Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Lipid metabolism4743 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A27295 | 18710604 | Br J Nutr | Flaxseed oil prevents trans-10, cis-12-conjugated linoleic acid-induced insulin resistance in mice. | 2008 | Details |
| A27305 | 18684130 | Hepatol Res | Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease. | 2008 | Details |
| A27320 | 18648737 | J Gastroenterol | Liver diseases and metabolic syndrome. | 2008 | Details |
| A27395 | 18484349 | Ann Med | Association of liver disease with postprandial large intestinal triglyceride-rich lipoprotein accumulation and pro/antioxidant imbalance in normolipidemic non-alcoholic steatohepatitis. | 2008 | Details |
| A27409 | 18452148 | Hepatology | Prevention of free fatty acid-induced hepatic lipotoxicity by 18beta-glycyrrhetinic acid through lysosomal and mitochondrial pathways. | 2008 | Details |
| A27414 | 18433732 | Biochem Pharmacol | Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases. | 2008 | Details |
| A27415 | 18430557 | J Nutr Biochem | The role of fatty acids in the development and progression of nonalcoholic fatty liver disease. | 2008 | Details |
| A27433 | 18395289 | J Hepatol | Antibiotics protect against fructose-induced hepatic lipid accumulation in mice: role of endotoxin. | 2008 | Details |
| A27437 | 18388185 | Am J Physiol Gastrointest Liver Physiol | Gene expression in human NAFLD. | 2008 | Details |
| A27441 | 18376369 | Ann Hepatol | Hepatic expression of ghrelin and adiponectin and their receptors in patients with nonalcoholic fatty liver disease. | 2008 | Details |
| A27457 | 18349115 | Am J Physiol Endocrinol Metab | A moderate increase in carnitine palmitoyltransferase 1a activity is sufficient to substantially reduce hepatic triglyceride levels. | 2008 | Details |
| A27459 | 18346305 | Br J Nutr | Dietary single cell protein reduces fatty liver in obese Zucker rats. | 2008 | Details |
| A27480 | 18311774 | Hepatology | Adiponectin gene polymorphisms modulate acute adiponectin response to dietary fat: Possible pathogenetic role in NASH. | 2008 | Details |
| A27486 | 18299981 | Dig Dis Sci | The transition from fatty liver to NASH associates with SAMe depletion in db/db mice fed a methionine choline-deficient diet. | 2008 | Details |
| A27505 | 18242210 | Gastroenterology | Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease. | 2007 | Details |
| A27508 | 18240340 | World J Gastroenterol | The blind men 'see' the elephant-the many faces of fatty liver disease. | 2008 | Details |
| A27519 | 18203899 | J Nutr | Green tea extract protects leptin-deficient, spontaneously obese mice from hepatic steatosis and injury. | 2008 | Details |
| A27537 | 18171348 | J Gastroenterol Hepatol | PPAR agonists treatment is effective in a nonalcoholic fatty liver disease animal model by modulating fatty-acid metabolic enzymes. | 2008 | Details |
| A27562 | 18061659 | Mol Aspects Med | Mitochondrial involvement in non-alcoholic steatohepatitis. | 2007 | Details |
| A27577 | 17935056 | Diab Vasc Dis Res | The role of fenofibrate in clinical practice. | 2007 | Details |
| A27611 | 17906183 | J Am Coll Nutr | Body fat distribution and insulin resistance: beyond obesity in nonalcoholic fatty liver disease among overweight men. | 2007 | Details |
| A27634 | 17868334 | J Gastroenterol Hepatol | Interstrain differences in susceptibility to non-alcoholic steatohepatitis. | 2007 | Details |
| A27640 | 17826687 | Drug Discov Today | Modulation of sterol regulatory element binding proteins (SREBPs) as potential treatments for non-alcoholic fatty liver disease (NAFLD). | 2007 | Details |
| A27652 | 17729403 | World J Gastroenterol | Pathogenesis and management issues for non-alcoholic fatty liver disease. | 2007 | Details |
| A27662 | 17567459 | J Gastroenterol Hepatol | Role of mitochondria in non-alcoholic fatty liver disease. | 2007 | Details |
