Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A10685 | 31236880 | Bull Exp Biol Med | Effect of Linagliptin on the Ratio of Apoptosis Regulators in the Model of Non-Alcoholic Fatty Liver Disease in db/db Mice. | 2019 | Details |
| A10720 | 31222979 | J Cell Mol Med | Hepatic functional and pathological changes of type 1 diabetic mice in growing and maturation time. | 2019 | Details |
| A10740 | 31214277 | Oxid Med Cell Longev | TNFα-Mediated Necroptosis Aggravates Ischemia-Reperfusion Injury in the Fatty Liver by Regulating the Inflammatory Response. | 2019 | Details |
| A10742 | 31214115 | Front Endocrinol (Lausanne) | Hepatic DNA Damage Induced by Electronic Cigarette Exposure Is Associated With the Modulation of NAD+/PARP1/SIRT1 Axis. | 2019 | Details |
| A10754 | 31209199 | Cell Death Dis | Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis. | 2019 | Details |
| A10794 | 31189885 | Cell Death Dis | Ets-1 deficiency alleviates nonalcoholic steatohepatitis via weakening TGF-β1 signaling-mediated hepatocyte apoptosis. | 2019 | Details |
| A10823 | 31173180 | Int J Mol Med | Excess fructose and fatty acids trigger a model of non‑alcoholic fatty liver disease progression in vitro: Protective effect of the flavonoid silybin. | 2019 | Details |
| A10833 | 31168511 | Hepatol Commun | Lipocalin-2 Protects Against Diet-Induced Nonalcoholic Fatty Liver Disease by Targeting Hepatocytes. | 2019 | Details |
| A10866 | 31150631 | Chem Biol Interact | β-ionone inhibits nonalcoholic fatty liver disease and its association with hepatocarcinogenesis in male Wistar rats. | 2019 | Details |
| A10871 | 31147590 | Sci Rep | Effects of açai on oxidative stress, ER stress, and inflammation-related parameters in mice with high fat diet-fed induced NAFLD. | 2019 | Details |
| A10903 | 31132314 | J Gastroenterol Hepatol | Decrease in fat de novo synthesis and chemokine ligand expression in non-alcoholic fatty liver disease caused by inhibition of mixed lineage kinase domain-like pseudokinase. | 2019 | Details |
| A10941 | 31113010 | Br J Pharmacol | Bouchardatine analogue alleviates non-alcoholic hepatic fatty liver disease/non-alcoholic steatohepatitis in high-fat fed mice by inhibiting ATP synthase activity. | 2019 | Details |
| A10946 | 31109939 | Diabetes | The cGAS-cGAMP-STING Pathway: A Molecular Link Between Immunity and Metabolism. | 2019 | Details |
| A10972 | 31097771 | Sci Rep | The Differential Expression of Cide Family Members is Associated with Nafld Progression from Steatosis to Steatohepatitis. | 2019 | Details |
| A10976 | 31094472 | Ter Arkh | Biochemical and molecular-genetic indicators of inflammation and apoptosis in liver cirrhosis as an outcome of the progression of non-alcoholic steatohepatitis. | 2019 | Details |
| A10991 | 31089410 | Oxid Med Cell Longev | Higd1a Protects Cells from Lipotoxicity under High-Fat Exposure. | 2019 | Details |
| A10995 | 31087530 | Physiol Rep | Whole-body vibration for patients with nonalcoholic fatty liver disease: a 6-month prospective study. | 2019 | Details |
| A11041 | 31071511 | Biomed Pharmacother | Therapeutic effects of curcumin and ursodexycholic acid on non-alcoholic fatty liver disease. | 2019 | Details |
| A11095 | 31044438 | Hepatology | NOD-like receptor C4 Inflammasome Regulates the Growth of Colon Cancer Liver Metastasis in NAFLD. | 2019 | Details |
| A11176 | 31010354 | Free Radic Res | Evaluation of the therapeutic potential effect of Fas receptor gene knockdown in experimental model of non-alcoholic steatohepatitis. | 2019 | Details |
