lipid Metabolism in Hepatocellular Carcinoma Revealed by Liver Lipidomics. | 2017 | Details |
| A14905 | 29180630 | Sci Rep | ATF4 overexpression induces early onset of hyperlipidaemia and hepatic steatosis and enhances adipogenesis in zebrafish. | 2017 | Details |
| A14912 | 29175671 | J Nutr Biochem | Dietary omega-3 and omega-6 polyunsaturated fatty acids modulate hepatic pathology. | 2017 | Details |
| A14913 | 29175669 | J Nutr Biochem | Euterpe oleracea Mart. (açaí) seed extract associated with exercise training reduces hepatic steatosis in type 2 diabetic male rats. | 2017 | Details |
| A14917 | 29175182 | Food Chem Toxicol | Impact of diesel exhaust exposure on the liver of mice fed on omega-3 polyunsaturated fatty acids-deficient diet. | 2017 | Details |
| A14920 | 29174039 | Biomed Pharmacother | Lavatera critica, a green leafy vegetable, controls high fat diet induced hepatic lipid accumulation and oxidative stress through the regulation of lipogenesis and lipolysis genes. | 2017 | Details |
| A14921 | 29173646 | Nutr Res | Schisandra chinensis berry extract protects against steatosis by inhibiting histone acetylation in oleic acid-treated HepG2 cells and in the livers of diet-induced obese mice. | 2017 | Details |
| A14922 | 29172017 | Med Sci Monit | Scutellarin Prevents Nonalcoholic Fatty Liver Disease (NAFLD) and Hyperlipidemia via PI3K/AKT-Dependent Activation of Nuclear Factor (Erythroid-Derived 2)-Like 2 (Nrf2) in Rats. | 2017 | Details |
| A14923 | 29171472 | Ter Arkh | [CYP7A1 gene polymorphism and the characteristics of dyslipidemias in patients with nonalcoholic fatty liver disease concurrent with hypothyroidism]. | 2018 | Details |
| A14925 | 29170905 | Endocrine | Irisin in metabolic diseases. | 2017 | Details |
| A14950 | 29159325 | Hepatol Commun | Role of Aramchol in steatohepatitis and fibrosis in mice. | 2017 | Details |
| A14952 | 29158770 | Nutr Metab (Lond) | Does the enterolactone (ENL) affect fatty acid transporters and lipid metabolism in liver? | 2017 | Details |
| A14956 | 29158052 | Life Sci | Baicalin attenuates non-alcoholic steatohepatitis by suppressing key regulators of lipid metabolism, inflammation and fibrosis in mice. | 2017 | Details |
| A14957 | 29156529 | Biomed Pharmacother | Alpinetin improved high fat diet-induced non-alcoholic fatty liver disease (NAFLD) through improving oxidative stress, inflammatory response and lipid metabolism. | 2017 | Details |
| A14958 | 29156528 | Biomed Pharmacother | Actein ameliorates hepatic steatosis and fibrosis in high fat diet-induced NAFLD by regulation of insulin and leptin resistant. | 2017 | Details |
| A14963 | 29154964 | J Hepatol | Lipotoxicity and the gut-liver axis in NASH pathogenesis. | 2017 | Details |
| A14989 | 29137289 | Oncotarget | Lingguizhugan decoction improves non-alcoholic fatty liver disease by altering insulin resistance and lipid metabolism related genes: a whole trancriptome study by RNA-Seq. | 2017 | Details |
| A14995 | 29132235 | SLAS Discov | A Cell-Based Assay to Investigate Hypolipidemic Effects of Nonalcoholic Fatty Liver Disease Therapeutics. | 2017 | Details |
| A14999 | 29129819 | Metabolism | Nicotinic acetylcholine receptor α7 subunit improves energy homeostasis and inhibits inflammation in nonalcoholic fatty liver disease. | 2017 | Details |
| A15000 | 29129237 | Nutrition | Iron-induced pro-oxidant and pro-lipogenic responses in relation to impaired synthesis and accretion of long-chain polyunsaturated fatty acids in rat hepatic and extrahepatic tissues. | 2017 | Details |
| A15003 | 29128353 | Biochem Biophys Res Commun | Pyruvate dehydrogenase kinase 4 mediates lipogenesis and contributes to the pathogenesis of nonalcoholic steatohepatitis. | 2017 | Details |
| A15004 | 29128158 | Trends Endocrinol Metab | Mitogen-Activated Protein Kinase Regulation in Hepatic Metabolism. | 2017 | Details |
| A15010 | 29128059 | Clin Liver Dis | Pathophysiology of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis. | 2017 | Details |
| A15026 | 29125712 | Liver Transpl | Lipid metabolism and functional assessment of discarded human livers with steatosis undergoing 24 hours of normothermic machine perfusion. | 2018 | Details |
| A15052 | 29118014 | Am J Physiol Endocrinol Metab | Exercise training reduces intrahepatic lipid content in people with and people without nonalcoholic fatty liver. | 2017 | Details |
