Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Choline1715 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A05383 | 33275637 | PLoS One | The endothelial dysfunction blocker CU06-1004 ameliorates choline-deficient L-amino acid diet-induced non-alcoholic steatohepatitis in mice. | 2020 | Details |
| A05391 | 33273527 | Sci Rep | Deletion of the nuclear receptor RORα in macrophages does not modify the development of obesity, insulin resistance and NASH. | 2020 | Details |
| A05405 | 33269229 | Quant Imaging Med Surg | Collagen deposition in the liver is strongly and positively associated with T1rho elongation while fat deposition is associated with T1rho shortening: an experimental study of methionine and choline-deficient (MCD) diet rat model. | 2020 | Details |
| A05412 | 33268673 | Biomed Res | Plasma lipoprotein profile from nonalcoholic steatohepatitis model rats. | 2020 | Details |
| A05433 | 33259137 | Liver Transpl | Histidine-Rich Glycoprotein Alleviates Liver Ischemia/Reperfusion Injury in Mice With Nonalcoholic Steatohepatitis. | 2021 | Details |
| A05482 | 33239899 | Diabetes Metab Syndr Obes | CHDH-PNPLA3 Gene-Gene Interactions Predict Insulin Resistance in Children with Obesity. | 2020 | Details |
| A05523 | 33219609 | Liver Int | Serum aromatic and branched-chain amino acids associated with NASH demonstrate divergent associations with serum lipids. | 2020 | Details |
| A05536 | 33215899 | Transplantation | Live Confocal Imaging as a Novel Tool to Assess Liver Quality: Insights From a Murine Model. | 2020 | Details |
| A05549 | 33211913 | Vopr Pitan | [Effect of carnosine and α-lipoic acid on hepatocyte apoptosis and the cytokine profile in induced fatty liver disease in Wistar rats]. | 2020 | Details |
| A05552 | 33208407 | Gut | Sphingomyelin synthase 1 mediates hepatocyte pyroptosis to trigger non-alcoholic steatohepatitis. | 2020 | Details |
| A05570 | 33203828 | Med Sci Monit | Altered Inflammatory Pathway but Unaffected Liver Fibrosis in Mouse Models of Nonalcoholic Steatohepatitis Involving Interleukin-1 Receptor-Associated Kinase 1 Knockout. | 2020 | Details |
| A05590 | 33197790 | Environ Int | Unravelling the metabolic alterations of liver damage induced by thirdhand smoke. | 2020 | Details |
| A05608 | 33190588 | Autophagy | TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation. | 2020 | Details |
| A05612 | 33188625 | J Physiol Biochem | Regulation of peroxisome proliferator-activated receptor-gamma activity affects the hepatic stellate cell activation and the progression of NASH via TGF-β1/Smad signaling pathway. | 2020 | Details |
| A05627 | 33184021 | Nanomedicine | Formulation and intestinal absorption of naringenin loaded nanostructured lipid carrier and its inhibitory effects on nonalcoholic fatty liver disease. | 2020 | Details |
| A05645 | 33177546 | Sci Rep | PPARα agonist and metformin co-treatment ameliorates NASH in mice induced by a choline-deficient, amino acid-defined diet with 45% fat. | 2020 | Details |
| A05649 | 33173745 | Adv Sci (Weinh) | The Nuclear Orphan Receptor NR2F6 Promotes Hepatic Steatosis through Upregulation of Fatty Acid Transporter CD36. | 2020 | Details |
| A05663 | 33168782 | Aging (Albany NY) | Human mesenchymal stem cells treatment improved hepatic lesions and reversed gut microbiome disorder in non-alcoholic steatohepatitis. | 2020 | Details |
| A05672 | 33164440 | Zhongguo Zhong Yao Za Zhi | [Study on improvement provided by water extracts of Polygoni Multiflori Radix and Polygoni Multiflori Radix Praeparata on non-alcoholic steatohepatitis in mice induced by MCD]. | 2020 | Details |
