Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Choline1715 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A12332 | 30511198 | Dig Dis Sci | Disease Progression and Pharmacological Intervention in a Nutrient-Deficient Rat Model of Nonalcoholic Steatohepatitis. | 2018 | Details |
| A12341 | 30500173 | Anal Chem | LipidMS: An R Package for Lipid Annotation in Untargeted Liquid Chromatography-Data Independent Acquisition-Mass Spectrometry Lipidomics. | 2018 | Details |
| A12343 | 30499266 | J Biomed Opt | Diffuse reflectance spectroscopy accurately discriminates early and advanced grades of fatty liver in mice. | 2018 | Details |
| A12417 | 30463916 | Sci Transl Med | Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis. | 2018 | Details |
| A12425 | 30458883 | J Transl Med | Matrine attenuates endoplasmic reticulum stress and mitochondrion dysfunction in nonalcoholic fatty liver disease by regulating SERCA pathway. | 2018 | Details |
| A12503 | 30416839 | Liver Res | Gut microbiota, fatty liver disease, and hepatocellular carcinoma. | 2018 | Details |
| A12509 | 30415113 | Chemosphere | Hepatic metabolomics reveals that liver injury increases PCB 126-induced oxidative stress and metabolic dysfunction. | 2018 | Details |
| A12512 | 30414175 | J Sci Food Agric | Triticum aestivum ethanolic extract improves non-alcoholic fatty liver disease in mice fed a choline-deficient or high-fat diet. | 2019 | Details |
| A12534 | 30405191 | Sci Rep | Differential Effects of a Glucagon-Like Peptide 1 Receptor Agonist in Non-Alcoholic Fatty Liver Disease and in Response to Hepatectomy. | 2018 | Details |
| A12592 | 30372785 | Hepatology | Mouse Models of Nonalcoholic Steatohepatitis: Toward Optimization of Their Relevance to Human Nonalcoholic Steatohepatitis. | 2019 | Details |
| A12596 | 30369082 | J Diabetes Investig | Nicotinic alpha-7 acetylcholine receptor deficiency exacerbates hepatic inflammation and fibrosis in a mouse model of non-alcoholic steatohepatitis. | 2018 | Details |
| A12609 | 30365236 | Hepatol Res | Combining probiotics and an angiotensin-II type 1 receptor blocker has beneficial effects on hepatic fibrogenesis in a rat model of non-alcoholic steatohepatitis. | 2018 | Details |
| A12637 | 30356218 | Nature | De novo NAD+ synthesis enhances mitochondrial function and improves health. | 2018 | Details |
| A12667 | 30337225 | Mol Metab | Switching obese mothers to a healthy diet improves fetal hypoxemia, hepatic metabolites, and lipotoxicity in non-human primates. | 2018 | Details |
| A12679 | 30333136 | J Cell Sci | Lipid bilayer stress-activated IRE-1 modulates autophagy during endoplasmic reticulum stress. | 2018 | Details |
| A12683 | 30328321 | Yonsei Med J | S100A4 Gene is Crucial for Methionine-Choline-Deficient Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice. | 2018 | Details |
| A12702 | 30322964 | J Immunol | Differential Activation of Hepatic Invariant NKT Cell Subsets Plays a Key Role in Progression of Nonalcoholic Steatohepatitis. | 2018 | Details |
| A12719 | 30316865 | EBioMedicine | Targeting hepatic miR-221/222 for therapeutic intervention of nonalcoholic steatohepatitis in mice. | 2018 | Details |
| A12754 | 30300671 | Biochim Biophys Acta Mol Basis Dis | Vitamin E alleviates non-alcoholic fatty liver disease in phosphatidylethanolamine N-methyltransferase deficient mice. | 2018 | Details |
| A12762 | 30298748 | Am J Chin Med | Beneficial Effects of Korean Red Ginseng in the Progression of Non-Alcoholic Steatohepatitis via FABP4 Modulation. | 2018 | Details |
