Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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lipogenesis1889 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A08100 | 32245619 | Biochem Biophys Res Commun | Humanin attenuates palmitate-induced hepatic lipid accumulation and insulin resistance via AMPK-mediated suppression of the mTOR pathway. | 2020 | Details |
| A08101 | 32245586 | Chin J Nat Med | Selenium-enriched Bifidobacterium longum protected alcohol and high fat diet induced hepatic injury in mice. | 2020 | Details |
| A08130 | 32235829 | Cell Death Dis | TNF-Receptor-1 inhibition reduces liver steatosis, hepatocellular injury and fibrosis in NAFLD mice. | 2020 | Details |
| A08138 | 32231762 | World J Hepatol | High omega arachidonic acid/docosahexaenoic acid ratio induces mitochondrial dysfunction and altered lipid metabolism in human hepatoma cells. | 2020 | Details |
| A08151 | 32226996 | Food Funct | The protective mechanism of Lactobacillus plantarum FZU3013 against non-alcoholic fatty liver associated with hyperlipidemia in mice fed a high-fat diet. | 2020 | Details |
| A08178 | 32217466 | J Nutr Biochem | The modulation of Luffa cylindrica (L.) Roem supplementation on gene expression and amino acid profiles in liver for alleviating hepatic steatosis via gut microbiota in high-fat diet-fed mice: insight from hepatic transcriptome analysis. | 2020 | Details |
| A08186 | 32214246 | Nature | Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate. | 2020 | Details |
| A08205 | 32205994 | World J Gastroenterol | Mesencephalic astrocyte-derived neurotrophic factor ameliorates steatosis in HepG2 cells by regulating hepatic lipid metabolism. | 2020 | Details |
| A08206 | 32205419 | Gut | Intestinal gluconeogenesis prevents obesity-linked liver steatosis and non-alcoholic fatty liver disease. | 2020 | Details |
| A08234 | 32191577 | J Med Food | Eriocitrin Improves Adiposity and Related Metabolic Disorders in High-Fat Diet-Induced Obese Mice. | 2020 | Details |
| A08249 | 32188593 | BMJ Open Diabetes Res Care | Hepatic de novo lipogenesis is suppressed and fat oxidation is increased by omega-3 fatty acids at the expense of glucose metabolism. | 2020 | Details |
| A08258 | 32184858 | Iran J Pharm Res | In-vitro Synergistic Effect of Metformin and Berberine on High Glucose-induced Lipogenesis. | 2019 | Details |
| A08264 | 32181656 | J Agric Food Chem | Ginsenoside Rg2 Ameliorates High-Fat Diet-Induced Metabolic Disease through SIRT1. | 2020 | Details |
| A08273 | 32175323 | Front Med (Lausanne) | Hepatic Autonomic Nervous System and Neurotrophic Factors Regulate the Pathogenesis and Progression of Non-alcoholic Fatty Liver Disease. | 2020 | Details |
| A08279 | 32170962 | Hepatology | Genetic Pathways in Nonalcoholic Fatty Liver Disease: Insights From Systems Biology. | 2020 | Details |
| A08295 | 32165444 | Diabetes Care | Intrahepatic Fat and Postprandial Glycemia Increase After Consumption of a Diet Enriched in Saturated Fat Compared With Free Sugars. | 2020 | Details |
| A08301 | 32161197 | JCI Insight | Hydroxysteroid 17-β dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease. | 2020 | Details |
| A08309 | 32158242 | Diabetes Metab Syndr Obes | DHA Protects Against Hepatic Steatosis by Activating Sirt1 in a High Fat Diet-Induced Nonalcoholic Fatty Liver Disease Mouse Model. | 2020 | Details |
| A08313 | 32156377 | Food Res Int | Effect of okra fruit powder supplementation on metabolic syndrome and gut microbiota diversity in high fat diet-induced obese mice. | 2019 | Details |
