Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Metformin577 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A22819 | 24287794 | Endocrine | Non-alcoholic fatty liver disease: a diabetologist's perspective. | 2013 | Details |
| A22846 | 24274866 | Clin Liver Dis | The role of medications for the management of patients with NAFLD. | 2013 | Details |
| A22871 | 24264040 | Int J Mol Sci | Nonalcoholic Fatty liver: a possible new target for type 2 diabetes prevention and treatment. | 2013 | Details |
| A22886 | 24253218 | Int J Mol Med | Metformin prevents hepatic steatosis by regulating the expression of adipose differentiation-related protein. | 2013 | Details |
| A22925 | 24206433 | Aliment Pharmacol Ther | Systematic review with meta-analysis: non-alcoholic steatohepatitis - a case for personalised treatment based on pathogenic targets. | 2013 | Details |
| A22949 | 24185692 | Nat Med | Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin. | 2013 | Details |
| A23043 | 24081374 | Clin Drug Investig | Randomized, vitamin E-controlled trial of bicyclol plus metformin in non-alcoholic fatty liver disease patients with impaired fasting glucose. | 2014 | Details |
| A23061 | 24071688 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | [Effect of metformin on the expression of SIRT1 and UCP2 in rat liver of type 2 diabetes mellitus and nonalcoholic fatty liver]. | 2013 | Details |
| A23101 | 24040873 | Curr Pharm Des | The role of oral antidiabetic agents and incretin mimetics in type 2 diabetic patients with non-alcoholic fatty liver disease. | 2014 | Details |
| A23202 | 23964070 | Am J Physiol Endocrinol Metab | Metformin prevents liver tumorigenesis induced by high-fat diet in C57Bl/6 mice. | 2013 | Details |
| A23216 | 23951244 | PLoS One | Metformin protects rat hepatocytes against bile acid-induced apoptosis. | 2013 | Details |
| A23228 | 23939604 | Am Fam Physician | Nonalcoholic fatty liver disease: diagnosis and management. | 2013 | Details |
| A23229 | 23938069 | J Psychosoc Nurs Ment Health Serv | A "glucose eater" drug as a therapeutic agent in psychiatry. | 2013 | Details |
| A23241 | 23930163 | Int J Prev Med | Effect of a Probiotic and Metformin on Liver Aminotransferases in Non-alcoholic Steatohepatitis: A Double Blind Randomized Clinical Trial. | 2013 | Details |
| A23242 | 23930133 | Hepat Mon | The effect of pioglitazone and metformin on liver function tests, insulin resistance, and liver fat content in nonalcoholic Fatty liver disease: a randomized double blinded clinical trial. | 2013 | Details |
| A23276 | 23906870 | Exp Mol Pathol | Chemerin is highly expressed in hepatocytes and is induced in non-alcoholic steatohepatitis liver. | 2013 | Details |
| A23356 | 23845075 | Curr Diabetes Rev | The influence of diabetes in the pathogenesis and the clinical course of hepatocellular carcinoma: recent findings and new perspectives. | 2013 | Details |
| A23647 | 23600144 | Yao Xue Xue Bao | [Effects of pomegranate flowers polyphenols on liver PON expression of diabetes combining non-alcoholic fat liver diseases rats]. | 2013 | Details |
| A23706 | 23548993 | Tumori | Linking nonalcoholic fatty liver disease to hepatocellular carcinoma: from bedside to bench and back. | 2013 | Details |
| A23784 | 23482703 | World J Gastroenterol | NAFLD fibrosis score: a prognostic predictor for mortality and liver complications among NAFLD patients. | 2013 | Details |
| A23904 | 23394096 | Curr Pharm Des | Classical and innovative insulin sensitizing drugs for the prevention and treatment of NAFLD. | 2013 | Details |
| A23948 | 23359475 | Pharmacotherapy | Pharmacologic therapy for nonalcoholic fatty liver disease in adults. | 2013 | Details |
| A24007 | 23305008 | Klin Lab Diagn | [The unity of pathogenesis of insulin resistance syndrome and non-alcoholic fatty disease of liver. The metabolic disorder of fatty acids and triglycerides]. | 2012 | Details |
| A24008 | 23304532 | Int J Hepatol | Multidisciplinary pharmacotherapeutic options for nonalcoholic Fatty liver disease. | 2012 | Details |
