Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Fatty acid synthase594 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A46141 | 20799351 | Hepatology | Liver-specific suppressor of cytokine signaling-3 deletion in mice enhances hepatic insulin sensitivity and lipogenesis resulting in fatty liver and obesity. | 2010 | Details |
| A46222 | 20211032 | Lipids Health Dis | Dietary saponins of sea cucumber alleviate orotic acid-induced fatty liver in rats via PPARalpha and SREBP-1c signaling. | 2010 | Details |
| A46283 | 19783528 | J Lipid Res | A subset of dysregulated metabolic and survival genes is associated with severity of hepatic steatosis in obese Zucker rats. | 2009 | Details |
| A46420 | 18794597 | Eur J Gastroenterol Hepatol | Altered expression of transcription factors and genes regulating lipogenesis in liver and adipose tissue of mice with high fat diet-induced obesity and nonalcoholic fatty liver disease. | 2008 | Details |
| A46442 | 18627005 | Hepatology | Peroxisome proliferator-activated receptor-delta induces insulin-induced gene-1 and suppresses hepatic lipogenesis in obese diabetic mice. | 2008 | Details |
| A46778 | 15650132 | Am J Physiol Gastrointest Liver Physiol | Steatohepatitis develops rapidly in transgenic mice overexpressing Abcb11 and fed a methionine-choline-deficient diet. | 2005 | Details |
| A46908 | 34817678 | Eur J Nutr | Betaine in ameliorating alcohol-induced hepatic steatosis. | 2021 | Details |
| A46938 | 33485268 | Biochem Biophys Res Commun | Nuclear factor Y participates in alcoholic liver disease by activating SREBP1 expression in mice. | 2021 | Details |
| A46964 | 32129352 | Food Funct | Rosmarinic acid alleviates ethanol-induced lipid accumulation by repressing fatty acid biosynthesis. | 2020 | Details |
| A46980 | 31463983 | Lipids | Vitamin D Deficiency Attenuates Acute Alcohol-Induced Hepatic Lipid Accumulation in Mice. | 2019 | Details |
| A46989 | 31168926 | Mol Nutr Food Res | Myricetin Ameliorates Ethanol-Induced Lipid Accumulation in Liver Cells by Reducing Fatty Acid Biosynthesis. | 2019 | Details |
| A46995 | 30935969 | Metabolism | Chitinase-3-like-1 deficiency attenuates ethanol-induced liver injury by inhibition of sterol regulatory element binding protein 1-dependent triglyceride synthesis. | 2019 | Details |
| A47009 | 30179264 | Hepatology | Pharmacological Inhibition of CCR2/5 Signaling Prevents and Reverses Alcohol-Induced Liver Damage, Steatosis, and Inflammation in Mice. | 2019 | Details |
| A47035 | 28689299 | J Mol Med (Berl) | 4-O'-methylhonokiol protects from alcohol/carbon tetrachloride-induced liver injury in mice. | 2017 | Details |
| A47088 | 26459052 | Int Immunopharmacol | Ligustrazine prevents alcohol-induced liver injury by attenuating hepatic steatosis and oxidative stress. | 2015 | Details |
| A47091 | 26305715 | IUBMB Life | Curcumin attenuates ethanol-induced hepatic steatosis through modulating Nrf2/FXR signaling in hepatocytes. | 2015 | Details |
| A47122 | 25561792 | World J Gastroenterol | Delayed ethanol elimination and enhanced susceptibility to ethanol-induced hepatosteatosis after liver resection. | 2014 | Details |
| A47146 | 24930470 | Alcohol Clin Exp Res | Pyrroloquinoline quinone-secreting probiotic Escherichia coli Nissle 1917 ameliorates ethanol-induced oxidative damage and hyperlipidemia in rats. | 2014 | Details |
| A47151 | 24828027 | J Nutr | Luteolin alleviates alcoholic liver disease induced by chronic and binge ethanol feeding in mice. | 2014 | Details |
| A47154 | 24797033 | Alcohol Clin Exp Res | Involvement of insulin resistance in the protective effect of metformin against alcoholic liver injury. | 2014 | Details |
| A47177 | 24146112 | Arch Toxicol | Protective effects of dioscin against alcohol-induced liver injury. | 2013 | Details |
| A47180 | 24063989 | Life Sci | Low doses of curcumin protect alcohol-induced liver damage by modulation of the alcohol metabolic pathway, CYP2E1 and AMPK. | 2013 | Details |
| A47189 | 23707365 | J Hepatol | ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading. | 2013 | Details |
