Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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PPAR2265 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A05295 | 33309929 | J Proteomics | Proteome and phosphoproteome characterization of liver in the postprandial state from diet-induced obese and lean mice. | 2020 | Details |
| A05332 | 33299856 | Biomed Res Int | GCN2 Deficiency Enhances Protective Effects of Exercise on Hepatic Steatosis. | 2020 | Details |
| A05344 | 33293992 | Evid Based Complement Alternat Med | Effect of Sheng-Jiang Powder on Gut Microbiota in High-Fat Diet-Induced NAFLD. | 2020 | Details |
| A05351 | 33290156 | Can J Physiol Pharmacol | Theobromine ameliorates nonalcoholic fatty liver disease by regulating hepatic lipid metabolism via mTOR signaling pathway in vivo and in vitro. | 2020 | Details |
| A05353 | 33289147 | J Food Biochem | A high-fructose diet in rats induces systemic iron deficiency and hepatic iron overload by an inflammation mechanism. | 2020 | Details |
| A05366 | 33281535 | Food Nutr Res | Bile salt hydrolase-overexpressing Lactobacillus strains can improve hepatic lipid accumulation in vitro in an NAFLD cell model. | 2020 | Details |
| A05376 | 33278029 | Pharmacotherapy | Emerging therapies for the treatment of nonalcoholic steatohepatitis: A systematic review. | 2021 | Details |
| A05388 | 33273997 | Oxid Med Cell Longev | Plant Sterol Ester of α-Linolenic Acid Attenuates Nonalcoholic Fatty Liver Disease by Rescuing the Adaption to Endoplasmic Reticulum Stress and Enhancing Mitochondrial Biogenesis. | 2019 | Details |
| A05392 | 33272889 | Clin Res Hepatol Gastroenterol | Vitamin E in paediatric non-alcoholic fatty liver disease: a meta-analysis. | 2020 | Details |
| A05393 | 33272734 | Gastroenterol Hepatol | Silencing HIF-1α aggravates non-alcoholic fatty liver disease in vitro through inhibiting PPAR-α/ANGPTL4 singling pathway. | 2020 | Details |
| A05416 | 33268331 | Biol Open | iPSC-derived hepatocytes generated from NASH donors provide a valuable platform for disease modeling and drug discovery. | 2020 | Details |
| A05438 | 33257471 | Gut | Hepatic Krüppel-like factor 16 (KLF16) targets PPARα to improve steatohepatitis and insulin resistance. | 2020 | Details |
| A05472 | 33246954 | Sci Adv | CRISPR-mediated BMP9 ablation promotes liver steatosis via the down-regulation of PPARα expression. | 2020 | Details |
| A05493 | 33234364 | Phytomedicine | Naringenin alleviates nonalcoholic steatohepatitis in middle-aged Apoe-/-mice: role of SIRT1. | 2020 | Details |
| A05499 | 33229553 | Proc Natl Acad Sci U S A | Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease. | 2020 | Details |
| A05501 | 33228237 | Int J Mol Sci | Nutrients, Genetic Factors, and Their Interaction in Non-Alcoholic Fatty Liver Disease and Cardiovascular Disease. | 2020 | Details |
| A05528 | 33218077 | Int J Mol Sci | PNPLA3 I148M Up-Regulates Hedgehog and Yap Signaling in Human Hepatic Stellate Cells. | 2020 | Details |
| A05555 | 33207858 | Eur J Histochem | The selective blockade of metabotropic glutamate receptor-5 attenuates fat accumulation in an <em>in vitro</em> model of benign steatosis. | 2020 | Details |
| A05565 | 33204683 | Biomed Res Int | Research on the Mechanism of Qushi Huayu Decoction in the Intervention of Nonalcoholic Fatty Liver Disease Based on Network Pharmacology and Molecular Docking Technology. | 2020 | Details |
| A05574 | 33203036 | Int J Mol Sci | ASC, IL-18 and Galectin-3 as Biomarkers of Non-Alcoholic Steatohepatitis: A Proof of Concept Study. | 2020 | Details |
