Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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oxidative stress3585 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A46883 | 11589765 | Liver | Serum thioredoxin elucidates the significance of serum ferritin as a marker of oxidative stress in chronic liver diseases. | 2001 | Details |
| A46893 | 11293184 | Indian J Gastroenterol | Nonalcoholic steatohepatitis. | 2001 | Details |
| A46911 | 34558087 | Alcohol Clin Exp Res | A review of the role of ethanol-induced adipose tissue dysfunction in alcohol-associated liver disease. | 2021 | Details |
| A46912 | 34525389 | J Nutr Biochem | A mouse model of the regression of alcoholic hepatitis: Monitoring the regression of hepatic steatosis, inflammation, oxidative stress, and NAD+ metabolism upon alcohol withdrawal. | 2021 | Details |
| A46919 | 34267188 | Cell Death Dis | Depdc5 deficiency exacerbates alcohol-induced hepatic steatosis via suppression of PPARα pathway. | 2021 | Details |
| A46920 | 34265279 | Biochem Pharmacol | PPARα agonist WY-14,643 induces adipose atrophy and fails to blunt chronic ethanol-induced hepatic fat accumulation in mice lacking adipose FGFR1. | 2021 | Details |
| A46924 | 34116071 | Toxicol Appl Pharmacol | Liver-specific Nrf2 deficiency accelerates ethanol-induced lethality and hepatic injury in vivo. | 2021 | Details |
| A46941 | 33352397 | Cytokine | IL-8 exacerbates alcohol-induced fatty liver disease via the Akt/HIF-1α pathway in human IL-8-expressing mice. | 2020 | Details |
| A46943 | 33249138 | Free Radic Biol Med | The critical role of redox regulation of PTEN and peroxiredoxin III in alcoholic fatty liver. | 2020 | Details |
| A46947 | 33067186 | Dis Model Mech | Alcoholic hepatitis and metabolic disturbance in female mice: a more tractable model than Nrf2 -/- animals. | 2020 | Details |
| A46957 | 32544093 | JCI Insight | Chronic-plus-binge alcohol intake induces production of proinflammatory mtDNA-enriched extracellular vesicles and steatohepatitis via ASK1/p38MAPKα-dependent mechanisms. | 2020 | Details |
| A46962 | 32267550 | Alcohol Clin Exp Res | Dihydromyricetin Protects the Liver via Changes in Lipid Metabolism and Enhanced Ethanol Metabolism. | 2020 | Details |
| A46967 | 32045450 | PLoS One | Mesenchymal stem cells reduce alcoholic hepatitis in mice via suppression of hepatic neutrophil and macrophage infiltration, and of oxidative stress. | 2020 | Details |
| A46984 | 31295533 | J Hepatol | The epigenetic regulator SIRT6 protects the liver from alcohol-induced tissue injury by reducing oxidative stress in mice. | 2019 | Details |
| A46989 | 31168926 | Mol Nutr Food Res | Myricetin Ameliorates Ethanol-Induced Lipid Accumulation in Liver Cells by Reducing Fatty Acid Biosynthesis. | 2019 | Details |
| A46995 | 30935969 | Metabolism | Chitinase-3-like-1 deficiency attenuates ethanol-induced liver injury by inhibition of sterol regulatory element binding protein 1-dependent triglyceride synthesis. | 2019 | Details |
| A46998 | 30802717 | Redox Biol | Systemic inactivation of hypoxia-inducible factor prolyl 4-hydroxylase 2 in mice protects from alcohol-induced fatty liver disease. | 2019 | Details |
| A47011 | 30115921 | Nat Rev Dis Primers | Alcoholic liver disease. | 2018 | Details |
| A47013 | 30071471 | Redox Biol | Pomegranate prevents binge alcohol-induced gut leakiness and hepatic inflammation by suppressing oxidative and nitrative stress. | 2018 | Details |
| A47020 | 29452206 | J Hepatol | SNX10 mediates alcohol-induced liver injury and steatosis by regulating the activation of chaperone-mediated autophagy. | 2018 | Details |
| A47021 | 29368944 | Am J Physiol Gastrointest Liver Physiol | A specific amino acid formula prevents alcoholic liver disease in rodents. | 2018 | Details |
| A47038 | 28500689 | IUBMB Life | Blockade of hedgehog pathway is required for the protective effects of magnesium isoglycyrrhizinate against ethanol-induced hepatocyte steatosis and apoptosis. | 2017 | Details |
| A47041 | 28467182 | Exp Biol Med (Maywood) | Roles of silent information regulator 1-serine/arginine-rich splicing factor 10-lipin 1 axis in the pathogenesis of alcohol fatty liver disease. | 2017 | Details |
| A47049 | 27871879 | J Hepatol | Aging aggravates alcoholic liver injury and fibrosis in mice by downregulating sirtuin 1 expression. | 2016 | Details |