| A08328 | 32151552 | Surg Obes Relat Dis | Management of nonalcoholic fatty liver disease and the role of bariatric surgery: a brief review for surgeons. | 2020 | Details |
| A08330 | 32150756 | Hepatology | N6 -Methyladenosine Reader Protein YT521-B Homology Domain-Containing 2 Suppresses Liver Steatosis by Regulation of mRNA Stability of Lipogenic Genes. | 2020 | Details |
| A08351 | 32145387 | Prostaglandins Other Lipid Mediat | Lipocalin-type prostaglandin D2 synthase deletion induces dyslipidemia and non-alcoholic fatty liver disease. | 2020 | Details |
| A08360 | 32144313 | Sci Rep | Carbohydrate response element binding protein (ChREBP) correlates with colon cancer progression and contributes to cell proliferation. | 2020 | Details |
| A08364 | 32143184 | EBioMedicine | Compounds that modulate AMPK activity and hepatic steatosis impact the biosynthesis of microRNAs required to maintain lipid homeostasis in hepatocytes. | 2020 | Details |
| A08425 | 32116145 | RNA Biol | GR-mediated FTO transactivation induces lipid accumulation in hepatocytes via demethylation of m6A on lipogenic mRNAs. | 2020 | Details |
| A08460 | 32103588 | Mol Nutr Food Res | Regulation of Adipocyte and Macrophage Functions by mTORC1 and 2 in Metabolic Diseases. | 2020 | Details |
| A08479 | 32093158 | Nutrients | Beneficial Effects of Lactobacillus plantarum Strains on Non-Alcoholic Fatty Liver Disease in High Fat/High Fructose Diet-Fed Rats. | 2020 | Details |
| A08504 | 32083759 | Hepatology | Hepatic Carbohydrate Response Element Binding Protein Activation Limits Nonalcoholic Fatty Liver Disease Development in a Mouse Model for Glycogen Storage Disease Type 1a. | 2020 | Details |
| A08559 | 32061597 | Gastroenterology | Circadian Rhythms in the Pathogenesis and Treatment of Fatty Liver Disease. | 2020 | Details |
| A08567 | 32058943 | EBioMedicine | Mboat7 down-regulation by hyper-insulinemia induces fat accumulation in hepatocytes. | 2020 | Details |
| A08568 | 32058217 | Biomed Pharmacother | Iridoids of Valeriana fauriei contribute to alleviating hepatic steatosis in obese mice by lipophagy. | 2020 | Details |
| A08578 | 32054087 | Int J Mol Sci | In Steatotic Cells, ATP-Citrate Lyase mRNA Is Efficiently Translated through a Cap-Independent Mechanism, Contributing to the Stimulation of De Novo Lipogenesis. | 2020 | Details |
| A08580 | 32053033 | Expert Opin Ther Targets | Emerging therapeutic targets for NASH: key innovations at the preclinical level. | 2020 | Details |
| A08594 | 32045698 | Biochim Biophys Acta Mol Cell Biol Lipids | Imbalanced insulin substrate-1 and insulin substrate-2 signaling trigger hepatic steatosis in vitamin D deficient rats: 8-methoxypsoralen, a vitamin D receptor ligand with a promising anti-steatotic action. | 2020 | Details |
| A08596 | 32045588 | Toxicol Appl Pharmacol | Orlistat delays hepatocarcinogenesis in mice with hepatic co-activation of AKT and c-Met. | 2020 | Details |
| A08605 | 32043752 | Liver Int | Metabolic regulation of hepatic PNPLA3 expression and severity of liver fibrosis in patients with NASH. | 2020 | Details |
| A08640 | 32035613 | Biochem Biophys Res Commun | MicroRNA-103 represses hepatic de novo lipogenesis and alleviates NAFLD via targeting FASN and SCD1. | 2020 | Details |
| A08680 | 32024826 | Nat Commun | Liver governs adipose remodelling via extracellular vesicles in response to lipid overload. | 2020 | Details |
| A08729 | 32008345 | Orv Hetil | [Effects of physical activity in nonalcoholic fatty liver disease]. | 2020 | Details |