| A05575 | 33202851 | Antioxidants (Basel) | Antioxidant Lifestyle, Co-Morbidities and Quality of Life Empowerment Concerning Liver Fibrosis. | 2020 | Details |
| A05584 | 33199780 | Nat Commun | AdipoR1/AdipoR2 dual agonist recovers nonalcoholic steatohepatitis and related fibrosis via endoplasmic reticulum-mitochondria axis. | 2020 | Details |
| A05608 | 33190588 | Autophagy | TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation. | 2020 | Details |
| A05612 | 33188625 | J Physiol Biochem | Regulation of peroxisome proliferator-activated receptor-gamma activity affects the hepatic stellate cell activation and the progression of NASH via TGF-β1/Smad signaling pathway. | 2020 | Details |
| A05613 | 33187321 | Pharmaceuticals (Basel) | Germinated Soybean Embryo Extract Ameliorates Fatty Liver Injury in High-Fat Diet-Fed Obese Mice. | 2020 | Details |
| A05626 | 33184849 | J Cell Physiol | Co-option of PPARα in the regulation of lipogenesis and fatty acid oxidation in CLA-induced hepatic steatosis. | 2020 | Details |
| A05641 | 33178320 | Evid Based Complement Alternat Med | Sijunzi, Lizhong, and Fuzilizhong Decoction Alleviate Nonalcoholic Fatty Liver Disease through Activation of PPAR Pathway. | 2020 | Details |
| A05645 | 33177546 | Sci Rep | PPARα agonist and metformin co-treatment ameliorates NASH in mice induced by a choline-deficient, amino acid-defined diet with 45% fat. | 2020 | Details |
| A05696 | 33152542 | Clin Gastroenterol Hepatol | A Phase 2 Double Blinded, Randomized Controlled Trial of Saroglitazar in Patients With Nonalcoholic Steatohepatitis. | 2020 | Details |
| A05700 | 33150145 | J Hepatocell Carcinoma | Gut Microbiota, Peroxisome Proliferator-Activated Receptors, and Hepatocellular Carcinoma. | 2020 | Details |
| A05713 | 33144913 | Oxid Med Cell Longev | Amelioration by Idesia polycarpa Maxim. var. vestita Diels. of Oleic Acid-Induced Nonalcoholic Fatty Liver in HepG2 Cells through Antioxidant and Modulation of Lipid Metabolism. | 2020 | Details |
| A05755 | 33132309 | Biol Pharm Bull | Protective Effect of Fuzi Lizhong Decoction against Non-alcoholic Fatty Liver Disease via Anti-inflammatory Response through Regulating p53 and PPARG Signaling. | 2020 | Details |
| A05769 | 33126411 | Cells | The Role of PPARs in Disease. | 2020 | Details |
| A05771 | 33126224 | Aging (Albany NY) | GDF11 induces mild hepatic fibrosis independent of metabolic health. | 2020 | Details |
| A05787 | 33117273 | Front Endocrinol (Lausanne) | Palmitoleic Acid Decreases Non-alcoholic Hepatic Steatosis and Increases Lipogenesis and Fatty Acid Oxidation in Adipose Tissue From Obese Mice. | 2020 | Details |
| A05795 | 33114564 | Nutrients | Protective Effects of (E)-β-Caryophyllene (BCP) in Chronic Inflammation. | 2020 | Details |
| A05801 | 33114221 | Antioxidants (Basel) | Auranofin Attenuates Non-Alcoholic Fatty Liver Disease by Suppressing Lipid Accumulation and NLRP3 Inflammasome-Mediated Hepatic Inflammation In Vivo and In Vitro. | 2020 | Details |
| A05872 | 33093663 | Nat Rev Gastroenterol Hepatol | Nonalcoholic steatohepatitis: the role of peroxisome proliferator-activated receptors. | 2020 | Details |
| A05873 | 33093014 | Diabetes | ETV5 Regulates Hepatic Fatty Acid Metabolism Through PPAR Signaling Pathway. | 2020 | Details |
| A05920 | 33075820 | J Clin Endocrinol Metab | Adolescent Nonalcoholic Fatty Liver Disease and Type 2 Diabetes in Young Adulthood. | 2021 | Details |
| A05931 | 33072455 | Cureus | Pleiotropic Effects of Statins in the Light of Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis. | 2020 | Details |