| A27663 | 17567458 | J Gastroenterol Hepatol | Has natural selection in human populations produced two types of metabolic syndrome (with and without fatty liver)? | 2007 | Details |
| A27665 | 17711101 | Rocz Panstw Zakl Hig | Nonalcoholic fatty liver disease as a feature of the metabolic syndrome. | 2007 | Details |
| A27670 | 17706260 | Toxicol Appl Pharmacol | Gene expression profiling reveals underlying molecular mechanisms of the early stages of tamoxifen-induced rat hepatocarcinogenesis. | 2007 | Details |
| A27680 | 17683497 | J Gastroenterol Hepatol | Epigallocatechin gallate attenuates experimental non-alcoholic steatohepatitis induced by high fat diet. | 2007 | Details |
| A27684 | 17671740 | Int J Mol Med | Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease. | 2007 | Details |
| A27686 | 17669243 | Zhonghua Gan Zang Bing Za Zhi | [The relationship between insulin resistance and adiponectin gene expression in nonalcoholic fatty liver disease]. | 2007 | Details |
| A27690 | 17659704 | World J Gastroenterol | Metabolic liver disease of obesity and role of adipose tissue in the pathogenesis of nonalcoholic fatty liver disease. | 2007 | Details |
| A27694 | 17654743 | Hepatology | A lipidomic analysis of nonalcoholic fatty liver disease. | 2007 | Details |
| A27702 | 17619535 | Acta Gastroenterol Belg | Pathogenesis of steatohepatitis: insights from the study of animal models. | 2007 | Details |
| A27753 | 17519829 | Ann Hepatol | The genetics of nonalcoholic fatty liver disease. | 2007 | Details |
| A27769 | 17484887 | Gastroenterology | Reduction of hepatosteatosis and lipid levels by an adipose differentiation-related protein antisense oligonucleotide. | 2007 | Details |
| A27781 | 17464986 | Hepatology | Polymorphism in microsomal triglyceride transfer protein: a link between liver disease and atherogenic postprandial lipid profile in NASH? | 2007 | Details |
| A27858 | 17236119 | Z Gastroenterol | Lipid metabolism in the liver. | 2007 | Details |
| A27859 | 17230603 | World J Gastroenterol | Monounsaturated fat decreases hepatic lipid content in non-alcoholic fatty liver disease in rats. | 2007 | Details |
| A27860 | 17228028 | Obesity (Silver Spring) | Polyunsaturated fatty acid pattern in liver and erythrocyte phospholipids from obese patients. | 2007 | Details |
| A27865 | 17210084 | BMC Cardiovasc Disord | The effects of second-hand smoke on biological processes important in atherogenesis. | 2007 | Details |
| A27884 | 17140767 | Nutrition | Dietary habits and nutrient intake in non-alcoholic steatohepatitis. | 2006 | Details |
| A27893 | 17073635 | Curr Med Chem | Current pharmacological treatment of nonalcoholic fatty liver. | 2006 | Details |
| A27923 | 17007047 | World J Gastroenterol | Effect of nutritional counselling on hepatic, muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease. | 2006 | Details |
| A27936 | 16950832 | Gut | The role of the nuclear receptor constitutive androstane receptor in the pathogenesis of non-alcoholic steatohepatitis. | 2006 | Details |
| A27937 | 16949573 | Exp Mol Pathol | Transcriptional networks in a rat model for nonalcoholic fatty liver disease: a microarray analysis. | 2006 | Details |
| A27970 | 16842328 | Liver Int | Intracellular retention of hepatic serpins caused by severe hyperlipidemia. | 2006 | Details |
| A27999 | 16768110 | Nihon Rinsho | [NASH model-- role of interleukin-1 receptor]. | 2006 | Details |
| A28023 | 16697719 | Gastroenterology | Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease. | 2006 | Details |
| A28030 | 16680031 | Curr Opin Lipidol | New insights in the pathogenesis of non-alcoholic fatty liver disease. | 2006 | Details |
| A28033 | 16649140 | Cell Mol Life Sci | Regulation of fat metabolism in the liver: link to non-alcoholic hepatic steatosis and impact of physical exercise. | 2006 | Details |