| A08751 | 32001301 | Biochim Biophys Acta Mol Basis Dis | Hepatic FNDC5 is a potential local protective factor against Non-Alcoholic Fatty Liver. | 2020 | Details |
| A08758 | 31998789 | Biomed Res Int | Obesity-Induced Upregulation of ZBTB7A Promotes Lipid Accumulation through SREBP1. | 2020 | Details |
| A08771 | 31991181 | Life Sci | Role of hepatic neuropeptide Y-Y1 receptors in a methionine-choline-deficient model of non-alcoholic steatohepatitis. | 2020 | Details |
| A08772 | 31990961 | PLoS One | Acetyl-CoA carboxylase 1 and 2 inhibition ameliorates steatosis and hepatic fibrosis in a MC4R knockout murine model of nonalcoholic steatohepatitis. | 2020 | Details |
| A08791 | 31982488 | Pharmacol Res | Hypericin attenuates nonalcoholic fatty liver disease and abnormal lipid metabolism via the PKA-mediated AMPK signaling pathway in vitro and in vivo. | 2020 | Details |
| A08824 | 31976003 | Evid Based Complement Alternat Med | Sesamin, a Naturally Occurring Lignan, Inhibits Ligand-Induced Lipogenesis through Interaction with Liver X Receptor Alpha (LXRα) and Pregnane X Receptor (PXR). | 2019 | Details |
| A08827 | 31975362 | Planta Med | Patchouli Oil Attenuates High Fat Diet-induced Non-alcoholic Hepatic Steatosis. | 2020 | Details |
| A08839 | 31969775 | World J Gastroenterol | Inflammation and fibrosis in chronic liver diseases including non-alcoholic fatty liver disease and hepatitis C. | 2020 | Details |
| A08860 | 31959914 | Cell Death Differ | Inhibition of the mitochondrial citrate carrier, Slc25a1, reverts steatosis, glucose intolerance, and inflammation in preclinical models of NAFLD/NASH. | 2020 | Details |
| A08879 | 31953865 | Hepatology | Indole Alleviates Diet-Induced Hepatic Steatosis and Inflammation in a Manner Involving Myeloid Cell 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3. | 2020 | Details |
| A08883 | 31953228 | Biochim Biophys Acta Mol Cell Biol Lipids | Effects of peptidoglycan on the development of steatohepatitis. | 2020 | Details |
| A08888 | 31952262 | Int J Mol Sci | Beneficial Effects of SREBP Decoy Oligodeoxynucleotide in an Animal Model of Hyperlipidemia. | 2020 | Details |
| A08892 | 31950587 | J Dig Dis | Effects and therapeutic mechanism of Yinzhihuang on steatohepatitis in rats induced by a high-fat, high-cholesterol diet. | 2020 | Details |
| A08928 | 31935149 | Crit Rev Clin Lab Sci | Fructose and hepatic insulin resistance. | 2020 | Details |
| A08955 | 31926452 | J Nutr Biochem | The nonalcoholic fatty liver disease-like phenotype and lowered serum VLDL are associated with decreased expression and DNA hypermethylation of hepatic ApoB in male offspring of ApoE deficient mothers fed a with Western diet. | 2019 | Details |
| A08977 | 31918130 | Environ Pollut | Targeted metabolomics reveals that 2,3,7,8-tetrachlorodibenzofuran exposure induces hepatic steatosis in male mice. | 2019 | Details |
| A09050 | 31889412 | IUBMB Life | Inhibiting miR-27a and miR-142-5p attenuate nonalcoholic fatty liver disease by regulating Nrf2 signaling pathway. | 2019 | Details |
| A09059 | 33762794 | Toxicol Environ Chem | Perfluorobutanesulfonic Acid (PFBS) Induces Fat Accumulation in HepG2 Human Hepatoma. | 2020 | Details |
| A09078 | 31882889 | Sci Rep | Hepatic Mitochondrial Oxidative Metabolism and Lipogenesis Synergistically Adapt to Mediate Healthy Embryonic-to-Neonatal Transition in Chicken. | 2019 | Details |
| A09094 | 31879571 | PeerJ | Comparative RNA-sequencing profiled the differential gene expression of liver in response to acetyl-CoA carboxylase inhibitor GS-0976 in a mouse model of NASH. | 2019 | Details |