| A05936 | 33071788 | Front Pharmacol | Veratrilla baillonii Franch Could Alleviate Lipid Accumulation in LO2 Cells by Regulating Oxidative, Inflammatory, and Lipid Metabolic Signaling Pathways. | 2020 | Details |
| A05948 | 33066325 | Cancers (Basel) | Chemerin Is Induced in Non-Alcoholic Fatty Liver Disease and Hepatitis B-Related Hepatocellular Carcinoma. | 2020 | Details |
| A06005 | 33039693 | Contemp Clin Trials | Semaglutide for the treatment of non-alcoholic steatohepatitis: Trial design and comparison of non-invasive biomarkers. | 2020 | Details |
| A06009 | 33038502 | Contemp Clin Trials | A randomised, double-blind, placebo-controlled, multi-centre, dose-range, proof-of-concept, 24-week treatment study of lanifibranor in adult subjects with non-alcoholic steatohepatitis: Design of the NATIVE study. | 2020 | Details |
| A06053 | 33027655 | Cell Rep | The Lipid Handling Capacity of Subcutaneous Fat Is Programmed by mTORC2 during Development. | 2020 | Details |
| A06105 | 33006712 | Mol Biol Rep | Low-dose trans-resveratrol induce poly(ADP)-ribosylation-dependent increase of the PPAR-γ protein expression level in the in vitro model of non-alcoholic fatty liver disease. | 2020 | Details |
| A06109 | 33004402 | BMJ Open Diabetes Res Care | Metabolic and energetic benefits of microRNA-22 inhibition. | 2020 | Details |
| A06117 | 32998777 | Lipids Health Dis | Signaling and other functions of lipids in autophagy: a review. | 2020 | Details |
| A06125 | 32997872 | Mol Nutr Food Res | CREBH: A Complex Array of Regulatory Mechanisms in Nutritional Signaling, Metabolic Inflammation, and Metabolic Disease. | 2020 | Details |
| A06127 | 32996649 | FASEB J | N-glycosylation of CREBH improves lipid metabolism and attenuates lipotoxicity in NAFLD by modulating PPARα and SCD-1. | 2020 | Details |
| A06161 | 32982113 | World J Gastroenterol | Acupuncture improved lipid metabolism by regulating intestinal absorption in mice. | 2020 | Details |
| A06220 | 32963510 | PPAR Res | Diet Modifies Pioglitazone's Influence on Hepatic PPARγ-Regulated Mitochondrial Gene Expression. | 2020 | Details |
| A06222 | 32963289 | Sci Rep | Maternal exercise conveys protection against NAFLD in the offspring via hepatic metabolic programming. | 2020 | Details |
| A06223 | 32963259 | Sci Rep | Mechanistic study of attenuation of monosodium glutamate mixed high lipid diet induced systemic damage in rats by Coccinia grandis. | 2020 | Details |
| A06243 | 32953932 | Mol Ther Methods Clin Dev | Soluble Klotho Improves Hepatic Glucose and Lipid Homeostasis in Type 2 Diabetes. | 2020 | Details |
| A06248 | 32952590 | Evid Based Complement Alternat Med | Schisandra Fruit Vinegar Lowers Lipid Profile in High-Fat Diet Rats. | 2020 | Details |
| A06273 | 32945305 | Food Funct | Lactobacillus fermentum CQPC06 in naturally fermented pickles prevents non-alcoholic fatty liver disease by stabilizing the gut-liver axis in mice. | 2020 | Details |
| A06288 | 32940183 | Curr HIV Res | Association between Nonalcoholic Fatty Liver Disease and Bone Mineral Density in HIV-Infected Patients Receiving Long-term TDF-Based Antiretroviral Therapy. | 2021 | Details |
| A06299 | 32936538 | Aging Cell | Aging-induced aberrant RAGE/PPARα axis promotes hepatic steatosis via dysfunctional mitochondrial β oxidation. | 2020 | Details |
| A06330 | 32926754 | Hepatol Res | Effect of pemafibrate on fatty acid levels and liver enzymes in non-alcoholic fatty liver disease patients with dyslipidemia: A single-arm, pilot study. | 2020 | Details |