| A15079 | 29106945 | Metabolism | Activation of the STING-IRF3 pathway promotes hepatocyte inflammation, apoptosis and induces metabolic disorders in nonalcoholic fatty liver disease. | 2017 | Details |
| A15084 | 29104641 | Exp Ther Med | Targeting Sirt1 in a rat model of high-fat diet-induced non-alcoholic fatty liver disease: Comparison of Gegen Qinlian decoction and resveratrol. | 2017 | Details |
| A15091 | 29101357 | Sci Rep | MicroRNA-27a regulates hepatic lipid metabolism and alleviates NAFLD via repressing FAS and SCD1. | 2017 | Details |
| A15104 | 29092796 | Mol Metab | AMPK activation caused by reduced liver lactate metabolism protects against hepatic steatosis in MCT1 haploinsufficient mice. | 2017 | Details |
| A15114 | 29088779 | Oncotarget | The additive effects of the TM6SF2 E167K and PNPLA3 I148M polymorphisms on lipid metabolism. | 2017 | Details |
| A15135 | 29080343 | Ann Hepatol | Bile Acids in Nonalcoholic Fatty Liver Disease: New Concepts and therapeutic advances. | 2017 | Details |
| A15140 | 29077272 | J Cell Mol Med | Inhibition of MD2-dependent inflammation attenuates the progression of non-alcoholic fatty liver disease. | 2017 | Details |
| A15145 | 29074727 | Gut | Liver Reptin/RUVBL2 controls glucose and lipid metabolism with opposite actions on mTORC1 and mTORC2 signalling. | 2017 | Details |
| A15151 | 29073114 | Proc Natl Acad Sci U S A | Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms. | 2017 | Details |
| A15153 | 29072704 | Cell Death Dis | Inhibition of Caspase-8 does not protect from alcohol-induced liver apoptosis but alleviates alcoholic hepatic steatosis in mice. | 2017 | Details |
| A15163 | 29066462 | Am J Physiol Endocrinol Metab | Genetic ablation of Cyp8b1 preserves host metabolic function by repressing steatohepatitis and altering gut microbiota composition. | 2017 | Details |
| A15167 | 29065507 | Nutrients | Fatty Acids Consumption: The Role Metabolic Aspects Involved in Obesity and Its Associated Disorders. | 2017 | Details |
| A15170 | 29065180 | PLoS One | Hepcidin in morbidly obese women with non-alcoholic fatty liver disease. | 2017 | Details |
| A15181 | 29059699 | Hepatol Res | Identification of the genomic region under epigenetic regulation during non-alcoholic fatty liver disease progression. | 2017 | Details |
| A15186 | 29057834 | Nutrients | Non-Alcoholic Fatty Liver Disease and Nutritional Implications: Special Focus on Copper. | 2017 | Details |
| A15189 | 29056532 | Mol Cell Endocrinol | LAMP3 regulates hepatic lipid metabolism through activating PI3K/Akt pathway. | 2017 | Details |
| A15197 | 29055919 | Ann Hepatol | The Expression of PNPLA3 Polymorphism could be the Key for Severe Liver Disease in NAFLD in Hispanic Population. | 2018 | Details |
| A15207 | 29049355 | PLoS One | Aberrant hepatic lipid storage and metabolism in canine portosystemic shunts. | 2017 | Details |
| A15215 | 29042644 | Sci Rep | HIV-1 viral protein R (Vpr) induces fatty liver in mice via LXRα and PPARα dysregulation: implications for HIV-specific pathogenesis of NAFLD. | 2017 | Details |
| A15232 | 29031784 | J Ethnopharmacol | Isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomics for the investigation of the effect of Hugan Qingzhi on non-alcoholic fatty liver disease in rats. | 2017 | Details |
| A15235 | 29031242 | J Nutr Biochem | Dietary creatine supplementation lowers hepatic triacylglycerol by increasing lipoprotein secretion in rats fed high-fat diet. | 2017 | Details |
| A15237 | 29028831 | PLoS One | Short-term vitamin E treatment impairs reactive oxygen species signaling required for adipose tissue expansion, resulting in fatty liver and insulin resistance in obese mice. | 2017 | Details |
| A15247 | 29024899 | Biomed Pharmacother | Mangiferin ameliorates fatty liver via modulation of autophagy and inflammation in high-fat-diet induced mice. | 2017 | Details |
| A15260 | 29018509 | Oxid Med Cell Longev | circRNA_0046367 Prevents Hepatoxicity of Lipid Peroxidation: An Inhibitory Role against Hepatic Steatosis. | 2017 | Details |
| A15272 | 28991837 | J Pediatr Gastroenterol Nutr | Serum Osteocalcin Levels in Children With Nonalcoholic Fatty Liver Disease. | 2018 | Details |
| A15293 | 28982243 | J Agric Food Chem | Solanum nigrum Polyphenol Extracts Inhibit Hepatic Inflammation, Oxidative Stress, and Lipogenesis in High-Fat-Diet-Treated Mice. | 2017 | Details |
| A15312 | 28971098 | Front Nutr | The Nutraceutic Silybin Counteracts Excess Lipid Accumulation and Ongoing Oxidative Stress in an In Vitro Model of Non-Alcoholic Fatty Liver Disease Progression. | 2017 | Details |