| A12798 | 30283798 | World J Clin Cases | PNPLA3 rs139051 is associated with phospholipid metabolite profile and hepatic inflammation in nonalcoholic fatty liver disease. | 2018 | Details |
| A12822 | 30266645 | Int J Biol Macromol | Lycium barbarum polysaccharides improve hepatic injury through NFkappa-B and NLRP3/6 pathways in a methionine choline deficient diet steatohepatitis mouse model. | 2018 | Details |
| A12823 | 30266576 | Diabetes Metab | Clinical and metabolic characterization of obese subjects without non-alcoholic fatty liver: A targeted metabolomics approach. | 2018 | Details |
| A12827 | 30266038 | Br J Pharmacol | Diethyldithiocarbamate, an anti-abuse drug, alleviates steatohepatitis and fibrosis in rodents through modulating lipid metabolism and oxidative stress. | 2018 | Details |
| A12832 | 30262993 | Int J Biol Sci | Polydatin attenuates diet-induced nonalcoholic steatohepatitis and fibrosis in mice. | 2018 | Details |
| A12838 | 30261289 | Biochim Biophys Acta Mol Basis Dis | Involvement of G protein-coupled receptor kinase 2 (GRK2) in the development of non-alcoholic steatosis and steatohepatitis in mice and humans. | 2018 | Details |
| A12841 | 30259536 | Hepatology | Angiopoietin-2 Promotes Pathological Angiogenesis and Is a Therapeutic Target in Murine Nonalcoholic Fatty Liver Disease. | 2019 | Details |
| A12869 | 30249323 | J Food Drug Anal | Effect of Phyllanthus emblica L. fruit on methionine and choline-deficiency diet-induced nonalcoholic steatohepatitis. | 2018 | Details |
| A12883 | 30242180 | Sci Rep | HIF-1-dependent lipin1 induction prevents excessive lipid accumulation in choline-deficient diet-induced fatty liver. | 2018 | Details |
| A12903 | 30233587 | Front Immunol | Mucosal-Associated Invariant T Cells Improve Nonalcoholic Fatty Liver Disease Through Regulating Macrophage Polarization. | 2018 | Details |
| A12933 | 30219279 | J Control Release | Therapeutic inhibition of spleen tyrosine kinase in inflammatory macrophages using PLGA nanoparticles for the treatment of non-alcoholic steatohepatitis. | 2018 | Details |
| A12947 | 30213555 | Gastroenterology | Expression of STING Is Increased in Liver Tissues From Patients With NAFLD and Promotes Macrophage-Mediated Hepatic Inflammation and Fibrosis in Mice. | 2018 | Details |
| A12968 | 30202895 | Toxicol Sci | Modulation of Tetrachloroethylene-Associated Kidney Effects by Nonalcoholic Fatty Liver or Steatohepatitis in Male C57BL/6J Mice. | 2019 | Details |
| A12993 | 30191499 | Dig Dis Sci | Silybin Alleviates Hepatic Steatosis and Fibrosis in NASH Mice by Inhibiting Oxidative Stress and Involvement with the Nf-κB Pathway. | 2018 | Details |
| A12998 | 30188729 | Mol Pharm | Polyurethane Nanoparticle-Loaded Fenofibrate Exerts Inhibitory Effects on Nonalcoholic Fatty Liver Disease in Mice. | 2018 | Details |
| A13009 | 30183139 | Mol Nutr Food Res | Gamma-Tocotrienol Attenuates the Hepatic Inflammation and Fibrosis by Suppressing Endoplasmic Reticulum Stress in Mice. | 2018 | Details |
| A13013 | 30180767 | Am J Chin Med | Gypenoside UL4-Rich Gynostemma pentaphyllum Extract Exerts a Hepatoprotective Effect on Diet-Induced Nonalcoholic Fatty Liver Disease. | 2018 | Details |
| A13014 | 30180301 | Basic Clin Pharmacol Toxicol | Protective effect of isochlorogenic acid B on liver fibrosis in non-alcoholic steatohepatitis of mice. | 2018 | Details |
| A13021 | 30178233 | Front Med | Mechanistic and therapeutic advances in non-alcoholic fatty liver disease by targeting the gut microbiota. | 2018 | Details |
| A13047 | 30166404 | Drug Metab Dispos | Gene-by-Environment Interaction of Bcrp-/- and Methionine- and Choline-Deficient Diet-Induced Nonalcoholic Steatohepatitis Alters SN-38 Disposition. | 2018 | Details |