| A06357 | 32916992 | Molecules | LRRK2 Regulates CPT1A to Promote β-Oxidation in HepG2 Cells. | 2020 | Details |
| A06364 | 32914480 | Phytother Res | Rosmarinic acid exerts an antagonistic effect on nonalcoholic fatty liver disease by regulating the YAP1/TAZ-PPARγ/PGC-1α signaling pathway. | 2020 | Details |
| A06365 | 32914125 | Curr Res Food Sci | Piceatannol attenuates fat accumulation and oxidative stress in steatosis-induced HepG2 cells. | 2020 | Details |
| A06394 | 32896622 | Biochim Biophys Acta Mol Cell Biol Lipids | 12α-Hydroxylated bile acid induces hepatic steatosis with dysbiosis in rats. | 2020 | Details |
| A06395 | 32895402 | Sci Rep | Long-term effects of western diet consumption in male and female mice. | 2020 | Details |
| A06413 | 32888948 | Physiol Behav | The effect of aerobic, resistance, and combined training on PPAR-α, SIRT1 gene expression, and insulin resistance in high-fat diet-induced NAFLD male rats. | 2020 | Details |
| A06426 | 32884949 | J Immunol Res | Kangtaizhi Granule Alleviated Nonalcoholic Fatty Liver Disease in High-Fat Diet-Fed Rats and HepG2 Cells via AMPK/mTOR Signaling Pathway. | 2020 | Details |
| A06427 | 32884438 | Yonago Acta Med | Pemafibrate Dramatically Ameliorated the Values of Liver Function Tests and Fibrosis Marker in Patients with Non-Alcoholic Fatty Liver Disease. | 2020 | Details |
| A06440 | 32880477 | Arch Physiol Biochem | High sugar but not high fat diet consumption induces hepatic metabolic disruption and up-regulation of mitochondrial fission-associated protein Drp1 in a model of moderate obesity. | 2020 | Details |
| A06444 | 32879962 | Adv Nutr | A Comprehensive Systematic Review of the Effects of Naringenin, a Citrus-Derived Flavonoid, on Risk Factors for Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A06450 | 32878147 | Molecules | Potential Anti-Diabetic Activity of Pueraria lobata Flower (Flos Puerariae) Extracts. | 2020 | Details |
| A06454 | 32877213 | Am J Physiol Gastrointest Liver Physiol | High-fat diet induces fibrosis in mice lacking CYP2A5 and PPARα: a new model for steatohepatitis-associated fibrosis. | 2020 | Details |
| A06478 | 32863955 | Theranostics | Fibrinogen-like protein 2 aggravates nonalcoholic steatohepatitis via interaction with TLR4, eliciting inflammation in macrophages and inducing hepatic lipid metabolism disorder. | 2020 | Details |
| A06492 | 32856322 | J Pharm Pharmacol | Therapeutic effects of açaí seed extract on hepatic steatosis in high-fat diet-induced obesity in male mice: a comparative effect with rosuvastatin. | 2020 | Details |
| A06505 | 32849604 | Front Immunol | Adoptive Cell Transfer of Regulatory T Cells Exacerbates Hepatic Steatosis in High-Fat High-Fructose Diet-Fed Mice. | 2020 | Details |
| A06552 | 32827918 | Int Immunopharmacol | Bavachinin inhibits cholesterol synthesis enzyme FDFT1 expression via AKT/mTOR/SREBP-2 pathway. | 2020 | Details |
| A06570 | 32823613 | Nutrients | Ethyl Acetate Fraction of Amomum xanthioides Ameliorates Nonalcoholic Fatty Liver Disease in a High-Fat Diet Mouse Model. | 2020 | Details |
| A06598 | 32812930 | Metabol Open | PIN1, a perspective on genetic biomarker for nonalcoholic fatty liver disease (NAFLD). | 2019 | Details |
| A06608 | 32810487 | Metabolism | Revealing the role of peroxisome proliferator-activated receptor β/δ in nonalcoholic fatty liver disease. | 2020 | Details |
| A06629 | 32801014 | Clin Gastroenterol Hepatol | Associations Between Reproductive and Hormone-Related Factors and Risk of Nonalcoholic Fatty Liver Disease in a Multiethnic Population. | 2020 | Details |