| A47056 | 27679493 | Gut | MicroRNA-223 ameliorates alcoholic liver injury by inhibiting the IL-6-p47phox-oxidative stress pathway in neutrophils. | 2016 | Details |
| A47058 | 27630043 | Nat Commun | MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C. | 2016 | Details |
| A47059 | 27455313 | Nutrients | Barley Sprouts Extract Attenuates Alcoholic Fatty Liver Injury in Mice by Reducing Inflammatory Response. | 2016 | Details |
| A47066 | 27080262 | Br J Nutr | Decreased hepatic iron in response to alcohol may contribute to alcohol-induced suppression of hepcidin. | 2016 | Details |
| A47067 | 27044810 | Biomed Pharmacother | Diallyl trisulfide attenuates ethanol-induced hepatic steatosis by inhibiting oxidative stress and apoptosis. | 2016 | Details |
| A47073 | 26854922 | Food Chem Toxicol | Ethanol and fatty acids impair lipid homeostasis in an in vitro model of hepatic steatosis. | 2016 | Details |
| A47075 | 26801973 | BMC Complement Altern Med | Hepatoprotective effect of licorice, the root of Glycyrrhiza uralensis Fischer, in alcohol-induced fatty liver disease. | 2016 | Details |
| A47077 | 26637972 | Biofactors | Endogenously elevated n-3 polyunsaturated fatty acids alleviate acute ethanol-induced liver steatosis. | 2015 | Details |
| A47078 | 26626356 | J Microbiol | Lactobacillus rhamnosus CCFM1107 treatment ameliorates alcohol-induced liver injury in a mouse model of chronic alcohol feeding. | 2015 | Details |
| A47085 | 26497211 | Oncotarget | Identification of cytochrome CYP2E1 as critical mediator of synergistic effects of alcohol and cellular lipid accumulation in hepatocytes in vitro. | 2015 | Details |
| A47088 | 26459052 | Int Immunopharmacol | Ligustrazine prevents alcohol-induced liver injury by attenuating hepatic steatosis and oxidative stress. | 2015 | Details |
| A47091 | 26305715 | IUBMB Life | Curcumin attenuates ethanol-induced hepatic steatosis through modulating Nrf2/FXR signaling in hepatocytes. | 2015 | Details |
| A47096 | 26030870 | PLoS One | Establishment of the tree shrew as an alcohol-induced Fatty liver model for the study of alcoholic liver diseases. | 2015 | Details |
| A47106 | 25892964 | Int J Biol Sci | The effects of insulin pre-administration in mice exposed to ethanol: alleviating hepatic oxidative injury through anti-oxidative, anti-apoptotic activities and deteriorating hepatic steatosis through SRBEP-1c activation. | 2015 | Details |
| A47112 | 25789959 | Medicine (Baltimore) | Changes in tumor necrosis factor-α, heat shock protein 70, malondialdehyde, and superoxide dismutase in patients with different severities of alcoholic fatty liver disease: a prospective observational study. | 2015 | Details |
| A47126 | 25494594 | Lipids Health Dis | Protective effect of corn peptides against alcoholic liver injury in men with chronic alcohol consumption: a randomized double-blind placebo-controlled study. | 2014 | Details |
| A47127 | 25462064 | Redox Biol | Intestinal CYP2E1: A mediator of alcohol-induced gut leakiness. | 2014 | Details |
| A47128 | 25462060 | Redox Biol | Regulation of the effects of CYP2E1-induced oxidative stress by JNK signaling. | 2014 | Details |
| A47129 | 25455889 | Food Chem Toxicol | Berberine protects liver from ethanol-induced oxidative stress and steatosis in mice. | 2014 | Details |
| A47134 | 25362106 | J Pharmacol Exp Ther | Demethyleneberberine, a natural mitochondria-targeted antioxidant, inhibits mitochondrial dysfunction, oxidative stress, and steatosis in alcoholic liver disease mouse model. | 2014 | Details |
| A47135 | 25355486 | Acta Biochim Biophys Sin (Shanghai) | FGF21 treatment ameliorates alcoholic fatty liver through activation of AMPK-SIRT1 pathway. | 2014 | Details |
| A47139 | 25228362 | Pharmacology | Emodin ameliorates ethanol-induced fatty liver injury in mice. | 2014 | Details |
| A47141 | 25107314 | Drug Alcohol Depend | Altered oxidative stress/antioxidant status in blood of alcoholic subjects is associated with alcoholic liver disease. | 2014 | Details |
| A47146 | 24930470 | Alcohol Clin Exp Res | Pyrroloquinoline quinone-secreting probiotic Escherichia coli Nissle 1917 ameliorates ethanol-induced oxidative damage and hyperlipidemia in rats. | 2014 | Details |