| A28046 | 16603729 | Am J Physiol Gastrointest Liver Physiol | Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation. | 2006 | Details |
| A28049 | 16595594 | J Clin Endocrinol Metab | Glycosylphosphatidylinositol-specific phospholipase d in nonalcoholic Fatty liver disease: a preliminary study. | 2006 | Details |
| A28072 | 16516152 | Biochem Biophys Res Commun | Adaptive failure to high-fat diet characterizes steatohepatitis in Alms1 mutant mice. | 2006 | Details |
| A28096 | 16439872 | AIDS | Altered hepatic expression of SREBP-1 and PPARgamma is associated with liver injury in insulin-resistant lipodystrophic HIV-infected patients. | 2006 | Details |
| A28099 | 16425410 | World J Gastroenterol | Changes in lipid metabolism in chronic hepatitis C. | 2005 | Details |
| A28146 | 16265100 | Nat Clin Pract Gastroenterol Hepatol | Mechanisms of Disease: pathogenesis of nonalcoholic fatty liver disease. | 2005 | Details |
| A28175 | 16225477 | Aliment Pharmacol Ther | Review article: hepatic steatosis and insulin resistance. | 2005 | Details |
| A28188 | 16202646 | Hepatol Res | Hepatitis C as a metabolic disease: Implication for the pathogenesis of NASH. | 2005 | Details |
| A28218 | 16101243 | Nihon Rinsho | [Tumor suppressor gene PTEN and non-alcoholic steatohepatitis (NASH)]. | 2005 | Details |
| A28236 | 15998427 | Liver Int | Hepatic gene expression in patients with obesity-related non-alcoholic steatohepatitis. | 2005 | Details |
| A28247 | 15970480 | Front Biosci | Uncoupling protein-2 and non-alcoholic fatty liver disease. | 2005 | Details |
| A28285 | 15797948 | J Clin Endocrinol Metab | Plasma adiponectin in nonalcoholic fatty liver is related to hepatic insulin resistance and hepatic fat content, not to liver disease severity. | 2005 | Details |
| A28287 | 15784031 | Am J Gastroenterol | Systemic markers of lipid peroxidation and antioxidants in patients with nonalcoholic Fatty liver disease. | 2005 | Details |
| A28290 | 15769642 | Front Biosci | Insulin resistance in NASH. | 2005 | Details |
| A28297 | 15754775 | Chang Gung Med J | An adipocentric view of liver fibrosis and cirrhosis. | 2004 | Details |
| A28299 | 15747110 | Diabetologia | Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms. | 2005 | Details |
| A28332 | 15625647 | Clin Gastroenterol Hepatol | Nonalcoholic fatty liver disease: a review of current understanding and future impact. | 2004 | Details |
| A28362 | 15489564 | Eur J Gastroenterol Hepatol | Non-alcoholic steatohepatitis. | 2004 | Details |
| A28375 | 15336441 | J Hepatol | A novel aminosterol reverses diabetes and fatty liver disease in obese mice. | 2004 | Details |
| A28378 | 15331069 | Clin Liver Dis | The potential role of genes in nonalcoholic fatty liver disease. | 2004 | Details |
| A28408 | 15166226 | J Biol Chem | Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. | 2004 | Details |
| A28438 | 14762795 | Gastroenterology | Steatosis and hepatitis C virus: mechanisms and significance for hepatic and extrahepatic disease. | 2004 | Details |
| A28451 | 14631324 | Diabetes Metab | Contribution of hepatic de novo lipogenesis and reesterification of plasma non esterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver disease. | 2003 | Details |
| A28470 | 12971963 | J Hepatol | Oxidative stress, KLF6 and transforming growth factor-beta up-regulation differentiate non-alcoholic steatohepatitis progressing to fibrosis from uncomplicated steatosis in rats. | 2003 | Details |
| A28565 | 10902968 | Liver | The role of hepatic peroxisome proliferator-activated receptors (PPARs) in health and disease. | 2000 | Details |
| A28570 | 10422091 | Nutrition | Nutritional and metabolic effects of alcoholism: their relationship with alcoholic liver disease. | 1999 | Details |
| A28624 | 35217816 | Acta Pharmacol Sin | The role of REV-ERB in NASH. | 2022 | Details |
