Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Lipid metabolism4743 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A02397 | 34387896 | Hepatology | Hepatocyte-specific deletion of adipose triglyceride lipase (adipose triglyceride lipase/patatin-like phospholipase domain containing 2) ameliorates dietary induced steatohepatitis in mice. | 2021 | Details |
| A02406 | 34384565 | J Pharmacol Sci | Protective effect of SGL5213, a potent intestinal sodium-glucose cotransporter 1 inhibitor, in nonalcoholic fatty liver disease in mice. | 2021 | Details |
| A02413 | 34382907 | Autophagy | Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy. | 2021 | Details |
| A02434 | 34372491 | Viruses | Findings from Studies Are Congruent with Obesity Having a Viral Origin, but What about Obesity-Related NAFLD? | 2021 | Details |
| A02436 | 34371959 | Nutrients | Whey Protein Supplementation Improves the Glycemic Response and May Reduce Non-Alcoholic Fatty Liver Disease Related Biomarkers in Women with Polycystic Ovary Syndrome (PCOS). | 2021 | Details |
| A02437 | 34371946 | Nutrients | Expression of Jejunal Taste Receptors in Women with Morbid Obesity. | 2021 | Details |
| A02446 | 34368214 | Front Nutr | Dietary Interventions in Patients With Non-alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis. | 2021 | Details |
| A02451 | 34366846 | Front Pharmacol | Metformin Alleviates Hepatic Steatosis and Insulin Resistance in a Mouse Model of High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease by Promoting Transcription Factor EB-Dependent Autophagy. | 2021 | Details |
| A02458 | 34364973 | Biochim Biophys Acta Gen Subj | Copper and lipid metabolism: A reciprocal relationship. | 2021 | Details |
| A02467 | 34361619 | Molecules | Antioxidant and Antisteatotic Activities of Fucoidan Fractions from Marine and Terrestrial Sources. | 2021 | Details |
| A02479 | 34359438 | Foods | Comparison of Egg Yolk and Soybean Phospholipids on Hepatic Fatty Acid Profile and Liver Protection in Rats Fed a High-Fructose Diet. | 2021 | Details |
| A02490 | 34355282 | Metabolomics | Short-term changes in the serum metabolome after laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass. | 2021 | Details |
| A02493 | 34353693 | J Ayurveda Integr Med | Intervention by picroside II on FFAs induced lipid accumulation and lipotoxicity in HepG2 cells. | 2021 | Details |
| A02498 | 34351342 | Food Funct | CD36 and DGAT2 facilitate the lipid-lowering effect of chitooligosaccharides via fatty acid intake and triglyceride synthesis signaling. | 2021 | Details |
| A02502 | 34349877 | Nutr Res Pract | Efficacy of nobiletin in improving hypercholesterolemia and nonalcoholic fatty liver disease in high-cholesterol diet-fed mice. | 2021 | Details |
| A02509 | 34347479 | J Agric Food Chem | Hepatic Lipidomics Analysis Reveals the Ameliorative Effects of Highland Barley β-Glucan on Western Diet-Induced Nonalcoholic Fatty Liver Disease Mice. | 2021 | Details |
| A02517 | 34343577 | Metabolism | Intestine-liver crosstalk in Type 2 Diabetes and non-alcoholic fatty liver disease. | 2021 | Details |
| A02520 | 34342231 | J Agric Food Chem | Phloridzin Ameliorates Lipid Deposition in High-Fat-Diet-Fed Mice with Nonalcoholic Fatty Liver Disease via Inhibiting the mTORC1/SREBP-1c Pathway. | 2021 | Details |
| A02523 | 34341928 | Environ Sci Pollut Res Int | Metronidazole enhances steatosis-related early-stage hepatocarcinogenesis in high fat diet-fed rats through DNA double-strand breaks and modulation of autophagy. | 2021 | Details |
| A02540 | 34335574 | Front Immunol | Inhibition of Extracellular Cathepsin D Reduces Hepatic Lipid Accumulation and Leads to Mild Changes in Inflammationin NASH Mice. | 2021 | Details |
