Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A21629 | 25170079 | J Biol Chem | Fibroblast growth factor 21 is regulated by the IRE1α-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosis. | 2014 | Details |
| A21643 | 25157160 | Proc Natl Acad Sci U S A | Ghrelin promotes hepatic lipogenesis by activation of mTOR-PPARγ signaling pathway. | 2014 | Details |
| A21667 | 25137852 | Zhongguo Zhong Xi Yi Jie He Za Zhi | [Effect of zhenqing recipe on non-alcoholic fatty liver in type 2 diabetes rats and the expression of SIK1]. | 2014 | Details |
| A21782 | 25048611 | PLoS One | Inflammatory stress increases hepatic CD36 translational efficiency via activation of the mTOR signalling pathway. | 2014 | Details |
| A21792 | 25043405 | Hepatology | Fructose leads to hepatic steatosis in zebrafish that is reversed by mechanistic target of rapamycin (mTOR) inhibition. | 2014 | Details |
| A21923 | 24963148 | EMBO Mol Med | A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis. | 2014 | Details |
| A21947 | 24946279 | J Hepatol | ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis. | 2014 | Details |
| A21981 | 24917523 | Hepatology | Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis. | 2014 | Details |
| A22082 | 24830603 | Exp Mol Pathol | Lipidomic analysis of the liver from high-fat diet induced obese mice identifies changes in multiple lipid classes. | 2014 | Details |
| A22153 | 24785259 | Endocr J | Association of polymorphisms in GCKR and TRIB1 with nonalcoholic fatty liver disease and metabolic syndrome traits. | 2014 | Details |
| A22272 | 24699882 | Endocrine | Identification and validation co-differentially expressed genes with NAFLD and insulin resistance. | 2014 | Details |
| A22448 | 24566880 | Nat Rev Gastroenterol Hepatol | NAFLD. Metabolic make-up of NASH: from fat and sugar to amino acids. | 2014 | Details |
| A22507 | 24506864 | Cell Metab | The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue. | 2014 | Details |
| A22509 | 24505350 | PLoS One | Role of docosahexaenoic acid treatment in improving liver histology in pediatric nonalcoholic fatty liver disease. | 2014 | Details |
| A22603 | 24419221 | Nat Commun | Genome-scale metabolic modelling of hepatocytes reveals serine deficiency in patients with non-alcoholic fatty liver disease. | 2014 | Details |
| A22641 | 24389359 | J Mol Endocrinol | TRIB1 downregulates hepatic lipogenesis and glycogenesis via multiple molecular interactions. | 2014 | Details |
| A22729 | 24351862 | Int J Mol Sci | p27 Is a critical prognostic biomarker in non-alcoholic steatohepatitis-related hepatocellular carcinoma. | 2013 | Details |
| A23216 | 23951244 | PLoS One | Metformin protects rat hepatocytes against bile acid-induced apoptosis. | 2013 | Details |
| A23245 | 23929677 | Hepatology | Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice. | 2014 | Details |
| A23261 | 23920043 | Mol Genet Metab | Mitochondrial DNA methylation as a next-generation biomarker and diagnostic tool. | 2013 | Details |
| A23392 | 23820633 | Diabetologia | Fatty acids differentially regulate insulin resistance through endoplasm reticulum stress-mediated induction of tribbles homologue 3: a potential link between dietary fat composition and the pathophysiological outcomes of obesity. | 2013 | Details |
| A23533 | 23703028 | Mol Cell Biochem | Endoplasmic reticulum stress leads to lipid accumulation through upregulation of SREBP-1c in normal hepatic and hepatoma cells. | 2013 | Details |
| A23690 | 23562079 | Cell Metab | Molecular and genetic crosstalks between mTOR and ERRα are key determinants of rapamycin-induced nonalcoholic fatty liver. | 2013 | Details |
| A23721 | 23537653 | Biochem Biophys Res Commun | Hydrogen peroxide impairs autophagic flux in a cell model of nonalcoholic fatty liver disease. | 2013 | Details |
| A23838 | 23435355 | Biochem Pharmacol | Betulinic acid alleviates non-alcoholic fatty liver by inhibiting SREBP1 activity via the AMPK-mTOR-SREBP signaling pathway. | 2013 | Details |
| A24178 | 23144979 | PLoS One | The A736V TMPRSS6 polymorphism influences hepatic iron overload in nonalcoholic fatty liver disease. | 2012 | Details |
