Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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PPAR2265 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A48942 | 23700549 | Adipocyte | Valsartan restores inflammatory response by macrophages in adipose and hepatic tissues of LPS-infused mice. | 2013 | Details |
| A48951 | 23388073 | Lipids Health Dis | Activation of peroxisome proliferator activated receptor alpha ameliorates ethanol mediated liver fibrosis in mice. | 2013 | Details |
| A48964 | 23027617 | Carcinogenesis | Preventive effects of branched-chain amino acid supplementation on the spontaneous development of hepatic preneoplastic lesions in C57BL/KsJ-db/db obese mice. | 2012 | Details |
| A48975 | 22543705 | Acta Pharmacol Sin | Protective effects of tiopronin against high fat diet-induced non-alcoholic steatohepatitis in rats. | 2012 | Details |
| A48978 | 22452372 | Br J Pharmacol | Curcumin ameliorates hepatic fibrosis in type 2 diabetes mellitus - insights into its mechanisms of action. | 2012 | Details |
| A48979 | 22449800 | Lab Invest | Curcumin eliminates the inhibitory effect of advanced glycation end-products (AGEs) on gene expression of AGE receptor-1 in hepatic stellate cells in vitro. | 2012 | Details |
| A48981 | 22412843 | PLoS One | Prolyl isomerase Pin1 regulates mouse embryonic fibroblast differentiation into adipose cells. | 2012 | Details |
| A48983 | 22352842 | Br J Pharmacol | Curcumin inhibits gene expression of receptor for advanced glycation end-products (RAGE) in hepatic stellate cells in vitro by elevating PPARγ activity and attenuating oxidative stress. | 2012 | Details |
| A49017 | 21195127 | Mol Cell Endocrinol | Curcumin diminishes the impacts of hyperglycemia on the activation of hepatic stellate cells by suppressing membrane translocation and gene expression of glucose transporter-2. | 2010 | Details |
| A49027 | 20969493 | Scand J Gastroenterol | Adenovirus-mediated peroxisome proliferator activated receptor gamma overexpression prevents nutritional fibrotic steatohepatitis in mice. | 2010 | Details |
| A49034 | 20658448 | Diagn Interv Radiol | Utility of diffusion-weighted MRI for assessing liver fibrosis in patients with chronic active hepatitis. | 2010 | Details |
| A49037 | 20512524 | Mol Cell Biochem | Differential response of two models of genetically modified mice fed with high fat and cholesterol diets: relationship to the study of non-alcoholic steatohepatitis. | 2010 | Details |
| A49063 | 19594758 | Br J Pharmacol | Curcumin suppresses expression of low-density lipoprotein (LDL) receptor, leading to the inhibition of LDL-induced activation of hepatic stellate cells. | 2009 | Details |
| A49101 | 17644211 | J Hepatol | Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis. | 2007 | Details |
| A49105 | 17510198 | Am J Physiol Gastrointest Liver Physiol | Undernutrition enhances alcohol-induced hepatocyte proliferation in the liver of rats fed via total enteral nutrition. | 2007 | Details |
| A49252 | 35809408 | Comput Biol Med | In silico and in vitro analysis of PPAR - α / γ dual agonists: Comparative evaluation of potential phytochemicals with anti-obesity drug orlistat. | 2022 | Details |
| A49279 | 35803320 | Metabolism | Recent guidelines for non-alcoholic fatty liver disease (NAFLD): Are they already outdated and in need of supplementation? | 2022 | Details |
| A49296 | 35796150 | J Intern Med | Current treatment of non-alcoholic fatty liver disease. | 2022 | Details |
| A49359 | 35779187 | Cell Stress Chaperones | Modulation of endoplasmic reticulum stress via sulforaphane-mediated AMPK upregulation against nonalcoholic fatty liver disease in rats. | 2022 | Details |