| A47147 | 24859453 | J Hepatol | Inhibition of heat shock protein 90 alleviates steatosis and macrophage activation in murine alcoholic liver injury. | 2014 | Details |
| A47152 | 24815155 | Transplant Proc | Γ-glutamyl transferase as an early and sensitive marker in ethanol-induced liver injury of rats. | 2014 | Details |
| A47157 | 24740309 | PLoS One | Zeaxanthin dipalmitate therapeutically improves hepatic functions in an alcoholic fatty liver disease model through modulating MAPK pathway. | 2014 | Details |
| A47159 | 24722988 | J Biol Chem | Identification of 5' AMP-activated kinase as a target of reactive aldehydes during chronic ingestion of high concentrations of ethanol. | 2014 | Details |
| A47160 | 24713392 | Am J Pathol | M2 kupffer cells promote hepatocyte senescence: an IL-6-dependent protective mechanism against alcoholic liver disease. | 2014 | Details |
| A47163 | 24581955 | Alcohol | Influence of fat/carbohydrate ratio on progression of fatty liver disease and on development of osteopenia in male rats fed alcohol via total enteral nutrition (TEN). | 2014 | Details |
| A47164 | 24513924 | Food Funct | Polyphenol-rich extract of Nelumbo nucifera leaves inhibits alcohol-induced steatohepatitis via reducing hepatic lipid accumulation and anti-inflammation in C57BL/6J mice. | 2014 | Details |
| A47171 | 24269813 | Biochem Biophys Res Commun | Activation of farnesoid X receptor attenuates hepatic injury in a murine model of alcoholic liver disease. | 2013 | Details |
| A47172 | 24262277 | Gastroenterology | Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver. | 2013 | Details |
| A47176 | 24155903 | PLoS One | Dietary zinc deficiency exaggerates ethanol-induced liver injury in mice: involvement of intrahepatic and extrahepatic factors. | 2013 | Details |
| A47177 | 24146112 | Arch Toxicol | Protective effects of dioscin against alcohol-induced liver injury. | 2013 | Details |
| A47185 | 23907024 | Food Chem Toxicol | A role for lipid rafts in the protection afforded by docosahexaenoic acid against ethanol toxicity in primary rat hepatocytes. | 2013 | Details |
| A47186 | 23815146 | Nutr Rev | Ethanol metabolism and its effects on the intestinal epithelial barrier. | 2013 | Details |
| A47188 | 23798569 | Dis Model Mech | Ethanol metabolism and oxidative stress are required for unfolded protein response activation and steatosis in zebrafish with alcoholic liver disease. | 2013 | Details |
| A47193 | 23641075 | J Cell Sci | Lamin aggregation is an early sensor of porphyria-induced liver injury. | 2013 | Details |
| A47200 | 23058988 | J Ethnopharmacol | Herbal medicines for the prevention of alcoholic liver disease: a review. | 2012 | Details |
| A47203 | 23010494 | Free Radic Biol Med | Hepatic mitochondrial dysfunction induced by fatty acids and ethanol. | 2012 | Details |
| A47206 | 22905112 | PLoS One | Reduced susceptibility of DNA methyltransferase 1 hypomorphic (Dnmt1N/+) mice to hepatic steatosis upon feeding liquid alcohol diet. | 2012 | Details |
| A47212 | 22684045 | Gastroenterology | β-Catenin regulates hepatic mitochondrial function and energy balance in mice. | 2012 | Details |
| A47216 | 22532405 | Mol Biosyst | Metabolic profiling of an alcoholic fatty liver in zebrafish (Danio rerio). | 2012 | Details |
| A47224 | 22356308 | J Dig Dis | Oxidative stress and redox signaling mechanisms of alcoholic liver disease: updated experimental and clinical evidence. | 2012 | Details |
| A47229 | 22206017 | PLoS One | Neonatal androgenization exacerbates alcohol-induced liver injury in adult rats, an effect abrogated by estrogen. | 2011 | Details |
| A47239 | 21790669 | Alcohol Clin Exp Res | Limited therapeutic effect of N-acetylcysteine on hepatic insulin resistance in an experimental model of alcohol-induced steatohepatitis. | 2011 | Details |
| A47243 | 21663494 | J Med Food | Hepatoprotective effect of aged black garlic on chronic alcohol-induced liver injury in rats. | 2011 | Details |
| A47256 | 21087523 | J Transl Med | Exploring the molecular mechanisms underlying the potentiation of exogenous growth hormone on alcohol-induced fatty liver diseases in mice. | 2010 | Details |
| A47257 | 20981870 | Phytother Res | Osthole improves alcohol-induced fatty liver in mice by reduction of hepatic oxidative stress. | 2010 | Details |
