Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Phosphatidylcholine289 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A36720 | 17391797 | J Hepatol | The phosphatidylethanolamine N-methyltransferase gene V175M single nucleotide polymorphism confers the susceptibility to NASH in Japanese population. | 2007 | Details |
| A37157 | 16376450 | J Hepatol | Mice heterozygous for the Mdr2 gene demonstrate decreased PEMT activity and diminished steatohepatitis on the MCD diet. | 2005 | Details |
| A37540 | 15460086 | Postgrad Med | Cardiovascular risk beyond LDL-C levels. Other lipids are performers in cholesterol story. | 2004 | Details |
| A43059 | 32680469 | BMC Gastroenterol | Plasma Lipidome, PNPLA3 polymorphism and hepatic steatosis in hereditary hemochromatosis. | 2020 | Details |
| A43094 | 32586106 | Antioxid Redox Signal | Phospholipase D as a Potential Modulator of Metabolic Syndrome: Impact of Functional Foods. | 2020 | Details |
| A43128 | 32490323 | Hepatol Commun | Hepatic Choline Transport Is Inhibited During Fatty Acid-Induced Lipotoxicity and Obesity. | 2020 | Details |
| A43131 | 32482717 | J Lipid Res | Lecithin:cholesterol acyltransferase: symposium on 50 years of biomedical research from its discovery to latest findings. | 2020 | Details |
| A43135 | 32471727 | J Hepatol | MARC1 variant rs2642438 increases hepatic phosphatidylcholines and decreases severity of non-alcoholic fatty liver disease in humans. | 2020 | Details |
| A43389 | 31851339 | J Nutr | Dietary Choline Supplementation Attenuates High-Fat-Diet-Induced Hepatocellular Carcinoma in Mice. | 2020 | Details |
| A43429 | 31737665 | Biomed Res Int | Lipid Metabolism Alterations in a Rat Model of Chronic and Intergenerational Exposure to Arsenic. | 2019 | Details |
| A43551 | 31434800 | JCI Insight | Human PNPLA3-I148M variant increases hepatic retention of polyunsaturated fatty acids. | 2019 | Details |
| A43698 | 31084205 | Ann Clin Biochem | The association between lecithin-cholesterol acyltransferase activity and fatty liver index. | 2019 | Details |
| A43945 | 30379616 | Annu Rev Physiol | Phospholipid Remodeling in Physiology and Disease. | 2018 | Details |
| A44235 | 31032137 | J Drug Alcohol Res | Alcohol-Induced Hepatic Steatosis: A Comparative Study to Identify Possible Indicator(s) of Alcoholic Fatty Liver Disease. | 2018 | Details |
| A44482 | 28489415 | Am J Respir Cell Mol Biol | Hepatic Steatosis Accompanies Pulmonary Alveolar Proteinosis. | 2017 | Details |
| A44779 | 27334756 | Mol Cell Biochem | Annexin A6 protein is downregulated in human hepatocellular carcinoma. | 2016 | Details |
| A44897 | 26924096 | Gastroenterology | Extracellular Vesicles as Messengers Between Hepatocytes and Macrophages in Nonalcoholic Steatohepatitis. | 2016 | Details |
| A45448 | 24511104 | J Lipid Res | PNPLA3 mediates hepatocyte triacylglycerol remodeling. | 2014 | Details |
| A45606 | 23703836 | Hepatology | Finding the balance: the role of S-adenosylmethionine and phosphatidylcholine metabolism in development of nonalcoholic fatty liver disease. | 2013 | Details |
| A45615 | 23640498 | Arterioscler Thromb Vasc Biol | Sphingomyelin synthase 2 activity and liver steatosis: an effect of ceramide-mediated peroxisome proliferator-activated receptor γ2 suppression. | 2013 | Details |
| A45763 | 22877991 | Biochim Biophys Acta | Physiological roles of phosphatidylethanolamine N-methyltransferase. | 2012 | Details |
| A45905 | 22152250 | Zhonghua Gan Zang Bing Za Zhi | [Efficacy comparison between bicyclol and polyene phosphatidylcholine treatments for the patients with nonalcoholic fatty liver disease]. | 2011 | Details |
| A46130 | 20860563 | Liver Int | Cross-regulation of cannabinoid CB₁ and CB₂ receptors governs hepatic steatosis. | 2010 | Details |
