Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Metformin577 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A16196 | 28509327 | Int J Cancer | The occurrence of hepatocellular carcinoma in different risk stratifications of clinically noncirrhotic nonalcoholic fatty liver disease. | 2017 | Details |
| A16533 | 28332301 | J Diabetes | Randomized trial comparing the effects of gliclazide, liraglutide, and metformin on diabetes with non-alcoholic fatty liver disease. | 2017 | Details |
| A16600 | 28290049 | Curr Diab Rep | Type 2 Diabetes and Hepatocellular Carcinoma: Risk Factors and Pathogenesis. | 2017 | Details |
| A16774 | 28185715 | Clin Ther | Effects of Oral Antidiabetic Drugs on Changes in the Liver-to-Spleen Ratio on Computed Tomography and Inflammatory Biomarkers in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease. | 2017 | Details |
| A16830 | 28142230 | Korean J Intern Med | Compound K attenuates glucose intolerance and hepatic steatosis through AMPK-dependent pathways in type 2 diabetic OLETF rats. | 2017 | Details |
| A16841 | 28133479 | Gastroenterol Res Pract | Metformin and Diammonium Glycyrrhizinate Enteric-Coated Capsule versus Metformin Alone versus Diammonium Glycyrrhizinate Enteric-Coated Capsule Alone in Patients with Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus. | 2017 | Details |
| A16851 | 28127194 | World J Gastroenterol | Three-dimensional perfused human in vitro model of non-alcoholic fatty liver disease. | 2017 | Details |
| A16925 | 28089623 | Dig Liver Dis | Which treatment for type 2 diabetes associated with non-alcoholic fatty liver disease? | 2016 | Details |
| A16988 | 28062870 | Rev Gastroenterol Peru | [Metabolic parameters in patients with steatosis non alcoholic liver and controlled diabetes type 2 versus uncontrolled diabetes type 2]. | 2017 | Details |
| A17018 | 28042486 | Int J Hepatol | A Combination of Leucine, Metformin, and Sildenafil Treats Nonalcoholic Fatty Liver Disease and Steatohepatitis in Mice. | 2016 | Details |
| A17056 | 28019064 | Hepatol Res | Novel antidiabetic medications for non-alcoholic fatty liver disease with type 2 diabetes mellitus. | 2017 | Details |
| A17162 | 27939359 | Pharmacol Res | A story of metformin-butyrate synergism to control various pathological conditions as a consequence of gut microbiome modification: Genesis of a wonder drug? | 2016 | Details |
| A17189 | 27920819 | Res Pharm Sci | Co-administration of metformin and N-acetylcysteine with dietary control improves the biochemical and histological manifestations in rats with non-alcoholic fatty liver. | 2016 | Details |
| A17203 | 27916420 | Biomed Pharmacother | Potential involvement of JNK1 repression in the hepatic effect of sitagliptin and metformin in rats subjected to high fat diet and chronic mild distress. | 2016 | Details |
| A17207 | 27914133 | J Korean Med Sci | Lobeglitazone, a Novel Thiazolidinedione, Improves Non-Alcoholic Fatty Liver Disease in Type 2 Diabetes: Its Efficacy and Predictive Factors Related to Responsiveness. | 2017 | Details |
| A17250 | 27889809 | Diabetologia | Reversal of type 2 diabetes in youth who adhere to a very-low-energy diet: a pilot study. | 2016 | Details |
| A17383 | 27812974 | Exp Suppl | Structure and Regulation of AMPK. | 2017 | Details |
| A17690 | 27656480 | J Clin Diagn Res | Comparative Effect of Insulin Sensitizers and Statin on Metabolic Profile and Ultrasonographical Score in Non Alcoholic Fatty Liver Disease. | 2016 | Details |
| A17698 | 27649410 | PLoS One | Renin-Angiotensin System Inhibitors, Type 2 Diabetes and Fibrosis Progression: An Observational Study in Patients with Nonalcoholic Fatty Liver Disease. | 2016 | Details |
| A17740 | 27627981 | Diabetologia | Twelve week liraglutide or sitagliptin does not affect hepatic fat in type 2 diabetes: a randomised placebo-controlled trial. | 2016 | Details |
| A17802 | 27577854 | Am J Physiol Endocrinol Metab | Treatment of nonalcoholic fatty liver disease: role of AMPK. | 2016 | Details |
| A17870 | 27512874 | Medicine (Baltimore) | Comparative efficacy of interventions on nonalcoholic fatty liver disease (NAFLD): A PRISMA-compliant systematic review and network meta-analysis. | 2016 | Details |