| A05766 | 33127749 | J Pharmacol Exp Ther | Transporter Activity Changes in Nonalcoholic Steatohepatitis: Assessment with Plasma Coproporphyrin I and III. | 2020 | Details |
| A05819 | 33106416 | Proc Natl Acad Sci U S A | Stimulation of soluble guanylate cyclase exerts antiinflammatory actions in the liver through a VASP/NF-κB/NLRP3 inflammasome circuit. | 2020 | Details |
| A05821 | 33106137 | Curr Pharm Des | Therapeutic effect of Prdx1 on NAFLD mice may be related to the activation of Nrf-2/HO-1 pathway. | 2020 | Details |
| A05834 | 33103092 | JHEP Rep | Purinergic signalling in liver diseases: Pathological functions and therapeutic opportunities. | 2020 | Details |
| A05955 | 33062150 | Oxid Med Cell Longev | Prevention of Nonalcoholic Hepatic Steatosis by Shenling Baizhu Powder: Involvement of Adiponectin-Induced Inhibition of Hepatic SREBP-1c. | 2020 | Details |
| A05962 | 33060605 | Sci Rep | Clusterin overexpression protects against western diet-induced obesity and NAFLD. | 2020 | Details |
| A05988 | 33050067 | Biomolecules | Pharmaceutical Efficacy of Gypenoside LXXV on Non-Alcoholic Steatohepatitis (NASH). | 2020 | Details |
| A06077 | 33014604 | Biomed Opt Express | Intravital longitudinal imaging of hepatic lipid droplet accumulation in a murine model for nonalcoholic fatty liver disease. | 2020 | Details |
| A06092 | 33010248 | Gastroenterology | Steatohepatitis Impairs T-cell-Directed Immunotherapies Against Liver Tumors in Mice. | 2020 | Details |
| A06112 | 33002297 | Mol Nutr Food Res | Huangjinya Black Tea Alleviates Obesity and Insulin Resistance via Modulating Fecal Metabolome in High-Fat Diet-Fed Mice. | 2020 | Details |
| A06141 | 32991778 | Mol Nutr Food Res | Methionine- and Choline-Deficient Diet Enhances Adipose Lipolysis and Leptin Release in aP2-Cre Fatp4-Knockout Mice. | 2020 | Details |
| A06149 | 32987153 | Cell Mol Gastroenterol Hepatol | Tristetraprolin Promotes Hepatic Inflammation and Tumor Initiation but Restrains Cancer Progression to Malignancy. | 2020 | Details |
| A06160 | 32982365 | Clin Exp Gastroenterol | Gut Dysbiosis and Increased Intestinal Permeability Drive microRNAs, NLRP-3 Inflammasome and Liver Fibrosis in a Nutritional Model of Non-Alcoholic Steatohepatitis in Adult Male Sprague Dawley Rats. | 2020 | Details |
| A06161 | 32982113 | World J Gastroenterol | Acupuncture improved lipid metabolism by regulating intestinal absorption in mice. | 2020 | Details |
| A06162 | 32982112 | World J Gastroenterol | Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis via AMPK and mTOR regulation. | 2020 | Details |
| A06205 | 32968123 | Sci Rep | Automated thermal imaging for the detection of fatty liver disease. | 2020 | Details |
| A06226 | 32961796 | Int J Mol Sci | miR-29a Modulates GSK3β/SIRT1-Linked Mitochondrial Proteostatic Stress to Ameliorate Mouse Non-Alcoholic Steatohepatitis. | 2020 | Details |
| A06239 | 32957701 | Biomolecules | Rescue of Hepatic Phospholipid Remodeling Defectin iPLA2β-Null Mice Attenuates Obese but Not Non-Obese Fatty Liver. | 2020 | Details |
| A06266 | 32947564 | J Pediatr Gastroenterol Nutr | Lipidomics in Nonalcoholic Fatty Liver Disease: Exploring Serum Lipids as Biomarkers for Pediatric Nonalcoholic Fatty Liver Disease. | 2020 | Details |
| A06271 | 32945412 | Mol Med Rep | Novel oral plasminogen activator inhibitor‑1 inhibitor TM5275 attenuates hepatic fibrosis under metabolic syndrome via suppression of activated hepatic stellate cells in rats. | 2020 | Details |