| A11253 | 30973105 | Comb Chem High Throughput Screen | Effect of Chinese Herbal Monomer Hairy Calycosin on Nonalcoholic Fatty Liver Rats and its Mechanism. | 2019 | Details |
| A11276 | 30962743 | Yonago Acta Med | Gene Expression Analysis of the Activating Factor 3/Nuclear Protein 1 Axis in a Non-alcoholic Steatohepatitis Mouse Model. | 2019 | Details |
| A11280 | 30959577 | Hepatology | Fructose Promotes Leaky Gut, Endotoxemia, and Liver Fibrosis Through Ethanol-Inducible Cytochrome P450-2E1-Mediated Oxidative and Nitrative Stress. | 2019 | Details |
| A11295 | 30951375 | FASEB J | The immunoregulatory effects of CD8 T-cell-derived perforin on diet-induced nonalcoholic steatohepatitis. | 2019 | Details |
| A11309 | 30945293 | J Pathol | Bone marrow-derived macrophage contributes to fibrosing steatohepatitis through activating hepatic stellate cells. | 2019 | Details |
| A11313 | 30943218 | PLoS One | Lipidomic and transcriptomic analysis of western diet-induced nonalcoholic steatohepatitis (NASH) in female Ldlr -/- mice. | 2019 | Details |
| A11368 | 30920415 | Am J Gastroenterol | Angiotensin II Type 1 Receptor rs5186 Gene Variant Predicts Incident NAFLD and Associated Hypertension: Role of Dietary Fat-Induced Pro-Inflammatory Cell Activation. | 2019 | Details |
| A11380 | 30918325 | Lab Invest | Human relaxin-2 attenuates hepatic steatosis and fibrosis in mice with non-alcoholic fatty liver disease. | 2019 | Details |
| A11397 | 30913263 | PLoS One | Non-invasive assessment of NAFLD as systemic disease-A machine learning perspective. | 2019 | Details |
| A11406 | 30908654 | J Cell Physiol | Inhibition of lncRNA HULC improves hepatic fibrosis and hepatocyte apoptosis by inhibiting the MAPK signaling pathway in rats with nonalcoholic fatty liver disease. | 2019 | Details |
| A11604 | 30823334 | Environ Pollut | Environmental perfluoroalkyl acid exposures are associated with liver disease characterized by apoptosis and altered serum adipocytokines. | 2019 | Details |
| A11609 | 30820969 | Hepatology | Dual Specificity Phosphatase 12 Regulates Hepatic Lipid Metabolism Through Inhibition of the Lipogenesis and Apoptosis Signal-Regulating Kinase 1 Pathways. | 2019 | Details |
| A11614 | 30819129 | BMC Cancer | Molecular Pathogenesis of Cholangiocarcinoma. | 2019 | Details |
| A11638 | 30809789 | Semin Liver Dis | Inflammation and Liver Cancer: Molecular Mechanisms and Therapeutic Targets. | 2019 | Details |
| A11641 | 30809000 | Mod Pathol | Detection of DNA damage response in nonalcoholic fatty liver disease via p53-binding protein 1 nuclear expression. | 2019 | Details |
| A11730 | 30773868 | Zhen Ci Yan Jiu | [Progress of researches on acupuncture treatment of diseases by regulating endoplasmic reticulum stress]. | 2019 | Details |
| A11806 | 30732555 | Eur J Sport Sci | Mechanisms of beneficial effects of exercise training on non-alcoholic fatty liver disease (NAFLD): Roles of oxidative stress and inflammation. | 2019 | Details |
| A11818 | 30721572 | Liver Int | Randomized trial comparing effects of weight loss by liraglutide with lifestyle modification in non-alcoholic fatty liver disease. | 2019 | Details |
| A11841 | 30711404 | J Hepatol | Autophagy in liver diseases: Time for translation? | 2019 | Details |
| A11847 | 30708325 | Redox Biol | Mst1 inhibition attenuates non-alcoholic fatty liver disease via reversing Parkin-related mitophagy. | 2019 | Details |
| A11866 | 30703849 | Hepatology | F-box/WD Repeat-Containing Protein 5 Mediates the Ubiquitination of Apoptosis Signal-Regulating Kinase 1 and Exacerbates Nonalcoholic Steatohepatitis in Mice. | 2019 | Details |