| A18027 | 27405060 | J Hepatol | Hepatic B cell leukemia-3 promotes hepatic steatosis and inflammation through insulin-sensitive metabolic transcription factors. | 2016 | Details |
| A18069 | 27372863 | Med Hypotheses | Fructose surges damage hepatic adenosyl-monophosphate-dependent kinase and lead to increased lipogenesis and hepatic insulin resistance. | 2016 | Details |
| A18078 | 27363235 | Adolesc Med State Art Rev | Gastrointestinal Conditions in the Obese Patient. | 2016 | Details |
| A18204 | 27288055 | J Endocrinol | Metformin increases hepatic leptin receptor and decreases steatosis in mice. | 2016 | Details |
| A18205 | 27287838 | Orv Hetil | [Non-alcoholic fatty liver disease and hepatocellular carcinoma - 2016]. | 2016 | Details |
| A18464 | 27110380 | BMJ Open Gastroenterol | Statins, antidiabetic medications and liver histology in patients with diabetes with non-alcoholic fatty liver disease. | 2016 | Details |
| A18470 | 27107966 | Best Pract Res Clin Obstet Gynaecol | Hepatic manifestations of women with polycystic ovary syndrome. | 2016 | Details |
| A18539 | 27063274 | Clin Liver Dis | Current Pharmacologic Therapy for Nonalcoholic Fatty Liver Disease. | 2016 | Details |
| A18554 | 28702244 | Clin Diabetes Endocrinol | Treatment of Nonalcoholic Fatty Liver Disease (NAFLD) in patients with Type 2 Diabetes Mellitus. | 2016 | Details |
| A18582 | 27048250 | Diabetologia | Hepatic glucose and lipid metabolism. | 2016 | Details |
| A18671 | 27003143 | Dig Dis Sci | Novel Pharmacotherapy Options for NASH. | 2016 | Details |
| A18741 | 26976710 | Endocrinol Nutr | Effect of incretin therapies compared to pioglitazone and gliclazide in non-alcoholic fatty liver disease in diabetic patients not controlled on metformin alone: An observational, pilot study. | 2016 | Details |
| A18749 | 26972165 | Best Pract Res Clin Obstet Gynaecol | Metabolic syndrome, diet and exercise. | 2016 | Details |
| A18782 | 26945512 | Chem Biol Interact | Metformin administration induces hepatotoxic effects in paraoxonase-1-deficient mice. | 2016 | Details |
| A18788 | 26941037 | J Endocrinol | Metformin improves hepatic IRS2/PI3K/Akt signaling in insulin-resistant rats of NASH and cirrhosis. | 2016 | Details |
| A18805 | 26930651 | PLoS One | Metformin Changes the Relationship between Blood Monocyte Toll-Like Receptor 4 Levels and Nonalcoholic Fatty Liver Disease-Ex Vivo Studies. | 2016 | Details |
| A19099 | 26770262 | Therap Adv Gastroenterol | Practice patterns in NAFLD and NASH: real life differs from published guidelines. | 2016 | Details |
| A19295 | 26642701 | Clin Lab | Therapeutic Effect of Metformin on Chemerin in Non-Obese Patients with Non-Alcoholic Fatty Liver Disease (NAFLD). | 2015 | Details |
| A19296 | 26641143 | Expert Rev Gastroenterol Hepatol | The role of insulin resistance in nonalcoholic steatohepatitis and liver disease development--a potential therapeutic target? | 2015 | Details |
| A19322 | 26629827 | PLoS One | Hyperreactivity of Blood Leukocytes in Patients with NAFLD to Ex Vivo Lipopolysaccharide Treatment Is Modulated by Metformin and Phosphatidylcholine but Not by Alpha Ketoglutarate. | 2015 | Details |
| A19431 | 26571396 | J Clin Invest | Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver. | 2015 | Details |
| A19544 | 26498267 | Environ Toxicol Pharmacol | Fucoidan ameliorates steatohepatitis and insulin resistance by suppressing oxidative stress and inflammatory cytokines in experimental non-alcoholic fatty liver disease. | 2015 | Details |
| A19673 | 26420354 | Eur J Pharmacol | Deficiency in apolipoprotein A-I ablates the pharmacological effects of metformin on plasma glucose homeostasis and hepatic lipid deposition. | 2015 | Details |
| A19724 | 26394261 | Appl Physiol Nutr Metab | Combining metformin therapy with caloric restriction for the management of type 2 diabetes and nonalcoholic fatty liver disease in obese rats. | 2015 | Details |
| A19739 | 26381272 | Diabetes Metab Res Rev | Comparative efficacy of anti-diabetic agents on nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized and non-randomized studies. | 2015 | Details |
| A19745 | 26378648 | Semin Liver Dis | Pharmacotherapy for Nonalcoholic Fatty Liver Disease. | 2015 | Details |
