Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
stats1
stats2
stats3
stats4
Search for:
apoptosis1710 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A08264 | 32181656 | J Agric Food Chem | Ginsenoside Rg2 Ameliorates High-Fat Diet-Induced Metabolic Disease through SIRT1. | 2020 | Details |
| A08275 | 32171848 | Chem Biol Interact | Sphingolipids and the link between alcohol and cancer. | 2020 | Details |
| A08292 | 32166700 | J Endocrinol Invest | A preliminary study: proteomic analysis of exosomes derived from thyroid-stimulating hormone-stimulated HepG2 cells. | 2020 | Details |
| A08327 | 32151660 | Metabolism | Current and emerging pharmacological options for the treatment of nonalcoholic steatohepatitis. | 2020 | Details |
| A08342 | 32147362 | J Hepatol | Selonsertib for patients with bridging fibrosis or compensated cirrhosis due to NASH: Results from randomized phase III STELLAR trials. | 2020 | Details |
| A08360 | 32144313 | Sci Rep | Carbohydrate response element binding protein (ChREBP) correlates with colon cancer progression and contributes to cell proliferation. | 2020 | Details |
| A08363 | 32143527 | Nutrients | The Effects of Endoplasmic-Reticulum-Resident Selenoproteins in a Nonalcoholic Fatty Liver Disease Pig Model Induced by a High-Fat Diet. | 2020 | Details |
| A08396 | 32126269 | Biochim Biophys Acta Mol Basis Dis | Chemical hypoxia induces pro-inflammatory signals in fat-laden hepatocytes and contributes to cellular crosstalk with Kupffer cells through extracellular vesicles. | 2020 | Details |
| A08399 | 32124935 | Int J Mol Med | CYP4A11 is involved in the development of nonalcoholic fatty liver disease via ROS‑induced lipid peroxidation and inflammation. | 2020 | Details |
| A08441 | 32110174 | Food Nutr Res | Purple sweet potato color protects against hepatocyte apoptosis through Sirt1 activation in high-fat-diet-treated mice. | 2020 | Details |
| A08462 | 32102237 | Int J Mol Sci | Molecular Mechanisms: Connections between Nonalcoholic Fatty Liver Disease, Steatohepatitis and Hepatocellular Carcinoma. | 2020 | Details |
| A08468 | 32099613 | Gastroenterol Hepatol Bed Bench | Effects of high fat medium conditions on cellular gene expression profile: a network analysis approach. | 2019 | Details |
| A08480 | 32093016 | Cells | The VDAC1-based R-Tf-D-LP4 Peptide as a Potential Treatment for Diabetes Mellitus. | 2020 | Details |
| A08483 | 32092316 | Clin Chim Acta | Bnip3 in mitophagy: Novel insights and potential therapeutic target for diseases of secondary mitochondrial dysfunction. | 2020 | Details |
| A08499 | 32085637 | Nutrients | A Diterpenoid, 14-Deoxy-11, 12-Didehydroandrographolide, in Andrographis paniculata Reduces Steatohepatitis and Liver Injury in Mice Fed a High-Fat and High-Cholesterol Diet. | 2020 | Details |
| A08507 | 32083086 | Front Med (Lausanne) | Critical Role of microRNA-21 in the Pathogenesis of Liver Diseases. | 2020 | Details |
| A08509 | 32081971 | Sci Rep | CCN1 promotes hepatic steatosis and inflammation in non-alcoholic steatohepatitis. | 2020 | Details |
| A08524 | 32075112 | Int J Mol Sci | Secondhand Smoke Induces Liver Steatosis through Deregulation of Genes Involved in Hepatic Lipid Metabolism. | 2020 | Details |
| A08575 | 32054840 | Cell Death Dis | Antagonizing circRNA_002581-miR-122-CPEB1 axis alleviates NASH through restoring PTEN-AMPK-mTOR pathway regulated autophagy. | 2020 | Details |
