Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A43577 | 31360687 | J Cancer Prev | Therapeutic Effects of Amino Acids in Liver Diseases: Current Studies and Future Perspectives. | 2019 | Details |
| A43840 | 30734689 | Endocr Metab Immune Disord Drug Targets | Silibinin Ameliorates Fructose-induced Lipid Accumulation and Activates Autophagy in HepG2 Cells. | 2019 | Details |
| A43853 | 30677403 | Cell Mol Gastroenterol Hepatol | Treating Nonalcoholic Fatty Liver Disease From the Outside In? | 2019 | Details |
| A43884 | 30576689 | Metabolism | Ectopic lipid deposition mediates insulin resistance in adipose specific 11β-hydroxysteroid dehydrogenase type 1 transgenic mice. | 2018 | Details |
| A43981 | 30230463 | Med Sci (Paris) | [Reptin: a new therapeutic target for metabolic syndrome and fatty liver diseases]. | 2018 | Details |
| A44326 | 28994372 | Med Sci (Paris) | [Clarifying the role of RIPK3 and necroptosis in non-alcoholic steatohepatitis]. | 2017 | Details |
| A44388 | 28739056 | Nutr Res | Supplementation with Vitis vinifera L. skin extract improves insulin resistance and prevents hepatic lipid accumulation and steatosis in high-fat diet-fed mice. | 2017 | Details |
| A44583 | 28096081 | Am J Physiol Endocrinol Metab | Mice with hyperbilirubinemia due to Gilbert's syndrome polymorphism are resistant to hepatic steatosis by decreased serine 73 phosphorylation of PPARα. | 2017 | Details |
| A44762 | 27391855 | ACS Chem Biol | Discovery of a Selective Covalent Inhibitor of Lysophospholipase-like 1 (LYPLAL1) as a Tool to Evaluate the Role of this Serine Hydrolase in Metabolism. | 2016 | Details |
| A44764 | 27385159 | Diabetes | Inhibition of Pyruvate Dehydrogenase Kinase 2 Protects Against Hepatic Steatosis Through Modulation of Tricarboxylic Acid Cycle Anaplerosis and Ketogenesis. | 2016 | Details |
| A44873 | 27013235 | Genes Dev | The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation. | 2016 | Details |
| A44945 | 26644352 | FASEB J | Second-generation antisense oligonucleotides against β-catenin protect mice against diet-induced hepatic steatosis and hepatic and peripheral insulin resistance. | 2015 | Details |
| A44958 | 26615875 | Biochim Biophys Acta | Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ. | 2015 | Details |
| A45338 | 25123628 | J Nutr Biochem | Alpha-lipoic acid improves high-fat diet-induced hepatic steatosis by modulating the transcription factors SREBP-1, FoxO1 and Nrf2 via the SIRT1/LKB1/AMPK pathway. | 2014 | Details |
| A45533 | 24095738 | Cell Rep | The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome. | 2013 | Details |
| A45792 | 22715101 | J Biol Chem | The ABCG5 ABCG8 sterol transporter opposes the development of fatty liver disease and loss of glycemic control independently of phytosterol accumulation. | 2012 | Details |
| A45959 | 21856859 | J Pharmacol Exp Ther | Differential roles of unsaturated and saturated fatty acids on autophagy and apoptosis in hepatocytes. | 2011 | Details |
| A45960 | 21841000 | J Biol Chem | L-tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of rapamycin. | 2011 | Details |
| A45994 | 21701901 | Hepatol Int | Murine gamma herpes virus 68 infection promotes fatty liver formation and hepatic insulin resistance in C57BL/6J mice. | 2011 | Details |
| A46196 | 20423314 | Curr Med Chem | Pathophysiological role of pigment epithelium-derived factor (PEDF) in hepatic disorders. | 2010 | Details |
| A46216 | 20225248 | Hepatology | Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway. | 2010 | Details |
| A46248 | 20034933 | J Biol Chem | A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis. | 2009 | Details |
| A46362 | 19307976 | Eur J Gastroenterol Hepatol | Overexpression of liver-specific cytochrome P4502E1 impairs hepatic insulin signaling in a transgenic mouse model of nonalcoholic fatty liver disease. | 2009 | Details |
| A46411 | 18972440 | Hepatology | Alpha-lipoic acid decreases hepatic lipogenesis through adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways. | 2008 | Details |
