Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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lipogenesis1889 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A06394 | 32896622 | Biochim Biophys Acta Mol Cell Biol Lipids | 12α-Hydroxylated bile acid induces hepatic steatosis with dysbiosis in rats. | 2020 | Details |
| A06412 | 32888949 | Metabolism | Hrd1-mediated ACLY ubiquitination alleviate NAFLD in db/db mice. | 2020 | Details |
| A06473 | 32865925 | Int J Med Mushrooms | Pharmacological Investigation of Ceraceomyces tessulatus (Agaricomycetes) in Mice with Nonalcoholic Steatohepatitis. | 2020 | Details |
| A06478 | 32863955 | Theranostics | Fibrinogen-like protein 2 aggravates nonalcoholic steatohepatitis via interaction with TLR4, eliciting inflammation in macrophages and inducing hepatic lipid metabolism disorder. | 2020 | Details |
| A06491 | 32856978 | J Med Food | Fisetin Alleviates Hepatic and Adipocyte Fibrosis and Insulin Resistance in Diet-Induced Obese Mice. | 2020 | Details |
| A06506 | 32849314 | Front Endocrinol (Lausanne) | Fructose Consumption During Pregnancy Influences Milk Lipid Composition and Offspring Lipid Profiles in Guinea Pigs. | 2020 | Details |
| A06528 | 32839596 | Nat Metab | Fructose stimulated de novo lipogenesis is promoted by inflammation. | 2020 | Details |
| A06552 | 32827918 | Int Immunopharmacol | Bavachinin inhibits cholesterol synthesis enzyme FDFT1 expression via AKT/mTOR/SREBP-2 pathway. | 2020 | Details |
| A06586 | 32819566 | Biochem Biophys Res Commun | Genetic ablation of Fas-activated serine/threonine kinase ameliorates obesity-related hepatic glucose and lipid metabolic disorders via sirtuin-1 signaling. | 2020 | Details |
| A06589 | 32818435 | Cell Metab | Triose Kinase Controls the Lipogenic Potential of Fructose and Dietary Tolerance. | 2020 | Details |
| A06599 | 32812776 | Am J Physiol Gastrointest Liver Physiol | An overview of deregulated lipid metabolism in nonalcoholic fatty liver disease with special focus on lysosomal acid lipase. | 2020 | Details |
| A06600 | 32812775 | Am J Physiol Gastrointest Liver Physiol | Duodenal-jejunal bypass improves nonalcoholic fatty liver disease independently of weight loss in rodents with diet-induced obesity. | 2020 | Details |
| A06608 | 32810487 | Metabolism | Revealing the role of peroxisome proliferator-activated receptor β/δ in nonalcoholic fatty liver disease. | 2020 | Details |
| A06611 | 32809824 | J Med Chem | Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting. | 2020 | Details |
| A06653 | 32792584 | Sci Rep | Administration of small-molecule guanabenz acetate attenuates fatty liver and hyperglycemia associated with obesity. | 2020 | Details |
| A06677 | 32783933 | Cell Rep | Activation of a Specific Gut Bacteroides-Folate-Liver Axis Benefits for the Alleviation of Nonalcoholic Hepatic Steatosis. | 2020 | Details |
| A06685 | 32780887 | FASEB J | Hepatic E4BP4 induction promotes lipid accumulation by suppressing AMPK signaling in response to chemical or diet-induced ER stress. | 2020 | Details |
| A06691 | 32779442 | Cell J | Nicotinamide Phosphoribosyltransferase Knockdown Leads to Lipid Accumulation in HepG2 Cells through The SIRT1-AMPK Pathway. | 2020 | Details |
| A06693 | 32777485 | Phytomedicine | Cajanolactone A, a stilbenoid from cajanus cajan, prevents ovariectomy-induced obesity and liver steatosis in mice fed a regular diet. | 2020 | Details |