| A06343 | 32922061 | Clin Exp Gastroenterol | Changes in Function and Dynamics in Hepatic and Splenic Macrophages in Non-Alcoholic Fatty Liver Disease. | 2020 | Details |
| A06350 | 32920003 | Life Sci | Hypoxia aggravates non-alcoholic fatty liver disease in presence of high fat choline deficient diet: A pilot study. | 2020 | Details |
| A06352 | 32919135 | Bioorg Chem | Design, synthesis and structure-activity relationship studies of novel partial FXR agonists for the treatment of fatty liver. | 2020 | Details |
| A06366 | 32913449 | J Cancer | Reduction of Polyunsaturated Fatty Acids with Tumor Progression in a Lean Non-Alcoholic Steatohepatitis-Associated Hepatocellular Carcinoma Mouse Model. | 2020 | Details |
| A06446 | 32879216 | Biol Pharm Bull | A Lipid-Based Nanocarrier Containing Active Vitamin D3 Ameliorates NASH in Mice via Direct and Intestine-Mediated Effects on Liver Inflammation. | 2020 | Details |
| A06454 | 32877213 | Am J Physiol Gastrointest Liver Physiol | High-fat diet induces fibrosis in mice lacking CYP2A5 and PPARα: a new model for steatohepatitis-associated fibrosis. | 2020 | Details |
| A06474 | 32865911 | Crit Rev Oncog | Role of the Gut Microbiome in Nonalcoholic Fatty Liver Disease Progression. | 2020 | Details |
| A06478 | 32863955 | Theranostics | Fibrinogen-like protein 2 aggravates nonalcoholic steatohepatitis via interaction with TLR4, eliciting inflammation in macrophages and inducing hepatic lipid metabolism disorder. | 2020 | Details |
| A06504 | 32849904 | Evid Based Complement Alternat Med | Si-Wu-Tang Alleviates Nonalcoholic Fatty Liver Disease via Blocking TLR4-JNK and Caspase-8-GSDMD Signaling Pathways. | 2020 | Details |
| A06538 | 32833043 | Arch Toxicol | A novel model of non-alcoholic steatohepatitis with fibrosis and carcinogenesis in connexin 32 dominant-negative transgenic rats. | 2020 | Details |
| A06562 | 32824383 | Cancers (Basel) | Distinct Mechanisms Are Responsible for Nrf2-Keap1 Pathway Activation at Different Stages of Rat Hepatocarcinogenesis. | 2020 | Details |
| A06614 | 32808060 | Eur J Nutr | Betaine prevented high-fat diet-induced NAFLD by regulating the FGF10/AMPK signaling pathway in ApoE-/- mice. | 2020 | Details |
| A06660 | 32791310 | Diabetes Metab | Trimethylamine N-oxide levels are associated with NASH in obese subjects with type 2 diabetes. | 2020 | Details |
| A06662 | 32790863 | Endocrinology | DPP-4 Inhibition with Anagliptin Reduces Lipotoxicity-Induced Insulin Resistance and Steatohepatitis in Male Mice. | 2020 | Details |
| A06681 | 32782033 | Microsc Microanal | Effect of Betaine Supplementation on Liver Tissue and Ultrastructural Changes in Methionine-Choline-Deficient Diet-Induced NAFLD. | 2020 | Details |
| A06685 | 32780887 | FASEB J | Hepatic E4BP4 induction promotes lipid accumulation by suppressing AMPK signaling in response to chemical or diet-induced ER stress. | 2020 | Details |
| A06696 | 32777136 | FASEB J | Betulinic acid improves nonalcoholic fatty liver disease through YY1/FAS signaling pathway. | 2020 | Details |
| A06713 | 32772909 | Comb Chem High Throughput Screen | Evaluation of Insulin Resistance Induced Brain Tissue Dysfunction in Obese Dams and their Neonates: Role of Ipriflavone Amelioration. | 2021 | Details |
| A06730 | 32766475 | Hepatol Commun | Lack of Augmenter of Liver Regeneration Disrupts Cholesterol Homeostasis of Liver in Mice by Inhibiting the AMPK Pathway. | 2020 | Details |
