Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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oxidative stress3585 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A47909 | 29486473 | Cell Physiol Biochem | ShenFu Preparation Protects AML12 Cells Against Palmitic Acid-Induced Injury Through Inhibition of Both JNK/Nox4 and JNK/NFκB Pathways. | 2018 | Details |
| A47923 | 29191940 | Am J Physiol Gastrointest Liver Physiol | Loss of cellular FLICE-inhibitory protein promotes acute cholestatic liver injury and inflammation from bile duct ligation. | 2017 | Details |
| A48010 | 26634212 | Biomed Res Int | The Influence of α-Lipoic Acid and Garlic Administration on Biomarkers of Oxidative Stress and Inflammation in Rabbits Exposed to Oxidized Nutrition Oils. | 2015 | Details |
| A48018 | 26447154 | Am J Clin Nutr | α-Tocopherol bioavailability is lower in adults with metabolic syndrome regardless of dairy fat co-ingestion: a randomized, double-blind, crossover trial. | 2015 | Details |
| A48019 | 26436133 | Adv Hepatol | NADPH Oxidases in Chronic Liver Diseases. | 2014 | Details |
| A48021 | 26340976 | Biol Trace Elem Res | Steatohepatitis is developed by a diet high in fat, sucrose, and cholesterol without increasing iron concentration in rat liver. | 2015 | Details |
| A48061 | 25374730 | Case Reports Hepatol | Nonalcoholic steatohepatitis in a patient with ataxia-telangiectasia. | 2014 | Details |
| A48082 | 24632196 | Free Radic Biol Med | Mechanism for HIF-1 activation by cholesterol under normoxia: a redox signaling pathway for liver damage. | 2014 | Details |
| A48092 | 24204981 | PLoS One | Aliskiren attenuates steatohepatitis and increases turnover of hepatic fat in mice fed with a methionine and choline deficient diet. | 2013 | Details |
| A48109 | 23226929 | Mediators Inflamm | Simulating sleep apnea by exposure to intermittent hypoxia induces inflammation in the lung and liver. | 2012 | Details |
| A48115 | 22922425 | Gastroenterology | NF-κB essential modifier is required for hepatocyte proliferation and the oval cell reaction after partial hepatectomy in mice. | 2012 | Details |
| A48121 | 22556142 | Am J Physiol Gastrointest Liver Physiol | Steatohepatitis in laboratory opossums exhibiting a high lipemic response to dietary cholesterol and fat. | 2012 | Details |
| A48124 | 22521608 | Toxicol Appl Pharmacol | Cyclosporine A and palmitic acid treatment synergistically induce cytotoxicity in HepG2 cells. | 2012 | Details |
| A48141 | 21697078 | Am J Clin Nutr | Disrupted fat distribution and composition due to medium-chain triglycerides in mice with a β-oxidation defect. | 2011 | Details |
| A48154 | 21161013 | World J Hepatol | Gender-related variations in iron metabolism and liver diseases. | 2010 | Details |
| A48161 | 20953409 | Vet Med Int | Lycopene prevents development of steatohepatitis in experimental nonalcoholic steatohepatitis model induced by high-fat diet. | 2010 | Details |
| A48164 | 20861239 | Endocrinology | Caloric restriction reverses hepatic insulin resistance and steatosis in rats with low aerobic capacity. | 2010 | Details |
| A48165 | 20857543 | N Engl J Med | Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. | 2010 | Details |
| A48175 | 20666722 | Curr Med Chem | Chymase as an important target for preventing complications of metabolic syndrome. | 2010 | Details |
| A48203 | 19901911 | Lab Invest | Curcumin limits the fibrogenic evolution of experimental steatohepatitis. | 2009 | Details |
| A48244 | 18952085 | Gastroenterology | Suppressive effects of retinoids on iron-induced oxidative stress in the liver. | 2008 | Details |
| A48247 | 18807886 | No To Hattatsu | [Immunohistochemical analysis of hepatic steatosis in autopsy cases of severe motor and intellectual disabilities]. | 2008 | Details |
| A48257 | 18316359 | Diabetes | Increased expression and activity of the transcription factor FOXO1 in nonalcoholic steatohepatitis. | 2008 | Details |
| A48267 | 18032466 | Am J Physiol Regul Integr Comp Physiol | Attenuation of acute and chronic liver injury in rats by iron-deficient diet. | 2007 | Details |