| A08585 | 32050765 | J Agric Food Chem | Theaflavin TF3 Relieves Hepatocyte Lipid Deposition through Activating an AMPK Signaling Pathway by targeting Plasma Kallikrein. | 2020 | Details |
| A08635 | 32037512 | Br J Pharmacol | P7C3-A20 alleviates fatty liver by shaping gut microbiota and inducing FGF21/FGF1, via the AMP-activated protein kinase/CREB regulated transcription coactivator 2 pathway. | 2020 | Details |
| A08659 | 32029622 | Science | An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis. | 2020 | Details |
| A08670 | 32027419 | J Gastroenterol Hepatol | Effects of constant light exposure on sphingolipidomics and progression of NASH in high-fat-fed rats. | 2020 | Details |
| A08683 | 32023702 | Zhonghua Gan Zang Bing Za Zhi | [Effect of metformin on mitochondrial pathway of apoptosis and oxidative stress in cell model of nonalcoholic fatty liver disease]. | 2020 | Details |
| A08712 | 32015322 | Cell Death Dis | Hepatocyte apoptosis is tumor promoting in murine nonalcoholic steatohepatitis. | 2020 | Details |
| A08751 | 32001301 | Biochim Biophys Acta Mol Basis Dis | Hepatic FNDC5 is a potential local protective factor against Non-Alcoholic Fatty Liver. | 2020 | Details |
| A08764 | 31993306 | Acta Pharm Sin B | Cytochrome P450 endoplasmic reticulum-associated degradation (ERAD): therapeutic and pathophysiological implications. | 2019 | Details |
| A08791 | 31982488 | Pharmacol Res | Hypericin attenuates nonalcoholic fatty liver disease and abnormal lipid metabolism via the PKA-mediated AMPK signaling pathway in vitro and in vivo. | 2020 | Details |
| A08799 | 31981449 | Clin Transl Sci | A 3-week nonalcoholic steatohepatitis mouse model shows elafibranor benefits on hepatic inflammation and cell death. | 2020 | Details |
| A08821 | 31978521 | J Ethnopharmacol | Phenols fragment of Veronica ciliata Fisch. ameliorate free radical-induced nonalcoholic fatty liver disease by mediating PI3K/Akt signaling pathway. | 2020 | Details |
| A08822 | 31978277 | Mol Nutr Food Res | Lipoatrophy-Associated Insulin Resistance and Hepatic Steatosis are Attenuated by Intake of Diet Rich in Omega 3 Fatty Acids. | 2020 | Details |
| A08826 | 31975365 | Histol Histopathol | Cathepsin-B dependent autophagy ameliorates steatoheaptitis in chronic exercise rats. | 2020 | Details |
| A08851 | 31965945 | Curr Drug Discov Technol | Alcoholic and Non-Alcoholic Liver Diseases: Promising Molecular Drug Targets and their Clinical Development. | 2021 | Details |
| A08873 | 31955065 | Int Immunopharmacol | Baicalin and its nanoliposomes ameliorates nonalcoholic fatty liver disease via suppression of TLR4 signaling cascade in mice. | 2020 | Details |
| A08898 | 31949129 | Cell Death Dis | Targeting alkaline ceramidase 3 alleviates the severity of nonalcoholic steatohepatitis by reducing oxidative stress. | 2020 | Details |
| A08940 | 31930271 | Food Funct | The preventive effect of phenolic-rich extracts from Chinese sumac fruits against nonalcoholic fatty liver disease in rats induced by a high-fat diet. | 2020 | Details |
| A08989 | 31914044 | Medicine (Baltimore) | Urinary fatty acid and retinol binding protein-4 predict CKD progression in severe NAFLD patients with hypertension: 4-year study with clinical and experimental approaches. | 2020 | Details |
| A09006 | 31907123 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | [Intervention of Catalpol on High-fat Diet Induced Nonalcoholic Fatty Liver Disease in Mice]. | 2019 | Details |
| A09056 | 31888083 | Int J Mol Sci | Ipragliflozin Ameliorates Endoplasmic Reticulum Stress and Apoptosis through Preventing Ectopic Lipid Deposition in Renal Tubules. | 2019 | Details |