| A06713 | 32772909 | Comb Chem High Throughput Screen | Evaluation of Insulin Resistance Induced Brain Tissue Dysfunction in Obese Dams and their Neonates: Role of Ipriflavone Amelioration. | 2021 | Details |
| A06734 | 32765812 | Nutr Res Pract | Folic acid supplementation prevents high fructose-induced non-alcoholic fatty liver disease by activating the AMPK and LKB1 signaling pathways. | 2020 | Details |
| A06736 | 32765626 | Evid Based Complement Alternat Med | Improvement in Menopause-Associated Hepatic Lipid Metabolic Disorders by Herbal Formula HPC03 on Ovariectomized Rats. | 2020 | Details |
| A06748 | 32760938 | Food Funct | Dietary citrus peel essential oil ameliorates hypercholesterolemia and hepatic steatosis by modulating lipid and cholesterol homeostasis. | 2020 | Details |
| A06753 | 32759548 | Biol Pharm Bull | Amelioration of the Lipogenesis, Oxidative Stress and Apoptosis of Hepatocytes by a Novel Proteoglycan from Ganoderma lucidum. | 2020 | Details |
| A06773 | 32751983 | Biomolecules | Arachidonic Acid as an Early Indicator of Inflammation during Non-Alcoholic Fatty Liver Disease Development. | 2020 | Details |
| A06797 | 32742127 | World J Gastroenterol | Monoacylglycerol lipase reprograms lipid precursors signaling in liver disease. | 2020 | Details |
| A06805 | 32738448 | J Hepatol | Reduced Nogo expression inhibits diet-induced metabolic disorders by regulating ChREBP and insulin activity. | 2020 | Details |
| A06820 | 32734608 | J Pharm Pharmacol | HWL-088, a new and highly effective FFA1/PPARδ dual agonist, attenuates nonalcoholic steatohepatitis by regulating lipid metabolism, inflammation and fibrosis. | 2020 | Details |
| A06832 | 32730863 | Toxicol In Vitro | Fructose-palmitate based high calorie induce steatosis in HepG2 cells via mitochondrial dysfunction: An in vitro approach. | 2020 | Details |
| A06861 | 32719069 | J Pharmacol Exp Ther | The GPR40 Full Agonist SCO-267 Improves Liver Parameters in a Mouse Model of Nonalcoholic Fatty Liver Disease without Affecting Glucose or Body Weight. | 2020 | Details |
| A06866 | 32717871 | Int J Mol Sci | Gut Microbiota Metabolites in NAFLD Pathogenesis and Therapeutic Implications. | 2020 | Details |
| A06884 | 32710880 | Arch Biochem Biophys | Eicosapentaenoic acid-containing polar lipids from seaweed Susabinori (Pyropia yezoensis) alleviate hepatic steatosis in obese db/db mice. | 2020 | Details |
| A06900 | 32705195 | Mol Med Rep | Trimetazidine improves hepatic lipogenesis and steatosis in non‑alcoholic fatty liver disease via AMPK‑ChREBP pathway. | 2020 | Details |
| A06912 | 32699301 | Sci Rep | Hyperglycemia-stimulating diet induces liver steatosis in sheep. | 2020 | Details |
| A06917 | 32698101 | Growth Horm IGF Res | Growth hormone ameliorates high glucose-induced steatosis on in vitro cultured human HepG2 hepatocytes by inhibiting de novo lipogenesis via ChREBP and FAS suppression. | 2020 | Details |
| A06932 | 32694791 | Nat Metab | The small intestine shields the liver from fructose-induced steatosis. | 2020 | Details |
| A06934 | 32694515 | Sci Rep | The food contaminant deoxynivalenol provokes metabolic impairments resulting in non-alcoholic fatty liver (NAFL) in mice. | 2020 | Details |
| A06951 | 32688339 | Endocr Connect | FGF21 regulates hepatic metabolic pathways to improve steatosis and inflammation. | 2020 | Details |
| A06991 | 32670821 | J Tradit Complement Med | Beneficial effects of Chinese herbs in the treatment of fatty liver diseases. | 2020 | Details |
| A06996 | 32666969 | Food Funct | Ameliorative effects and molecular mechanisms of vine tea on western diet-induced NAFLD. | 2020 | Details |