| A11867 | 30703836 | Dtsch Med Wochenschr | [The Diabetic Heart and Heart Failure - Update on Mechanisms and Therapy]. | 2019 | Details |
| A11871 | 30701940 | Ter Arkh | The clinical significance of insulin resistance in non-diabetic patients with early forms of non-alcoholic fatty liver disease. | 2018 | Details |
| A11874 | 30701776 | Ter Arkh | Intrahepatic cholestasis in nonalcoholic fatty liver disease. | 2018 | Details |
| A11897 | 30689995 | Eur J Pharmacol | Betaine modulates oxidative stress, inflammation, apoptosis, autophagy, and Akt/mTOR signaling in methionine-choline deficiency-induced fatty liver disease. | 2019 | Details |
| A11917 | 30682878 | Medicina (Kaunas) | Oxidative Stress and Antioxidant Biomarkers in Clinical and Experimental Models of Non-Alcoholic Fatty Liver Disease. | 2019 | Details |
| A12062 | 30618753 | Front Pharmacol | Herbal Extracts and Natural Products in Alleviating Non-alcoholic Fatty Liver Disease via Activating Autophagy. | 2018 | Details |
| A12121 | 30594638 | Biochim Biophys Acta Gene Regul Mech | Role of long non-coding RNAs in metabolic control. | 2018 | Details |
| A12166 | 30576769 | Cell Mol Gastroenterol Hepatol | Targeted Delivery of Stk25 Antisense Oligonucleotides to Hepatocytes Protects Mice Against Nonalcoholic Fatty Liver Disease. | 2018 | Details |
| A12220 | 30557902 | Diabetes Metab Res Rev | Apolipoprotein CIII and diabetes. Is there a link? | 2019 | Details |
| A12255 | 30544824 | Int J Mol Sci | Oleuropein Induces AMPK-Dependent Autophagy in NAFLD Mice, Regardless of the Gender. | 2018 | Details |
| A12259 | 30543441 | Mol Pharm | Rapeseed Protein-Derived Antioxidant Peptide RAP Ameliorates Nonalcoholic Steatohepatitis and Related Metabolic Disorders in Mice. | 2018 | Details |
| A12271 | 30539788 | Cell Mol Gastroenterol Hepatol | Macrophage Raptor Deficiency-Induced Lysosome Dysfunction Exacerbates Nonalcoholic Steatohepatitis. | 2018 | Details |
| A12359 | 30487357 | Exp Anim | AIM-deficient mouse fed a high-trans fat, high-cholesterol diet: a new animal model for nonalcoholic fatty liver disease. | 2018 | Details |
| A12362 | 30484323 | Antioxid Redox Signal | Isosteviol Protects Free Fatty Acid- and High Fat Diet-Induced Hepatic Injury via Modulating PKC-β/p66Shc/ROS and Endoplasmic Reticulum Stress Pathways. | 2019 | Details |
| A12376 | 30481403 | IUBMB Life | IL-17A-mediated ERK1/2/p65 signaling pathway is associated with cell apoptosis after non-alcoholic steatohepatitis. | 2018 | Details |
| A12391 | 30473026 | Life Sci | p53 as a double-edged sword in the progression of non-alcoholic fatty liver disease. | 2018 | Details |
| A12425 | 30458883 | J Transl Med | Matrine attenuates endoplasmic reticulum stress and mitochondrion dysfunction in nonalcoholic fatty liver disease by regulating SERCA pathway. | 2018 | Details |
| A12440 | 30454891 | Biochem Biophys Res Commun | Suppressing NLRP2 expression accelerates hepatic steatosis: A mechanism involving inflammation and oxidative stress. | 2018 | Details |
| A12477 | 30430605 | Aliment Pharmacol Ther | Randomised clinical trial: emricasan versus placebo significantly decreases ALT and caspase 3/7 activation in subjects with non-alcoholic fatty liver disease. | 2018 | Details |
| A12518 | 30411754 | Food Funct | Blueberry, combined with probiotics, alleviates non-alcoholic fatty liver disease via IL-22-mediated JAK1/STAT3/BAX signaling. | 2018 | Details |