| A47222 | 22413959 | Alcohol Clin Exp Res | Carvedilol attenuates the progression of alcohol fatty liver disease in rats. | 2012 | Details |
| A47244 | 21645218 | Liver Int | Role of cannabinoid receptors in alcoholic hepatic injury: steatosis and fibrogenesis are increased in CB2 receptor-deficient mice and decreased in CB1 receptor knockouts. | 2011 | Details |
| A47262 | 20192205 | J Agric Food Chem | Fruiting body of Niuchangchih (Antrodia camphorata) protects livers against chronic alcohol consumption damage. | 2010 | Details |
| A47266 | 20041784 | J Med Food | Protective effect of Codonopsis lanceolata root extract against alcoholic fatty liver in the rat. | 2009 | Details |
| A47302 | 18395093 | Gastroenterology | Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury. | 2008 | Details |
| A47311 | 17655900 | Toxicol Appl Pharmacol | Differential gene expression and lipid metabolism in fatty liver induced by acute ethanol treatment in mice. | 2007 | Details |
| A48958 | 23184344 | Eur J Nutr | Inhibition of DNA-dependent protein kinase reduced palmitate and oleate-induced lipid accumulation in HepG2 cells. | 2012 | Details |
| A49125 | 16622296 | Endocrine | Modulation of fatty acid metabolism as a potential approach to the treatment of obesity and the metabolic syndrome. | 2006 | Details |
| A49252 | 35809408 | Comput Biol Med | In silico and in vitro analysis of PPAR - α / γ dual agonists: Comparative evaluation of potential phytochemicals with anti-obesity drug orlistat. | 2022 | Details |
| A49265 | 35806447 | Int J Mol Sci | New Insights of OLFM2 and OLFM4 in Gut-Liver Axis and Their Potential Involvement in Nonalcoholic Fatty Liver Disease. | 2022 | Details |
| A49352 | 35780841 | Life Sci | Ellagic acid ameliorates high fructose-induced hyperuricemia and non-alcoholic fatty liver in Wistar rats: Focusing on the role of C1q/tumor necrosis factor-related protein-3 and ATP citrate lyase. | 2022 | Details |
| A49359 | 35779187 | Cell Stress Chaperones | Modulation of endoplasmic reticulum stress via sulforaphane-mediated AMPK upregulation against nonalcoholic fatty liver disease in rats. | 2022 | Details |
| A49416 | 35757439 | Food Nutr Res | Citrus maxima and tea regulate AMPK signaling pathway to retard the progress of nonalcoholic fatty liver disease. | 2022 | Details |
| A49683 | 35672152 | Pharm Biol | Camel milk protein hydrosylate alleviates hepatic steatosis and hypertension in high fructose-fed rats. | 2022 | Details |
| A49848 | 35621963 | Mar Drugs | Monkfish Peptides Mitigate High Fat Diet-Induced Hepatic Steatosis in Mice. | 2022 | Details |
| A49944 | 35586049 | Front Pharmacol | Artemether Ameliorates Non-Alcoholic Steatohepatitis by Repressing Lipogenesis, Inflammation, and Fibrosis in Mice. | 2022 | Details |
| A50003 | 35565930 | Nutrients | Bifidobacterium animalis ssp. lactis MG741 Reduces Body Weight and Ameliorates Nonalcoholic Fatty Liver Disease via Improving the Gut Permeability and Amelioration of Inflammatory Cytokines. | 2022 | Details |
| A50007 | 35565666 | Nutrients | Myristica fragrans Extract Regulates Gut Microbes and Metabolites to Attenuate Hepatic Inflammation and Lipid Metabolism Disorders via the AhR-FAS and NF-κB Signaling Pathways in Mice with Non-Alcoholic Fatty Liver Disease. | 2022 | Details |
| A50061 | 35538760 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | [Mechanism of Triclosan in the Treatment of Nonalcoholic Fatty Liver Disease Based on Network Pharmacology]. | 2022 | Details |
| A50193 | 35483638 | J Control Release | Celastrol-loaded lactosylated albumin nanoparticles attenuate hepatic steatosis in non-alcoholic fatty liver disease. | 2022 | Details |
| A50217 | 35469167 | JHEP Rep | Lipid alterations in chronic liver disease and liver cancer. | 2022 | Details |
| A50310 | 35436630 | Biochem Biophys Res Commun | Hydrochloride Berberine ameliorates alcohol-induced liver injury by regulating inflammation and lipid metabolism. | 2022 | Details |
| A50383 | 35409465 | Int J Environ Res Public Health | Sclerocarya birrea (Marula) Extract Inhibits Hepatic Steatosis in db/db Mice. | 2022 | Details |