| A24286 | 23038002 | J Toxicol Sci | Hepatoprotective effect of tamoxifen on steatosis and non-alcoholic steatohepatitis in mouse models. | 2012 | Details |
| A24343 | 22982943 | Gastroenterology | Sterile inflammation in the liver. | 2012 | Details |
| A24446 | 22884488 | Clin Biochem | Serum levels of pigment epithelium-derived factor (PEDF) are independently associated with procollagen III N-terminal peptide levels in patients with nonalcoholic fatty liver disease. | 2012 | Details |
| A24492 | 22843123 | Endocrine | Administration of ghrelin improves inflammation, oxidative stress, and apoptosis during and after non-alcoholic fatty liver disease development. | 2012 | Details |
| A24744 | 22544329 | Cell Cycle | The DNA damage checkpoint protein ATM promotes hepatocellular apoptosis and fibrosis in a mouse model of non-alcoholic fatty liver disease. | 2012 | Details |
| A24833 | 22449814 | Curr Opin Lipidol | Connecting mTORC1 signaling to SREBP-1 activation. | 2012 | Details |
| A24964 | 22307032 | Gastroenterology | Hepatic cannabinoid receptor-1 mediates diet-induced insulin resistance via inhibition of insulin signaling and clearance in mice. | 2012 | Details |
| A25093 | 22179204 | Mol Med Rep | Increased hepatic expression of dipeptidyl peptidase-4 in non-alcoholic fatty liver disease and its association with insulin resistance and glucose metabolism. | 2011 | Details |
| A25178 | 22110478 | Exp Diabetes Res | Role of transcription factor modifications in the pathogenesis of insulin resistance. | 2011 | Details |
| A25187 | 22106162 | Orv Hetil | [Role of autophagy in the pathogenesis of liver diseases]. | 2011 | Details |
| A25375 | 21910084 | Adv Exp Med Biol | Sphingolipids and hepatic steatosis. | 2011 | Details |
| A25412 | 21878620 | J Biol Chem | Expression and characterization of a PNPLA3 protein isoform (I148M) associated with nonalcoholic fatty liver disease. | 2011 | Details |
| A25473 | 21794038 | Hepatol Res | Weight loss amelioration of non-alcoholic steatohepatitis linked to shifts in hepatic ceramide expression and serum ceramide levels. | 2011 | Details |
| A25575 | 21703174 | J Hepatol | Cdc42 and Rac1 are major contributors to the saturated fatty acid-stimulated JNK pathway in hepatocytes. | 2011 | Details |
| A25725 | 21502677 | Ann Hepatol | Familial hypobetalipoproteinemia in a hospital survey: genetics, metabolism and non-alcoholic fatty liver disease. | 2011 | Details |
| A25753 | 21479224 | PLoS One | Tuberous sclerosis complex-1 deficiency attenuates diet-induced hepatic lipid accumulation. | 2011 | Details |
| A25958 | 21266239 | Methods Enzymol | Measurement of ER stress response and inflammation in the mouse model of nonalcoholic fatty liver disease. | 2011 | Details |
| A26046 | 21168455 | J Hepatol | Potent antifibrotic activity of mTOR inhibitors sirolimus and everolimus but not of cyclosporine A and tacrolimus in experimental liver fibrosis. | 2010 | Details |
| A26062 | 21147505 | J Hepatol | Glycogen synthase kinase-3 (GSK-3) inhibition attenuates hepatocyte lipoapoptosis. | 2010 | Details |
| A26108 | 21084751 | J Clin Invest | Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice. | 2010 | Details |
| A26339 | 20626336 | Curr Vasc Pharmacol | Hypocholesterolemia. | 2011 | Details |
| A26351 | 20607654 | Histol Histopathol | A role for mammalian target of rapamycin (mTOR) pathway in non alcoholic steatohepatitis related-cirrhosis. | 2010 | Details |
| A26643 | 23105881 | Indian J Clin Biochem | Role of plasma amino acids and gaba in alcoholic and non-alcoholic fatty liver disease-a pilot study. | 2010 | Details |
| A26656 | 20038265 | Immunopharmacol Immunotoxicol | Metformin regulates palmitate-induced apoptosis and ER stress response in HepG2 liver cells. | 2010 | Details |
| A26689 | 19948145 | Curr Biol | An emerging role of mTOR in lipid biosynthesis. | 2009 | Details |
| A26941 | 19502653 | Ann Hepatol | Common SPINK-1 mutations do not predispose to the development of non-alcoholic fatty liver disease. | 2009 | Details |
| A26962 | 19452573 | World J Gastroenterol | Signal transduction mechanism of TRB3 in rats with non-alcoholic fatty liver disease. | 2009 | Details |