| A49368 | 35774609 | Front Pharmacol | Exploring Ganweikang Tablet as a Candidate Drug for NAFLD Through Network Pharmacology Analysis and Experimental Validation. | 2022 | Details |
| A49376 | 35769889 | Diabetes Metab Syndr Obes | Pro-Neurotensin as a Potential Novel Diagnostic Biomarker for Detection of Nonalcoholic Fatty Liver Disease. | 2022 | Details |
| A49378 | 35769097 | Front Bioeng Biotechnol | LncRNA MALAT1 Promotes PPARα/CD36-Mediated Hepatic Lipogenesis in Nonalcoholic Fatty Liver Disease by Modulating miR-206/ARNT Axis. | 2022 | Details |
| A49403 | 35762159 | Curr Opin Clin Nutr Metab Care | Intrahepatic triglyceride content: influence of metabolic and genetics drivers. | 2022 | Details |
| A49405 | 35761655 | Food Res Int | Pueraria lobata starch regulates gut microbiota and alleviates high-fat high-cholesterol diet induced non-alcoholic fatty liver disease in mice. | 2022 | Details |
| A49431 | 35750235 | Metabolism | Higd1a facilitates exercise-mediated alleviation of fatty liver in diet-induced obese mice. | 2022 | Details |
| A49433 | 35750137 | J Hepatol | Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease - novel insights into cellular communication circuits. | 2022 | Details |
| A49434 | 35749236 | J Nat Prod | Xyloketal B Reverses Nutritional Hepatic Steatosis, Steatohepatitis, and Liver Fibrosis through Activation of the PPARα/PGC1α Signaling Pathway. | 2022 | Details |
| A49448 | 35746892 | Diabetes Metab J | Peroxisomal Fitness: A Potential Protective Mechanism of Fenofibrate against High Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice. | 2022 | Details |
| A49451 | 35745260 | Nutrients | Ferulic Acid Prevents Nonalcoholic Fatty Liver Disease by Promoting Fatty Acid Oxidation and Energy Expenditure in C57BL/6 Mice Fed a High-Fat Diet. | 2022 | Details |
| A49455 | 35745142 | Nutrients | Alisol B Alleviates Hepatocyte Lipid Accumulation and Lipotoxicity via Regulating RARα-PPARγ-CD36 Cascade and Attenuates Non-Alcoholic Steatohepatitis in Mice. | 2022 | Details |
| A49471 | 35743232 | Int J Mol Sci | SIRT2 Deficiency Exacerbates Hepatic Steatosis via a Putative Role of the ER Stress Pathway. | 2022 | Details |
| A49472 | 35743193 | Int J Mol Sci | A Transcriptomic Response to Lactiplantibacillus plantarum-KCC48 against High-Fat Diet-Induced Fatty Liver Diseases in Mice. | 2022 | Details |
| A49506 | 35733070 | Mol Biol Rep | Metformin protects against ethanol-induced liver triglyceride accumulation by the LKB1/AMPK/ACC pathway. | 2022 | Details |
| A49524 | 35726797 | Food Funct | Astragalus mongholicus polysaccharides ameliorate hepatic lipid accumulation and inflammation as well as modulate gut microbiota in NAFLD rats. | 2022 | Details |
| A49555 | 35715982 | Liver Transpl | Waitlist and Post-Transplantation Outcomes of Lean Individuals with Non-Alcoholic Fatty Liver Disease. | 2022 | Details |
| A49577 | 35708630 | J Med Food | Nil-Surin Rice Bran Hydrolysates Improve Lipid Metabolism and Hepatic Steatosis by Regulating Secretion of Adipokines and Expression of Lipid-Metabolism Genes. | 2022 | Details |
| A49597 | 35696209 | J Food Drug Anal | Apigenin ameliorates hepatic lipid accumulation by activating the autophagy-mitochondria pathway. | 2021 | Details |
| A49615 | 35691075 | Phytomedicine | Saikosaponin D attenuates metabolic associated fatty liver disease by coordinately tuning PPARα and INSIG/SREBP1c pathway. | 2022 | Details |
| A49643 | 35682720 | Int J Mol Sci | Maternal Pyrroloquinoline Quinone Supplementation Improves Offspring Liver Bioactive Lipid Profiles throughout the Lifespan and Protects against the Development of Adult NAFLD. | 2022 | Details |