| A12539 | 30402207 | Oxid Med Cell Longev | miR-26a Potentially Contributes to the Regulation of Fatty Acid and Sterol Metabolism In Vitro Human HepG2 Cell Model of Nonalcoholic Fatty Liver Disease. | 2018 | Details |
| A12545 | 30400243 | Molecules | Stable Isotope-Labeled Lipidomics to Unravel the Heterogeneous Development Lipotoxicity. | 2018 | Details |
| A12553 | 30394550 | Hepatology | A Regulatory Role of Apoptosis Antagonizing Transcription Factor in the Pathogenesis of Nonalcoholic Fatty Liver Disease and Hepatocellular Carcinoma. | 2019 | Details |
| A12576 | 30382148 | Sci Rep | Augmented liver inflammation in a microsomal prostaglandin E synthase 1 (mPGES-1)-deficient diet-induced mouse NASH model. | 2018 | Details |
| A12657 | 30343673 | Biol Sex Differ | Tissue-specific pathways and networks underlying sexual dimorphism in non-alcoholic fatty liver disease. | 2018 | Details |
| A12662 | 30340105 | Int Immunopharmacol | Asiatic acid from Potentilla chinensis alleviates non-alcoholic fatty liver by regulating endoplasmic reticulum stress and lipid metabolism. | 2018 | Details |
| A12683 | 30328321 | Yonsei Med J | S100A4 Gene is Crucial for Methionine-Choline-Deficient Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice. | 2018 | Details |
| A12688 | 30327349 | Proc Natl Acad Sci U S A | Molecular profiling of nonalcoholic fatty liver disease-associated hepatocellular carcinoma using SB transposon mutagenesis. | 2018 | Details |
| A12726 | 30315247 | Sci Rep | NLRP3 Inflammasome Modulates Post-Burn Lipolysis and Hepatic Fat Infiltration via Fatty Acid Synthase. | 2018 | Details |
| A12734 | 30312023 | Anat Rec (Hoboken) | Role of MicroRNAs in the Development of Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease. | 2018 | Details |
| A12768 | 30297615 | Nutrients | Gut Microbiota's Relationship with Liver Disease and Role in Hepatoprotection by Dietary Natural Products and Probiotics. | 2018 | Details |
| A12800 | 30283077 | Int J Obes (Lond) | Ascorbic acid inhibits visceral obesity and nonalcoholic fatty liver disease by activating peroxisome proliferator-activated receptor α in high-fat-diet-fed C57BL/6J mice. | 2018 | Details |
| A12821 | 30268890 | Free Radic Biol Med | Mechanisms involved in the death of steatotic WIF-B9 hepatocytes co-exposed to benzo[a]pyrene and ethanol: a possible key role for xenobiotic metabolism and nitric oxide. | 2018 | Details |
| A12822 | 30266645 | Int J Biol Macromol | Lycium barbarum polysaccharides improve hepatic injury through NFkappa-B and NLRP3/6 pathways in a methionine choline deficient diet steatohepatitis mouse model. | 2018 | Details |
| A12827 | 30266038 | Br J Pharmacol | Diethyldithiocarbamate, an anti-abuse drug, alleviates steatohepatitis and fibrosis in rodents through modulating lipid metabolism and oxidative stress. | 2018 | Details |
| A12832 | 30262993 | Int J Biol Sci | Polydatin attenuates diet-induced nonalcoholic steatohepatitis and fibrosis in mice. | 2018 | Details |
| A12856 | 30254132 | Dis Model Mech | A nonalcoholic fatty liver disease model in human induced pluripotent stem cell-derived hepatocytes, created by endoplasmic reticulum stress-induced steatosis. | 2018 | Details |
| A12860 | 30252499 | Biomarkers | Circulating liver-specific microRNAs as noninvasive diagnostic biomarkers of hepatic diseases in human. | 2018 | Details |
| A12864 | 30250076 | Nat Rev Gastroenterol Hepatol | Apoptosis and necroptosis in the liver: a matter of life and death. | 2018 | Details |