| A24067 | 24648894 | Biomed Rep | Metformin in non-alcoholic fatty liver disease: A systematic review and meta-analysis. | 2012 | Details |
| A24090 | 23236362 | PLoS One | Improved glycaemia correlates with liver fat reduction in obese, type 2 diabetes, patients given glucagon-like peptide-1 (GLP-1) receptor agonists. | 2012 | Details |
| A24093 | 23234816 | Hepatogastroenterology | Investigation of the effects of Chlorella vulgaris supplementation in patients with non-alcoholic fatty liver disease: a randomized clinical trial. | 2012 | Details |
| A24141 | 23185203 | Arch Med Sci | Metformin and its clinical use: new insights for an old drug in clinical practice. | 2012 | Details |
| A24229 | 23075871 | Dig Dis | Clinical spectrum and therapy of non-alcoholic steatohepatitis. | 2012 | Details |
| A24238 | 23087748 | Hepat Mon | Effects of metformin, pioglitazone, and silymarin treatment on non-alcoholic Fatty liver disease: a randomized controlled pilot study. | 2012 | Details |
| A24298 | 23028442 | PLoS One | Metformin prevents and reverses inflammation in a non-diabetic mouse model of nonalcoholic steatohepatitis. | 2012 | Details |
| A24375 | 22960565 | J Proteomics | Proteomic analysis of liver mitochondria of apolipoprotein E knockout mice treated with metformin. | 2012 | Details |
| A24387 | 22949894 | Case Rep Gastroenterol | Dipeptidyl Peptidase IV Inhibitor Improves Insulin Resistance and Steatosis in a Refractory Nonalcoholic Fatty Liver Disease Patient: A Case Report. | 2012 | Details |
| A24422 | 22913901 | Postgrad Med | Managing diabetes in patients with chronic liver disease. | 2012 | Details |
| A24627 | 22676459 | Cardiovasc Diabetol | Relation between augmentation index and adiponectin during one-year metformin treatment for nonalcoholic steatohepatosis: effects beyond glucose lowering? | 2012 | Details |
| A24629 | 22673924 | Int J Vitam Nutr Res | Therapeutic effect of metformin and vitamin E versus prescriptive diet in obese adolescents with fatty liver. | 2011 | Details |
| A24655 | 25755424 | J Clin Exp Hepatol | Management of Non-alcoholic Fatty Liver Disease and Steatohepatitis. | 2012 | Details |
| A24674 | 22617751 | Curr Opin Lipidol | Nonalcoholic fatty liver disease and lipids. | 2012 | Details |
| A24752 | 22536512 | Int J Hepatol | Paraoxonase activity and expression is modulated by therapeutics in experimental rat nonalcoholic Fatty liver disease. | 2012 | Details |
| A24764 | 22525431 | Lab Invest | Metformin protects against the development of fructose-induced steatosis in mice: role of the intestinal barrier function. | 2012 | Details |
| A24766 | 22521558 | Clin Res Hepatol Gastroenterol | Non-alcoholic fatty liver disease in children. | 2012 | Details |
| A24772 | 22519397 | Curr Med Chem | Mechanisms involved in the protective effects of metformin against nonalcoholic fatty liver disease. | 2012 | Details |
| A24898 | 22382613 | Minerva Endocrinol | Neuroendocrine and endocrine dysfunction in the hyperinsulinemic PCOS patient: the role of metformin. | 2012 | Details |
| A24950 | 22326465 | J Hepatol | Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging menace. | 2012 | Details |
| A24973 | 22291824 | Arch Med Sci | Safety and impact on cardiovascular events of long-term multifactorial treatment in patients with metabolic syndrome and abnormal liver function tests: a post hoc analysis of the randomised ATTEMPT study. | 2011 | Details |
| A24984 | 22278337 | Diabetologia | Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials. | 2012 | Details |
| A25072 | 22194737 | Exp Diabetes Res | The role of metformin in the management of NAFLD. | 2011 | Details |
| A25101 | 22170794 | Eur J Endocrinol | Fetuin A in nonalcoholic fatty liver disease: in vivo and in vitro studies. | 2011 | Details |
| A25203 | 22096112 | Eur J Endocrinol | Recent advances in cardiovascular aspects of polycystic ovary syndrome. | 2011 | Details |
| A25238 | 22059955 | Health Technol Assess | Insulin sensitisers in the treatment of non-alcoholic fatty liver disease: a systematic review. | 2011 | Details |