| A13052 | 30160786 | J Gastroenterol Hepatol | Caspase-independent hepatocyte death: A result of the decrease of lysophosphatidylcholine acyltransferase 3 in non-alcoholic steatohepatitis. | 2018 | Details |
| A13141 | 30120404 | Pediatr Res | In a pilot study, reduced fatty acid desaturase 1 function was associated with nonalcoholic fatty liver disease and response to treatment in children. | 2018 | Details |
| A13145 | 30116360 | Exp Ther Med | 2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside attenuates methionine and choline-deficient diet-induced non-alcoholic fatty liver disease. | 2018 | Details |
| A13149 | 30114411 | Life Sci | C-type natriuretic peptide (CNP) in endothelial cells attenuates hepatic fibrosis and inflammation in non-alcoholic steatohepatitis. | 2018 | Details |
| A13168 | 30103942 | Cell Immunol | Fatty acid activates NLRP3 inflammasomes in mouse Kupffer cells through mitochondrial DNA release. | 2018 | Details |
| A13172 | 30102772 | Hepatology | Macrophage-Specific Hypoxia-Inducible Factor-1α Contributes to Impaired Autophagic Flux in Nonalcoholic Steatohepatitis. | 2019 | Details |
| A13209 | 30083132 | Front Endocrinol (Lausanne) | Interventional Potential of Recombinant Feline Hepatocyte Growth Factor in a Mouse Model of Non-alcoholic Steatohepatitis. | 2018 | Details |
| A13239 | 30068869 | Biol Pharm Bull | Molybdate Attenuates Lipid Accumulation in the Livers of Mice Fed a Diet Deficient in Methionine and Choline. | 2018 | Details |
| A13275 | 30055803 | Biochem Biophys Res Commun | Autophagy is involved in acetylshikonin ameliorating non-alcoholic steatohepatitis through AMPK/mTOR pathway. | 2018 | Details |
| A13300 | 30042374 | Int J Mol Sci | Silibinin Ameliorates O-GlcNAcylation and Inflammation in a Mouse Model of Nonalcoholic Steatohepatitis. | 2018 | Details |
| A13301 | 30042157 | J Lipid Res | Mitochondrial dysfunction-related lipid changes occur in nonalcoholic fatty liver disease progression. | 2018 | Details |
| A13314 | 30036865 | Cell Physiol Biochem | Cangju Qinggan Jiangzhi Decoction Reduces the Development of NonAlcoholic Steatohepatitis and Activation of Kupffer Cells. | 2018 | Details |
| A13333 | 30026784 | Nutr Metab (Lond) | Changes in lysophospholipids and liver status after weight loss: the RESMENA study. | 2018 | Details |
| A13348 | 30019185 | J Physiol Biochem | Cathepsin B inhibition ameliorates the non-alcoholic steatohepatitis through suppressing caspase-1 activation. | 2018 | Details |
| A13440 | 29973631 | Sci Rep | Association of Lipoprotein-Associated Phospholipase A2 with the Prevalence of Nonalcoholic Fatty Liver Disease: A Result from the APAC Study. | 2018 | Details |
| A13455 | 29963902 | Antioxid Redox Signal | A Cross Talk Between BRG1 and Males Absent on the First Contributes to Reactive Oxygen Species Production in a Mouse Model of Nonalcoholic Steatohepatitis. | 2018 | Details |
| A13465 | 29959134 | Drug Metab Dispos | Glycyrrhizin Alleviates Nonalcoholic Steatohepatitis via Modulating Bile Acids and Meta-Inflammation. | 2018 | Details |
| A13479 | 29956204 | Adv Exp Med Biol | Pathogenesis of NASH: How Metabolic Complications of Overnutrition Favour Lipotoxicity and Pro-Inflammatory Fatty Liver Disease. | 2018 | Details |
| A13500 | 29947103 | Eur J Clin Invest | Plasma lecithin:cholesterol acyltransferase and phospholipid transfer protein activity independently associate with nonalcoholic fatty liver disease. | 2018 | Details |