| A09148 | 31858105 | J Nutr | Niacin Ameliorates Hepatic Steatosis by Inhibiting De Novo Lipogenesis Via a GPR109A-Mediated PKC-ERK1/2-AMPK Signaling Pathway in C57BL/6 Mice Fed a High-Fat Diet. | 2020 | Details |
| A09151 | 31857195 | J Hepatol | ARRB1 inhibits non-alcoholic steatohepatitis progression by promoting GDF15 maturation. | 2019 | Details |
| A09175 | 31847612 | Expert Opin Investig Drugs | The molecular basis for current targets of NASH therapies. | 2019 | Details |
| A09184 | 31845054 | J Gastroenterol | Intestinal microbiome and NAFLD: molecular insights and therapeutic perspectives. | 2019 | Details |
| A09189 | 31842467 | Int J Mol Sci | Resveratrol Treatment Enhances the Cellular Response to Leptin by Increasing OBRb Content in Palmitate-Induced Steatotic HepG2 Cells. | 2019 | Details |
| A09200 | 31838177 | Int J Biochem Cell Biol | Resveratrol alleviates non-alcoholic fatty liver disease through epigenetic modification of the Nrf2 signaling pathway. | 2019 | Details |
| A09201 | 31838076 | Gastroenterology | Lactotrehalose, an Analog of Trehalose, Increases Energy Metabolism Without Promoting Clostridioides difficile Infection in Mice. | 2019 | Details |
| A09212 | 31834842 | J Med Food | Effects of Eriobotrya japonica Water Extract on Alcoholic and Nonalcoholic Fatty Liver Impairment. | 2019 | Details |
| A09222 | 31832001 | World J Gastroenterol | LB100 ameliorates nonalcoholic fatty liver disease via the AMPK/Sirt1 pathway. | 2019 | Details |
| A09245 | 31819934 | Food Funct | Acerola polysaccharides ameliorate high-fat diet-induced non-alcoholic fatty liver disease through reduction of lipogenesis and improvement of mitochondrial functions in mice. | 2020 | Details |
| A09288 | 31805015 | J Clin Invest | Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease. | 2020 | Details |
| A09354 | 31781248 | Stem Cells Int | Human Umbilical Cord-Derived Mesenchymal Stem Cell Therapy Ameliorates Nonalcoholic Fatty Liver Disease in Obese Type 2 Diabetic Mice. | 2019 | Details |
| A09358 | 31779730 | Br J Nutr | Dietary protein insufficiency: an important consideration in fatty liver disease? | 2019 | Details |
| A09366 | 31776293 | Sci Transl Med | Targeting diacylglycerol acyltransferase 2 for the treatment of nonalcoholic steatohepatitis. | 2019 | Details |
| A09367 | 31776016 | Environ Res | Adolescent exposure to environmental level of PCBs (Aroclor 1254) induces non-alcoholic fatty liver disease in male mice. | 2019 | Details |
| A09376 | 31770672 | Mol Ther Nucleic Acids | Long Noncoding RNA lnc-HC Regulates PPARγ-Mediated Hepatic Lipid Metabolism through miR-130b-3p. | 2019 | Details |
| A09397 | 31760464 | Cell Mol Life Sci | Fructose-mediated effects on gene expression and epigenetic mechanisms associated with NAFLD pathogenesis. | 2020 | Details |
| A09419 | 31756997 | Metabolites | Glucose-6 Phosphate, A Central Hub for Liver Carbohydrate Metabolism. | 2019 | Details |
| A09442 | 31748681 | Lab Invest | Maternal diet intervention before pregnancy primes offspring lipid metabolism in liver. | 2019 | Details |
| A09472 | 31731192 | Biomed Pharmacother | Role of farnesoid X receptor in hepatic steatosis in nonalcoholic fatty liver disease. | 2019 | Details |
| A09516 | 31713637 | Cell Mol Life Sci | Recent advances in the pathogenesis of hereditary fructose intolerance: implications for its treatment and the understanding of fructose-induced non-alcoholic fatty liver disease. | 2019 | Details |