| A06740 | 32764281 | Nutrients | The Relationship between Choline Bioavailability from Diet, Intestinal Microbiota Composition, and Its Modulation of Human Diseases. | 2020 | Details |
| A06752 | 32759852 | Int J Mol Sci | Effective Combination Therapy of Angiotensin-II Receptor Blocker and Rifaximin for Hepatic Fibrosis in Rat Model of Nonalcoholic Steatohepatitis. | 2020 | Details |
| A06792 | 32744096 | Am J Physiol Endocrinol Metab | Neurodegeneration in juvenile Iberian pigs with diet-induced nonalcoholic fatty liver disease. | 2020 | Details |
| A06812 | 32738061 | Hepatology | Prenatal Exposure to Perfluoroalkyl Substances Associated With Increased Susceptibility to Liver Injury in Children. | 2020 | Details |
| A06820 | 32734608 | J Pharm Pharmacol | HWL-088, a new and highly effective FFA1/PPARδ dual agonist, attenuates nonalcoholic steatohepatitis by regulating lipid metabolism, inflammation and fibrosis. | 2020 | Details |
| A06855 | 32720691 | Hum Mol Genet | Insights into genetic variants associated with NASH-fibrosis from metabolite profiling. | 2020 | Details |
| A06861 | 32719069 | J Pharmacol Exp Ther | The GPR40 Full Agonist SCO-267 Improves Liver Parameters in a Mouse Model of Nonalcoholic Fatty Liver Disease without Affecting Glucose or Body Weight. | 2020 | Details |
| A06866 | 32717871 | Int J Mol Sci | Gut Microbiota Metabolites in NAFLD Pathogenesis and Therapeutic Implications. | 2020 | Details |
| A06868 | 32717288 | J Hepatol | Targeting NFATc4 attenuates non-alcoholic steatohepatitis in mice. | 2020 | Details |
| A06873 | 32715385 | Arch Pharm Res | Ganoderic acid A attenuates high-fat-diet-induced liver injury in rats by regulating the lipid oxidation and liver inflammation. | 2020 | Details |
| A06882 | 32711187 | Transl Res | The GLP-1R agonist liraglutide limits hepatic lipotoxicity and inflammatory response in mice fed a methionine-choline deficient diet. | 2020 | Details |
| A06899 | 32705262 | Mol Med Rep | Expression of Notch family is altered in non‑alcoholic fatty liver disease. | 2020 | Details |
| A06903 | 32702591 | Phytomedicine | The water extract of Sophorae tonkinensis Radix et Rhizoma alleviates non-alcoholic fatty liver disease and its mechanism. | 2020 | Details |
| A06913 | 32699233 | Sci Rep | MCD diet-induced steatohepatitis generates a diurnal rhythm of associated biomarkers and worsens liver injury in Klf10 deficient mice. | 2020 | Details |
| A07017 | 32655370 | Front Cell Neurosci | Dyslipidemic Diet Induces Mobilization of Peripheral Neutrophils and Monocytes That Exacerbate Hemorrhagic Brain Injury and Neuroinflammation. | 2020 | Details |
| A07050 | 32641615 | J Oleo Sci | Basil Essential Oil and Its Nanoemulsion Mitigate Non Alcoholic Steatohepatitis in Rat Model with Special Reference to Gut Microbiota. | 2020 | Details |
| A07110 | 32619269 | FEBS Lett | SHP-1 ameliorates nonalcoholic steatohepatitis by inhibiting proinflammatory cytokine production. | 2020 | Details |
| A07176 | 32592532 | Phytother Res | Sophoricoside is a selective LXRβ antagonist with potent therapeutic effects on hepatic steatosis of mice. | 2020 | Details |
| A07183 | 32591434 | Gut | Loss of hepatic Mboat7 leads to liver fibrosis. | 2020 | Details |
| A07208 | 32582754 | Front Nutr | PTEN: A Thrifty Gene That Causes Disease in Times of Plenty? | 2020 | Details |
| A07213 | 32579995 | Toxicol Lett | Long-term profile of serological biomarkers, hepatic inflammation, and fibrosis in a mouse model of non-alcoholic fatty liver disease. | 2020 | Details |
| A07242 | 32570937 | Nutrients | Treatment of Non-Alcoholic Steatosis: Preclinical Study of a New Nutraceutical Multitarget Formulation. | 2020 | Details |