| A26992 | 19387108 | J Alzheimers Dis | Hepatic ceramide may mediate brain insulin resistance and neurodegeneration in type 2 diabetes and non-alcoholic steatohepatitis. | 2009 | Details |
| A27455 | 18360697 | Int J Mol Med | SREBP-1c, regulated by the insulin and AMPK signaling pathways, plays a role in nonalcoholic fatty liver disease. | 2008 | Details |
| A27472 | 18324772 | J Agric Food Chem | Dietary phosphatidylinositol prevents the development of nonalcoholic fatty liver disease in Zucker (fa/fa) rats. | 2008 | Details |
| A27662 | 17567459 | J Gastroenterol Hepatol | Role of mitochondria in non-alcoholic fatty liver disease. | 2007 | Details |
| A27671 | 17702954 | Am J Physiol Gastrointest Liver Physiol | Involvement of AMP-activated protein kinase in beneficial effects of betaine on high-sucrose diet-induced hepatic steatosis. | 2007 | Details |
| A27959 | 16898568 | Curr Diab Rep | Fatty acid-induced inflammation and insulin resistance in skeletal muscle and liver. | 2006 | Details |
| A28193 | 16198620 | Hepatol Res | Insulin resistance and clinical aspects of non-alcoholic steatohepatitis (NASH). | 2005 | Details |
| A28452 | 14620622 | Dig Liver Dis | Impaired insulin-mediated amino acid plasma disappearance in non-alcoholic fatty liver disease: a feature of insulin resistance. | 2003 | Details |
| A28548 | 11584365 | Hepatology | Disrupted signaling and inhibited regeneration in obese mice with fatty livers: implications for nonalcoholic fatty liver disease pathophysiology. | 2001 | Details |
| A28774 | 35024320 | Acta Pharm Sin B | A small molecule UPR modulator for diabetes identified by high throughput screening. | 2021 | Details |
| A28891 | 34860284 | Psychopharmacology (Berl) | Anxiety and cognitive-related effects of Δ 9-tetrahydrocannabinol (THC) are differentially mediated through distinct GSK-3 vs. Akt-mTOR pathways in the nucleus accumbens of male rats. | 2021 | Details |
| A29069 | 34624527 | Cell Mol Gastroenterol Hepatol | Antagonizing STK25 Signaling Suppresses the Development of Hepatocellular Carcinoma Through Targeting Metabolic, Inflammatory, and Pro-Oncogenic Pathways. | 2021 | Details |
| A29380 | 34159305 | JHEP Rep | Novel vectors and approaches for gene therapy in liver diseases. | 2021 | Details |
| A29912 | 33284878 | Int J Clin Exp Pathol | Differential expression and bioinformatic analysis of circRNA in nonalcoholic steatohepatitis cirrhosis. | 2020 | Details |
| A29919 | 33277568 | Sci Rep | Discovery of a novel fibroblast activation protein (FAP) inhibitor, BR103354, with anti-diabetic and anti-steatotic effects. | 2020 | Details |
| A30599 | 32140659 | Hepatol Commun | Pirfenidone Is an Agonistic Ligand for PPARα and Improves NASH by Activation of SIRT1/LKB1/pAMPK. | 2020 | Details |
| A31310 | 30826467 | Biochim Biophys Acta Mol Basis Dis | Reduced biliverdin reductase-A levels are associated with early alterations of insulin signaling in obesity. | 2019 | Details |
| A31544 | 30315846 | Cancer Lett | Selonsertib (GS-4997), an ASK1 inhibitor, antagonizes multidrug resistance in ABCB1- and ABCG2-overexpressing cancer cells. | 2018 | Details |
| A31583 | 30248539 | Biomed Pharmacother | Effect of silibinin on CFLAR-JNK pathway in oleic acid-treated HepG2 cells. | 2018 | Details |
| A32083 | 29234200 | J Clin Exp Hepatol | Nutrition and Muscle in Cirrhosis. | 2017 | Details |
| A32865 | 27232633 | Biol Chem | Regulation of glycosylphosphatidylinositol-anchored proteins and GPI-phospholipase D in a c-Myc transgenic mouse model of hepatocellular carcinoma and human HCC. | 2016 | Details |
| A32895 | 27147666 | J Neurosci | Cannabidiol Counteracts Amphetamine-Induced Neuronal and Behavioral Sensitization of the Mesolimbic Dopamine Pathway through a Novel mTOR/p70S6 Kinase Signaling Pathway. | 2016 | Details |
| A32934 | 27062266 | Hepatol Res | L-carnitine prevents metabolic steatohepatitis in obese diabetic KK-Ay mice. | 2016 | Details |
| A33049 | 26791024 | Arch Dermatol Res | Hydrogen sulfide diminishes the levels of thymic stromal lymphopoietin in activated mast cells. | 2016 | Details |