| A19763 | 26367736 | Eur Rev Med Pharmacol Sci | Effect of silymarin plus vitamin E in patients with non-alcoholic fatty liver disease. A randomized clinical pilot study. | 2015 | Details |
| A19828 | 26321269 | Pharmacol Rep | Liver sinusoidal endothelial cells (LSECs) function and NAFLD; NO-based therapy targeted to the liver. | 2015 | Details |
| A19885 | 26284591 | Clin Gastroenterol Hepatol | Hepatocellular Carcinoma From Epidemiology to Prevention: Translating Knowledge into Practice. | 2015 | Details |
| A20016 | 26203576 | Rev Med Chil | [Second Consensus of the Chilean Society of Endocrinology and Diabetes about insulin resistance]. | 2015 | Details |
| A20033 | 26198758 | Hepatol Int | Effect of metformin treatment on circulating osteoprotegerin in patients with nonalcoholic fatty liver disease. | 2015 | Details |
| A20038 | 26195184 | Expert Opin Biol Ther | Liraglutide improves carotid intima-media thickness in patients with type 2 diabetes and non-alcoholic fatty liver disease: an 8-month prospective pilot study. | 2015 | Details |
| A20094 | 26159280 | Dig Dis | Challenges and Management of Liver Cirrhosis: Practical Issues in the Therapy of Patients with Cirrhosis due to NAFLD and NASH. | 2015 | Details |
| A20122 | 26140084 | World J Hepatol | Systematic review: Preventive and therapeutic applications of metformin in liver disease. | 2015 | Details |
| A20256 | 26060704 | Iran J Public Health | Effect of Vitamin E and Metformin on Fatty Liver Disease in Obese Children- Randomized Clinical Trial. | 2014 | Details |
| A20286 | 26045616 | Am J Physiol Gastrointest Liver Physiol | Metformin prevents ischemia reperfusion-induced oxidative stress in the fatty liver by attenuation of reactive oxygen species formation. | 2015 | Details |
| A20305 | 26038701 | Pharmacol Res Perspect | Metformin protects primary rat hepatocytes against oxidative stress-induced apoptosis. | 2015 | Details |
| A20362 | 26016715 | Diabetes | Mechanism of Altered Metformin Distribution in Nonalcoholic Steatohepatitis. | 2015 | Details |
| A20420 | 25976242 | Acta Diabetol | GCKR polymorphism influences liver fat content in patients with type 2 diabetes. | 2015 | Details |
| A20497 | 25921668 | Clin Liver Dis | Nonalcoholic Fatty liver disease, diabetes, obesity, and hepatocellular carcinoma. | 2015 | Details |
| A20580 | 25873949 | Int J Endocrinol | Liver Injury Indicating Fatty Liver but Not Serologic NASH Marker Improves under Metformin Treatment in Polycystic Ovary Syndrome. | 2015 | Details |
| A20669 | 25817233 | Life Sci | AMP-kinase pathway is involved in tumor necrosis factor alpha-induced lipid accumulation in human hepatoma cells. | 2015 | Details |
| A20775 | 25742316 | Biochem J | Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity. | 2015 | Details |
| A20819 | 25714579 | J Pediatr Gastroenterol Nutr | Improvement in liver histology is associated with reduction in dyslipidemia in children with nonalcoholic fatty liver disease. | 2015 | Details |
| A20870 | 25676019 | Front Med | Metformin and metabolic diseases: a focus on hepatic aspects. | 2015 | Details |
| A20871 | 25672270 | Int J Mol Med | MicroRNA profiles following metformin treatment in a mouse model of non-alcoholic steatohepatitis. | 2015 | Details |
| A20875 | 25671801 | Horm Metab Res | Does metformin treatment influence bone formation in patients with nonalcoholic fatty liver disease? | 2015 | Details |
| A21063 | 27508191 | J Hepatocell Carcinoma | A clinical perspective of the link between metabolic syndrome and hepatocellular carcinoma. | 2015 | Details |
| A21103 | 25534988 | Biochem Pharmacol | The liver-selective NO donor, V-PYRRO/NO, protects against liver steatosis and improves postprandial glucose tolerance in mice fed high fat diet. | 2014 | Details |
| A21198 | 25484077 | Autophagy | Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway. | 2015 | Details |
| A21230 | 25468829 | Int J Obes (Lond) | Fetuin-A: a novel link between obesity and related complications. | 2014 | Details |
| A21281 | 34860874 | J Pharm Technol | Past, Present, and Future Research Avenues for Metformin: A Literature Review. | 2014 | Details |
| A21310 | 25414939 | Postgrad Med | Diabetes mellitus as a novel risk factor for gastrointestinal malignancies. | 2014 | Details |