| A49683 | 35672152 | Pharm Biol | Camel milk protein hydrosylate alleviates hepatic steatosis and hypertension in high fructose-fed rats. | 2022 | Details |
| A49714 | 35661191 | Aliment Pharmacol Ther | Review article: vascular effects of PPARs in the context of NASH. | 2022 | Details |
| A49733 | 35654975 | Nat Genet | A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation. | 2022 | Details |
| A49738 | 35654225 | Mol Cell Endocrinol | Treatment with spexin mitigates diet-induced hepatic steatosis in vivo and in vitro through activation of galanin receptor 2. | 2022 | Details |
| A49739 | 35654114 | Metabolism | GW9662, a peroxisome proliferator-activated receptor gamma antagonist, attenuates the development of non-alcoholic fatty liver disease. | 2022 | Details |
| A49747 | 35651050 | Food Res Int | Que Zui tea ameliorates hepatic lipid accumulation and oxidative stress in high fat diet induced nonalcoholic fatty liver disease. | 2022 | Details |
| A49754 | 35646540 | Acta Pharm Sin B | Bile acid coordinates microbiota homeostasis and systemic immunometabolism in cardiometabolic diseases. | 2021 | Details |
| A49784 | 35639028 | FASEB J | A new preclinical model of western diet-induced progression of non-alcoholic steatohepatitis to hepatocellular carcinoma. | 2022 | Details |
| A49792 | 35636169 | Phytomedicine | Pharmacological effects of polydatin in the treatment of metabolic diseases: A review. | 2022 | Details |
| A49802 | 35633911 | World J Gastroenterol | Peroxisome proliferator-activated receptor-alpha activation and dipeptidyl peptidase-4 inhibition target dysbiosis to treat fatty liver in obese mice. | 2022 | Details |
| A49803 | 35633082 | Hepatology | Gut-specific inhibition of PPARα as a novel approach of NAFLD treatment. | 2022 | Details |
| A49812 | 35629938 | Metabolites | Individuals with Metabolic Syndrome Show Altered Fecal Lipidomic Profiles with No Signs of Intestinal Inflammation or Increased Intestinal Permeability. | 2022 | Details |
| A49839 | 35624762 | Antioxidants (Basel) | Styrylpyrones from Phellinus linteus Mycelia Alleviate Non-Alcoholic Fatty Liver by Modulating Lipid and Glucose Metabolic Homeostasis in High-Fat and High-Fructose Diet-Fed Mice. | 2022 | Details |
| A49895 | 35605662 | J Biol Chem | Selective PPARδ agonist seladelpar suppresses bile acid synthesis by reducing hepatocyte CYP7A1 via the fibroblast growth factor 21 signaling pathway. | 2022 | Details |
| A49905 | 35602098 | Oxid Med Cell Longev | A Molecular Insight into the Role of Antioxidants in Nonalcoholic Fatty Liver Diseases. | 2022 | Details |
| A49914 | 35598367 | Biomed Pharmacother | Natural PPARs agonists for the treatment of nonalcoholic fatty liver disease. | 2022 | Details |
| A49922 | 35594708 | Biomed Pharmacother | Exogenous administration of unacylated ghrelin attenuates hepatic steatosis in high-fat diet-fed rats by modulating glucose homeostasis, lipogenesis, oxidative stress, and endoplasmic reticulum stress. | 2022 | Details |
| A49925 | 35592528 | Oxid Med Cell Longev | Ficus hirta Vahl. Ameliorates Nonalcoholic Fatty Liver Disease through Regulating Lipid Metabolism and Gut Microbiota. | 2022 | Details |
| A49973 | 35577161 | J Ethnopharmacol | Network pharmacology analysis on mechanism of Jian Pi Qing Gan Yin decoction ameliorating high fat diet-induced non-alcoholic fatty liver disease and validated in vivo. | 2022 | Details |
| A50011 | 35563600 | Int J Mol Sci | Chronic Intermittent Hypoxia Exposure Alternative to Exercise Alleviates High-Fat-Diet-Induced Obesity and Fatty Liver. | 2022 | Details |
| A50017 | 35563117 | Int J Mol Sci | Functional and Structural Insights into Human PPARα/δ/γ Subtype Selectivity of Bezafibrate, Fenofibric Acid, and Pemafibrate. | 2022 | Details |