| A47269 | 19714808 | J Proteome Res | Liver proteome analysis in a rodent model of alcoholic steatosis. | 2009 | Details |
| A47273 | 19645728 | Alcohol Clin Exp Res | Intestinal dysbiosis: a possible mechanism of alcohol-induced endotoxemia and alcoholic steatohepatitis in rats. | 2009 | Details |
| A47274 | 19637192 | Hepatology | Zinc supplementation reverses alcohol-induced steatosis in mice through reactivating hepatocyte nuclear factor-4alpha and peroxisome proliferator-activated receptor-alpha. | 2009 | Details |
| A47276 | 19606259 | J Biomed Biotechnol | Curcumin decreased oxidative stress, inhibited NF-kappaB activation, and improved liver pathology in ethanol-induced liver injury in rats. | 2009 | Details |
| A47278 | 19372631 | J Pharmacol Sci | Magnolia officinalis reverses alcoholic fatty liver by inhibiting the maturation of sterol regulatory element-binding protein-1c. | 2009 | Details |
| A47290 | 19003881 | Hepatology | Ethanol and arachidonic acid synergize to activate Kupffer cells and modulate the fibrogenic response via tumor necrosis factor alpha, reduced glutathione, and transforming growth factor beta-dependent mechanisms. | 2008 | Details |
| A47303 | 18369908 | Methods Mol Biol | A voluntary oral-feeding rat model for pathological alcoholic liver injury. | 2008 | Details |
| A47309 | 17850215 | Alcohol Clin Exp Res | Lysosomal leakage and lack of adaptation of hepatoprotective enzyme contribute to enhanced susceptibility to ethanol-induced liver injury in female rats. | 2007 | Details |
| A47312 | 17616758 | Am J Clin Nutr | Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium. | 2007 | Details |
| A47326 | 16958678 | J Gastroenterol Hepatol | Unfolding new mechanisms of alcoholic liver disease in the endoplasmic reticulum. | 2006 | Details |
| A47358 | 12711653 | Alcohol Alcohol | Polyenylphosphatidylcholine corrects the alcohol-induced hepatic oxidative stress by restoring s-adenosylmethionine. | 2003 | Details |
| A47359 | 12635862 | Int J Tissue React | Long-term ethanol administration enhances age-dependent modulation of redox state in different brain regions in the rat: protection by acetyl carnitine. | 2002 | Details |
| A47368 | 11762137 | Pathol Biol (Paris) | Alcoholic liver injury: pathogenesis and therapy in 2001. | 2001 | Details |
| A47373 | 11268819 | Am J Addict | Liver diseases by alcohol and hepatitis C: early detection and new insights in pathogenesis lead to improved treatment. | 2001 | Details |
| A47380 | 10397283 | Alcohol Clin Exp Res | Microsomal ethanol-oxidizing system (MEOS): the first 30 years (1968-1998)--a review. | 1999 | Details |
| A47405 | 9113278 | Alcohol Clin Exp Res | Polyenylphosphatidylcholine decreases alcohol-induced oxidative stress in the baboon. | 1997 | Details |
| A47612 | 35091323 | Redox Biol | PERK prevents hepatic lipotoxicity by activating the p62-ULK1 axis-mediated noncanonical KEAP1-Nrf2 pathway. | 2022 | Details |
| A47654 | 34192554 | Toxicol Lett | NFATc4 mediates ethanol-triggered hepatocyte senescence. | 2021 | Details |
| A47676 | 33839215 | Food Chem Toxicol | Fasting-mediated metabolic and toxicity reprogramming impacts circulating microRNA levels in humans. | 2021 | Details |
| A47706 | 33293768 | J Clin Biochem Nutr | Trans-portal hepatic infusion of cultured bone marrow-derived mesenchymal stem cells in a steatohepatitis murine model. | 2020 | Details |
| A47773 | 32184395 | Cell Death Dis | Correction: Targeting alkaline ceramidase 3 alleviates the severity of nonalcoholic steatohepatitis by reducing oxidative stress. | 2020 | Details |
| A47820 | 31389060 | J Appl Toxicol | Free radicals, antioxidants, nuclear factor-E2-related factor-2 and liver damage. | 2019 | Details |
| A47831 | 31201023 | Transfus Clin Biol | The emerging roles of eryptosis in liver diseases. | 2019 | Details |
| A47873 | 30393432 | J Toxicol Pathol | Hepatic lesions induced by feeding Western diets to Zucker fatty rats, an insulin-resistant model. | 2018 | Details |
| A47882 | 30105281 | Cell Mol Gastroenterol Hepatol | Iron Inhibits the Secretion of Apolipoprotein E in Cultured Human Adipocytes. | 2018 | Details |
| A47901 | 29687726 | Antioxid Redox Signal | The Association of Peroxiredoxin 4 with the Initiation and Progression of Hepatocellular Carcinoma. | 2018 | Details |