| A50438 | 35392289 | Front Nutr | Activating Effects of the Bioactive Compounds From Coffee By-Products on FGF21 Signaling Modulate Hepatic Mitochondrial Bioenergetics and Energy Metabolism in vitro. | 2022 | Details |
| A50653 | 35313531 | Metabol Open | Acute intermittent hypoxia drives hepatic de novo lipogenesis in humans and rodents. | 2022 | Details |
| A50713 | 35290413 | PLoS One | Abelmoschus esculentus subfractions ameliorate hepatic lipogenesis and lipid uptake via regulating dipeptidyl peptidase-4-With improving insulin resistance. | 2022 | Details |
| A50733 | 35283810 | Front Microbiol | Alleviation of Hepatic Steatosis: Dithizone-Related Gut Microbiome Restoration During Paneth Cell Dysfunction. | 2022 | Details |
| A50792 | 35264693 | Sci Rep | Clitorin ameliorates western diet-induced hepatic steatosis by regulating lipogenesis and fatty acid oxidation in vivo and in vitro. | 2022 | Details |
| A50812 | 35212695 | Food Funct | Citrus depressa Hayata peel ameliorates nonalcoholic fatty liver and modulates the activity of hepatic drug-metabolizing enzymes and transporters in rats fed a high-fat diet. | 2022 | Details |
| A50872 | 34723832 | J Mol Endocrinol | miR-23a/b-3p promotes hepatic lipid accumulation by regulating Srebp-1c and Fas. | 2021 | Details |
| A51760 | 34303283 | Tissue Cell | CTRP3 ameliorates fructose-induced metabolic associated fatty liver disease via inhibition of xanthine oxidase-associated oxidative stress. | 2021 | Details |
| A51882 | 33485967 | J Biol Chem | Changes in retinoid metabolism and signaling associated with metabolic remodeling during fasting and in type I diabetes. | 2021 | Details |
| A51914 | 33273564 | Sci Rep | Short-term Cudrania tricuspidata fruit vinegar administration attenuates obesity in high-fat diet-fed mice by improving fat accumulation and metabolic parameters. | 2020 | Details |
| A51988 | 32587408 | Sci Rep | Ursodeoxycholic acid improves feto-placental and offspring metabolic outcomes in hypercholanemic pregnancy. | 2020 | Details |
| A52002 | 32477454 | World J Diabetes | Maternal low protein diet induces persistent expression changes in metabolic genes in male rats. | 2020 | Details |
| A52005 | 32432943 | Autophagy | Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway. | 2020 | Details |
| A52060 | 31752080 | Nutrients | Genetic Deletion of Syndecan-4 Alters Body Composition, Metabolic Phenotypes, and the Function of Metabolic Tissues in Female Mice Fed A High-Fat Diet. | 2019 | Details |
| A52101 | 31243135 | J Virol | Transforming Growth Factor β Acts as a Regulatory Molecule for Lipogenic Pathways among Hepatitis C Virus Genotype-Specific Infections. | 2019 | Details |
| A52114 | 31053639 | J Biol Chem | An ANGPTL4-ceramide-protein kinase Cζ axis mediates chronic glucocorticoid exposure-induced hepatic steatosis and hypertriglyceridemia in mice. | 2019 | Details |
| A52164 | 30520016 | Int J Cancer | Impact of systemic and tumor lipid metabolism on everolimus efficacy in advanced pancreatic neuroendocrine tumors (pNETs). | 2019 | Details |
| A52171 | 30463291 | Nutrients | Ishige okamurae Extract Suppresses Obesity and Hepatic Steatosis in High Fat Diet-Induced Obese Mice. | 2018 | Details |
| A52173 | 30425250 | Nat Commun | Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN. | 2018 | Details |
| A52193 | 30246717 | Chin Med J (Engl) | Role of X-Box Binding Protein-1 in Fructose-Induced De Novo Lipogenesis in HepG2 Cells. | 2018 | Details |
| A52204 | 30133327 | FASEB J | Chronic psychosocial defeat differently affects lipid metabolism in liver and white adipose tissue and induces hepatic oxidative stress in mice fed a high-fat diet. | 2018 | Details |
| A52275 | 29402742 | Bioorg Med Chem Lett | Novel SIRT1 activator MHY2233 improves glucose tolerance and reduces hepatic lipid accumulation in db/db mice. | 2018 | Details |
| A52282 | 29329215 | Nutrients | Dietary Supplement of Large Yellow Tea Ameliorates Metabolic Syndrome and Attenuates Hepatic Steatosis in db/db Mice. | 2018 | Details |
| A52286 | 29173222 | Br J Nutr | Maternal conjugated linoleic acid modulates TAG metabolism in adult rat offspring. | 2017 | Details |