| A48275 | 17682318 | J Med | Thioacetamide-induced hepatic damage in a rat nutritional model of steatohepatitis. | 2003 | Details |
| A48298 | 17037330 | Nihon Naika Gakkai Zasshi | [Diagnosis of and therapy for nonalcoholic steatohepatitis]. | 2006 | Details |
| A48310 | 16921198 | J Biol Chem | CuZn-SOD deficiency causes ApoB degradation and induces hepatic lipid accumulation by impaired lipoprotein secretion in mice. | 2006 | Details |
| A48332 | 16283935 | BMC Gastroenterol | Measurement of the total antioxidant response using a novel automated method in subjects with nonalcoholic steatohepatitis. | 2005 | Details |
| A48340 | 16162162 | Liver Int | High glucose stimulates hepatic stellate cells to proliferate and to produce collagen through free radical production and activation of mitogen-activated protein kinase. | 2005 | Details |
| A48348 | 15738389 | Proc Natl Acad Sci U S A | Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia. | 2005 | Details |
| A48350 | 15634340 | FEBS J | Altered expression of CD1d molecules and lipid accumulation in the human hepatoma cell line HepG2 after iron loading. | 2005 | Details |
| A48354 | 15570868 | Nihon Shokakibyo Gakkai Zasshi | [Treatment of nonalcoholic steatohepatitis (NASH)]. | 2004 | Details |
| A48365 | 15135345 | Hepatol Res | Control of oxidative stress and reduction in biochemical markers by Vitamin E treatment in patients with nonalcoholic steatohepatitis: a pilot study. | 2004 | Details |
| A48395 | 12590226 | J Clin Gastroenterol | Optimal management of nonalcoholic fatty liver/steatohepatitis. | 2003 | Details |
| A48411 | 12099000 | Nihon Shokakibyo Gakkai Zasshi | [Mechanism of the onset and development of nonalcoholic steatohepatitis and PPAR]. | 2002 | Details |
| A48413 | 12060674 | FASEB J | Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A. | 2002 | Details |
| A48434 | 11097478 | J Hepatol | Characterization of pathogenic and prognostic factors of nonalcoholic steatohepatitis associated with obesity. | 2000 | Details |
| A48453 | 10085596 | Gastroenterol Hepatol | [Nonalcoholic steatohepatitis]. | 1999 | Details |
| A48529 | 34672164 | Minerva Med | SARS-CoV-2, alcohol consumption and liver injury. | 2021 | Details |
| A48533 | 34616107 | J Clin Biochem Nutr | Spirulina platensis and its ingredient biopterin glucoside improved insulin sensitivity in non-alcoholic steatohepatitis model. | 2021 | Details |
| A48562 | 34068269 | Int J Mol Sci | Alcohol-Related Liver Disease: Basic Mechanisms and Clinical Perspectives. | 2021 | Details |
| A48583 | 33624852 | J Food Biochem | Red yeast rice prevents chronic alcohol-induced liver disease by attenuating oxidative stress and inflammatory response in mice. | 2021 | Details |
| A48591 | 33477615 | Antioxidants (Basel) | The Influence of a Conjugated Pneumococcal Vaccination on Plasma Antibody Levels against Oxidized Low-Density Lipoprotein in Metabolic Disease Patients: A Single-Arm Pilot Clinical Trial. | 2021 | Details |
| A48594 | 33426525 | Brain Commun | Diet-dependent gut microbiota impacts on adult neurogenesis through mitochondrial stress modulation. | 2020 | Details |
| A48598 | 33330821 | Glob Health Med | Hepatocyte ploidy and pathological mutations in hepatocellular carcinoma: impact on oncogenesis and therapeutics. | 2020 | Details |
| A48603 | 33213164 | Klin Onkol | Hepatocellular carcinoma from the view of gastroenterologist/hepatologist. | 2020 | Details |
| A48612 | 33113429 | Biomed Pharmacother | Plant-derived natural therapeutics targeting cannabinoid receptors in metabolic syndrome and its complications: A review. | 2020 | Details |
| A48614 | 32987701 | Antioxidants (Basel) | Mitochondrial Glutathione: Recent Insights and Role in Disease. | 2020 | Details |
| A48618 | 32903449 | Front Pharmacol | Therapeutic Efficacy of Antioxidants in Ameliorating Obesity Phenotype and Associated Comorbidities. | 2020 | Details |
| A48627 | 32722345 | Cells | The Effects of PK11195 and Protoporphyrin IX Can Modulate Chronic Alcohol Intoxication in Rat Liver Mitochondria under the Opening of the Mitochondrial Permeability Transition Pore. | 2020 | Details |