| A28698 | 35116066 | Evid Based Complement Alternat Med | Evaluation of the Mechanism of Modified Lingguizhugan Decoction in the Treatment of Nonalcoholic Fatty Liver Disease. | 2022 | Details |
| A28755 | 35058729 | J Ginseng Res | Oral administration of Jinan Red Ginseng and licorice extract mixtures ameliorates nonalcoholic steatohepatitis by modulating lipogenesis. | 2021 | Details |
| A28764 | 35039505 | Nat Commun | RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state. | 2022 | Details |
| A28953 | 34781860 | Curr Med Chem | Dehydrocholesterol Reductase 24 (DHCR24): Medicinal Chemistry, Pharmacology and Novel Therapeutic Options. | 2022 | Details |
| A28956 | 34781165 | Redox Biol | The sex steroid precursor dehydroepiandrosterone prevents nonalcoholic steatohepatitis by activating the AMPK pathway mediated by GPR30. | 2021 | Details |
| A28972 | 34760013 | Res Pharm Sci | Attenuating effects of allantoin on oxidative stress in a mouse model of nonalcoholic steatohepatitis: role of SIRT1/Nrf2 pathway. | 2021 | Details |
| A29027 | 34679736 | Antioxidants (Basel) | Oxidative Stress Linked Organ Lipid Hydroperoxidation and Dysregulation in Mouse Model of Nonalcoholic Steatohepatitis: Revealed by Lipidomic Profiling of Liver and Kidney. | 2021 | Details |
| A29063 | 34638751 | Int J Mol Sci | Anti-Obesity Effect of Polygalin C Isolated from Polygala japonica Houtt. via Suppression of the Adipogenic and Lipogenic Factors in 3T3-L1 Adipocytes. | 2021 | Details |
| A29255 | 34352389 | Biochim Biophys Acta Mol Cell Biol Lipids | Proresolving lipid mediators and liver disease. | 2021 | Details |
| A29264 | 34341511 | Acta Pharmacol Sin | Histone deacetylase inhibitor givinostat attenuates nonalcoholic steatohepatitis and liver fibrosis. | 2021 | Details |
| A29345 | 34221233 | Oxid Med Cell Longev | Protein Phosphatase 4 Promotes Hepatocyte Lipoapoptosis by Regulating RAC1/MLK3/JNK Pathway. | 2021 | Details |
| A29422 | 34093943 | Int J Clin Exp Pathol | Screening of non-alcoholic steatohepatitis (NASH)-related datasets and identification of NASH-related genes. | 2021 | Details |
| A29454 | 34041450 | iScience | Myeloid Nrf2 deficiency aggravates non-alcoholic steatohepatitis progression by regulating YAP-mediated NLRP3 inflammasome signaling. | 2021 | Details |
| A29514 | 33959012 | Front Pharmacol | Xanthohumol ameliorates Diet-Induced Liver Dysfunction via Farnesoid X Receptor-Dependent and Independent Signaling. | 2021 | Details |
| A29610 | 33801718 | Cancers (Basel) | Overexpression of Human Syndecan-1 Protects against the Diethylnitrosamine-Induced Hepatocarcinogenesis in Mice. | 2021 | Details |
| A29616 | 33796224 | Oncotarget | Characterization of the inflammatory microenvironment and hepatic macrophage subsets in experimental hepatocellular carcinoma models. | 2021 | Details |
| A29664 | 33718362 | Front Cell Dev Biol | The Chromatin Remodeling Protein BRG1 Regulates SREBP Maturation by Activating SCAP Transcription in Hepatocytes. | 2021 | Details |
| A29670 | 33713792 | Biochim Biophys Acta Mol Basis Dis | Liver X receptors and liver physiology. | 2021 | Details |
| A29736 | 33604255 | J Clin Transl Hepatol | New Drugs on the Block-Emerging Treatments for Nonalcoholic Steatohepatitis. | 2020 | Details |
| A29839 | 33422984 | Eur J Med Chem | Design of novel Xenopus GLP-1-based dual glucagon-like peptide 1 (GLP-1)/glucagon receptor agonists. | 2020 | Details |
| A29858 | 33383845 | Antioxidants (Basel) | Genistein Modulated Lipid Metabolism, Hepatic PPARγ, and Adiponectin Expression in Bilateral Ovariectomized Rats with Nonalcoholic Steatohepatitis (NASH). | 2020 | Details |
| A29876 | 33354276 | Oxid Med Cell Longev | Honokiol Alleviates Methionine-Choline Deficient Diet-Induced Hepatic Steatosis and Oxidative Stress in C57BL/6 Mice by Regulating CFLAR-JNK Pathway. | 2020 | Details |