| A52287 | 29115530 | Mol Med Rep | Curcumin suppresses Notch‑1 signaling: Improvements in fatty liver and insulin resistance in rats. | 2017 | Details |
| A52289 | 29074588 | Arterioscler Thromb Vasc Biol | GLP-1 Elicits an Intrinsic Gut-Liver Metabolic Signal to Ameliorate Diet-Induced VLDL Overproduction and Insulin Resistance. | 2017 | Details |
| A52334 | 28431322 | J Nutr Biochem | Xanthohumol and 8-prenylnaringenin ameliorate diabetic-related metabolic dysfunctions in mice. | 2017 | Details |
| A52358 | 28214879 | J Nutrigenet Nutrigenomics | Thiamine Deprivation Produces a Liver ATP Deficit and Metabolic and Genomic Effects in Mice: Findings Are Parallel to Those of Biotin Deficiency and Have Implications for Energy Disorders. | 2017 | Details |
| A52453 | 26980761 | Cancer Res | Oncoprotein HBXIP Modulates Abnormal Lipid Metabolism and Growth of Breast Cancer Cells by Activating the LXRs/SREBP-1c/FAS Signaling Cascade. | 2016 | Details |
| A52464 | 26829127 | J Agric Food Chem | Trace Mineral Overload Induced Hepatic Oxidative Damage and Apoptosis in Pigs with Long-Term High-Level Dietary Mineral Exposure. | 2016 | Details |
| A52476 | 26562264 | Endocrinology | Androgen Deficiency Exacerbates High-Fat Diet-Induced Metabolic Alterations in Male Mice. | 2015 | Details |
| A52501 | 26287659 | Int J Dev Neurosci | Short term exendin-4 treatment reduces markers of metabolic disorders in female offspring of obese rat dams. | 2015 | Details |
| A52530 | 25941430 | J Clin Exp Hepatol | Study of the effects of cyclooxygenase-2 inhibitor on the promotion of hepatic tumorigenesis in rats fed a high fat diet. | 2015 | Details |
| A52564 | 25582085 | Nutr Res | Early hepatic insult in the offspring of obese maternal mice. | 2014 | Details |
| A52574 | 25445284 | Gene | L-Carnitine intake prevents irregular feeding-induced obesity and lipid metabolism disorder. | 2014 | Details |
| A52592 | 25220251 | J Hepatol | Hepatitis C viral proteins perturb metabolic liver zonation. | 2014 | Details |
| A52628 | 24605027 | World J Gastroenterol | Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer. | 2014 | Details |
| A52631 | 24486395 | Eur J Pharmacol | Silymarin ameliorates fructose induced insulin resistance syndrome by reducing de novo hepatic lipogenesis in the rat. | 2014 | Details |
| A52650 | 24184811 | Gastroenterology | Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21. | 2013 | Details |
| A52707 | 23176795 | Nutr Res | Genistein reduced insulin resistance index through modulating lipid metabolism in ovariectomized rats. | 2012 | Details |
| A52818 | 21336545 | Naunyn Schmiedebergs Arch Pharmacol | Overweight induced by chronic risperidone exposure is correlated with overexpression of the SREBP-1c and FAS genes in mouse liver. | 2011 | Details |
| A52839 | 21060311 | Int J Obes (Lond) | Perinatal nutrient restriction induces long-lasting alterations in the circadian expression pattern of genes regulating food intake and energy metabolism. | 2010 | Details |
| A52902 | 19796707 | Biochim Biophys Acta | Hypothalamic lipotoxicity and the metabolic syndrome. | 2009 | Details |
| A52923 | 19500808 | Metabolism | A herbal extract with acetyl-coenzyme A carboxylase inhibitory activity and its potential for treating metabolic syndrome. | 2009 | Details |
| A53013 | 17466711 | Am J Obstet Gynecol | Gender-specific programmed hepatic lipid dysregulation in intrauterine growth-restricted offspring. | 2007 | Details |
| A53050 | 16477380 | Mol Cell Biochem | Peroxisome proliferator-activated receptor-alpha selective ligand reduces adiposity, improves insulin sensitivity and inhibits atherosclerosis in LDL receptor-deficient mice. | 2006 | Details |
| A53078 | 15543204 | Lab Invest | Overexpression of fatty acid synthase in chemically and hormonally induced hepatocarcinogenesis of the rat. | 2005 | Details |
| A53130 | 11679439 | Diabetes | Acute inhibition of glucose-6-phosphate translocator activity leads to increased de novo lipogenesis and development of hepatic steatosis without affecting VLDL production in rats. | 2001 | Details |