| A48650 | 32371195 | J Hepatol | Danger signals in liver injury and restoration of homeostasis. | 2020 | Details |
| A48663 | 32010333 | Exp Ther Med | Prevention of arachidonic acid-induced liver injury by controlling oxidative stress-mediated transglutaminase activation with garlic extracts. | 2019 | Details |
| A48672 | 31823815 | Hum Genomics | Investigating RNA expression profiles altered by nicotinamide mononucleotide therapy in a chronic model of alcoholic liver disease. | 2019 | Details |
| A48685 | 31509430 | Am J Physiol Gastrointest Liver Physiol | Rifaximin prevents ethanol-induced liver injury in obese KK-Ay mice through modulation of small intestinal microbiota signature. | 2019 | Details |
| A48696 | 31368881 | Endocr Metab Immune Disord Drug Targets | Key Relevance of Epigenetic Programming of Adiponectin Gene in Pathogenesis of Metabolic Disorders. | 2020 | Details |
| A48717 | 30817309 | Rev Neurosci | The effects of dietary methionine restriction on the function and metabolic reprogramming in the liver and brain - implications for longevity. | 2019 | Details |
| A48718 | 30748014 | Alcohol Clin Exp Res | The Chemical Chaperone 4-Phenylbutyric Acid Prevents Alcohol-Induced Liver Injury in Obese KK-Ay Mice. | 2019 | Details |
| A48726 | 30562963 | Cancers (Basel) | Oncogenic Activation of Nrf2, Though as a Master Antioxidant Transcription Factor, Liberated by Specific Knockout of the Full-Length Nrf1α that Acts as a Dominant Tumor Repressor. | 2018 | Details |
| A48733 | 30338039 | Oncotarget | Inhibitory effects of pentoxifylline on inflammation-related tumorigenesis in rat colon. | 2018 | Details |
| A48737 | 30279623 | J Clin Biochem Nutr | Nrf2-mediated anti-oxidant effects contribute to suppression of non-alcoholic steatohepatitis-associated hepatocellular carcinoma in murine model. | 2018 | Details |
| A48738 | 30267745 | Toxicol Appl Pharmacol | Nrf1 is paved as a new strategic avenue to prevent and treat cancer, neurodegenerative and other diseases. | 2018 | Details |
| A48741 | 30165058 | Toxicol Appl Pharmacol | Nrf2 in alcoholic liver disease. | 2018 | Details |
| A48744 | 29966389 | Nutrients | Curcumin in Liver Diseases: A Systematic Review of the Cellular Mechanisms of Oxidative Stress and Clinical Perspective. | 2018 | Details |
| A48772 | 29246445 | Biochim Biophys Acta Mol Basis Dis | Protective effect of genetic deletion of pannexin1 in experimental mouse models of acute and chronic liver disease. | 2017 | Details |
| A48822 | 27574547 | World J Hepatol | Antifibrotic effects of ambrisentan, an endothelin-A receptor antagonist, in a non-alcoholic steatohepatitis mouse model. | 2016 | Details |
| A48841 | 26808690 | PLoS One | Hepatic Deficiency of Augmenter of Liver Regeneration Exacerbates Alcohol-Induced Liver Injury and Promotes Fibrosis in Mice. | 2016 | Details |
| A48843 | 26773358 | Environ Toxicol Pharmacol | Protective effects of carnosine alone and together with alpha-tocopherol on lipopolysaccharide (LPS) plus ethanol-induced liver injury. | 2015 | Details |
| A48848 | 26701066 | Toxicol Appl Pharmacol | Genetically obese (ob/ob) mice are resistant to the lethal effects of thioacetamide hepatotoxicity. | 2015 | Details |
| A48851 | 26651978 | Curr Drug Metab | Indole-3-Carbinol (I3C) and its Major Derivatives: Their Pharmacokinetics and Important Roles in Hepatic Protection. | 2016 | Details |
| A48852 | 26609559 | Redox Biol | Curcumin inhibits activation of TRPM2 channels in rat hepatocytes. | 2015 | Details |
| A48855 | 26540078 | Biomolecules | Update on Alcoholic Hepatitis. | 2015 | Details |
| A48856 | 26540040 | Int J Mol Sci | The Role of Oxidative Stress and Antioxidants in Liver Diseases. | 2015 | Details |
| A48861 | 26336926 | Am J Physiol Gastrointest Liver Physiol | The p66Shc protein controls redox signaling and oxidation-dependent DNA damage in human liver cells. | 2015 | Details |
| A48870 | 26019805 | Iran J Basic Med Sci | Modulation of IKKβ/NF-κB and TGF-β1/Smad via Fuzheng Huayu recipe involves in prevention of nutritional steatohepatitis and fibrosis in mice. | 2015 | Details |