| A13526 | 29930468 | World J Gastroenterol | Dynamic alterations in the gut microbiota and metabolome during the development of methionine-choline-deficient diet-induced nonalcoholic steatohepatitis. | 2018 | Details |
| A13594 | 29890136 | Biochem Biophys Res Commun | Hepatocyte-specific deletion of Brg1 alleviates methionine-and-choline-deficient diet (MCD) induced non-alcoholic steatohepatitis in mice. | 2018 | Details |
| A13601 | 29883724 | Chem Biol Interact | Alisol A 24-acetate ameliorates nonalcoholic steatohepatitis by inhibiting oxidative stress and stimulating autophagy through the AMPK/mTOR pathway. | 2018 | Details |
| A13604 | 29883377 | Nutrients | Circulating Phospholipid Patterns in NAFLD Patients Associated with a Combination of Metabolic Risk Factors. | 2018 | Details |
| A13621 | 29870802 | Biochimie | Enhanced expression and distinctive characterization of a long-acting FGF21 and its potential to alleviate nonalcoholic steatohepatitis. | 2018 | Details |
| A13641 | 29859019 | Br J Pharmacol | A long-acting FGF21 alleviates hepatic steatosis and inflammation in a mouse model of non-alcoholic steatohepatitis partly through an FGF21-adiponectin-IL17A pathway. | 2018 | Details |
| A13651 | 29855729 | EJNMMI Res | Evaluation of hepatic integrin αvβ3 expression in non-alcoholic steatohepatitis (NASH) model mouse by 18F-FPP-RGD2 PET. | 2018 | Details |
| A13686 | 29805971 | Int J Chronic Dis | Reduction of Liver Span and Parameters of Inflammation in Nonalcoholic Fatty Liver Disease Patients Treated with Lycosome Formulation of Phosphatidylcholine: A Preliminary Report. | 2018 | Details |
| A13715 | 29795111 | Cell Death Dis | Carnitine palmitoyltransferase gene upregulation by linoleic acid induces CD4+ T cell apoptosis promoting HCC development. | 2018 | Details |
| A13718 | 29792946 | Toxicol Appl Pharmacol | Investigation of nonalcoholic fatty liver disease-induced drug metabolism by comparative global toxicoproteomics. | 2018 | Details |
| A13783 | 29760499 | Sci Rep | Hepatic stellate cells secrete Ccl5 to induce hepatocyte steatosis. | 2018 | Details |
| A13786 | 29758334 | J Hepatol | Genetic inactivation of Nrf2 prevents clonal expansion of initiated cells in a nutritional model of rat hepatocarcinogenesis. | 2018 | Details |
| A13798 | 29750881 | Physiol Res | Pathophysiological characteristics of non-alcoholic steatohepatitis-like changes in cholesterol-loaded type 2 diabetic rats. | 2018 | Details |
| A13829 | 29735977 | Cell Mol Immunol | Increased Tim-3 expression alleviates liver injury by regulating macrophage activation in MCD-induced NASH mice. | 2018 | Details |
| A13840 | 29733743 | J Immunotoxicol | Use of an animal model to test whether non-alcoholic fatty liver disease increases the risk of idiosyncratic drug-induced liver injury. | 2018 | Details |
| A13866 | 29719629 | Oncotarget | Improvement of non-alcoholic steatohepatitis by hepatocyte-like cells generated from iPSCs with Oct4/Sox2/Klf4/Parp1. | 2018 | Details |
| A13873 | 29717162 | Sci Rep | Growth differentiation factor 15 ameliorates nonalcoholic steatohepatitis and related metabolic disorders in mice. | 2018 | Details |
| A13874 | 29715085 | Anticancer Res | Chemerin in a Mouse Model of Non-alcoholic Steatohepatitis and Hepatocarcinogenesis. | 2018 | Details |
| A13889 | 29707653 | Wellcome Open Res | Methyl donor deficient diets cause distinct alterations in lipid metabolism but are poorly representative of human NAFLD. | 2017 | Details |
| A13914 | 29696816 | J Dig Dis | Deletion of Smad4 reduces hepatic inflammation and fibrogenesis during nonalcoholic steatohepatitis progression. | 2018 | Details |