| A25319 | 21958877 | Eur J Pharmacol | Metformin regulates hepatic lipid metabolism through activating AMP-activated protein kinase and inducing ATGL in laying hens. | 2011 | Details |
| A25323 | 21956711 | Diabetologia | Exenatide decreases hepatic fibroblast growth factor 21 resistance in non-alcoholic fatty liver disease in a mouse model of obesity and in a randomised controlled trial. | 2011 | Details |
| A25361 | 21926952 | Minerva Ginecol | [Polycystic ovarian syndrome incidence in young women with non-alcoholic fatty liver disease]. | 2011 | Details |
| A25499 | 21765869 | Therap Adv Gastroenterol | The role of insulin-sensitizing agents in the treatment of nonalcoholic steatohepatitis. | 2011 | Details |
| A25502 | 21764223 | Med Hypotheses | Full-spectrum antioxidant therapy featuring astaxanthin coupled with lipoprivic strategies and salsalate for management of non-alcoholic fatty liver disease. | 2011 | Details |
| A25518 | 21748770 | Hepatology | Rosiglitazone versus rosiglitazone and metformin versus rosiglitazone and losartan in the treatment of nonalcoholic steatohepatitis in humans: a 12-month randomized, prospective, open- label trial. | 2011 | Details |
| A25655 | 21577310 | World J Gastrointest Pharmacol Ther | Is there any progress in the treatment of non-alcoholic fatty liver disease? | 2011 | Details |
| A25661 | 21569072 | Clin Endocrinol (Oxf) | Long-term metformin treatment is able to reduce the prevalence of metabolic syndrome and its hepatic involvement in young hyperinsulinaemic overweight patients with polycystic ovarian syndrome. | 2011 | Details |
| A25665 | 21565479 | Nutr Metab Cardiovasc Dis | Management of metabolic syndrome in children and adolescents. | 2011 | Details |
| A25666 | 21564529 | Am J Transplant | Should metformin be our antiglycemic agent of choice post-transplantation? | 2011 | Details |
| A25701 | 21521847 | JAMA | Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial. | 2011 | Details |
| A25754 | 21478462 | Diabetes Care | Prevalence of and risk factors for hepatic steatosis and nonalcoholic Fatty liver disease in people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study. | 2011 | Details |
| A25822 | 21426695 | Zhonghua Er Ke Za Zhi | [Metformin prevents non-alcoholic fatty liver disease in rats: role of phospholipase A2/lysophosphatidylcholine lipoapoptosis pathway in hepatocytes]. | 2011 | Details |
| A25836 | 21412139 | Am J Med Sci | Nonalcoholic fatty liver disease and type 2 diabetes mellitus: the hidden epidemic. | 2011 | Details |
| A25837 | 21411114 | Metabolism | Treatment with insulin sensitizer metformin improves arterial properties, metabolic parameters, and liver function in patients with nonalcoholic fatty liver disease: a randomized, placebo-controlled trial. | 2011 | Details |
| A25881 | 21356259 | J Hepatol | Insulin resistance and liver microcirculation in a rat model of early NAFLD. | 2011 | Details |
| A26004 | 21218508 | Diabetes Metab Res Rev | Metformin and atorvastatin combination further protect the liver in type 2 diabetes with hyperlipidaemia. | 2011 | Details |
| A26006 | 21216209 | Endocrinol Nutr | [Fatty liver and its clinical management in obese adolescents]. | 2011 | Details |
| A26026 | 21191681 | Indian J Gastroenterol | Nonalcoholic fatty liver disease in India - a lot done, yet more required! | 2010 | Details |
| A26176 | 20955440 | Aliment Pharmacol Ther | Meta-analysis: insulin sensitizers for the treatment of non-alcoholic steatohepatitis. | 2010 | Details |
| A26328 | 20647417 | Ann Pharmacother | Hepatotoxicity associated with metformin therapy in treatment of type 2 diabetes mellitus with nonalcoholic fatty liver disease. | 2010 | Details |
| A26364 | 20584230 | Int J Clin Pract | Pharmacological and non-pharmacological treatment of non-alcoholic fatty liver disease. | 2010 | Details |
| A26404 | 23148155 | Ther Adv Endocrinol Metab | Advances in the treatment of nonalcoholic fatty liver disease. | 2010 | Details |
| A26483 | 20388946 | J Physiol Pharmacol | Therapy of nonalcoholic fatty liver disease: current status. | 2009 | Details |