| A48871 | 25954479 | World J Hepatol | Control of oxidative stress in hepatocellular carcinoma: Helpful or harmful? | 2015 | Details |
| A48889 | 25509693 | J Med Assoc Thai | Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study. | 2014 | Details |
| A48928 | 24217957 | Alcohol Alcohol | Notch1-nuclear factor κB involves in oxidative stress-induced alcoholic steatohepatitis. | 2013 | Details |
| A48934 | 24032513 | Mini Rev Med Chem | Triglyceride Metabolism and Hepatic Diseases. | 2013 | Details |
| A48963 | 23057725 | Hepatol Res | Fatty liver Shionogi-ob/ob mouse: A new candidate for a non-alcoholic steatohepatitis model. | 2012 | Details |
| A48978 | 22452372 | Br J Pharmacol | Curcumin ameliorates hepatic fibrosis in type 2 diabetes mellitus - insights into its mechanisms of action. | 2012 | Details |
| A48983 | 22352842 | Br J Pharmacol | Curcumin inhibits gene expression of receptor for advanced glycation end-products (RAGE) in hepatic stellate cells in vitro by elevating PPARγ activity and attenuating oxidative stress. | 2012 | Details |
| A48999 | 21951423 | Hepatol Res | Therapeutic effects of ezetimibe for non-alcoholic steatohepatitis in fatty liver shionogi-ob/ob mice. | 2011 | Details |
| A49006 | 21545524 | J Gastroenterol Hepatol | Pathogenesis of alcohol-induced liver disease: classical concepts and recent advances. | 2011 | Details |
| A49009 | 21466434 | Curr Pharm Biotechnol | Silymarin in the prevention and treatment of liver diseases and primary liver cancer. | 2012 | Details |
| A49012 | 21338451 | Hepatol Res | Evolution of hepatic fibrosis research. | 2011 | Details |
| A49016 | 21256123 | Chem Biol Interact | Murine hepatic aldehyde dehydrogenase 1a1 is a major contributor to oxidation of aldehydes formed by lipid peroxidation. | 2011 | Details |
| A49017 | 21195127 | Mol Cell Endocrinol | Curcumin diminishes the impacts of hyperglycemia on the activation of hepatic stellate cells by suppressing membrane translocation and gene expression of glucose transporter-2. | 2010 | Details |
| A49022 | 21112115 | J Hepatol | Insulin resistance and oxidative stress: two therapeutic targets in non-alcoholic steatohepatitis. | 2010 | Details |
| A49025 | 20979658 | Lipids Health Dis | Heme oxygenase-1 prevents non-alcoholic steatohepatitis through suppressing hepatocyte apoptosis in mice. | 2010 | Details |
| A49029 | 20953207 | Acta Pharmacol Sin | Tumor initiation and progression in hepatocellular carcinoma: risk factors, classification, and therapeutic targets. | 2010 | Details |
| A49035 | 20594211 | J Gastroenterol Hepatol | Molecular basis for a functional role of cytochrome P450 2E1 in non-alcoholic steatohepatitis. | 2010 | Details |
| A49036 | 20570793 | Orv Hetil | [Role of environmental factors in the etiology of hepatocellular carcinoma]. | 2010 | Details |
| A49048 | 20064513 | Gastroenterology | Gender dimorphic formation of mouse Mallory-Denk bodies and the role of xenobiotic metabolism and oxidative stress. | 2010 | Details |
| A49073 | 19174085 | Gastroenterol Hepatol | [Basic mechanisms of hepatocellular injury. Role of inflammatory lipid mediators]. | 2009 | Details |
| A49075 | 18947977 | Nutrition | Nutritional lipid-induced oxidative stress leads to mitochondrial dysfunction followed by necrotic death in FaO hepatocytes. | 2008 | Details |
| A49079 | 18793162 | Biochem Soc Trans | NOX family NADPH oxidases in liver and in pancreatic islets: a role in the metabolic syndrome and diabetes? | 2008 | Details |
| A49085 | 18473847 | Curr Pharm Des | Advanced glycation end products (AGEs) and their involvement in liver disease. | 2008 | Details |
| A49087 | 18443813 | Histochem Cell Biol | Intermediate filament cytoskeleton of the liver in health and disease. | 2008 | Details |
| A49091 | 18336675 | J Gastroenterol Hepatol | Oxidative stress in alcoholic liver disease: role of NADPH oxidase complex. | 2008 | Details |
| A49093 | 18329127 | J Hepatol | Ballooned hepatocytes in steatohepatitis: the value of keratin immunohistochemistry for diagnosis. | 2008 | Details |