| A46779 | 15632182 | J Biol Chem | Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling. | 2005 | Details |
| A46803 | 15254578 | J Clin Invest | Molecular mediators of hepatic steatosis and liver injury. | 2004 | Details |
| A46934 | 33676386 | Physiol Res | Downregulation of long non-coding RNA AIRN promotes mitophagy in alcoholic fatty hepatocytes by promoting ubiquitination of mTOR. | 2021 | Details |
| A46963 | 32206109 | Theranostics | NIK links inflammation to hepatic steatosis by suppressing PPARα in alcoholic liver disease. | 2020 | Details |
| A46966 | 32087348 | J Hepatol | Hepatic stellate cell activation promotes alcohol-induced steatohepatitis through Igfbp3 and SerpinA12. | 2020 | Details |
| A47001 | 30721374 | Cell Biol Toxicol | Activation of SIRT1 by L-serine increases fatty acid oxidation and reverses insulin resistance in C2C12 myotubes. | 2019 | Details |
| A47019 | 29457836 | Hepatology | DEP domain-containing mTOR-interacting protein suppresses lipogenesis and ameliorates hepatic steatosis and acute-on-chronic liver injury in alcoholic liver disease. | 2018 | Details |
| A47041 | 28467182 | Exp Biol Med (Maywood) | Roles of silent information regulator 1-serine/arginine-rich splicing factor 10-lipin 1 axis in the pathogenesis of alcohol fatty liver disease. | 2017 | Details |
| A47117 | 25644346 | J Nutr | L-serine supplementation attenuates alcoholic fatty liver by enhancing homocysteine metabolism in mice and rats. | 2014 | Details |
| A47119 | 25595739 | Alcohol Alcohol | The role of lipin-1 in the pathogenesis of alcoholic fatty liver. | 2015 | Details |
| A47172 | 24262277 | Gastroenterology | Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver. | 2013 | Details |
| A47234 | 21913943 | Alcohol Clin Exp Res | Housekeeping gene variability in the liver of alcoholic patients. | 2011 | Details |
| A47609 | 35156314 | Obesity (Silver Spring) | Suppression of RIP1 activity via S415 dephosphorylation ameliorates obesity-related hepatic insulin resistance. | 2022 | Details |
| A47612 | 35091323 | Redox Biol | PERK prevents hepatic lipotoxicity by activating the p62-ULK1 axis-mediated noncanonical KEAP1-Nrf2 pathway. | 2022 | Details |
| A47616 | 35053615 | Cancers (Basel) | CD26/DPP4 as a Therapeutic Target in Nonalcoholic Steatohepatitis Associated Hepatocellular Carcinoma. | 2022 | Details |
| A47712 | 33143193 | Biomolecules | Sphingomyelinases and Liver Diseases. | 2020 | Details |
| A47737 | 32705602 | Adv Exp Med Biol | CGI-58: Versatile Regulator of Intracellular Lipid Droplet Homeostasis. | 2020 | Details |
| A47830 | 31213776 | Drug Des Devel Ther | Salvianolic acid A attenuates CCl4-induced liver fibrosis by regulating the PI3K/AKT/mTOR, Bcl-2/Bax and caspase-3/cleaved caspase-3 signaling pathways. | 2019 | Details |
| A47831 | 31201023 | Transfus Clin Biol | The emerging roles of eryptosis in liver diseases. | 2019 | Details |
| A47958 | 28128716 | Immunotherapy | Immunosuppression strategies in liver transplantation patient; patients with hepatocellular carcinoma. | 2017 | Details |
| A48097 | 23857333 | Hepatology | Regulation of FOXO3 by phosphorylation and methylation in hepatitis C virus infection and alcohol exposure. | 2013 | Details |
| A48350 | 15634340 | FEBS J | Altered expression of CD1d molecules and lipid accumulation in the human hepatoma cell line HepG2 after iron loading. | 2005 | Details |
| A48693 | 31401190 | Biochimie | Apolipoprotein A-I improves hepatic autophagy through the AMPK pathway. | 2019 | Details |
| A48713 | 30917505 | Int J Mol Sci | Role of SIRT-3, p-mTOR and HIF-1α in Hepatocellular Carcinoma Patients Affected by Metabolic Dysfunctions and in Chronic Treatment with Metformin. | 2019 | Details |
| A48788 | 28715695 | Eur J Cancer | New liver cancer biomarkers: PI3K/AKT/mTOR pathway members and eukaryotic translation initiation factors. | 2017 | Details |
| A48814 | 27734263 | Med Oncol | Statin attenuates cell proliferative ability via TAZ (WWTR1) in hepatocellular carcinoma. | 2016 | Details |
| A48842 | 26797127 | J Biol Chem | Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21. | 2016 | Details |