| A02546 | 34332979 | Life Sci | Dimethyl fumarate reduces oxidative stress, inflammation and fat deposition by modulation of Nrf2, SREBP-1c and NF-κB signaling in HFD fed mice. | 2021 | Details |
| A02561 | 34328120 | Biomed Pharmacother | Molecular mechanism of DLBS3733, a bioactive fraction of Lagerstroemia speciosa (L.) Pers., on ameliorating hepatic lipid accumulation in HepG2 cells. | 2021 | Details |
| A02568 | 34326886 | Evid Based Complement Alternat Med | Pharmacological Mechanisms Underlying the Hepatoprotective Effects of Ecliptae herba on Hepatocellular Carcinoma. | 2021 | Details |
| A02572 | 34326208 | Science | Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion. | 2021 | Details |
| A02582 | 34323067 | J Agric Food Chem | Regulation on Citrate Influx and Metabolism through Inhibiting SLC13A5 and ACLY: A Novel Mechanism Mediating the Therapeutic Effects of Curcumin on NAFLD. | 2021 | Details |
| A02583 | 34322898 | Hepatology | Guanine Nucleotide-Binding Protein G(i) Subunit Alpha 2 Exacerbates NASH Progression by Regulating Peroxiredoxin 1-Related Inflammation and Lipophagy. | 2021 | Details |
| A02597 | 34320238 | Hepatology | SIMPLE Is an Endosomal Regulator That Protects Against NAFLD by Targeting the Lysosomal Degradation of EGFR. | 2021 | Details |
| A02600 | 34315516 | Chin Med | Herbal therapy for ameliorating nonalcoholic fatty liver disease via rebuilding the intestinal microecology. | 2021 | Details |
| A02601 | 34314787 | Adv Drug Deliv Rev | Therapeutic targets, novel drugs, and delivery systems for diabetes associated NAFLD and liver fibrosis. | 2021 | Details |
| A02603 | 34312684 | J Mol Med (Berl) | Lipid metabolism, inflammation, and foam cell formation in health and metabolic disorders: targeting mTORC1. | 2021 | Details |
| A02606 | 34311531 | Biomed Pharmacother | FTZ attenuates liver steatosis and fibrosis in the minipigs with type 2 diabetes by regulating the AMPK signaling pathway. | 2021 | Details |
| A02616 | 34308853 | Nan Fang Yi Ke Da Xue Xue Bao | [Parathyroid hormone-related protein aggravates nonalcoholic fatty liver disease induced by methionine choline-deficient diet in mice]. | 2021 | Details |
| A02622 | 34306045 | PPAR Res | Activation of the Peroxisome Proliferator-Activated Receptors (PPAR-α/γ) and the Fatty Acid Metabolizing Enzyme Protein CPT1A by Camel Milk Treatment Counteracts the High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A02632 | 34302259 | Endocrine | Prospective assessment of liver stiffness by shear wave elastography in childhood obesity: a pilot study. | 2021 | Details |
| A02641 | 34298998 | Int J Mol Sci | Raman Study on Lipid Droplets in Hepatic Cells Co-Cultured with Fatty Acids. | 2021 | Details |
| A02649 | 34298442 | Biomaterials | Nanocapsule-mediated sustained H2 release in the gut ameliorates metabolic dysfunction-associated fatty liver disease. | 2021 | Details |
| A02653 | 34297426 | Hepatology | Gastrodin Improves Nonalcoholic Fatty Liver Disease Through Activation of the Adenosine Monophosphate-Activated Protein Kinase Signaling Pathway. | 2021 | Details |
| A02661 | 34294580 | Dig Liver Dis | Distinctive features of hepatocellular carcinoma in non-alcoholic fatty liver disease. | 2021 | Details |
| A02662 | 34294375 | J Pharmacol Sci | Ferulic acid attenuates non-alcoholic steatohepatitis by reducing oxidative stress and inflammation through inhibition of the ROCK/NF-κB signaling pathways. | 2021 | Details |
| A02673 | 34289507 | Semin Liver Dis | Role of FXR in Bile Acid and Metabolic Homeostasis in NASH: Pathogenetic Concepts and Therapeutic Opportunities. | 2021 | Details |