| A13955 | 29672963 | Biofactors | Butein protects the nonalcoholic fatty liver through mitochondrial reactive oxygen species attenuation in rats. | 2018 | Details |
| A14103 | 29583004 | J Agric Food Chem | Effects of Stigmasterol and β-Sitosterol on Nonalcoholic Fatty Liver Disease in a Mouse Model: A Lipidomic Analysis. | 2018 | Details |
| A14141 | 29566909 | Best Pract Res Clin Gastroenterol | NAFLD, Helicobacter species and the intestinal microbiome. | 2017 | Details |
| A14155 | 29560749 | Artif Cells Nanomed Biotechnol | Targeted delivery of microRNA 146b mimic to hepatocytes by lactosylated PDMAEMA nanoparticles for the treatment of NAFLD. | 2018 | Details |
| A14172 | 29552625 | Cell Mol Gastroenterol Hepatol | Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2). | 2017 | Details |
| A14234 | 29512720 | Mol Med Rep | Alogliptin alleviates hepatic steatosis in a mouse model of nonalcoholic fatty liver disease by promoting CPT1a expression via Thr172 phosphorylation of AMPKα in the liver. | 2018 | Details |
| A14250 | 29505790 | Biochem Biophys Res Commun | Berberine alleviates hepatic lipid accumulation by increasing ABCA1 through the protein kinase C δ pathway. | 2018 | Details |
| A14260 | 29498345 | Br J Nutr | 20-Week follow-up of hepatic steatosis installation and liver mitochondrial structure and activity and their interrelation in rats fed a high-fat-high-fructose diet. | 2018 | Details |
| A14275 | 29488482 | Ter Arkh | [Optimization of therapy for hepatobiliary disorders in psoriatic patients]. | 2019 | Details |
| A14298 | 29476945 | Ultrasonics | Ultrasound parametric imaging of hepatic steatosis using the homodyned-K distribution: An animal study. | 2018 | Details |
| A14301 | 29474931 | Biochim Biophys Acta Mol Cell Biol Lipids | Alpha-syntrophin null mice are protected from non-alcoholic steatohepatitis in the methionine-choline-deficient diet model but not the atherogenic diet model. | 2018 | Details |
| A14394 | 29428719 | Biochem Biophys Res Commun | Combination effects of alogliptin and pioglitazone on steatosis and hepatic fibrosis formation in a mouse model of non-alcoholic steatohepatitis. | 2018 | Details |
| A14417 | 29416063 | Nat Commun | AhR and SHP regulate phosphatidylcholine and S-adenosylmethionine levels in the one-carbon cycle. | 2018 | Details |
| A14438 | 29406832 | Can J Physiol Pharmacol | Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates nonalcoholic fatty liver disease. | 2018 | Details |
| A14473 | 29397594 | Zhonghua Nei Ke Za Zhi | [Efficacy of probiotics on the treatment of non-alcoholic fatty liver disease]. | 2018 | Details |
| A14557 | 29355950 | J Pharm Pharmacol | Lansoprazole prevents the progression of liver fibrosis in non-alcoholic steatohepatitis model rats. | 2018 | Details |
| A14558 | 29355688 | Toxicol Lett | Metabolomics profiling of steatosis progression in HepaRG® cells using sodium valproate. | 2018 | Details |
| A14569 | 29350612 | Microsc Microanal | The Effects of Betaine on the Nuclear Fractal Dimension, Chromatin Texture, and Proliferative Activity in Hepatocytes in Mouse Model of Nonalcoholic Fatty Liver Disease. | 2018 | Details |
| A14598 | 29331340 | J Hepatol | Hsp72 protects against liver injury via attenuation of hepatocellular death, oxidative stress, and JNK signaling. | 2018 | Details |
| A14607 | 29326427 | Lab Invest | Severe steatosis induces portal hypertension by systemic arterial hyporeactivity and hepatic vasoconstrictor hyperreactivity in rats. | 2018 | Details |
| A14679 | 29290620 | Mol Metab | Pharmacological stimulation of p53 with low-dose doxorubicin ameliorates diet-induced nonalcoholic steatosis and steatohepatitis. | 2017 | Details |