| A07260 | 32562818 | Pharmacol Res | ZLY032, the first-in-class dual FFA1/PPARδ agonist, improves glucolipid metabolism and alleviates hepatic fibrosis. | 2020 | Details |
| A07269 | 32559586 | J Nutr Biochem | Citrus reticulata Blanco peel extract ameliorates hepatic steatosis, oxidative stress and inflammation in HF and MCD diet-induced NASH C57BL/6 J mice. | 2020 | Details |
| A07294 | 32553647 | Ann Hepatol | Hepatic autophagy fluctuates during the development of non-alcoholic fatty liver disease. | 2020 | Details |
| A07304 | 32546802 | Sci Rep | Liver-specific knockout of B cell lymphoma 6 suppresses progression of non-alcoholic steatohepatitis in mice. | 2020 | Details |
| A07356 | 32526845 | Int J Mol Sci | N-Acetylcysteine Reduced Ischemia and Reperfusion Damage Associated with Steatohepatitis in Mice. | 2020 | Details |
| A07361 | 32526482 | Cell Mol Gastroenterol Hepatol | Acetyl-CoA Carboxylase Inhibition Improves Multiple Dimensions of NASH Pathogenesis in Model Systems. | 2020 | Details |
| A07443 | 32494762 | Curr Dev Nutr | Targeted Nutrient Modifications in Purified Diets Differentially Affect Nonalcoholic Fatty Liver Disease and Metabolic Disease Development in Rodent Models. | 2020 | Details |
| A07447 | 32492133 | J Biochem | Arachidonate 12S-lipoxygenase of platelet-type in hepatic stellate cells of methionine and choline-deficient diet-fed mice. | 2020 | Details |
| A07461 | 32486073 | Cancers (Basel) | Exercise Attenuates the Transition from Fatty Liver to Steatohepatitis and Reduces Tumor Formation in Mice. | 2020 | Details |
| A07493 | 32475638 | Biochem Biophys Res Commun | Fucoxanthin inhibits hepatic oxidative stress, inflammation, and fibrosis in diet-induced nonalcoholic steatohepatitis model mice. | 2020 | Details |
| A07512 | 32461992 | Biomed Res Int | Heme Oxygenase-1 Suppresses Wnt Signaling Pathway in Nonalcoholic Steatohepatitis-Related Liver Fibrosis. | 2020 | Details |
| A07524 | 32455496 | Hepatol Res | Metabolomic/lipidomic-based analysis of plasma to diagnose hepatocellular ballooning in patients with non-alcoholic fatty liver disease: A multicenter study. | 2020 | Details |
| A07526 | 32455155 | Regen Ther | Development of a non-alcoholic steatohepatitis model with rapid accumulation of fibrosis, and its treatment using mesenchymal stem cells and their small extracellular vesicles. | 2020 | Details |
| A07551 | 32445755 | Toxicol Appl Pharmacol | PBPK modeling of impact of nonalcoholic fatty liver disease on toxicokinetics of perchloroethylene in mice. | 2020 | Details |
| A07576 | 32438122 | J Nutr Biochem | Resveratrol prevents liver damage in MCD-induced steatohepatitis mice by promoting SIGIRR gene transcription. | 2020 | Details |
| A07600 | 32429478 | Cells | Exogenous Liposomal Ceramide-C6 Ameliorates Lipidomic Profile, Energy Homeostasis, and Anti-Oxidant Systems in NASH. | 2020 | Details |
| A07620 | 32417373 | Life Sci | CREBH knockout accelerates hepatic fibrosis in mouse models of diet-induced nonalcoholic fatty liver disease. | 2020 | Details |
| A07641 | 32411189 | PPAR Res | Loss of Hepatocyte-Specific PPARγ Expression Ameliorates Early Events of Steatohepatitis in Mice Fed the Methionine and Choline-Deficient Diet. | 2020 | Details |
| A07663 | 32405177 | J Clin Exp Hepatol | NASH-inducing Diets in Göttingen Minipigs. | 2019 | Details |
| A07664 | 32404278 | Biochim Biophys Acta Mol Cell Biol Lipids | Niacin increases diet-induced hepatic steatosis in B6129 mice. | 2020 | Details |