| A15328 | 28965030 | J Nutr Biochem | Baked corn (Zea mays L.) and bean (Phaseolus vulgaris L.) snack consumption lowered serum lipids and differentiated liver gene expression in C57BL/6 mice fed a high-fat diet by inhibiting PPARγ and SREBF2. | 2017 | Details |
| A15343 | 28955746 | Biochem Biophys Rep | Scaffold-free 3D bio-printed human liver tissue stably maintains metabolic functions useful for drug discovery. | 2017 | Details |
| A15346 | 28954437 | Nutrients | Isocaloric Dietary Changes and Non-Alcoholic Fatty Liver Disease in High Cardiometabolic Risk Individuals. | 2017 | Details |
| A15347 | 28953935 | PLoS One | Association of MTTP gene variants with pediatric NAFLD: A candidate-gene-based analysis of single nucleotide variations in obese children. | 2017 | Details |
| A15350 | 28953222 | Nutrients | Animal Models of Nonalcoholic Fatty Liver Disease-A Starter's Guide. | 2017 | Details |
| A15359 | 28947639 | J Investig Med | Influence of dietary macronutrients on liver fat accumulation and metabolism. | 2017 | Details |
| A15361 | 28946547 | Cancer Biomark | Pioglitazone suppresses inflammation and fibrosis in nonalcoholic fatty liver disease by down-regulating PDGF and TIMP-2: Evidence from in vitro study. | 2017 | Details |
| A15363 | 28945101 | DNA Cell Biol | Implications of Sortilin in Lipid Metabolism and Lipid Disorder Diseases. | 2017 | Details |
| A15368 | 28942436 | Horm Mol Biol Clin Investig | The color of fat and its central role in the development and progression of metabolic diseases. | 2017 | Details |
| A15369 | 28942246 | Free Radic Biol Med | Inhibition of hepatocyte nuclear factor 1b induces hepatic steatosis through DPP4/NOX1-mediated regulation of superoxide. | 2017 | Details |
| A15374 | 28940752 | Mol Nutr Food Res | Supplementation with Docosahexaenoic Acid and Extra Virgin Olive Oil Prevents Liver Steatosis Induced by a High-Fat Diet in Mice through PPAR-α and Nrf2 Upregulation with Concomitant SREBP-1c and NF-kB Downregulation. | 2017 | Details |
| A15375 | 28940700 | Hepatology | Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis. | 2018 | Details |
| A15386 | 28935446 | Mitochondrion | Mitochondrial adaptation in steatotic mice. | 2017 | Details |
| A15392 | 28932253 | Evid Based Complement Alternat Med | Yinchen Linggui Zhugan Decoction Ameliorates Nonalcoholic Fatty Liver Disease in Rats by Regulating the Nrf2/ARE Signaling Pathway. | 2017 | Details |
| A15395 | 28931802 | Med Sci Monit | Hepatitis C Virus Infection Increases c-Jun N-Terminal Kinase (JNK) Phosphorylation and Accentuates Hepatocyte Lipoapoptosis. | 2017 | Details |
| A15403 | 28928235 | Am J Physiol Endocrinol Metab | Testosterone protects high-fat/low-carbohydrate diet-induced nonalcoholic fatty liver disease in castrated male rats mainly via modulating endoplasmic reticulum stress. | 2017 | Details |
| A15419 | 28922680 | Horm Metab Res | Pivotal Role of TNF-α in the Development and Progression of Nonalcoholic Fatty Liver Disease in a Murine Model. | 2017 | Details |
| A15428 | 28918598 | J Bioenerg Biomembr | Triacsin C reduces lipid droplet formation and induces mitochondrial biogenesis in primary rat hepatocytes. | 2017 | Details |
| A15443 | 28904866 | FEBS Open Bio | IMM-H007, a new therapeutic candidate for nonalcoholic fatty liver disease, improves hepatic steatosis in hamsters fed a high-fat diet. | 2017 | Details |
| A15454 | 28899857 | Am J Physiol Endocrinol Metab | High-fat, high-fructose, high-cholesterol feeding causes severe NASH and cecal microbiota dysbiosis in juvenile Ossabaw swine. | 2017 | Details |
| A15455 | 28899784 | Biochem Biophys Res Commun | MiR-181b regulates steatosis in nonalcoholic fatty liver disease via targeting SIRT1. | 2017 | Details |
| A15463 | 28895119 | FEBS Lett | FXR controls CHOP expression in steatohepatitis. | 2017 | Details |
| A15475 | 28887301 | J Biol Chem | The phospholipase PNPLA7 functions as a lysophosphatidylcholine hydrolase and interacts with lipid droplets through its catalytic domain. | 2017 | Details |
| A15477 | 28886741 | BMC Complement Altern Med | Taurine and tea polyphenols combination ameliorate nonalcoholic steatohepatitis in rats. | 2017 | Details |
| A15478 | 28883965 | Trop Dis Travel Med Vaccines | Hepatic steatosis in HCV-infected persons in the direct-acting antiviral era. | 2016 | Details |