| A07005 | 32663610 | Biochim Biophys Acta Mol Cell Biol Lipids | Glucosamine regulates hepatic lipid accumulation by sensing glucose levels or feeding states of normal and excess. | 2020 | Details |
| A07016 | 32655764 | Oxid Med Cell Longev | Gentiopicroside Ameliorates Oxidative Stress and Lipid Accumulation through Nuclear Factor Erythroid 2-Related Factor 2 Activation. | 2020 | Details |
| A07034 | 32650222 | Nutr Res | Distinct utilization of biotin in and between adipose and brain during aging is associated with a lipogenic shift in Wistar rat brain. | 2020 | Details |
| A07078 | 32630596 | Int J Mol Sci | SGL 121 Attenuates Nonalcoholic Fatty Liver Disease through Adjusting Lipid Metabolism Through AMPK Signaling Pathway. | 2020 | Details |
| A07121 | 32614078 | J Food Sci | Relationship between structure and efficacy of sea cucumber saponins echinoside A and its derivatives on hemolytic activity and prevention of nonalcoholic fatty liver disease. | 2020 | Details |
| A07125 | 32613381 | Cell Biol Toxicol | Human hepatic in vitro models reveal distinct anti-NASH potencies of PPAR agonists. | 2020 | Details |
| A07133 | 32607888 | Methods Mol Biol | In Vivo Investigation of High-Fat Diet-Induced Hepatic Lipid Dysfunctions. | 2020 | Details |
| A07161 | 32595752 | Evid Based Complement Alternat Med | Adlay Seed (Coix lacryma-jobi L.) Extracts Exhibit a Prophylactic Effect on Diet-Induced Metabolic Dysfunction and Nonalcoholic Fatty Liver Disease in Mice. | 2020 | Details |
| A07166 | 32594969 | J Dev Orig Health Dis | Post-weaning exposure to high-sucrose diet induces early non-alcoholic fatty liver disease onset and progression in male mice: role of dysfunctional white adipose tissue. | 2020 | Details |
| A07171 | 32593710 | Life Sci | Bisphenol-A exposure worsens hepatic steatosis in ovariectomized mice fed on a high-fat diet: Role of endoplasmic reticulum stress and fibrogenic pathways. | 2020 | Details |
| A07199 | 32585242 | Life Sci | IGFBP5 modulates lipid metabolism and insulin sensitivity through activating AMPK pathway in non-alcoholic fatty liver disease. | 2020 | Details |
| A07212 | 32580141 | EBioMedicine | Thrombospondin 1 improves hepatic steatosis in diet-induced insulin-resistant mice and is associated with hepatic fat content in humans. | 2020 | Details |
| A07214 | 32579753 | J Food Sci | Psoralea corylifolia L. extract ameliorates nonalcoholic fatty liver disease in free-fatty-acid-incubated HEPG2 cells and in high-fat diet-fed mice. | 2020 | Details |
| A07223 | 32576050 | Gut Microbes | Sex-specific maternal calcium requirements for the prevention of nonalcoholic fatty liver disease by altering the intestinal microbiota and lipid metabolism in the high-fat-diet-fed offspring mice. | 2020 | Details |
| A07225 | 32575640 | Molecules | Effect of Carotenoids from Phaeodactylum tricornutum on Palmitate-Treated HepG2 Cells. | 2020 | Details |
| A07226 | 32574665 | Life Sci | Combination of luteolin and lycopene effectively protect against the "two-hit" in NAFLD through Sirt1/AMPK signal pathway. | 2020 | Details |
| A07231 | 32573497 | JCI Insight | Leptin decreases de novo lipogenesis in patients with lipodystrophy. | 2020 | Details |
| A07248 | 32567701 | Hepatology | An Endoplasmic Reticulum Stress-MicroRNA-26a Feedback Circuit in NAFLD. | 2020 | Details |
| A07303 | 32548088 | Front Chem | Rapamycin-Loaded mPEG-PLGA Nanoparticles Ameliorate Hepatic Steatosis and Liver Injury in Non-alcoholic Fatty Liver Disease. | 2020 | Details |