| A09065 | 31887369 | J Hepatol | A randomized, placebo-controlled trial of emricasan in patients with NASH and F1-F3 fibrosis. | 2019 | Details |
| A09076 | 31883408 | Liver Int | Farnesoid X receptor activation induces the degradation of hepatotoxic 1-deoxysphingolipids in non-alcoholic fatty liver disease. | 2020 | Details |
| A09091 | 31880257 | Curr Protein Pept Sci | Role of BCL-2 Family Proteins in Apoptosis and its Regulation by Nutrients. | 2020 | Details |
| A09132 | 31862949 | Sci Rep | Upregulation of cancer-associated gene expression in activated fibroblasts in a mouse model of non-alcoholic steatohepatitis. | 2019 | Details |
| A09166 | 31850710 | Clin Lab | MiR-218-XOR-ROS Pathway Regulates the Progression of Nonalcoholic Steatohepatitis. | 2019 | Details |
| A09191 | 31841118 | Aging (Albany NY) | Effects of XIAP on high fat diet-induced hepatic steatosis: a mechanism involving NLRP3 inflammasome and oxidative stress. | 2019 | Details |
| A09196 | 31839747 | Int J Med Sci | PPAR δ inhibition protects against palmitic acid-LPS induced lipidosis and injury in cultured hepatocyte L02 cell. | 2019 | Details |
| A09213 | 31834465 | Naunyn Schmiedebergs Arch Pharmacol | NLRP3 inhibitor glibenclamide attenuates high-fat diet and streptozotocin-induced non-alcoholic fatty liver disease in rat: studies on oxidative stress, inflammation, DNA damage and insulin signalling pathway. | 2019 | Details |
| A09273 | 31809303 | J Chin Med Assoc | CircularRNA as novel biomarkers in liver diseases. | 2020 | Details |
| A09313 | 31795130 | Nutrients | Lotus Seedpod Extracts Reduced Lipid Accumulation and Lipotoxicity in Hepatocytes. | 2019 | Details |
| A09337 | 31786336 | Biochim Biophys Acta Mol Basis Dis | Protective effect of metformin against palmitate-induced hepatic cell death. | 2019 | Details |
| A09363 | 31777643 | Int J Physiol Pathophysiol Pharmacol | Role of mitochondrial depolarization and disrupted mitochondrial homeostasis in non-alcoholic steatohepatitis and fibrosis in mice. | 2019 | Details |
| A09381 | 31769484 | Clin Sci (Lond) | Dapagliflozin not only improves hepatic injury and pancreatic endoplasmic reticulum stress, but also induces hepatic gluconeogenic enzymes expression in obese rats. | 2019 | Details |
| A09394 | 31761566 | Cell Metab | Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis. | 2019 | Details |
| A09399 | 31760308 | J Nutr Biochem | Probiotic culture supernatant improves metabolic function through FGF21-adiponectin pathway in mice. | 2019 | Details |
| A09415 | 31757735 | Presse Med | [Pharmacological treatment of NASH]. | 2019 | Details |
| A09421 | 31756344 | Life Sci | Active vitamin D supplementation alleviates initiation and progression of nonalcoholic fatty liver disease by repressing the p53 pathway. | 2019 | Details |
| A09439 | 31749893 | Diabetol Metab Syndr | Long-term treatment with metformin in the prevention of fatty liver in Zucker diabetic fatty rats. | 2019 | Details |
| A09453 | 31742325 | Clin Sci (Lond) | Processes exacerbating apoptosis in non-alcoholic steatohepatitis. | 2019 | Details |
| A09488 | 31726115 | J Hepatol | A defect in endothelial autophagy occurs in patients with non-alcoholic steatohepatitis and promotes inflammation and fibrosis. | 2019 | Details |
| A09534 | 31705800 | Hepatology | Interleukin-22 Ameliorates Neutrophil-Driven Nonalcoholic Steatohepatitis Through Multiple Targets. | 2020 | Details |