| A26573 | 20186137 | Obesity (Silver Spring) | Effects of metformin and weight loss on serum alanine aminotransferase activity in the diabetes prevention program. | 2010 | Details |
| A26577 | 20179669 | Int J Obes (Lond) | Metformin versus dietary treatment in nonalcoholic hepatic steatosis: a randomized study. | 2010 | Details |
| A26656 | 20038265 | Immunopharmacol Immunotoxicol | Metformin regulates palmitate-induced apoptosis and ER stress response in HepG2 liver cells. | 2010 | Details |
| A26703 | 19929925 | J Gastroenterol Hepatol | Endoplasmic reticulum stress involved in the course of lipogenesis in fatty acids-induced hepatic steatosis. | 2009 | Details |
| A26709 | 19921118 | Adv Ther | Insulin sensitizers in nonalcoholic fatty liver disease and steatohepatitis: Current status. | 2009 | Details |
| A26775 | 19811343 | Scand J Gastroenterol | Metformin in patients with non-alcoholic fatty liver disease: a randomized, controlled trial. | 2009 | Details |
| A26800 | 19761871 | Contemp Clin Trials | Treatment of nonalcoholic fatty liver disease in children: TONIC trial design. | 2009 | Details |
| A26844 | 19667999 | Eur J Gastroenterol Hepatol | Efficacy of insulin-sensitizing agents in nonalcoholic fatty liver disease. | 2010 | Details |
| A26984 | 19412008 | J Pediatr Gastroenterol Nutr | Pharmacological interventions for nonalcoholic fatty liver disease in adults and in children: a systematic review. | 2009 | Details |
| A27091 | 19195628 | Diabetes Metab | How to measure hepatic insulin resistance? | 2008 | Details |
| A27123 | 19135440 | Eur J Pharmacol | Comparative therapeutic effects of metformin and vitamin E in a model of non-alcoholic steatohepatitis in the young rat. | 2008 | Details |
| A27129 | 21686813 | BMJ Case Rep | Non-alcoholic fatty liver disease in a patient with maturity onset diabetes in the young. | 2009 | Details |
| A27130 | 21180532 | Therap Adv Gastroenterol | Current status of therapy in nonalcoholic Fatty liver disease. | 2009 | Details |
| A27163 | 19065650 | Hepatology | Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Selected practical issues in their evaluation and management. | 2009 | Details |
| A27193 | 19013463 | Gastroenterology | Clinical correlates of histopathology in pediatric nonalcoholic steatohepatitis. | 2008 | Details |
| A27218 | 18956296 | Semin Liver Dis | Current and emerging therapies in nonalcoholic fatty liver disease. | 2008 | Details |
| A27230 | 18945255 | Aliment Pharmacol Ther | Clinical trial: pilot study of metformin for the treatment of non-alcoholic steatohepatitis. | 2008 | Details |
| A27249 | 18839053 | Acta Diabetol | The effect of metformin on leptin in obese patients with type 2 diabetes mellitus and nonalcoholic fatty liver disease. | 2008 | Details |
| A27290 | 18721166 | Pediatr Diabetes | Treatment of non-alcoholic fatty liver disease with metformin versus lifestyle intervention in insulin-resistant adolescents. | 2008 | Details |
| A27298 | 18702346 | Pol Merkur Lekarski | [Non-alcoholic fatty liver disease--new view]. | 2008 | Details |
| A27326 | 18640473 | Clin Ther | Metformin use in children with nonalcoholic fatty liver disease: an open-label, 24-month, observational pilot study. | 2008 | Details |
| A27356 | 18565127 | Int J Clin Pract | The effects of 8 months of metformin on circulating GGT and ALT levels in obese women with polycystic ovarian syndrome. | 2008 | Details |
| A27358 | 18564173 | Diabetes Obes Metab | Current treatment of non-alcoholic fatty liver disease. | 2008 | Details |
| A27411 | 18445142 | Aliment Pharmacol Ther | Clinical trial: insulin-sensitizing agents may reduce consequences of insulin resistance in individuals with non-alcoholic steatohepatitis. | 2008 | Details |
| A27580 | 18007551 | Ann Hepatol | Metformin is effective in achieving biochemical response in patients with nonalcoholic fatty liver disease (NAFLD) not responding to lifestyle interventions. | 2008 | Details |
| A27587 | 17983937 | Endocrinol Metab Clin North Am | Use of insulin sensitizers in NASH. | 2007 | Details |