| A46675 | 16679290 | Cell Metab | The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis. | 2006 | Details |
| A46776 | 15670659 | Alcohol | Role of fatty liver, dietary fatty acid supplements, and obesity in the progression of alcoholic liver disease: introduction and summary of the symposium. | 2004 | Details |
| A46818 | 14720455 | Curr Gastroenterol Rep | New concepts of the pathogenesis of alcoholic liver disease lead to novel treatments. | 2004 | Details |
| A46822 | 14653214 | Rinsho Byori | [Laboratory data for assessment of nutrition in liver disease--with special reference to alcoholic hepatitis and nonalcoholic steatohepatitis (NASH)]. | 2003 | Details |
| A47036 | 28667706 | Pathol Int | An autopsy case of non-traumatic fat embolism syndrome. | 2017 | Details |
| A47240 | 21763219 | J Chromatogr B Analyt Technol Biomed Life Sci | Metabolomics study of alcohol-induced liver injury and hepatocellular carcinoma xenografts in mice. | 2011 | Details |
| A47284 | 19170661 | Alcohol Clin Exp Res | Quantitative lipid metabolomic changes in alcoholic micropigs with fatty liver disease. | 2009 | Details |
| A47299 | 18498552 | Alcohol Clin Exp Res | Effect of transgenic extrahepatic expression of betaine-homocysteine methyltransferase on alcohol or homocysteine-induced fatty liver. | 2008 | Details |
| A47312 | 17616758 | Am J Clin Nutr | Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium. | 2007 | Details |
| A47355 | 12940921 | Aliment Pharmacol Ther | Review article: Nutritional therapy in alcoholic liver disease. | 2003 | Details |
| A47358 | 12711653 | Alcohol Alcohol | Polyenylphosphatidylcholine corrects the alcohol-induced hepatic oxidative stress by restoring s-adenosylmethionine. | 2003 | Details |
| A47368 | 11762137 | Pathol Biol (Paris) | Alcoholic liver injury: pathogenesis and therapy in 2001. | 2001 | Details |
| A47373 | 11268819 | Am J Addict | Liver diseases by alcohol and hepatitis C: early detection and new insights in pathogenesis lead to improved treatment. | 2001 | Details |
| A47380 | 10397283 | Alcohol Clin Exp Res | Microsomal ethanol-oxidizing system (MEOS): the first 30 years (1968-1998)--a review. | 1999 | Details |
| A47400 | 9278563 | J Nutr | Polyenylphosphatidylcholine attenuates alcohol-induced fatty liver and hyperlipemia in rats. | 1997 | Details |
| A47405 | 9113278 | Alcohol Clin Exp Res | Polyenylphosphatidylcholine decreases alcohol-induced oxidative stress in the baboon. | 1997 | Details |
| A47406 | 9364195 | Life Sci | Polyenylphosphatidylcholine decreases alcoholic hyperlipemia without affecting the alcohol-induced rise of HDL-cholesterol. | 1997 | Details |
| A47447 | 8403799 | Clin Sci (Lond) | Plasma membrane form of phosphatidate phosphohydrolase: a possible role in signal transduction during liver fibrogenesis. | 1993 | Details |
| A47475 | 2258155 | Hepatology | Attenuation of alcohol-induced hepatic fibrosis by polyunsaturated lecithin. | 1990 | Details |
| A47487 | 2480864 | Clin Ter | [Alcoholic liver diseases and their treatment]. | 1989 | Details |
| A47575 | 6884708 | Gastroenterology | In vivo evaluation of lipoprotein cholesterol ester metabolism in patients with liver disease. | 1983 | Details |
| A47587 | 6840680 | Hepatology | Plasma lipid and lipoprotein response to fat feeding in alcoholic liver disease. | 1983 | Details |
| A48159 | 21068006 | J Lipid Res | Specificity and rate of human and mouse liver and plasma phosphatidylcholine synthesis analyzed in vivo. | 2010 | Details |
| A48200 | 19947262 | Zhongguo Zhen Jiu | [Observation on therapeutic effect of acupuncture for treatment of patients with nonalcoholic steatohepatitis]. | 2009 | Details |
| A48695 | 31376210 | FEBS Open Bio | A novel assay for measuring recombinant human lysophosphatidylcholine acyltransferase 3 activity. | 2019 | Details |