| A33409 | 26052340 | Nutr Metab (Lond) | E2F8 promotes hepatic steatosis through FABP3 expression in diet-induced obesity in zebrafish. | 2015 | Details |
| A33907 | 24910242 | Cell Metab | Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition. | 2014 | Details |
| A34237 | 23996730 | Hepatology | Transforming growth factor beta signaling in hepatocytes participates in steatohepatitis through regulation of cell death and lipid metabolism in mice. | 2013 | Details |
| A34247 | 23974795 | Mol Pharmacol | Ursodeoxycholyl lysophosphatidylethanolamide inhibits lipoapoptosis by shifting fatty acid pools toward monosaturated and polyunsaturated fatty acids in mouse hepatocytes. | 2013 | Details |
| A34355 | 23665184 | J Hepatol | Pleiotropic effects of methionine adenosyltransferases deregulation as determinants of liver cancer progression and prognosis. | 2013 | Details |
| A35214 | 21425308 | Hepatology | Mitochondrial antiviral signaling protein defect links impaired antiviral response and liver injury in steatohepatitis in mice. | 2011 | Details |
| A35409 | 20815019 | Hepatology | Activation of LKB1-Akt pathway independent of phosphoinositide 3-kinase plays a critical role in the proliferation of hepatocellular carcinoma from nonalcoholic steatohepatitis. | 2010 | Details |
| A35448 | 20652658 | Adv Ther | Telaprevir: a new hope in the treatment of chronic hepatitis C? | 2010 | Details |
| A35838 | 19571235 | Am J Physiol Gastrointest Liver Physiol | Glycine and urea kinetics in nonalcoholic steatohepatitis in human: effect of intralipid infusion. | 2009 | Details |
| A36019 | 19195626 | Diabetes Metab | Insulin resistance and steatosis in humans. | 2008 | Details |
| A36326 | 18456456 | J Autoimmun | Activation of ATM signaling pathway is involved in oxidative stress-induced expression of mito-inhibitory p21WAF1/Cip1 in chronic non-suppurative destructive cholangitis in primary biliary cirrhosis: an immunohistochemical study. | 2008 | Details |
| A36465 | 18082745 | Gastroenterology | Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease. | 2007 | Details |
| A36760 | 17322381 | Am J Pathol | Erythrophagocytosis by liver macrophages (Kupffer cells) promotes oxidative stress, inflammation, and fibrosis in a rabbit model of steatohepatitis: implications for the pathogenesis of human nonalcoholic steatohepatitis. | 2007 | Details |
| A36810 | 17211854 | J Cell Biochem | Fat-loaded HepG2 spheroids exhibit enhanced protection from Pro-oxidant and cytokine induced damage. | 2007 | Details |
| A42238 | 35121169 | Mol Metab | Disrupted liver oxidative metabolism in glycine N-methyltransferase-deficient mice is mitigated by dietary methionine restriction. | 2022 | Details |
| A42243 | 35115401 | Proc Natl Acad Sci U S A | Cullin neddylation inhibitor attenuates hyperglycemia by enhancing hepatic insulin signaling through insulin receptor substrate stabilization. | 2022 | Details |
| A42305 | 34917919 | Metabol Open | DRAK2-SRSF6-regulated RNA alternative splicing is a promising therapeutic target in NAFLD/NASH. | 2021 | Details |
| A42339 | 34822790 | Cell Mol Gastroenterol Hepatol | Ste20-like Kinase STK25: A Potential Target in Prevention and Therapy of NASH-Associated Hepatocellular Carcinoma? | 2021 | Details |
| A42456 | 34486131 | Alcohol Clin Exp Res | Trehalose activates hepatic transcription factor EB (TFEB) but fails to ameliorate alcohol-impaired TFEB and liver injury in mice. | 2021 | Details |
| A42654 | 33869980 | J Endocr Soc | Removal of Epididymal Visceral Adipose Tissue Prevents Obesity-Induced Multi-organ Insulin Resistance in Male Mice. | 2021 | Details |
| A42835 | 33338513 | J Hepatol | Increased expression of key SARS-CoV-2 entry points in multiple tissues in individuals with NAFLD. | 2020 | Details |
| A42908 | 33142057 | J Med Chem | A Novel N-Substituted Valine Derivative with Unique Peroxisome Proliferator-Activated Receptor γ Binding Properties and Biological Activities. | 2020 | Details |
| A42934 | 33044023 | J Cell Physiol | Exenatide improves random-pattern skin flap survival via TFE3 mediated autophagy augment. | 2020 | Details |