| A02679 | 34288010 | Hepatology | Modeling PNPLA3-Associated NAFLD Using Human-Induced Pluripotent Stem Cells. | 2021 | Details |
| A02689 | 34281337 | J Agric Food Chem | γ-Linolenic Acid Prevents Lipid Metabolism Disorder in Palmitic Acid-Treated Alpha Mouse Liver-12 Cells by Balancing Autophagy and Apoptosis via the LKB1-AMPK-mTOR Pathway. | 2021 | Details |
| A02693 | 34280397 | Eur J Pharmacol | Thymosin beta 4 alleviates non-alcoholic fatty liver by inhibiting ferroptosis via up-regulation of GPX4. | 2021 | Details |
| A02711 | 34276221 | Diabetes Metab Syndr Obes | Biochanin A Regulates Cholesterol Metabolism Further Delays the Progression of Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A02729 | 34270263 | J Proteome Res | Integration of Metabolomics and Transcriptomics Reveals Ketone Body and Lipid Metabolism Disturbance Related to ER Stress in the Liver. | 2021 | Details |
| A02751 | 34260003 | Neurochem Res | Resveratrol Protects SH-SY5Y Cells Against Oleic Acid-Induced Glucolipid Metabolic Dysfunction and Cell Injuries Via the Wnt/β-Catenin Signalling Pathway. | 2021 | Details |
| A02755 | 34257827 | Oxid Med Cell Longev | Changes in Key Mitochondrial Lipids Accompany Mitochondrial Dysfunction and Oxidative Stress in NAFLD. | 2021 | Details |
| A02766 | 34251802 | J Agric Food Chem | Oleanolic Acid Targets the Gut-Liver Axis to Alleviate Metabolic Disorders and Hepatic Steatosis. | 2021 | Details |
| A02770 | 34249975 | Front Med (Lausanne) | Adiponectin, Leptin, and IGF-1 Are Useful Diagnostic and Stratification Biomarkers of NAFLD. | 2021 | Details |
| A02786 | 34241659 | Arch Toxicol | Sex-dependent dynamics of metabolism in primary mouse hepatocytes. | 2021 | Details |
| A02800 | 34234682 | Front Pharmacol | The Anti-Obesity Effect of Traditional Chinese Medicine on Lipid Metabolism. | 2021 | Details |
| A02807 | 34233850 | Hepatobiliary Pancreat Dis Int | Key factors and potential drug combinations of nonalcoholic steatohepatitis: Bioinformatic analysis and experimental validation-based study. | 2021 | Details |
| A02810 | 34233158 | Mol Cell | SREBP-1c impairs ULK1 sulfhydration-mediated autophagic flux to promote hepatic steatosis in high-fat-diet-fed mice. | 2021 | Details |
| A02838 | 34224699 | Eur J Pharmacol | Dapagliflozin attenuates steatosis in livers of high-fat diet-induced mice and oleic acid-treated L02 cells via regulating AMPK/mTOR pathway. | 2021 | Details |
| A02839 | 34224565 | J Nutr | Brown Rice Inhibits Development of Nonalcoholic Fatty Liver Disease in Obese Zucker (fa/fa) Rats by Increasing Lipid Oxidation Via Activation of Retinoic Acid Synthesis. | 2021 | Details |
| A02872 | 34211098 | Commun Biol | Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance. | 2021 | Details |
| A02876 | 34209386 | Biomedicines | Role of Leptin in Non-Alcoholic Fatty Liver Disease. | 2021 | Details |
| A02881 | 34206629 | Nutrients | Perinatal High-Salt Diet Induces Gut Microbiota Dysbiosis, Bile Acid Homeostasis Disbalance, and NAFLD in Weanling Mice Offspring. | 2021 | Details |
| A02894 | 34204055 | Nutrients | Matcha Green Tea Alleviates Non-Alcoholic Fatty Liver Disease in High-Fat Diet-Induced Obese Mice by Regulating Lipid Metabolism and Inflammatory Responses. | 2021 | Details |
| A02896 | 34203342 | Metabolites | Betatrophin Levels Are Related to the Early Histological Findings in Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A02897 | 34203309 | Int J Mol Sci | Mitochondrial Lipid Homeostasis at the Crossroads of Liver and Heart Diseases. | 2021 | Details |