| A48969 | 22873368 | Curr Cancer Drug Targets | mTor as a potential target for the prevention and treatment of hepatocellular carcinoma. | 2012 | Details |
| A49047 | 20072945 | Curr Opin Mol Ther | Alipogene tiparvovec, an adeno-associated virus encoding the Ser(447)X variant of the human lipoprotein lipase gene for the treatment of patients with lipoprotein lipase deficiency. | 2009 | Details |
| A49125 | 16622296 | Endocrine | Modulation of fatty acid metabolism as a potential approach to the treatment of obesity and the metabolic syndrome. | 2006 | Details |
| A49154 | 16137475 | Gastroenterol Hepatol | [Etiopathogenesis of non-alcoholic steatohepatitis]. | 2005 | Details |
| A49557 | 35714571 | Biochem Biophys Res Commun | LncNONMMUG027912 alleviates lipid accumulation through AMPKα/mTOR/SREBP1C axis in nonalcoholic fatty liver. | 2022 | Details |
| A49582 | 35705854 | J Mol Med (Berl) | The scaffold-dependent function of RIPK1 in experimental non-alcoholic steatohepatitis. | 2022 | Details |
| A49733 | 35654975 | Nat Genet | A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation. | 2022 | Details |
| A49736 | 35654350 | J Ethnopharmacol | Danhe granule ameliorates nonalcoholic steatohepatitis and fibrosis in rats by inhibiting ceramide de novo synthesis related to CerS6 and CerK. | 2022 | Details |
| A50085 | 35532955 | Metab Syndr Relat Disord | Nonalcoholic Fatty Liver Disease Patients Exhibit Reduced CD47 and Increased Sphingosine, Cholesterol, and Monocyte Chemoattractant Protein-1 Levels in the Erythrocyte Membranes. | 2022 | Details |
| A50150 | 35503172 | Adv Exp Med Biol | De Novo Sphingolipid Biosynthesis in Atherosclerosis. | 2022 | Details |
| A50205 | 35476028 | J Mol Med (Berl) | Receptor-interacting protein kinase-1 ablation in liver parenchymal cells promotes liver fibrosis in murine NASH without affecting other symptoms. | 2022 | Details |
| A50313 | 35436113 | J Agric Food Chem | Protective Effect and Mechanism of Plant-Based Monoterpenoids in Non-alcoholic Fatty Liver Diseases. | 2022 | Details |
| A50400 | 35405150 | Metabolism | Schisandrin B mitigates hepatic steatosis and promotes fatty acid oxidation by inducing autophagy through AMPK/mTOR signaling pathway. | 2022 | Details |
| A50556 | 35343085 | Clin Transl Med | MD2 deficiency prevents high-fat diet-induced AMPK suppression and lipid accumulation through regulating TBK1 in non-alcoholic fatty liver disease. | 2022 | Details |
| A50632 | 35320000 | Sci Transl Med | Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of Ppp2r1b. | 2022 | Details |
| A50705 | 35293570 | Nucleic Acids Res | Dysregulated RNA polyadenylation contributes to metabolic impairment in non-alcoholic fatty liver disease. | 2022 | Details |
| A50911 | 33731774 | Acta Pharmacol Sin | Role of the mTOR-autophagy-ER stress pathway in high fructose-induced metabolic-associated fatty liver disease. | 2021 | Details |
| A51137 | 35527487 | Nan Fang Yi Ke Da Xue Xue Bao | [Dihydromyricetin reduces lipid accumulation in LO2 cells via AMPK/mTOR-mediated lipophagy pathway and inhibits HepG2 cell proliferation in vitro]. | 2022 | Details |
| A51161 | 35427802 | Clin Res Hepatol Gastroenterol | The mTORC1/AMPK pathway plays a role in the beneficial effects of semaglutide (GLP-1 receptor agonist) on the liver of obese mice. | 2022 | Details |
| A51167 | 35395857 | J Exp Clin Cancer Res | The role of TBK1 in cancer pathogenesis and anticancer immunity. | 2022 | Details |
| A51248 | 35464439 | Front Immunol | D-Mannose Regulates Hepatocyte Lipid Metabolism via PI3K/Akt/mTOR Signaling Pathway and Ameliorates Hepatic Steatosis in Alcoholic Liver Disease. | 2022 | Details |
| A51469 | 32426239 | Toxicol Rep | MicroRNAs and Xenobiotic Toxicity: An Overview. | 2020 | Details |
| A51669 | 35070060 | World J Diabetes | Gut microbiota-derived metabolites are novel targets for improving insulin resistance. | 2022 | Details |
| A51850 | 33687947 | Cancer Res | Fat Induces Glucose Metabolism in Nontransformed Liver Cells and Promotes Liver Tumorigenesis. | 2021 | Details |