| A49144 | 16296871 | Drugs | Pathophysiological basis for antioxidant therapy in chronic liver disease. | 2005 | Details |
| A49284 | 35800450 | Front Pharmacol | Protective Effect of Danshen Zexie Decoction Against Non-Alcoholic Fatty Liver Disease Through Inhibition of ROS/NLRP3/IL-1β Pathway by Nrf2 Signaling Activation. | 2022 | Details |
| A49643 | 35682720 | Int J Mol Sci | Maternal Pyrroloquinoline Quinone Supplementation Improves Offspring Liver Bioactive Lipid Profiles throughout the Lifespan and Protects against the Development of Adult NAFLD. | 2022 | Details |
| A49751 | 35647758 | J Clin Endocrinol Metab | Normal HDL cholesterol efflux and anti-inflammatory capacities in type 2 diabetes despite lipidomic abnormalities. | 2022 | Details |
| A50124 | 35511653 | Minerva Gastroenterol (Torino) | Treatment with phosphatidylcholine of patients with non-alcoholic fatty liver disease: a prospective pilot study. | 2022 | Details |
| A50217 | 35469167 | JHEP Rep | Lipid alterations in chronic liver disease and liver cancer. | 2022 | Details |
| A50244 | 35460694 | J Biol Chem | MicroRNA-200c coordinates HNF1 homeobox B and apolipoprotein O functions to modulate lipid homeostasis in alcoholic fatty liver disease. | 2022 | Details |
| A50257 | 35452693 | J Hepatol | Lack of VMP1 impairs hepatic lipoprotein secretion and promotes non-alcoholic steatohepatitis. | 2022 | Details |
| A50303 | 35438091 | Food Funct | Changes in the serum metabolomic profiles of subjects with NAFLD in response to n-3 PUFAs and phytosterol ester: a double-blind randomized controlled trial. | 2022 | Details |
| A50321 | 35434590 | JHEP Rep | Metabolic signatures across the full spectrum of non-alcoholic fatty liver disease. | 2022 | Details |
| A50378 | 35411667 | Hepatol Commun | Variants in mitochondrial amidoxime reducing component 1 and hydroxysteroid 17-beta dehydrogenase 13 reduce severity of nonalcoholic fatty liver disease in children and suppress fibrotic pathways through distinct mechanisms. | 2022 | Details |
| A50440 | 35391786 | J Lipids | Age- and Diet-Dependent Changes in Hepatic Lipidomic Profiles of Phospholipids in Male Mice: Age Acceleration in Cyp2b-Null Mice. | 2022 | Details |
| A50464 | 35380992 | J Clin Invest | Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis. | 2022 | Details |
| A50483 | 35368766 | Evid Based Complement Alternat Med | An Open-Label Exploratory Clinical Trial Evaluating the Effects of GLS (Coptidis Rhizoma-Evodiae Fructus 2 : 1) on Fibroblast Growth Factor 21 in Patients with Nonalcoholic Fatty Liver Disease. | 2022 | Details |
| A50506 | 35359878 | Front Pharmacol | Regression of Liver Steatosis Following Phosphatidylcholine Administration: A Review of Molecular and Metabolic Pathways Involved. | 2022 | Details |
| A50700 | 35295576 | Front Physiol | Polyene Phosphatidylcholine Ameliorates High Fat Diet-Induced Non-alcoholic Fatty Liver Disease via Remodeling Metabolism and Inflammation. | 2022 | Details |
| A50769 | 35273160 | Nat Commun | Deep proteomic profiling unveils arylsulfatase A as a non-alcoholic steatohepatitis inducible hepatokine and regulator of glycemic control. | 2022 | Details |
| A51100 | 35766964 | J Med Food | Persimmon Water Extract Suppresses Hepatic Lipotoxicity by Regulating Lipid Metabolites. | 2022 | Details |
| A51134 | 35559233 | Front Pharmacol | Revealing the Mechanism of Huazhi Rougan Granule in the Treatment of Nonalcoholic Fatty Liver Through Intestinal Flora Based on 16S rRNA, Metagenomic Sequencing and Network Pharmacology. | 2022 | Details |
| A51171 | 35364359 | Nutr Res | Lower plasma glutathione, choline, and betaine concentrations are associated with fatty liver in postmenopausal women. | 2022 | Details |
