Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Lipid metabolism4743 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A26090 | 21122807 | Toxicol Appl Pharmacol | Reduction of liver fructokinase expression and improved hepatic inflammation and metabolism in liquid fructose-fed rats after atorvastatin treatment. | 2010 | Details |
| A26093 | 21115542 | Gut | Nor-ursodeoxycholic acid reverses hepatocyte-specific nemo-dependent steatohepatitis. | 2010 | Details |
| A26095 | 26190482 | Clin J Gastroenterol | The latest idea in NAFLD/NASH pathogenesis. | 2010 | Details |
| A26109 | 21079772 | PLoS One | Changes in hepatic gene expression upon oral administration of taurine-conjugated ursodeoxycholic acid in ob/ob mice. | 2010 | Details |
| A26112 | 21075404 | Metabolism | Lipid in the livers of adolescents with nonalcoholic steatohepatitis: combined effects of pathways on steatosis. | 2010 | Details |
| A26128 | 21054517 | J Gastroenterol Hepatol | Sophocarpine alleviates non-alcoholic steatohepatitis in rats. | 2011 | Details |
| A26133 | 21044016 | Curr Vasc Pharmacol | Novel role of NPC1L1 in the regulation of hepatic metabolism: potential contribution of ezetimibe in NAFLD/NASH treatment. | 2011 | Details |
| A26154 | 23051943 | Indian J Med Sci | Cryptogenic cirrhosis: metabolic liver disease due to insulin resistance. | 2010 | Details |
| A26161 | 20975077 | Exp Biol Med (Maywood) | Digital analysis of hepatic sections in mice accurately quantitates triglycerides and selected properties of lipid droplets. | 2010 | Details |
| A26173 | 20960378 | Semin Liver Dis | Novel insights into the pathophysiology of nonalcoholic fatty liver disease. | 2010 | Details |
| A26191 | 20936724 | Zhejiang Da Xue Xue Bao Yi Xue Ban | [Effect of sea cucumber cerebroside on lipid metabolism in fatty liver rats]. | 2010 | Details |
| A26205 | 20888662 | J Hepatol | Hepatic insulin resistance is associated with increased apoptosis and fibrogenesis in nonalcoholic steatohepatitis and chronic hepatitis C. | 2010 | Details |
| A26226 | 20868235 | Biol Chem | Bile acid retention and activation of endogenous hepatic farnesoid-X-receptor in the pathogenesis of fatty liver disease in ob/ob-mice. | 2010 | Details |
| A26228 | 20865648 | Horm Metab Res | Metabolic parameters and nonalcoholic fatty liver disease in hypopituitary men. | 2010 | Details |
| A26243 | 20845385 | Biotechnol J | Hepatoprotective effect of oleuropein in mice: mechanisms uncovered by gene expression profiling. | 2010 | Details |
| A26250 | 20840346 | J Eur Acad Dermatol Venereol | Psoriasis and non-alcoholic fatty liver disease. | 2010 | Details |
| A26252 | 20836990 | Biochem Biophys Res Commun | Nordihydroguaiaretic acid protects against high-fat diet-induced fatty liver by activating AMP-activated protein kinase in obese mice. | 2010 | Details |
| A26254 | 20828853 | J Hepatol | Rosiglitazone promotes fatty acyl CoA accumulation and excessive glycogen storage in livers of mice without adiponectin. | 2010 | Details |
| A26276 | 20801629 | J Nutr Biochem | Role of tumor necrosis factor α (TNFα) in the onset of fructose-induced nonalcoholic fatty liver disease in mice. | 2010 | Details |
| A26294 | 20701585 | Curr Diabetes Rev | Interrelationships between hepatic fat and insulin resistance in non-alcoholic fatty liver disease. | 2010 | Details |
| A26298 | 20687969 | Br J Nutr | The inhibitory effect of genistein on hepatic steatosis is linked to visceral adipocyte metabolism in mice with diet-induced non-alcoholic fatty liver disease. | 2010 | Details |
| A26299 | 20684516 | J Proteome Res | Liquid chromatography-mass spectrometry-based parallel metabolic profiling of human and mouse model serum reveals putative biomarkers associated with the progression of nonalcoholic fatty liver disease. | 2010 | Details |
| A26301 | 20683463 | Eur J Clin Nutr | Intake of n-3 polyunsaturated fatty acids and non-alcoholic fatty liver disease: a cross-sectional study in Japanese men and women. | 2010 | Details |
| A26304 | 20675007 | J Hepatol | Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride. | 2010 | Details |
| A26305 | 20673376 | Br J Nutr | A polyphenol extract modifies quantity but not quality of liver fatty acid content in high-fat-high-sucrose diet-fed rats: possible implication of the sirtuin pathway. | 2010 | Details |
| A26321 | 20653983 | Lipids Health Dis | Preventive effects of chronic exogenous growth hormone levels on diet-induced hepatic steatosis in rats. | 2010 | Details |
| A26327 | 20648472 | Hepatology | PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease. | 2010 | Details |
| A26329 | 20645852 | Annu Rev Nutr | The role of muscle insulin resistance in the pathogenesis of atherogenic dyslipidemia and nonalcoholic fatty liver disease associated with the metabolic syndrome. | 2010 | Details |
| A26335 | 20631297 | J Lipid Res | Mass spectrometric profiling of oxidized lipid products in human nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. | 2010 | Details |
| A26355 | 20602678 | Liver Int | Cannabinoid receptor 1 and 2 agonists increase lipid accumulation in hepatocytes. | 2010 | Details |
| A26377 | 20567026 | J Lipid Res | Berberine reduces methylation of the MTTP promoter and alleviates fatty liver induced by a high-fat diet in rats. | 2010 | Details |
| A26388 | 20548286 | Lab Invest | Attenuated progression of diet-induced steatohepatitis in glutathione-deficient mice. | 2010 | Details |
| A26401 | 20513351 | Biochem Biophys Res Commun | Chromium attenuates high-fat diet-induced nonalcoholic fatty liver disease in KK/HlJ mice. | 2010 | Details |
| A26405 | 22444262 | Animal | Porcine models for the metabolic syndrome, digestive and bone disorders: a general overview. | 2010 | Details |
| A26407 | 20506389 | J Cell Biochem | ERp57 is up-regulated in free fatty acids-induced steatotic L-02 cells and human nonalcoholic fatty livers. | 2010 | Details |
| A26418 | 20492324 | J Gastroenterol Hepatol | A fresh look at NASH pathogenesis. Part 1: the metabolic movers. | 2010 | Details |
| A26427 | 20473581 | Obes Surg | Hepatic gene networks in morbidly obese patients with nonalcoholic fatty liver disease. | 2010 | Details |
| A26428 | 20473151 | Curr Opin Clin Nutr Metab Care | Update on nonalcoholic fatty liver disease: genes involved in nonalcoholic fatty liver disease and associated inflammation. | 2010 | Details |
| A26434 | 20462650 | J Hepatol | Possible involvement and the mechanisms of excess trans-fatty acid consumption in severe NAFLD in mice. | 2010 | Details |
| A26438 | 20460920 | Dig Dis | Genetic and environmental susceptibility to non-alcoholic fatty liver disease. | 2010 | Details |
| A26441 | 20460917 | Dig Dis | Molecular mechanisms of hepatic fibrosis in non-alcoholic steatohepatitis. | 2010 | Details |
| A26443 | 20460915 | Dig Dis | Bile acids as regulators of hepatic lipid and glucose metabolism. | 2010 | Details |
| A26446 | 20460912 | Dig Dis | Liver fat in the pathogenesis of insulin resistance and type 2 diabetes. | 2010 | Details |
| A26466 | 20435456 | J Nutr Biochem | Hyperinsulinemia and ectopic fat deposition can develop in the face of hyperadiponectinemia in young obese rats. | 2011 | Details |
| A26499 | 20392512 | J Hepatol | Involvement of microsomal triglyceride transfer protein in nonalcoholic steatohepatitis in novel spontaneous mouse model. | 2010 | Details |
| A26537 | 20303728 | J Nutr Biochem | Integrated hepatic transcriptome and proteome analysis of mice with high-fat diet-induced nonalcoholic fatty liver disease. | 2010 | Details |
| A26546 | 20227267 | Prostaglandins Leukot Essent Fatty Acids | Regulation of hepatic gene expression by saturated fatty acids. | 2010 | Details |
| A26548 | 20226139 | Zhong Xi Yi Jie He Xue Bao | [Pathogenesis and treatment of non-alcoholic fatty liver disease]. | 2010 | Details |
| A26556 | 20210788 | Basic Clin Pharmacol Toxicol | Hepatic effects of rosiglitazone in rats with the metabolic syndrome. | 2010 | Details |
| A26558 | 20206411 | Gastroenterol Hepatol | [Obesity and liver disease]. | 2010 | Details |
| A26560 | 20204774 | Adv Exp Med Biol | Fenofibrate, a peroxisome proliferator-activated receptor alpha agonist, improves hepatic microcirculatory patency and oxygen availability in a high-fat-diet-induced fatty liver in mice. | 2010 | Details |
| A26582 | 20168226 | Curr Opin Gastroenterol | Recent advances in nonalcoholic fatty liver disease. | 2010 | Details |
| A26591 | 20143458 | World J Gastroenterol | Is the control of dietary cholesterol intake sufficiently effective to ameliorate nonalcoholic fatty liver disease? | 2010 | Details |
| A26601 | 20112035 | Amino Acids | Methionine limitation results in increased hepatic FAS activity, higher liver 18:1 to 18:0 fatty acid ratio and hepatic TAG accumulation in Atlantic salmon, Salmo salar. | 2010 | Details |
| A26603 | 20111022 | Obesity (Silver Spring) | Effect of dietary monosodium glutamate on HFCS-induced hepatic steatosis: expression profiles in the liver and visceral fat. | 2010 | Details |
| A26612 | 20093562 | Am J Physiol Gastrointest Liver Physiol | The hepatic response to FGF19 is impaired in patients with nonalcoholic fatty liver disease and insulin resistance. | 2010 | Details |
| A26652 | 20041406 | Hepatology | Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. | 2010 | Details |
| A26657 | 20036859 | Front Biosci (Elite Ed) | Biochemical characteristics and risk factors in non-alcoholic fatty liver. | 2010 | Details |
| A26660 | 20032580 | J Atheroscler Thromb | Expression of perilipin and adipophilin in nonalcoholic fatty liver disease; relevance to oxidative injury and hepatocyte ballooning. | 2009 | Details |
| A26670 | 20015565 | J Hepatol | The expression level of non-alcoholic fatty liver disease-related gene PNPLA3 in hepatocytes is highly influenced by hepatic lipid status. | 2009 | Details |
| A26709 | 19921118 | Adv Ther | Insulin sensitizers in nonalcoholic fatty liver disease and steatohepatitis: Current status. | 2009 | Details |
| A26714 | 19913842 | Metabolism | Analysis of transcriptome and metabolome profiles alterations in fatty liver induced by high-fat diet in rat. | 2009 | Details |
| A26737 | 19875987 | Obesity (Silver Spring) | Decreased liver fatty acid delta-6 and delta-5 desaturase activity in obese patients. | 2009 | Details |
| A26745 | 19847649 | Dig Dis Sci | The effects of a fat- and sugar-enriched diet and chronic stress on nonalcoholic fatty liver disease in male Wistar rats. | 2009 | Details |
| A26753 | 19832698 | Clin Sci (Lond) | Hypoxia aggravates non-alcoholic steatohepatitis in mice lacking hepatocellular PTEN. | 2009 | Details |
| A26782 | 19793175 | J Gastroenterol Hepatol | Serum ornithine carbamyltransferase reflects hepatic damage in diabetic obese mice. | 2009 | Details |
| A26789 | 19781663 | Biochim Biophys Acta | n-3 PUFA and lipotoxicity. | 2009 | Details |
| A26790 | 19780876 | J Gastroenterol Hepatol | Effect of miRNA-10b in regulating cellular steatosis level by targeting PPAR-alpha expression, a novel mechanism for the pathogenesis of NAFLD. | 2009 | Details |
| A26791 | 19779336 | Curr Opin Lipidol | Thiazolidinediones and the liver in humans. | 2009 | Details |
| A26814 | 19731235 | Hepatology | Modulation of glycosphingolipid metabolism significantly improves hepatic insulin sensitivity and reverses hepatic steatosis in mice. | 2009 | Details |
| A26820 | 19724016 | Am J Physiol Endocrinol Metab | Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice. | 2009 | Details |
| A26837 | 19681867 | Br J Pharmacol | Curcumin adds spice to the debate: lipid metabolism in liver disease. | 2009 | Details |
| A26840 | 19673631 | Expert Rev Gastroenterol Hepatol | Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal. | 2009 | Details |
| A26857 | 19637730 | Rev Invest Clin | [Pathophysiology of non-alcoholic steatohepatitis. An insulin resistance overview]. | 2009 | Details |
| A26871 | 19608932 | J Appl Physiol (1985) | Hepatic VLDL assembly is disturbed in a rat model of nonalcoholic fatty liver disease: is there a role for dietary coenzyme Q? | 2009 | Details |