| A02904 | 34202179 | Int J Mol Sci | The Alterations of Mitochondrial Function during NAFLD Progression-An Independent Effect of Mitochondrial ROS Production. | 2021 | Details |
| A02909 | 34200685 | Metabolites | Metabolomic Study of High-Fat Diet-Induced Obese (DIO) and DIO Plus CCl4-Induced NASH Mice and the Effect of Obeticholic Acid. | 2021 | Details |
| A02910 | 34200615 | Nutrients | Lipoic Acid Exacerbates Oxidative Stress and Lipid Accumulation in the Liver of Wistar Rats Fed a Hypercaloric Choline-Deficient Diet. | 2021 | Details |
| A02911 | 34200577 | Metabolites | Circulating Levels of Pro-Neurotensin and Its Relationship with Nonalcoholic Steatohepatitis and Hepatic Lipid Metabolism. | 2021 | Details |
| A02920 | 34199035 | Int J Mol Sci | The Role of Fatty Acids in Non-Alcoholic Fatty Liver Disease Progression: An Update. | 2021 | Details |
| A02923 | 34198853 | Int J Mol Sci | The Propensity of the Human Liver to Form Large Lipid Droplets Is Associated with PNPLA3 Polymorphism, Reduced INSIG1 and NPC1L1 Expression and Increased Fibrogenetic Capacity. | 2021 | Details |
| A02924 | 34198236 | Int Immunopharmacol | β-patchoulene protects against non-alcoholic steatohepatitis via interrupting the vicious circle among oxidative stress, histanoxia and lipid accumulation in rats. | 2021 | Details |
| A02926 | 34195525 | J Endocr Soc | The PRKAR1B p.R115K Variant is Associated with Lipoprotein Profile in African American Youth with Metabolic Challenges. | 2021 | Details |
| A02937 | 34191493 | Anal Chem | Exploring the Changes of Peroxisomal Polarity in the Liver of Mice with Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A02969 | 34179315 | Genes Dis | Bone morphogenetic protein 4 (BMP4) promotes hepatic glycogen accumulation and reduces glucose level in hepatocytes through mTORC2 signaling pathway. | 2020 | Details |
| A02976 | 34176536 | Nutr Res Rev | Carbohydrates deteriorate fatty liver by activating the inflammatory response. | 2021 | Details |
| A02981 | 34174520 | Nutr Res | Bile acids induced hepatic lipid accumulation in mice by inhibiting mRNA expression of patatin-like phospholipase domain containing 3 and microsomal triglyceride transfer protein. | 2021 | Details |
| A02992 | 34171492 | Pharmacol Res | Hepatic stellate cells role in the course of metabolic disorders development - A molecular overview. | 2021 | Details |
| A02993 | 34171462 | Biochim Biophys Acta Gene Regul Mech | Polymorphisms rs55710213 and rs56334587 regulate SCD1 expression by modulating HNF4A binding. | 2021 | Details |
| A02995 | 34171397 | J Ethnopharmacol | Emodin palliates high-fat diet-induced nonalcoholic fatty liver disease in mice via activating the farnesoid X receptor pathway. | 2021 | Details |
| A03002 | 34168429 | Drug Des Devel Ther | Metformin in Combination with Malvidin Prevents Progression of Non-Alcoholic Fatty Liver Disease via Improving Lipid and Glucose Metabolisms, and Inhibiting Inflammation in Type 2 Diabetes Rats. | 2021 | Details |
| A03030 | 34158256 | Dig Liver Dis | BRG1 regulates lipid metabolism in hepatocellular carcinoma through the PIK3AP1/PI3K/AKT pathway by mediating GLMP expression. | 2021 | Details |
| A03035 | 34156017 | Wiad Lek | INFLUENCE OF COMPLEX TREATMENT ON BIOCHEMICAL BLOOD PARAMETERS OF PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE AND CONCOMITANT PRE-DIABETES. | 2021 | Details |
| A03036 | 34156011 | Wiad Lek | THE EFFECT OF COMPREHENSIVE TREATMENT OF PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE IN COMBINATION WITH PREDIABETES ON THE LIPID PROFILE. | 2021 | Details |