| A09568 | 31692390 | Expert Rev Gastroenterol Hepatol | Progress in promising anti-fibrotic therapies. | 2019 | Details |
| A09602 | 31678261 | Food Chem Toxicol | Cigarette smoking differentially regulates inflammatory responses in a mouse model of nonalcoholic steatohepatitis depending on exposure time point. | 2019 | Details |
| A09668 | 31652837 | Cancers (Basel) | Deregulated Lysophosphatidic Acid Metabolism and Signaling in Liver Cancer. | 2019 | Details |
| A09671 | 31652578 | Int J Mol Sci | The SGLT2 Inhibitor Canagliflozin Prevents Carcinogenesis in a Mouse Model of Diabetes and Non-Alcoholic Steatohepatitis-Related Hepatocarcinogenesis: Association with SGLT2 Expression in Hepatocellular Carcinoma. | 2019 | Details |
| A09680 | 31651429 | AIDS | Vitamin E is an effective treatment for nonalcoholic steatohepatitis in HIV mono-infected patients. | 2020 | Details |
| A09763 | 31620616 | Yeungnam Univ J Med | Pharmacologic therapy for nonalcoholic steatohepatitis focusing on pathophysiology. | 2019 | Details |
| A09771 | 31616384 | Front Endocrinol (Lausanne) | Inhibiting Ceramide Synthesis Attenuates Hepatic Steatosis and Fibrosis in Rats With Non-alcoholic Fatty Liver Disease. | 2019 | Details |
| A09777 | 31614639 | Biomolecules | Allopurinol Prevents the Lipogenic Response Induced by an Acute Oral Fructose Challenge in Short-Term Fructose Fed Rats. | 2019 | Details |
| A09787 | 31610178 | Am J Pathol | Ferroptosis Affects the Progression of Nonalcoholic Steatohepatitis via the Modulation of Lipid Peroxidation-Mediated Cell Death in Mice. | 2019 | Details |
| A09807 | 31602953 | Zhongguo Zhong Yao Za Zhi | [Mechanism of Calculus Bovis Sativus in inhibiting hepatocyte lipid deposition based on serum pharmacology]. | 2019 | Details |
| A09824 | 31597900 | Nihon Yakurigaku Zasshi | [Mechanisms of hepatic stellate cell activation as a therapeutic target for the treatment of non-alcoholic steatohepatitis]. | 2019 | Details |
| A09830 | 31595673 | EMBO Mol Med | Liver ASK1 protects from non-alcoholic fatty liver disease and fibrosis. | 2019 | Details |
| A09856 | 31590120 | Curr Opin Pharmacol | New and emerging anti-fibrotic therapeutics entering or already in clinical trials in chronic liver diseases. | 2019 | Details |
| A09866 | 31584360 | Curr Med Chem | Stem Cell Transplant for Advanced Stage Liver Disorders: Current Scenario and Future Prospects. | 2020 | Details |
| A09881 | 31576092 | World J Gastroenterol | Zinc-α2-glycoprotein 1 attenuates non-alcoholic fatty liver disease by negatively regulating tumour necrosis factor-α. | 2019 | Details |
| A09886 | 31574533 | Carcinogenesis | Cyclin-like proteins tip regenerative balance in the liver to favour cancer formation. | 2020 | Details |
| A09900 | 31568762 | Exp Cell Res | Involvement of sarco/endoplasmic reticulum calcium ATPase-mediated calcium flux in the protective effect of oleic acid against lipotoxicity in hepatocytes. | 2019 | Details |
| A09937 | 31554274 | Int J Environ Res Public Health | Overview of the Pathogenesis, Genetic, and Non-Invasive Clinical, Biochemical, and Scoring Methods in the Assessment of NAFLD. | 2019 | Details |
| A09967 | 31541591 | J Pineal Res | Melatonin safeguards against fatty liver by antagonizing TRAFs-mediated ASK1 deubiquitination and stabilization in a β-arrestin-1 dependent manner. | 2019 | Details |
| A10001 | 31530714 | Gut | Rilpivirine attenuates liver fibrosis through selective STAT1-mediated apoptosis in hepatic stellate cells. | 2019 | Details |