| A07314 | 32542253 | Food Funct | S-petasin inhibits lipid accumulation in oleic acid-induced HepG2 cells through activation of the AMPK signaling pathway. | 2020 | Details |
| A07335 | 32532003 | Int J Mol Sci | Physiological Disturbance in Fatty Liver Energy Metabolism Converges on IGFBP2 Abundance and Regulation in Mice and Men. | 2020 | Details |
| A07361 | 32526482 | Cell Mol Gastroenterol Hepatol | Acetyl-CoA Carboxylase Inhibition Improves Multiple Dimensions of NASH Pathogenesis in Model Systems. | 2020 | Details |
| A07362 | 32526241 | Eur J Pharmacol | Berbamine induced AMPK activation regulates mTOR/SREBP-1c axis and Nrf2/ARE pathway to allay lipid accumulation and oxidative stress in steatotic HepG2 cells. | 2020 | Details |
| A07381 | 32519629 | J Dev Orig Health Dis | Hepatic lipid metabolism in adult rats using early weaning models: sex-related differences. | 2020 | Details |
| A07397 | 32514497 | JHEP Rep | Combined alcoholic and non-alcoholic steatohepatitis. | 2020 | Details |
| A07401 | 32514450 | JGH Open | Sodium-glucose cotransporter 2 inhibition does not reduce hepatic steatosis in overweight, insulin-resistant patients without type 2 diabetes. | 2019 | Details |
| A07435 | 32498134 | Hepatology | Acyl-Coenzyme A Thioesterase 9 Traffics Mitochondrial Short-Chain Fatty Acids Toward De Novo Lipogenesis and Glucose Production in the Liver. | 2020 | Details |
| A07480 | 32478287 | Nat Metab | Resolution of NASH and hepatic fibrosis by the GLP-1R/GcgR dual-agonist Cotadutide via modulating mitochondrial function and lipogenesis. | 2020 | Details |
| A07483 | 32477107 | Front Pharmacol | Gut-Derived Serotonin Contributes to the Progression of Non-Alcoholic Steatohepatitis via the Liver HTR2A/PPARγ2 Pathway. | 2020 | Details |
| A07486 | 32476787 | World J Gastroenterol | Folic acid attenuates high-fat diet-induced steatohepatitis via deacetylase SIRT1-dependent restoration of PPARα. | 2020 | Details |
| A07588 | 32434697 | Transl Res | Cathepsin B deficiency ameliorates liver lipid deposition, inflammatory cell infiltration, and fibrosis after diet-induced nonalcoholic steatohepatitis. | 2020 | Details |
| A07613 | 32420361 | Biomed Res Int | Catalpol Attenuates Hepatic Steatosis by Regulating Lipid Metabolism via AMP-Activated Protein Kinase Activation. | 2020 | Details |
| A07698 | 32387861 | Biomed Pharmacother | 2,3,5,4'-tetrahydroxystilbence-2-O-β-D-glucoside attenuates hepatic steatosis via IKKβ/NF-κB and Keap1-Nrf2 pathways in larval zebrafish. | 2020 | Details |
| A07699 | 32387461 | J Ethnopharmacol | Ginsenoside Mc1 improves liver steatosis and insulin resistance by attenuating ER stress. | 2020 | Details |
| A07704 | 32384593 | Nutrients | Beyond Body Weight-Loss: Dietary Strategies Targeting Intrahepatic Fat in NAFLD. | 2020 | Details |
| A07707 | 32383295 | Aliment Pharmacol Ther | Review article: the emerging role of genetics in precision medicine for patients with non-alcoholic steatohepatitis. | 2020 | Details |
| A07714 | 32380876 | J Med Food | Beneficial Effects of Insect Extracts on Nonalcoholic Fatty Liver Disease. | 2020 | Details |
| A07720 | 32376414 | J Hepatol | Acetyl-CoA carboxylase inhibition disrupts metabolic reprogramming during hepatic stellate cell activation. | 2020 | Details |
| A07739 | 32369776 | J Endocrinol | Oxygen therapy alleviates hepatic steatosis by inhibiting hypoxia-inducible factor-2α. | 2020 | Details |
| A07751 | 32365055 | J Clin Invest | Hepatic Slug epigenetically promotes liver lipogenesis, fatty liver disease, and type 2 diabetes. | 2020 | Details |