| A12891 | 30239004 | J Cell Physiol | Cholesterol burden in the liver induces mitochondrial dynamic changes and resistance to apoptosis. | 2018 | Details |
| A12895 | 30236852 | Biomed Pharmacother | Protective effects of Kangxian ruangan capsule against nonalcoholic fatty liver disease fibrosis in rats induced by MCD diet. | 2018 | Details |
| A12898 | 30235807 | Diseases | Emerging Therapeutic Targets and Experimental Drugs for the Treatment of NAFLD. | 2018 | Details |
| A12931 | 30221089 | PeerJ | Effects of resveratrol, exercises and their combination on Farnesoid X receptor, Liver X receptor and Sirtuin 1 gene expression and apoptosis in the liver of elderly rats with nonalcoholic fatty liver. | 2018 | Details |
| A12967 | 30205811 | BMC Med | An exploratory study examining how nano-liquid chromatography-mass spectrometry and phosphoproteomics can differentiate patients with advanced fibrosis and higher percentage collagen in non-alcoholic fatty liver disease. | 2018 | Details |
| A12987 | 30194936 | Eur J Pharmacol | Sparstolonin B (SsnB) attenuates liver fibrosis via a parallel conjugate pathway involving P53-P21 axis, TGF-beta signaling and focal adhesion that is TLR4 dependent. | 2018 | Details |
| A12993 | 30191499 | Dig Dis Sci | Silybin Alleviates Hepatic Steatosis and Fibrosis in NASH Mice by Inhibiting Oxidative Stress and Involvement with the Nf-κB Pathway. | 2018 | Details |
| A13042 | 30168806 | J Clin Invest | Mitochondrial role in the neonatal predisposition to developing nonalcoholic fatty liver disease. | 2018 | Details |
| A13103 | 30137403 | J Clin Endocrinol Metab | Ghrelin Reduces TNF-α-Induced Human Hepatocyte Apoptosis, Autophagy, and Pyroptosis: Role in Obesity-Associated NAFLD. | 2019 | Details |
| A13129 | 30125542 | Am J Pathol | Toll-Like Receptor-7 Signaling Promotes Nonalcoholic Steatohepatitis by Inhibiting Regulatory T Cells in Mice. | 2018 | Details |
| A13145 | 30116360 | Exp Ther Med | 2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside attenuates methionine and choline-deficient diet-induced non-alcoholic fatty liver disease. | 2018 | Details |
| A13156 | 30112044 | Exp Ther Med | Melatonin alleviates liver steatosis induced by prenatal dexamethasone exposure and postnatal high-fat diet. | 2018 | Details |
| A13160 | 30109182 | Acta Pharm Sin B | Garlic-derived compound S-allylmercaptocysteine inhibits hepatocarcinogenesis through targeting LRP6/Wnt pathway. | 2017 | Details |
| A13191 | 30092856 | Gene Expr | Stress of Strains: Inbred Mice in Liver Research. | 2018 | Details |
| A13254 | 30063256 | Hepatology | Dual-Specificity Phosphatase 9 Protects Against Nonalcoholic Fatty Liver Disease in Mice Through ASK1 Suppression. | 2018 | Details |
| A13274 | 30056271 | Redox Biol | Therapeutic effect of Sirtuin 3 on ameliorating nonalcoholic fatty liver disease: The role of the ERK-CREB pathway and Bnip3-mediated mitophagy. | 2018 | Details |
| A13276 | 30055626 | Lipids Health Dis | Resveratrol ameliorates maternal and post-weaning high-fat diet-induced nonalcoholic fatty liver disease via renin-angiotensin system. | 2018 | Details |
| A13306 | 30038584 | Front Physiol | Stanniocalcin 2 Ameliorates Hepatosteatosis Through Activation of STAT3 Signaling. | 2018 | Details |
| A13335 | 30026676 | Food Nutr Res | Bitter melon extract ameliorates palmitate-induced apoptosis via inhibition of endoplasmic reticulum stress in HepG2 cells and high-fat/high-fructose-diet-induced fatty liver. | 2018 | Details |
| A13345 | 30021122 | Pharmacol Res | Future trends in the treatment of non-alcoholic steatohepatitis. | 2018 | Details |