| A10027 | 31520549 | Fundam Clin Pharmacol | Tanshinone IIA reduces palmitate-induced apoptosis via inhibition of endoplasmic reticulum stress in HepG2 liver cells. | 2019 | Details |
| A10051 | 31512431 | Adv Gerontol | [The effect of high-dose metformin on the metabolic parameters and functional state of the liver of agouti-mice with the melanocortin obesity.] | 2019 | Details |
| A10082 | 31496048 | Physiol Rep | Dipeptidyl peptidase-4 inhibitors and aerobic exercise synergistically protect against liver injury in ovariectomized rats. | 2019 | Details |
| A10087 | 31493247 | Hormones (Athens) | Selenium and selenoprotein P in nonalcoholic fatty liver disease. | 2019 | Details |
| A10101 | 31484072 | Cell Rep | Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis. | 2019 | Details |
| A10218 | 31426291 | Int J Mol Sci | Antioxidant Versus Pro-Apoptotic Effects of Mushroom-Enriched Diets on Mitochondria in Liver Disease. | 2019 | Details |
| A10226 | 31421545 | Int Immunopharmacol | Scoparone alleviates inflammation, apoptosis and fibrosis of non-alcoholic steatohepatitis by suppressing the TLR4/NF-κB signaling pathway in mice. | 2019 | Details |
| A10232 | 31419516 | Pharmacol Ther | The unfolded protein response and hepatic lipid metabolism in non alcoholic fatty liver disease. | 2019 | Details |
| A10239 | 31417486 | Front Neurol | Deciphering the Link Between Hyperhomocysteinemia and Ceramide Metabolism in Alzheimer-Type Neurodegeneration. | 2019 | Details |
| A10291 | 31397685 | Clin Transl Gastroenterol | Multicenter Validation Study of a Diagnostic Algorithm to Detect NASH and Fibrosis in NAFLD Patients With Low NAFLD Fibrosis Score or Liver Stiffness. | 2019 | Details |
| A10329 | 31387169 | Biomed Pharmacother | Mitochondrial dysfunction in high-fat diet-induced nonalcoholic fatty liver disease: The alleviating effect and its mechanism of Polygonatum kingianum. | 2019 | Details |
| A10337 | 31384535 | Acta Pharm Sin B | Silibinin ameliorates hepatic lipid accumulation and oxidative stress in mice with non-alcoholic steatohepatitis by regulating CFLAR-JNK pathway. | 2019 | Details |
| A10348 | 31380156 | Curr Hepatol Rep | Pathogenesis of NASH: The Impact of Multiple Pathways. | 2018 | Details |
| A10359 | 31375359 | Mol Ther | A Mitochondrial VDAC1-Based Peptide Greatly Suppresses Steatosis and NASH-Associated Pathologies in a Mouse Model. | 2019 | Details |
| A10398 | 31355279 | Biomed Res Int | Hepatoprotective Effect of Jianpi Huoxue Formula on Nonalcoholic Fatty Liver Disease Induced by Methionine-Choline-Deficient Diet in Rat. | 2019 | Details |
| A10428 | 31341404 | Int J Med Sci | Possible association of arrestin domain-containing protein 3 and progression of non-alcoholic fatty liver disease. | 2019 | Details |
| A10445 | 31334443 | Hepatol Commun | Influence of Fat on Differential Receptor Interacting Serine/Threonine Protein Kinase 1 Activity Leading to Apoptotic Cell Death in Murine Liver Ischemia Reperfusion Injury Through Caspase 8. | 2019 | Details |
| A10458 | 31328113 | Prev Nutr Food Sci | Health Benefits of Carotenoids: A Role of Carotenoids in the Prevention of Non-Alcoholic Fatty Liver Disease. | 2019 | Details |
| A10562 | 31290703 | J Med Food | Lycopene and Tomato Sauce Improve Hepatic and Cardiac Cell Biomarkers in Rats. | 2019 | Details |
| A10601 | 31275407 | Evid Based Complement Alternat Med | Pharmacological Activities of Alisma orientale against Nonalcoholic Fatty Liver Disease and Metabolic Syndrome: Literature Review. | 2019 | Details |