| A07752 | 32364539 | J Clin Invest | Insulin-stimulated lipogenesis gets an epigenetic makeover. | 2020 | Details |
| A07756 | 32363320 | Hepatol Commun | Validation of PAS Kinase, a Regulator of Hepatic Fatty Acid and Triglyceride Synthesis, as a Therapeutic Target for Nonalcoholic Steatohepatitis. | 2020 | Details |
| A07809 | 32349939 | Ann Hepatol | Epidemiology and pathophysiology of the association between NAFLD and metabolically healthy or metabolically unhealthy obesity. | 2020 | Details |
| A07818 | 32346285 | Drug Des Devel Ther | Radix Polygoni Multiflori and Its Main Component Emodin Attenuate Non-Alcoholic Fatty Liver Disease in Zebrafish by Regulation of AMPK Signaling Pathway. | 2020 | Details |
| A07825 | 32343421 | Hepatology | Thyroid Hormone Signaling and the Liver. | 2020 | Details |
| A07832 | 32341017 | J Pharmacol Exp Ther | 7α,25-Dihydroxycholesterol Suppresses Hepatocellular Steatosis through GPR183/EBI2 in Mouse and Human Hepatocytes. | 2020 | Details |
| A07870 | 32329085 | Hepatology | The L-α-Lysophosphatidylinositol/G Protein-Coupled Receptor 55 System Induces the Development of Nonalcoholic Steatosis and Steatohepatitis. | 2020 | Details |
| A07887 | 32322309 | Diabetol Metab Syndr | Effect of circulating exosomes derived from normal-weight and obese women on gluconeogenesis, glycogenesis, lipogenesis and secretion of FGF21 and fetuin A in HepG2 cells. | 2020 | Details |
| A07906 | 32315893 | Nutr Res | Siphonaxanthin, a carotenoid from green algae Codium cylindricum, protects Ob/Ob mice fed on a high-fat diet against lipotoxicity by ameliorating somatic stresses and restoring anti-oxidative capacity. | 2020 | Details |
| A07912 | 32312974 | Nat Commun | Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance. | 2020 | Details |
| A07936 | 32305523 | Life Sci | Cystathionine gamma-lyase/H2S system suppresses hepatic acetyl-CoA accumulation and nonalcoholic fatty liver disease in mice. | 2020 | Details |
| A07938 | 32304952 | Environ Pollut | Exposure to 2,3,3',4,4',5-hexachlorobiphenyl promotes nonalcoholic fatty liver disease development in C57BL/6 mice. | 2020 | Details |
| A07940 | 32304142 | FASEB J | Characterization of the variability in the extent of nonalcoholic fatty liver induced by a high-fat diet in the genetically diverse Collaborative Cross mouse model. | 2020 | Details |
| A07952 | 32301540 | FASEB J | Smurf1 aggravates non-alcoholic fatty liver disease by stabilizing SREBP-1c in an E3 activity-independent manner. | 2020 | Details |
| A07966 | 32296880 | J Mol Med (Berl) | HIF-P4H-2 inhibition enhances intestinal fructose metabolism and induces thermogenesis protecting against NAFLD. | 2020 | Details |
| A07997 | 32284043 | Lipids Health Dis | Orotic acid-treated hepatocellular carcinoma cells resist steatosis by modification of fatty acid metabolism. | 2020 | Details |
| A08018 | 32279995 | Biochem Biophys Res Commun | LASS2 regulates hepatocyte steatosis by interacting with NDUFS2/OXPHOS related proteins. | 2020 | Details |
| A08059 | 32265720 | Front Pharmacol | The Impacts of Herbal Medicines and Natural Products on Regulating the Hepatic Lipid Metabolism. | 2020 | Details |
| A08062 | 32259637 | Mol Cell Endocrinol | Anti-steatotic linagliptin pleiotropic effects encompasses suppression of de novo lipogenesis and ER stress in high-fat-fed mice. | 2020 | Details |
| A08065 | 32258945 | Hepatol Commun | Bile Acid Diarrhea and NAFLD: Shared Pathways for Distinct Phenotypes. | 2020 | Details |