| A51250 | 35318125 | Biochim Biophys Acta Mol Basis Dis | Kupffer cells are protective in alcoholic steatosis. | 2022 | Details |
| A51252 | 35274962 | J Proteome Res | Metabolic Signature of Ethanol-Induced Hepatotoxicity in HepaRG Cells by Liquid Chromatography-Mass Spectrometry-Based Untargeted Metabolomics. | 2022 | Details |
| A51309 | 35711841 | J Cancer | Research progress in the role and mechanism of LPCAT3 in metabolic related diseases and cancer. | 2022 | Details |
| A51325 | 35617134 | Autophagy | VMP1 regulates hepatic lipoprotein secretion and NASH independent of autophagy. | 2022 | Details |
| A51571 | 35042855 | Nutr Diabetes | Metabolic biomarkers related to cardiac dysfunction in metabolic-dysfunction-associated fatty liver disease: a cross-sectional analysis. | 2022 | Details |
| A51686 | 34920733 | Cardiovasc Diabetol | Pharmacometabolomic profiles in type 2 diabetic subjects treated with liraglutide or glimepiride. | 2021 | Details |
| A51766 | 34274572 | Poult Sci | Untargeted and targeted metabolomics profiling reveals the underlying pathogenesis and abnormal arachidonic acid metabolism in laying hens with fatty liver hemorrhagic syndrome. | 2021 | Details |
| A51804 | 33987742 | Int J Legal Med | Application of Q-TOF-MS based metabonomics techniques to analyze the plasma metabolic profile changes on rats following death due to acute intoxication of phorate. | 2021 | Details |
| A51815 | 33946522 | Metabolites | Characterization of the Plasma Lipidome in Dairy Cattle Transitioning from Gestation to Lactation: Identifying Novel Biomarkers of Metabolic Impairment. | 2021 | Details |
| A51819 | 33940322 | Int Immunopharmacol | Untargeted lipidomics analysis of Mori Fructus polysaccharide on acute alcoholic liver injury in mice using ultra performance liquid chromatography-quadrupole-orbitrap-high resolution mass spectrometry. | 2021 | Details |
| A52012 | 32303571 | Dis Model Mech | A comprehensive study of phospholipid fatty acid rearrangements in metabolic syndrome: correlations with organ dysfunction. | 2020 | Details |
| A52051 | 31888144 | Int J Mol Sci | Altered Metabolic Profile and Adipocyte Insulin Resistance Mark Severe Liver Fibrosis in Patients with Chronic Liver Disease. | 2019 | Details |
| A52199 | 30200659 | Nutrients | Changes in Plasma Acylcarnitine and Lysophosphatidylcholine Levels Following a High-Fructose Diet: A Targeted Metabolomics Study in Healthy Women. | 2018 | Details |
| A52487 | 26446667 | BMC Vet Res | Blood plasma lipidome profile of dairy cows during the transition period. | 2015 | Details |
| A52616 | 24834723 | Ukr Biochem J | [The effect of N-stearoylethanolamine on liver phospholipid composition of rats with insulin resistance caused by alimentary obesity]. | 2014 | Details |
| A52653 | 24130792 | PLoS One | Diagnosing fatty liver disease: a comparative evaluation of metabolic markers, phenotypes, genotypes and established biomarkers. | 2013 | Details |
| A52890 | 19932908 | J Surg Res | Hepatocellular carcinoma associated lipid metabolism reprogramming. | 2009 | Details |
| A53031 | 16996649 | Neurobiol Aging | A metabolic link between S-adenosylhomocysteine and polyunsaturated fatty acid metabolism in Alzheimer's disease. | 2006 | Details |
| A53039 | 16750656 | Vascul Pharmacol | Adverse hepatic and cardiac responses to rosiglitazone in a new mouse model of type 2 diabetes: relation to dysregulated phosphatidylcholine metabolism. | 2006 | Details |
| A53109 | 12901271 | Wiad Lek | [Alcoholic liver disease]. | 2003 | Details |
| A53169 | 8141924 | Alcohol Alcohol Suppl | Impaired erythrocyte deformability and membrane fluidity in alcoholic liver disease: participation in disturbed hepatic microcirculation. | 1993 | Details |