| A21427 | 25327387 | Expert Rev Gastroenterol Hepatol | Diagnosis and management of cardiovascular risk in nonalcoholic fatty liver disease. | 2014 | Details |
| A21497 | 25274101 | Br J Nutr | Non-alcoholic fatty liver disease: need for a balanced nutritional source. | 2014 | Details |
| A21508 | 25267322 | Aliment Pharmacol Ther | Review article: the management of paediatric nonalcoholic fatty liver disease. | 2014 | Details |
| A21559 | 25232245 | World J Gastroenterol | Nonalcoholic fatty liver disease: a comprehensive review of a growing epidemic. | 2014 | Details |
| A21653 | 25152027 | Acta Pharmacol Sin | Alpha-lipoic acid attenuates insulin resistance and improves glucose metabolism in high fat diet-fed mice. | 2014 | Details |
| A21667 | 25137852 | Zhongguo Zhong Xi Yi Jie He Za Zhi | [Effect of zhenqing recipe on non-alcoholic fatty liver in type 2 diabetes rats and the expression of SIK1]. | 2014 | Details |
| A21697 | 25111690 | Lab Invest | Uric acid induces fat accumulation via generation of endoplasmic reticulum stress and SREBP-1c activation in hepatocytes. | 2014 | Details |
| A21723 | 25091053 | Clin Pharmacokinet | Pharmacokinetics in patients with chronic liver disease and hepatic safety of incretin-based therapies for the management of type 2 diabetes mellitus. | 2014 | Details |
| A21755 | 25069836 | Eat Weight Disord | The therapy of insulin resistance in other diseases besides type 2 diabetes. | 2014 | Details |
| A21802 | 25034293 | Dig Dis | Treatment of non-alcoholic fatty liver disease. | 2014 | Details |
| A21822 | 25024594 | World J Gastroenterol | Nonalcoholic fatty liver disease and polycystic ovary syndrome. | 2014 | Details |
| A21855 | 24997826 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | Effect of piglitazone and metformin on retinol-binding protein-4 and adiponectin in patients with type 2 diabetes mellitus complicated with non-alcohol fatty acid liver diseases. | 2014 | Details |
| A22030 | 24866317 | Rev Med Inst Mex Seguro Soc | [Nonalcoholic fatty liver disease in children]. | 2014 | Details |
| A22122 | 24799988 | World J Hepatol | Insulin sensitizers for the treatment of non-alcoholic fatty liver disease. | 2014 | Details |
| A22315 | 24669954 | Expert Opin Drug Metab Toxicol | Pharmacokinetic and toxicological considerations for the treatment of diabetes in patients with liver disease. | 2014 | Details |
| A22360 | 24638078 | PLoS One | Metformin ameliorates hepatic steatosis and inflammation without altering adipose phenotype in diet-induced obesity. | 2014 | Details |
| A22389 | 24626737 | Food Funct | A diet formula of Puerariae radix, Lycium barbarum, Crataegus pinnatifida, and Polygonati rhizoma alleviates insulin resistance and hepatic steatosis in CD-1 mice and HepG2 cells. | 2014 | Details |
| A22434 | 24580044 | Expert Rev Gastroenterol Hepatol | Metformin in the treatment of non-alcoholic fatty liver disease: safety, efficacy and mechanism. | 2014 | Details |
| A22461 | 24550584 | Indian J Pharmacol | Combination of vildagliptin and rosiglitazone ameliorates nonalcoholic fatty liver disease in C57BL/6 mice. | 2014 | Details |
| A22473 | 24532325 | J Sci Food Agric | Antihyperglycemic, hypolipidemic, hepatoprotective and antioxidative effects of dietary clove (Szyzgium aromaticum) bud powder in a high-fat diet/streptozotocin-induced diabetes rat model. | 2014 | Details |
| A22624 | 24402015 | Arq Bras Endocrinol Metabol | Exenatide improves type 2 diabetes concomitant with non-alcoholic fatty liver disease. | 2013 | Details |
| A22645 | 24385405 | Adv Ther | Effect of metformin on ballooning degeneration in nonalcoholic steatohepatitis (NASH): when to use metformin in nonalcoholic fatty liver disease (NAFLD). | 2014 | Details |
| A22759 | 24326426 | Am J Physiol Endocrinol Metab | Combining metformin and aerobic exercise training in the treatment of type 2 diabetes and NAFLD in OLETF rats. | 2013 | Details |
| A22783 | 24307947 | J Lipids | Grape seed proanthocyanidin rescues rats from steatosis: a comparative and combination study with metformin. | 2013 | Details |
| A22785 | 24304731 | Rev Invest Clin | [Decrease of liver fat content by aerobic exercise or metformin therapy in overweight or obese women]. | 2014 | Details |