| A51878 | 33499061 | J Clin Med | Detection and Characterization of Phosphorylation, Glycosylation, and Fatty Acid Bound to Fetuin A in Human Blood. | 2021 | Details |
| A51926 | 33170807 | JCI Insight | Depletion of protein kinase STK25 ameliorates renal lipotoxicity and protects against diabetic kidney disease. | 2020 | Details |
| A51935 | 33083279 | Liver Cancer | Dietary Restriction Suppresses Steatosis-Associated Hepatic Tumorigenesis in Hepatitis C Virus Core Gene Transgenic Mice. | 2020 | Details |
| A52005 | 32432943 | Autophagy | Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway. | 2020 | Details |
| A52019 | 32231246 | Cell Death Differ | OTULIN protects the liver against cell death, inflammation, fibrosis, and cancer. | 2020 | Details |
| A52114 | 31053639 | J Biol Chem | An ANGPTL4-ceramide-protein kinase Cζ axis mediates chronic glucocorticoid exposure-induced hepatic steatosis and hypertriglyceridemia in mice. | 2019 | Details |
| A52131 | 30920846 | Am J Physiol Gastrointest Liver Physiol | Intestinal serine protease inhibition increases FGF21 and improves metabolism in obese mice. | 2019 | Details |
| A52242 | 29786646 | Int J Mol Sci | Metabolic Reprogramming by 3-Iodothyronamine (T1AM): A New Perspective to Reverse Obesity through Co-Regulation of Sirtuin 4 and 6 Expression. | 2018 | Details |
| A52279 | 29371333 | Eur J Endocrinol | MECHANISMS IN ENDOCRINOLOGY: SGLT2 inhibitors: clinical benefits by restoration of normal diurnal metabolism? | 2018 | Details |
| A52368 | 28100772 | J Biol Chem | De Novo Sphingolipid Biosynthesis Is Required for Adipocyte Survival and Metabolic Homeostasis. | 2017 | Details |
| A52412 | 27382035 | Am J Physiol Endocrinol Metab | Targeting ceramide metabolism in obesity. | 2016 | Details |
| A52444 | 27086014 | Anal Bioanal Chem | Development and application of a comprehensive lipidomic analysis to investigate Tripterygium wilfordii-induced liver injury. | 2016 | Details |
| A52585 | 25365359 | PLoS One | Rho-kinase inhibition ameliorates metabolic disorders through activation of AMPK pathway in mice. | 2014 | Details |
| A52616 | 24834723 | Ukr Biochem J | [The effect of N-stearoylethanolamine on liver phospholipid composition of rats with insulin resistance caused by alimentary obesity]. | 2014 | Details |
| A52689 | 23510830 | Atherosclerosis | Enhanced adiponectin actions by overexpression of adiponectin receptor 1 in macrophages. | 2013 | Details |
| A52706 | 23226562 | PLoS One | Metabolic alterations and increased liver mTOR expression precede the development of autoimmune disease in a murine model of lupus erythematosus. | 2012 | Details |
| A52710 | 23118444 | J Lipid Res | AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism. | 2012 | Details |
| A52734 | 22664476 | J Clin Gastroenterol | Association of serum adipocytokines with insulin resistance and liver injury in patients with chronic hepatitis C genotype 4. | 2013 | Details |
| A52735 | 22662228 | PLoS One | Involvement of SIK3 in glucose and lipid homeostasis in mice. | 2012 | Details |
| A52819 | 21329805 | Methods Enzymol | Measuring signaling by the unfolded protein response. | 2011 | Details |
| A52822 | 21294903 | BMC Cancer | Establishing a relationship between prolactin and altered fatty acid β-oxidation via carnitine palmitoyl transferase 1 in breast cancer cells. | 2011 | Details |
| A52844 | 20876715 | Diabetes | Iron overload and diabetes risk: a shift from glucose to Fatty Acid oxidation and increased hepatic glucose production in a mouse model of hereditary hemochromatosis. | 2010 | Details |
| A52868 | 20448293 | Aging (Albany NY) | Protein kinase A is a target for aging and the aging heart. | 2010 | Details |
| A52889 | 19937189 | J Gastrointest Surg | Does LKB1 mediate activation of hepatic AMP-protein kinase (AMPK) and sirtuin1 (SIRT1) after Roux-en-Y gastric bypass in obese rats? | 2010 | Details |
| A52893 | 19859993 | World J Gastroenterol | Steatosis and insulin resistance in hepatitis C: a way out for the virus? | 2009 | Details |