| A09526 | 31709254 | Front Cell Dev Biol | Fatty Liver Due to Increased de novo Lipogenesis: Alterations in the Hepatic Peroxisomal Proteome. | 2019 | Details |
| A09539 | 31702809 | Mol Med Rep | Chronic aerobic exercise improves insulin sensitivity and modulates Nrf2 and NF‑κB/IκBα pathways in the skeletal muscle of rats fed with a high fat diet. | 2019 | Details |
| A09545 | 31700054 | Sci Rep | Isorhamnetin Alleviates Steatosis and Fibrosis in Mice with Nonalcoholic Steatohepatitis. | 2019 | Details |
| A09554 | 31695954 | Food Sci Biotechnol | Dansameum regulates hepatic lipogenesis and inflammation in vitro and in vivo. | 2019 | Details |
| A09597 | 31680967 | Front Pharmacol | Chinese Herbal Formula (CHF03) Attenuates Non-Alcoholic Fatty Liver Disease (NAFLD) Through Inhibiting Lipogenesis and Anti-Oxidation Mechanisms. | 2019 | Details |
| A09603 | 31678070 | Metabolism | Downregulation of PHGDH expression and hepatic serine level contribute to the development of fatty liver disease. | 2019 | Details |
| A09610 | 31676768 | Exp Mol Med | Hepatic triglyceride accumulation via endoplasmic reticulum stress-induced SREBP-1 activation is regulated by ceramide synthases. | 2019 | Details |
| A09629 | 31668954 | Environ Pollut | Prenatal exposure to diesel exhaust PM2.5 programmed non-alcoholic fatty liver disease differently in adult male offspring of mice fed normal chow and a high-fat diet. | 2019 | Details |
| A09634 | 31668386 | Mol Metab | Fibroblast growth factor 21 is required for the therapeutic effects of Lactobacillus rhamnosus GG against fructose-induced fatty liver in mice. | 2019 | Details |
| A09648 | 31659239 | Acta Pharmacol Sin | Uncarboxylated osteocalcin ameliorates hepatic glucose and lipid metabolism in KKAy mice via activating insulin signaling pathway. | 2019 | Details |
| A09662 | 31654717 | Cell Signal | Identification of Nogo-B as a new molecular target of peroxisome proliferator-activated receptor gamma. | 2019 | Details |
| A09668 | 31652837 | Cancers (Basel) | Deregulated Lysophosphatidic Acid Metabolism and Signaling in Liver Cancer. | 2019 | Details |
| A09681 | 31650383 | Mol Biol Rep | High fructose-containing drinking water-induced steatohepatitis in rats is prevented by the nicotinamide-mediated modulation of redox homeostasis and NADPH-producing enzymes. | 2019 | Details |
| A09728 | 31632961 | Front Cell Dev Biol | NFκB/Orai1 Facilitates Endoplasmic Reticulum Stress by Oxidative Stress in the Pathogenesis of Non-alcoholic Fatty Liver Disease. | 2019 | Details |
| A09740 | 31630414 | Hepatology | Fatty Acid Synthase Inhibitor TVB-2640 Reduces Hepatic de Novo Lipogenesis in Males With Metabolic Abnormalities. | 2020 | Details |
| A09776 | 31614650 | J Clin Med | Polyphenol-Rich Extracts from Toona sinensis Bark and Fruit Ameliorate Free Fatty Acid-Induced Lipogenesis through AMPK and LC3 Pathways. | 2019 | Details |
| A09777 | 31614639 | Biomolecules | Allopurinol Prevents the Lipogenic Response Induced by an Acute Oral Fructose Challenge in Short-Term Fructose Fed Rats. | 2019 | Details |
| A09788 | 31610126 | J Agric Food Chem | Reduction of Hepatic Lipogenesis by Loliolide and Pinoresinol from Lysimachia vulgaris via Degrading Liver X Receptors. | 2019 | Details |
| A09805 | 31604029 | Am J Physiol Gastrointest Liver Physiol | Intermittent restraint-induced sympathetic activation attenuates hepatic steatosis and inflammation in a high-fat diet-fed mouse model. | 2019 | Details |
| A09873 | 31581129 | Endocr Connect | Hyperinsulinaemia: does it tip the balance toward intrahepatic fat accumulation? | 2019 | Details |