| A06666 | 32788910 | EXCLI J | Octyl gallate induces hepatic steatosis in HepG2 cells through the regulation of SREBP-1c and PPAR-gamma gene expression. | 2020 | Details |
| A06680 | 32782883 | Cureus | An Observational Study of Reduction in Glycemic Parameters and Liver Stiffness by Saroglitazar 4 mg in Patients With Type 2 Diabetes Mellitus and Nonalcoholic Fatty Liver Disease. | 2020 | Details |
| A06695 | 32777481 | Biochim Biophys Acta Mol Cell Biol Lipids | Hepatic and circulating levels of PCSK9 in morbidly obese patients: Relation with severity of liver steatosis. | 2020 | Details |
| A06759 | 32757283 | Fundam Clin Pharmacol | Protective effect of fenofibrate against high-fat-high-fructose diet induced non-obese NAFLD in rats. | 2020 | Details |
| A06765 | 32755726 | Biochim Biophys Acta Mol Cell Biol Lipids | miR-3666 inhibits development of hepatic steatosis by negatively regulating PPARγ. | 2020 | Details |
| A06803 | 32739036 | Am J Med Sci | Validation of a Non-Laboratory Based Screening Tool for Predicting Non-Alcoholic Fatty Liver Disease in an Egyptian Setting. | 2020 | Details |
| A06809 | 32738301 | Biochim Biophys Acta Mol Cell Biol Lipids | Palmitoleic acid reduces high fat diet-induced liver inflammation by promoting PPAR-γ-independent M2a polarization of myeloid cells. | 2020 | Details |
| A06820 | 32734608 | J Pharm Pharmacol | HWL-088, a new and highly effective FFA1/PPARδ dual agonist, attenuates nonalcoholic steatohepatitis by regulating lipid metabolism, inflammation and fibrosis. | 2020 | Details |
| A06824 | 32733933 | Biomed Res Int | Ginsenoside Rb1 Alleviated High-Fat-Diet-Induced Hepatocytic Apoptosis via Peroxisome Proliferator-Activated Receptor γ. | 2020 | Details |
| A06853 | 32723353 | BMC Res Notes | Capparis spinosa improves the high fat diet-induced non-alcoholic steatohepatitis in rats: the possible role of FGF21. | 2020 | Details |
| A06868 | 32717288 | J Hepatol | Targeting NFATc4 attenuates non-alcoholic steatohepatitis in mice. | 2020 | Details |
| A06873 | 32715385 | Arch Pharm Res | Ganoderic acid A attenuates high-fat-diet-induced liver injury in rats by regulating the lipid oxidation and liver inflammation. | 2020 | Details |
| A06884 | 32710880 | Arch Biochem Biophys | Eicosapentaenoic acid-containing polar lipids from seaweed Susabinori (Pyropia yezoensis) alleviate hepatic steatosis in obese db/db mice. | 2020 | Details |
| A06917 | 32698101 | Growth Horm IGF Res | Growth hormone ameliorates high glucose-induced steatosis on in vitro cultured human HepG2 hepatocytes by inhibiting de novo lipogenesis via ChREBP and FAS suppression. | 2020 | Details |
| A06956 | 32687365 | J Med Chem | Design and Structural Optimization of Dual FXR/PPARδ Activators. | 2020 | Details |
| A06975 | 32680977 | Aging (Albany NY) | Co-exposure to multi-walled carbon nanotube and lead ions aggravates hepatotoxicity of nonalcoholic fatty liver via inhibiting AMPK/PPARγ pathway. | 2020 | Details |
| A06996 | 32666969 | Food Funct | Ameliorative effects and molecular mechanisms of vine tea on western diet-induced NAFLD. | 2020 | Details |
| A07016 | 32655764 | Oxid Med Cell Longev | Gentiopicroside Ameliorates Oxidative Stress and Lipid Accumulation through Nuclear Factor Erythroid 2-Related Factor 2 Activation. | 2020 | Details |
| A07022 | 32654591 | Biosci Biotechnol Biochem | Effect and mechanism of ginsenoside Rg1-regulating hepatic steatosis in HepG2 cells induced by free fatty acid. | 2020 | Details |