Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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PPAR2265 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A08992 | 31913326 | Sci Rep | Perceived stress and non-alcoholic fatty liver disease in apparently healthy men and women. | 2020 | Details |
| A09001 | 31908512 | Diabetes Metab Syndr Obes | The Circulating Micro-RNAs (-122, -34a and -99a) as Predictive Biomarkers for Non-Alcoholic Fatty Liver Diseases. | 2019 | Details |
| A09012 | 31905025 | Am J Physiol Gastrointest Liver Physiol | Investigating fibrosis and inflammation in an ex vivo NASH murine model. | 2020 | Details |
| A09021 | 31901728 | Redox Biol | Hepatocyte-specific Nrf2 deficiency mitigates high-fat diet-induced hepatic steatosis: Involvement of reduced PPARγ expression. | 2019 | Details |
| A09040 | 31893310 | Cell Mol Life Sci | Integrative genomics reveal a role for MCPIP1 in adipogenesis and adipocyte metabolism. | 2019 | Details |
| A09044 | 31891606 | PLoS One | Thrombospondin-I is a critical modulator in non-alcoholic steatohepatitis (NASH). | 2019 | Details |
| A09046 | 31889755 | J Clin Exp Hepatol | Peroxisome Proliferator-Activated Receptors and Their Agonists in Nonalcoholic Fatty Liver Disease. | 2019 | Details |
| A09047 | 31889754 | J Clin Exp Hepatol | Antidiabetic Drugs and Statins in Nonalcoholic Fatty Liver Disease. | 2019 | Details |
| A09066 | 31885789 | Oxid Med Cell Longev | Green Tea Prevents NAFLD by Modulation of miR-34a and miR-194 Expression in a High-Fat Diet Mouse Model. | 2019 | Details |
| A09073 | 31883528 | Lipids Health Dis | