Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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oxidative stress3585 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A50264 | 35449947 | ACS Omega | Polyphenol-Rich Extracts of Xylopia and Aframomum Species Show Metabolic Benefits by Lowering Hepatic Lipid Accumulation in Diet-Induced Obese Mice. | 2022 | Details |
| A50273 | 35447899 | Mar Drugs | Fucoxanthin Attenuates Free Fatty Acid-Induced Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism/Oxidative Stress/Inflammation via the AMPK/Nrf2/TLR4 Signaling Pathway. | 2022 | Details |
| A50274 | 35447548 | Biomed Pharmacother | Downregulation of hepatic fat accumulation, inflammation and fibrosis by nerolidol in purpose built western-diet-induced multiple-hit pathogenesis of NASH animal model. | 2022 | Details |
| A50290 | 35442594 | Int J Med Mushrooms | Meal Ingestion of Ceraceomyces tessulatus Strain BDM-X (Agaricomycetes) Protects against Nonalcoholic Steatohepatitis in Mice. | 2022 | Details |
| A50306 | 35437549 | Food Funct | L-Methionine supplementation attenuates high-fat fructose diet-induced non-alcoholic steatohepatitis by modulating lipid metabolism, fibrosis, and inflammation in rats. | 2022 | Details |
| A50321 | 35434590 | JHEP Rep | Metabolic signatures across the full spectrum of non-alcoholic fatty liver disease. | 2022 | Details |
| A50341 | 35428541 | Nutr Metab Cardiovasc Dis | Lipids and diastolic dysfunction: Recent evidence and findings. | 2022 | Details |
| A50360 | 35418153 | Diabetol Metab Syndr | Epigallocatechin-3-gallate ameliorates hepatic damages by relieve FGF21 resistance and promotion of FGF21-AMPK pathway in mice fed a high fat diet. | 2022 | Details |
| A50365 | 35416741 | Scand J Clin Lab Invest | Nonalcoholic fatty liver disease and its prognosis associates with shorter leucocyte telomeres in a 21-year follow-up study. | 2022 | Details |
| A50376 | 35412187 | Cell Biol Toxicol | Transcriptomic analysis in zebrafish larvae identifies iron-dependent mitochondrial dysfunction as a possible key event of NAFLD progression induced by benzo[a]pyrene/ethanol co-exposure. | 2022 | Details |
| A50386 | 35409028 | Int J Mol Sci | SGLT2 Inhibitors as the Most Promising Influencers on the Outcome of Non-Alcoholic Fatty Liver Disease. | 2022 | Details |
| A50391 | 35407014 | Foods | Tilapia-Head Chondroitin Sulfate Protects against Nonalcoholic Fatty Liver Disease via Modulating the Gut-Liver Axis in High-Fat-Diet-Fed C57BL/6 Mice. | 2022 | Details |
| A50416 | 35399623 | Evid Based Complement Alternat Med | Er-Chen Decoction Alleviates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Rats through Remodeling Gut Microbiota and Regulating the Serum Metabolism. | 2022 | Details |
| A50425 | 35396857 | J Food Biochem | Comparative effects of sesame lignans (sesamin, sesamolin, and sesamol) on oxidative stress and lipid metabolism in steatosis HepG2 cells. | 2022 | Details |
| A50438 | 35392289 | Front Nutr | Activating Effects of the Bioactive Compounds From Coffee By-Products on FGF21 Signaling Modulate Hepatic Mitochondrial Bioenergetics and Energy Metabolism in vitro. | 2022 | Details |
| A50463 | 35381388 | Mol Metab | Proteomic analysis reveals exercise training induced remodelling of hepatokine secretion and uncovers syndecan-4 as a regulator of hepatic lipid metabolism. | 2022 | Details |
| A50488 | 35366761 | Curr Med Chem | Beneficial Effects of Carvacrol on In Vitro Models of Metabolically-Associated Liver Steatosis and Endothelial Dysfunction: A Role for Fatty Acids in Interfering with Carvacrol Binding to Serum Albumin. | 2022 | Details |
| A50512 | 35357518 | Naunyn Schmiedebergs Arch Pharmacol | Phytochemicals targeting NAFLD through modulating the dual function of forkhead box O1 (FOXO1) transcription factor signaling pathways. | 2022 | Details |
| A50517 | 35355551 | Front Endocrinol (Lausanne) | Non-Alcoholic Fatty Liver Disease in HIV/HBV Patients - a Metabolic Imbalance Aggravated by Antiretroviral Therapy and Perpetuated by the Hepatokine/Adipokine Axis Breakdown. | 2022 | Details |
| A50564 | 35338970 | Bioorg Chem | Dihydroartemisinin alleviates steatosis and inflammation in nonalcoholic steatohepatitis by decreasing endoplasmic reticulum stress and oxidative stress. | 2022 | Details |
| A50566 | 35338494 | J Food Biochem | Zingerone ameliorates non-alcoholic fatty liver disease in rats by activating AMPK. | 2022 | Details |
| A50569 | 35335339 | Molecules | Garcinia Biflavonoid 1 Improves Lipid Metabolism in HepG2 Cells via Regulating PPARα. | 2022 | Details |
| A50572 | 35334916 | Nutrients | Mediterranean Diet: A Tool to Break the Relationship of Atrial Fibrillation with the Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease. | 2022 | Details |
| A50594 | 35330105 | Life (Basel) | Taurine Ameliorates Tunicamycin-Induced Liver Injury by Disrupting the Vicious Cycle between Oxidative Stress and Endoplasmic Reticulum Stress. | 2022 | Details |
| A50601 | 35328527 | Int J Mol Sci | SGLT-2 Inhibitors in NAFLD: Expanding Their Role beyond Diabetes and Cardioprotection. | 2022 | Details |
| A50603 | 35328352 | Int J Mol Sci | Beneficial Effects of Dietary Nitrite on a Model of Nonalcoholic Steatohepatitis Induced by High-Fat/High-Cholesterol Diets in SHRSP5/Dmcr Rats: A Preliminary Study. | 2022 | Details |
| A50618 | 35324769 | Toxics | Double-Sided Nano-ZnO: Superior Antibacterial Properties and Induced Hepatotoxicity in Zebrafish Embryos. | 2022 | Details |
| A50621 | 35323719 | Medicines (Basel) | Salubrious Effects of Green Tea Catechins on Fatty Liver Disease: A Systematic Review. | 2022 | Details |
| A50622 | 35323681 | Metabolites | Emerging Role of Nuclear Receptors for the Treatment of NAFLD and NASH. | 2022 | Details |
| A50643 | 35317606 | Thyroid | Thyroid Hormone Decreases Hepatic Steatosis, Inflammation, and Fibrosis in a Dietary Mouse Model of Nonalcoholic Steatohepatitis. | 2022 | Details |
| A50668 | 35308224 | Front Pharmacol | Pharmacological Effects and Molecular Protective Mechanisms of Astragalus Polysaccharides on Nonalcoholic Fatty Liver Disease. | 2022 | Details |
| A50681 | 35304272 | J Ethnopharmacol | Antrodia cinnamomea and its compound dehydroeburicoic acid attenuate nonalcoholic fatty liver disease by upregulating ALDH2 activity. | 2022 | Details |
| A50746 | 35280674 | Int J Biol Sci | Atractylenolide III ameliorates Non-Alcoholic Fatty Liver Disease by activating Hepatic Adiponectin Receptor 1-Mediated AMPK Pathway. | 2022 | Details |
| A50753 | 35277075 | Nutrients | Simvastatin Improves Microcirculatory Function in Nonalcoholic Fatty Liver Disease and Downregulates Oxidative and ALE-RAGE Stress. | 2022 | Details |
| A50760 | 35276900 | Nutrients | Baicalin Attenuates Oxidative Stress in a Tissue-Engineered Liver Model of NAFLD by Scavenging Reactive Oxygen Species. | 2022 | Details |
| A50761 | 35276784 | Nutrients | Effects of Fish Oil Supplementation on Oxidative Stress Biomarkers and Liver Damage in Hypercholesterolemic Rats. | 2022 | Details |
| A50770 | 35272243 | Phytomedicine | Therapeutic effect and mechanism of polysaccharides from Anoectochilus Roxburghii (Wall.) Lindl. in diet-induced obesity. | 2022 | Details |
| A50776 | 35269912 | Int J Mol Sci | Natural Compounds for Counteracting Nonalcoholic Fatty Liver Disease (NAFLD): Advantages and Limitations of the Suggested Candidates. | 2022 | Details |
| A50956 | 35520248 | RSC Adv | Blond and blood juice supplementation in high fat diet fed mice: effect on antioxidant status and DDAH/ADMA pathway. | 2019 | Details |
| A50968 | 35547559 | RSC Adv | Rosmarinic acid attenuates hepatic steatosis by modulating ER stress and autophagy in oleic acid-induced HepG2 cells. | 2018 | Details |
| A51076 | 16239046 | J Hepatol | Nrf1 gene expression in the liver: a single gene linking oxidative stress to NAFLD, NASH and hepatic tumours. | 2005 | Details |
| A51100 | 35766964 | J Med Food | Persimmon Water Extract Suppresses Hepatic Lipotoxicity by Regulating Lipid Metabolites. | 2022 | Details |
| A51148 | 35470867 | J Food Biochem | Dietary sinapic acid attenuated high-fat diet-induced lipid metabolism and oxidative stress in male Syrian hamsters. | 2022 | Details |
| A51179 | 35344087 | Histochem Cell Biol | Early unhealthy eating habits underlie morpho-functional changes in the liver and adipose tissue in male rats. | 2022 | Details |
| A51181 | 35331110 | Curr Mol Med | Oxidative damage by 3-nitrotyrosine in young adults with obesity: its implication in chronic and contagious diseases. | 2022 | Details |
| A51303 | 35777586 | J Hepatol | Augmenter of liver regeneration: mitochondrial function and steatohepatitis. | 2022 | Details |
| A51314 | 35696549 | J Cell Physiol | Dynein light chain LC8 alleviates nonalcoholic steatohepatitis by inhibiting NF-κB signaling and reducing oxidative stress. | 2022 | Details |
| A51323 | 35624663 | Antioxidants (Basel) | Empagliflozin-Enhanced Antioxidant Defense Attenuates Lipotoxicity and Protects Hepatocytes by Promoting FoxO3a- and Nrf2-Mediated Nuclear Translocation via the CAMKK2/AMPK Pathway. | 2022 | Details |
| A51327 | 35592421 | Front Pharmacol | Scoparone Improves Nonalcoholic Steatohepatitis Through Alleviating JNK/Sab Signaling Pathway-Mediated Mitochondrial Dysfunction. | 2022 | Details |
| A51328 | 35588918 | Pharmacol Res | The effects of sodium-glucose cotransporter 2 inhibitors on hepatocellular carcinoma: From molecular mechanisms to potential clinical implications. | 2022 | Details |
| A51343 | 35467032 | J Cell Biochem | Physical exercise positively modulates nonalcoholic steatohepatitis-related hepatic endoplasmic reticulum stress. | 2022 | Details |
| A51348 | 35419738 | Inflammation | Melatonin Attenuates Inflammation, Oxidative Stress, and DNA Damage in Mice with Nonalcoholic Steatohepatitis Induced by a Methionine- and Choline-Deficient Diet. | 2022 | Details |
| A51395 | 35830259 | FASEB J | Intervention with isoleucine or valine corrects hyperinsulinemia and reduces intrahepatic diacylglycerols, liver steatosis, and inflammation in Ldlr-/-.Leiden mice with manifest obesity-associated NASH. | 2022 | Details |
| A51414 | 35698494 | Vet World | Hepatoprotection of Cinnamomum burmannii ethanolic extract against high-fat and cholesterol diet in Sprague-Dawley rats (Rattus norvegicus). | 2022 | Details |
| A51423 | 35625937 | Biomedicines | Phospholipid Membrane Transport and Associated Diseases. | 2022 | Details |
| A51444 | 35340879 | Exp Ther Med | Ganoderic acid A ameliorates non-alcoholic streatohepatitis (NASH) induced by high-fat high-cholesterol diet in mice. | 2022 | Details |
| A51447 | 35326188 | Antioxidants (Basel) | Cholesterol Induces Oxidative Stress, Mitochondrial Damage and Death in Hepatic Stellate Cells to Mitigate Liver Fibrosis in Mice Model of NASH. | 2022 | Details |
| A51453 | 35285180 | FEBS J | HPS protects the liver against steatosis, cell death, inflammation, and fibrosis in mice with steatohepatitis. | 2022 | Details |
| A51477 | 30627433 | J Nutr Sci | Hot water extract of turmeric (Curcuma longa) prevents non-alcoholic steatohepatitis in mice by inhibiting hepatic oxidative stress and inflammation. | 2018 | Details |
| A51510 | 35720187 | Oxid Med Cell Longev | Melatonin Alleviates PM2.5-Induced Hepatic Steatosis and Metabolic-Associated Fatty Liver Disease in ApoE-/- Mice. | 2022 | Details |
| A51520 | 35668935 | Front Pharmacol | Croton urucurana Baill. Ameliorates Metabolic Associated Fatty Liver Disease in Rats. | 2022 | Details |
| A51536 | 35491295 | Trends Endocrinol Metab | SGLT-2 inhibitors and GLP-1 receptor agonists in metabolic dysfunction-associated fatty liver disease. | 2022 | Details |
| A51542 | 35409324 | Int J Mol Sci | Meta-Inflammation and De Novo Lipogenesis Markers Are Involved in Metabolic Associated Fatty Liver Disease Progression in BTBR ob/ob Mice. | 2022 | Details |
| A51553 | 35205361 | Genes (Basel) | Altered Mitochondrial Quality Control in Rats with Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) Induced by High-Fat Feeding. | 2022 | Details |
| A51588 | 34760237 | Food Sci Nutr | Ameliorative effects of Cirsium japonicum extract and main component cirsimaritin in mice model of high-fat diet-induced metabolic dysfunction-associated fatty liver disease. | 2021 | Details |
| A51590 | 34738404 | Zhongguo Zhong Yao Za Zhi | [Mechanism of Gynostemma pentaphyllum in treatment of metabolism associated fatty liver disease based on network pharmacology and molecular docking]. | 2021 | Details |
| A51605 | 35723871 | FASEB J | Loss of SQSTM1/p62 Induces Obesity and Exacerbates Alcohol-induced Liver Injury in Aged Mice. | 2022 | Details |
| A51626 | 35495929 | Front Nutr | Astaxanthin From Haematococcus pluvialis Prevents High-Fat Diet-Induced Hepatic Steatosis and Oxidative Stress in Mice by Gut-Liver Axis Modulating Properties. | 2022 | Details |
| A51627 | 35493783 | Anim Reprod | Rodent models in placental research. Implications for fetal origins of adult disease. | 2022 | Details |
| A51673 | 35046618 | World J Gastroenterol | Imaging of the chemotherapy-induced hepatic damage: Yellow liver, blue liver, and pseudocirrhosis. | 2021 | Details |
| A51693 | 34864457 | Clin Nutr | The effects of different parenteral nutrition lipid formulations on clinical and laboratory endpoints in patients receiving home parenteral nutrition: A systematic review. | 2021 | Details |
| A51699 | 34818545 | Cell Rep | The asymmetric Pitx2 gene regulates gut muscular-lacteal development and protects against fatty liver disease. | 2021 | Details |
| A51716 | 34660695 | Front Mol Biosci | Trimethylamine-N-Oxide Pathway: A Potential Target for the Treatment of MAFLD. | 2021 | Details |
| A51738 | 34453451 | J Food Biochem | Nutritional and phytochemical profile of pomegranate ("Wonderful variety") peel and its effects on hepatic oxidative stress and metabolic alterations. | 2021 | Details |
| A51746 | 34409856 | Antioxid Redox Signal | Mitochondrial Adaptive Responses to Hypertriglyceridemia and Bioactive Lipids. | 2021 | Details |
| A51760 | 34303283 | Tissue Cell | CTRP3 ameliorates fructose-induced metabolic associated fatty liver disease via inhibition of xanthine oxidase-associated oxidative stress. | 2021 | Details |
| A51770 | 34237158 | Neuropathol Appl Neurobiol | Modulation of mitochondrial and inflammatory homeostasis through RIP140 is neuroprotective in an adrenoleukodystrophy mouse model. | 2021 | Details |
| A51775 | 34153542 | J Proteomics | Characterization of the liver proteome in dairy cows experiencing negative energy balance at early lactation. | 2021 | Details |
| A51797 | 34030573 | Gut Microbes | Gut Akkermansia muciniphila ameliorates metabolic dysfunction-associated fatty liver disease by regulating the metabolism of L-aspartate via gut-liver axis. | 2021 | Details |
| A51798 | 34019585 | PLoS One | FGF21 serum levels are related to insulin resistance, metabolic changes and obesity in Mexican people living with HIV (PLWH). | 2021 | Details |
| A51808 | 33962074 | Cell Mol Gastroenterol Hepatol | Sestrin Proteins Protect Against Lipotoxicity-Induced Oxidative Stress in the Liver via Suppression of C-Jun N-Terminal Kinases. | 2021 | Details |
| A51821 | 33935806 | Front Physiol | Hepatic Oxidative Stress, Apoptosis, and Inflammation in Broiler Chickens With Wooden Breast Myopathy. | 2021 | Details |
| A51837 | 33809061 | Cells | Molecular Mechanisms of Obesity-Linked Cardiac Dysfunction: An Up-Date on Current Knowledge. | 2021 | Details |
| A51856 | 33649799 | Mol Med Rep | Bioinformatics analysis of differentially expressed proteins in alcoholic fatty liver disease treated with recombinant human cytoglobin. | 2021 | Details |
| A51874 | 33535680 | Int J Mol Sci | Effects of Pyrroloquinoline Quinone on Lipid Metabolism and Anti-Oxidative Capacity in a High-Fat-Diet Metabolic Dysfunction-Associated Fatty Liver Disease Chick Model. | 2021 | Details |
| A51885 | 33463949 | Crit Rev Immunol | Metabolic Triggers of Invariant Natural Killer T-Cell Activation during Sterile Autoinflammatory Disease. | 2020 | Details |
| A51914 | 33273564 | Sci Rep | Short-term Cudrania tricuspidata fruit vinegar administration attenuates obesity in high-fat diet-fed mice by improving fat accumulation and metabolic parameters. | 2020 | Details |
| A51928 | 33168096 | Hum Genomics | Aldh1l2 knockout mouse metabolomics links the loss of the mitochondrial folate enzyme to deregulation of a lipid metabolism observed in rare human disorder. | 2020 | Details |
| A51939 | 33073617 | Nutr Cancer | Herbal and Natural Dietary Products: Upcoming Therapeutic Approach for Prevention and Treatment of Hepatocellular Carcinoma. | 2020 | Details |
| A51960 | 32879342 | Sci Rep | Impaired brain homeostasis and neurogenesis in diet-induced overweight zebrafish: a preventive role from A. borbonica extract. | 2020 | Details |
| A51962 | 32864127 | J Anim Sci Biotechnol | Role of nutraceuticals during the transition period of dairy cows: a review. | 2020 | Details |
| A51987 | 32595984 | Cell Death Discov | The role of MDM2-p53 axis dysfunction in the hepatocellular carcinoma transformation. | 2020 | Details |
| A51996 | 32512788 | Antioxidants (Basel) | Cold-Pressed Nigella Sativa Oil Standardized to 3% Thymoquinone Potentiates Omega-3 Protection against Obesity-Induced Oxidative Stress, Inflammation, and Markers of Insulin Resistance Accompanied with Conversion of White to Beige Fat in Mice. | 2020 | Details |
| A52001 | 32478901 | J Food Biochem | Hypolipidemic and antioxidant activities of Trichosanthes kirilowii maxim seed oil and flavonoids in mice fed with a high-fat diet. | 2020 | Details |
| A52015 | 32290082 | Int J Mol Sci | Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities. | 2020 | Details |
| A52021 | 32219872 | Hepatology | Hydrogen Sulfide Alleviates Liver Injury Through the S-Sulfhydrated-Kelch-Like ECH-Associated Protein 1/Nuclear Erythroid 2-Related Factor 2/Low-Density Lipoprotein Receptor-Related Protein 1 Pathway. | 2021 | Details |
| A52026 | 32183350 | Nutrients | Maternal Fat-1 Transgene Protects Offspring from Excess Weight Gain, Oxidative Stress, and Reduced Fatty Acid Oxidation in Response to High-Fat Diet. | 2020 | Details |
| A52067 | 31681434 | Front Genet | Mining Public Toxicogenomic Data Reveals Insights and Challenges in Delineating Liver Steatosis Adverse Outcome Pathways. | 2019 | Details |
| A52068 | 31677841 | J Dairy Sci | Widespread basal cytochrome P450 expression in extrahepatic bovine tissues and isolated cells. | 2019 | Details |
| A52083 | 31557503 | Biochimie | Protocatechuic acid exhibits hepatoprotective, vasculoprotective, antioxidant and insulin-like effects in dexamethasone-induced insulin-resistant rats. | 2019 | Details |