| A50025 | 35559337 | Front Med (Lausanne) | The Apparent Asymmetrical Relationship Between Small Bowel Bacterial Overgrowth, Endotoxemia, and Liver Steatosis and Fibrosis in Cirrhotic and Non-Cirrhotic Patients: A Single-Center Pilot Study. | 2022 | Details |
| A50045 | 35547362 | PPAR Res | Molecular Dynamics Simulation and Essential Dynamics of Deleterious Proline 12 Alanine Single-Nucleotide Polymorphism in PPARγ2 Associated with Type 2 Diabetes, Cardiovascular Disease, and Nonalcoholic Fatty Liver Disease. | 2022 | Details |
| A50050 | 35545903 | Environ Sci Technol | Lipid Metabolic Disorder Induced by Pyrethroids in Nonalcoholic Fatty Liver Disease of Xenopus laevis. | 2022 | Details |
| A50061 | 35538760 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | [Mechanism of Triclosan in the Treatment of Nonalcoholic Fatty Liver Disease Based on Network Pharmacology]. | 2022 | Details |
| A50068 | 35537139 | Food Funct | Corn peptides improved obesity-induced non-alcoholic fatty liver disease through relieving lipid metabolism, insulin resistance and oxidative stress. | 2022 | Details |
| A50072 | 35535098 | J Clin Exp Hepatol | Nonalcoholic Steatohepatitis, Peroxisome Proliferator-Activated Receptors and Our Good Glitazar: Proof of the Pudding is in the Eating. | 2022 | Details |
| A50077 | 35535066 | J Clin Exp Hepatol | Saroglitazar for Nonalcoholic Fatty Liver Disease: A Single Centre Experience in 91 Patients. | 2021 | Details |
| A50101 | 35528835 | Front Cardiovasc Med | Salvia miltiorrhiza Bge. (Danshen) in the Treating Non-alcoholic Fatty Liver Disease Based on the Regulator of Metabolic Targets. | 2022 | Details |
| A50106 | 35525796 | Pathology | Prevalence and clinical significance of portal inflammation, portal plasma cells, interface hepatitis and biliary injury in liver biopsies from patients with non-alcoholic steatohepatitis. | 2022 | Details |
| A50112 | 35521658 | Antioxid Redox Signal | RGS7-ATF3-Tip60 Complex Promotes Hepatic Steatosis and Fibrosis by Directly Inducing TNFα. | 2022 | Details |
| A50136 | 35507280 | Curr Atheroscler Rep | Comprehensive Review and Updates on Holistic Approach Towards Non-Alcoholic Fatty Liver Disease Management with Cardiovascular Disease. | 2022 | Details |
| A50151 | 35502176 | Evid Based Complement Alternat Med | The Mechanism of Dendrobium officinale as a Treatment for Hyperlipidemia Based on Network Pharmacology and Experimental Validation. | 2022 | Details |
| A50173 | 35491023 | Biochemistry (Mosc) | Focus on Molecular Functions of Anti-Aging Deacetylase SIRT3. | 2022 | Details |
| A50211 | 35474058 | Mol Biol Rep | Correction to: Alternate-day fasting alleviates high fat diet induced non-alcoholic fatty liver disease through controlling PPARα/Fgf21 signaling. | 2022 | Details |
| A50217 | 35469167 | JHEP Rep | Lipid alterations in chronic liver disease and liver cancer. | 2022 | Details |
| A50234 | 35462859 | JHEP Rep | Epigenetics of alcohol-related liver diseases. | 2022 | Details |
| A50241 | 35461369 | Sci Rep | Effects of ALT-801, a GLP-1 and glucagon receptor dual agonist, in a translational mouse model of non-alcoholic steatohepatitis. | 2022 | Details |
| A50249 | 35457120 | Int J Mol Sci | PPAR-Targeted Therapies in the Treatment of Non-Alcoholic Fatty Liver Disease in Diabetic Patients. | 2022 | Details |
| A50252 | 35455445 | Pharmaceuticals (Basel) | Discovery of 5,7-Dimethoxy-2-(3,4,5-trimethoxyphenoxy)-chromen-4-one with Lipid Lowering Effects in Hepatocytes. | 2022 | Details |
| A50262 | 35450649 | Carbohydr Polym | Responsive oligochitosan nano-vesicles with ursodeoxycholic acid and exenatide for NAFLD synergistic therapy via SIRT1. | 2022 | Details |