| A03052 | 34153200 | Arch Physiol Biochem | The promising roles of medicinal plants and bioactive compounds on hepatic lipid metabolism in the treatment of non-alcoholic fatty liver disease in animal models: molecular targets. | 2021 | Details |
| A03069 | 34142875 | Crit Rev Food Sci Nutr | Research progress on intervention effect and mechanism of protocatechuic acid on nonalcoholic fatty liver disease. | 2021 | Details |
| A03071 | 34142329 | Fish Physiol Biochem | Metabolism and antioxidation regulation of total flavanones from Sedum sarmentosum Bunge against high-fat diet-induced fatty liver disease in Nile tilapia (Oreochromis niloticus). | 2021 | Details |
| A03076 | 34139927 | Pharm Biol | Tocopheryl quinone improves non-alcoholic steatohepatitis (NASH) associated dysmetabolism of glucose and lipids by upregulating the expression of glucagon-like peptide 1 (GLP-1) via restoring the balance of intestinal flora in rats. | 2021 | Details |
| A03092 | 34134614 | BMC Genomics | Transcriptomic coordination at hepatic steatosis indicates robust immune cell engagement prior to inflammation. | 2021 | Details |
| A03103 | 34130208 | Nutr Res | A rise in Proteobacteria is an indicator of gut-liver axis-mediated nonalcoholic fatty liver disease in high-fructose-fed adult mice. | 2021 | Details |
| A03112 | 34126083 | Am J Pathol | Vitamin C Deficiency Inhibits Nonalcoholic Fatty Liver Disease Progression through Impaired de Novo Lipogenesis. | 2021 | Details |
| A03120 | 34120768 | Mol Aspects Med | Autophagy in liver diseases: A review. | 2021 | Details |
| A03127 | 34119629 | J Nutr Biochem | Sugar kelp (Saccharina latissima) inhibits hepatic inflammation and fibrosis in a mouse model of diet-induced nonalcoholic steatohepatitis. | 2021 | Details |
| A03132 | 34118361 | Peptides | A synthetic peptide AWRK6 ameliorates metabolic associated fatty liver disease: involvement of lipid and glucose homeostasis. | 2021 | Details |
| A03137 | 34117215 | Cell Death Dis | Liver fat storage is controlled by HNF4α through induction of lipophagy and is reversed by a potent HNF4α agonist. | 2021 | Details |
| A03146 | 34114325 | EMBO Rep | SCFJFK is functionally linked to obesity and metabolic syndrome. | 2021 | Details |
| A03162 | 34107274 | Exp Cell Res | Lipid accumulation-induced hepatocyte senescence regulates the activation of hepatic stellate cells through the Nrf2-antioxidant response element pathway. | 2021 | Details |
| A03163 | 34106786 | Am J Physiol Cell Physiol | Impaired Ca2+ signaling due to hepatic steatosis mediates hepatic insulin resistance in Alström syndrome mice that is reversed by GLP-1 analog treatment. | 2021 | Details |
| A03170 | 34104598 | Cureus | Unraveling the Role of Hypothyroidism in Non-alcoholic Fatty Liver Disease Pathogenesis: Correlations, Conflicts, and the Current Stand. | 2021 | Details |
| A03183 | 34096925 | J Vis Exp | A Model of Experimental Steatosis In Vitro: Hepatocyte Cell Culture in Lipid Overload-Conditioned Medium. | 2021 | Details |
| A03193 | 34094429 | Chem Sci | In situ visualization of peroxisomal viscosity in the liver of mice with non-alcoholic fatty liver disease by near-infrared fluorescence and photoacoustic imaging. | 2020 | Details |
| A03200 | 34092291 | Chin J Nat Med | Silybin alleviates hepatic lipid accumulation in methionine-choline deficient diet-induced nonalcoholic fatty liver disease in mice via peroxisome proliferator-activated receptor α. | 2021 | Details |
| A03214 | 34087406 | Food Chem Toxicol | Quercetin and non-alcoholic fatty liver disease: A review based on experimental data and bioinformatic analysis. | 2021 | Details |
| A03217 | 34083664 | Sci Rep | Pirfenidone modifies hepatic miRNAs expression in a model of MAFLD/NASH. | 2021 | Details |