| A26875 | 19602132 | Liver Int | Liver fat and lipid oxidation in humans. | 2009 | Details |
| A26880 | 19592219 | Nutrition | Induction of non-alcoholic fatty liver disease and insulin resistance by feeding a high-fat diet in rats: does coenzyme Q monomethyl ether have a modulatory effect? | 2009 | Details |
| A26909 | 19556020 | J Hepatol | Second-hand smoke stimulates lipid accumulation in the liver by modulating AMPK and SREBP-1. | 2009 | Details |
| A26921 | 19546889 | Cell Res | Lipid accumulation in hepatocytes induces fibrogenic activation of hepatic stellate cells. | 2009 | Details |
| A26958 | 19464748 | J Hepatol | 3,5-diiodo-l-thyronine, by modulating mitochondrial functions, reverses hepatic fat accumulation in rats fed a high-fat diet. | 2009 | Details |
| A26966 | 19447517 | J Hepatol | Kupffer cells in non-alcoholic fatty liver disease: the emerging view. | 2009 | Details |
| A26989 | 19396962 | Curr Opin Gastroenterol | Recent advances in nonalcoholic fatty liver disease. | 2009 | Details |
| A27011 | 19359149 | Nutr Metab Cardiovasc Dis | Hepatic lipid metabolism and non-alcoholic fatty liver disease. | 2009 | Details |
| A27042 | 19285022 | Biochem Biophys Res Commun | The hepatic circadian clock is preserved in a lipid-induced mouse model of non-alcoholic steatohepatitis. | 2009 | Details |
| A27074 | 19222113 | Am J Chin Med | Therapeutic effect of puerarin on non-alcoholic rat fatty liver by improving leptin signal transduction through JAK2/STAT3 pathways. | 2009 | Details |
| A27100 | 19177596 | Hepatology | Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice. | 2009 | Details |
| A27117 | 19141695 | Am J Clin Nutr | Prolonged saturated fat-induced, glucose-dependent insulinotropic polypeptide elevation is associated with adipokine imbalance and liver injury in nonalcoholic steatohepatitis: dysregulated enteroadipocyte axis as a novel feature of fatty liver. | 2009 | Details |
| A27135 | 20469672 | Eksp Klin Gastroenterol | [Non-alcoholic fatty liver disease in dyslipidemia and insulin resistance: similarities and differences; differential approach to therapy]. | 2009 | Details |
| A27155 | 19072834 | Hepatology | Reduction of hepatic steatosis in rats and mice after treatment with a liver-targeted thyroid hormone receptor agonist. | 2009 | Details |
| A27186 | 19016656 | Clin Sci (Lond) | Is liver fat detrimental to vessels?: intersections in the pathogenesis of NAFLD and atherosclerosis. | 2008 | Details |
| A27199 | 19001666 | J Lipid Res | Effect of dietary monosodium glutamate on trans fat-induced nonalcoholic fatty liver disease. | 2008 | Details |
| A27203 | 18990087 | Biochem J | Viral hepatitis and fatty liver disease: how an unwelcome guest makes pâté of the host. | 2008 | Details |
| A27205 | 18989145 | Eur J Gastroenterol Hepatol | Treatment of preestablished diet-induced fatty liver by oral fatty acid-bile acid conjugates in rodents. | 2008 | Details |
| A27223 | 18956291 | Semin Liver Dis | Abnormalities of lipid metabolism in nonalcoholic fatty liver disease. | 2008 | Details |
| A27227 | 18949388 | Int J Mol Med | The significance of differences in fatty acid metabolism between obese and non-obese patients with non-alcoholic fatty liver disease. | 2008 | Details |
| A27236 | 18929493 | Trends Endocrinol Metab | Insulin resistance, inflammation, and non-alcoholic fatty liver disease. | 2008 | Details |
| A27255 | 18824034 | Prog Lipid Res | Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD). | 2008 | Details |
| A27288 | 18752326 | Hepatology | Inflammatory stress exacerbates lipid accumulation in hepatic cells and fatty livers of apolipoprotein E knockout mice. | 2008 | Details |
| A27292 | 18719669 | Obesity (Silver Spring) | Effect of endurance exercise on hepatic lipid content, enzymes, and adiposity in men and women. | 2008 | Details |
| A27293 | 18713300 | J Gastroenterol Hepatol | Polymorphism of human leptin receptor gene is associated with type 2 diabetic patients complicated with non-alcoholic fatty liver disease in China. | 2008 | Details |