| A50290 | 35442594 | Int J Med Mushrooms | Meal Ingestion of Ceraceomyces tessulatus Strain BDM-X (Agaricomycetes) Protects against Nonalcoholic Steatohepatitis in Mice. | 2022 | Details |
| A50300 | 35438556 | J Med Food | Fermented Curcuma longa L. Prevents Alcoholic Fatty Liver Disease in Mice by Regulating CYP2E1, SREBP-1c, and PPAR-α. | 2022 | Details |
| A50310 | 35436630 | Biochem Biophys Res Commun | Hydrochloride Berberine ameliorates alcohol-induced liver injury by regulating inflammation and lipid metabolism. | 2022 | Details |
| A50342 | 35428314 | Nutr Metab (Lond) | L-theanine prevents progression of nonalcoholic hepatic steatosis by regulating hepatocyte lipid metabolic pathways via the CaMKKβ-AMPK signaling pathway. | 2022 | Details |
| A50356 | 35420457 | Cannabis Cannabinoid Res | Expanding Research on Cannabis-Based Medicines for Liver Steatosis: A Low-Risk High-Reward Way Out of the Present Deadlock? | 2022 | Details |
| A50364 | 35417420 | Anesth Analg | Liver Fibrosis Marker and Postoperative Mortality in Patients Without Overt Liver Disease. | 2022 | Details |
| A50384 | 35409319 | Int J Mol Sci | Hepatic PTEN Signaling Regulates Systemic Metabolic Homeostasis through Hepatokines-Mediated Liver-to-Peripheral Organs Crosstalk. | 2022 | Details |
| A50425 | 35396857 | J Food Biochem | Comparative effects of sesame lignans (sesamin, sesamolin, and sesamol) on oxidative stress and lipid metabolism in steatosis HepG2 cells. | 2022 | Details |
| A50466 | 35379885 | Sci Rep | Metformin Ameliorates Hepatic Steatosis induced by olanzapine through inhibiting LXRα/PCSK9 pathway. | 2022 | Details |
| A50497 | 35364708 | Nat Prod Bioprospect | Indole alkaloids of Alstonia scholaris (L.) R. Br. alleviated nonalcoholic fatty liver disease in mice fed with high-fat diet. | 2022 | Details |
| A50512 | 35357518 | Naunyn Schmiedebergs Arch Pharmacol | Phytochemicals targeting NAFLD through modulating the dual function of forkhead box O1 (FOXO1) transcription factor signaling pathways. | 2022 | Details |
| A50532 | 35351574 | J Ethnopharmacol | Pretreatment of hydroethanolic extract of Dillenia indica L. attenuates oleic acid induced NAFLD in HepG2 cells via modulating SIRT-1/p-LKB-1/AMPK, HMGCR & PPAR-α signaling pathways. | 2022 | Details |
| A50557 | 35341816 | Environ Pollut | Early-life exposure to bisphenol A induces dysregulation of lipid homeostasis by the upregulation of SCD1 in male mice. | 2022 | Details |
| A50569 | 35335339 | Molecules | Garcinia Biflavonoid 1 Improves Lipid Metabolism in HepG2 Cells via Regulating PPARα. | 2022 | Details |
| A50581 | 35333579 | Sci Adv | Nuclear HMGB1 protects from nonalcoholic fatty liver disease through negative regulation of liver X receptor. | 2022 | Details |
| A50617 | 35325295 | J Gastroenterol | Systematic review and meta-analysis: analysis of variables influencing the interpretation of clinical trial results in NAFLD. | 2022 | Details |
| A50622 | 35323681 | Metabolites | Emerging Role of Nuclear Receptors for the Treatment of NAFLD and NASH. | 2022 | Details |
| A50668 | 35308224 | Front Pharmacol | Pharmacological Effects and Molecular Protective Mechanisms of Astragalus Polysaccharides on Nonalcoholic Fatty Liver Disease. | 2022 | Details |
| A50705 | 35293570 | Nucleic Acids Res | Dysregulated RNA polyadenylation contributes to metabolic impairment in non-alcoholic fatty liver disease. | 2022 | Details |
| A50726 | 35285996 | J Magn Reson Imaging | Prospective Evaluation of Virtual MR Elastography With Diffusion-Weighted Imaging in Subjects With Nonalcoholic Fatty Liver Disease. | 2022 | Details |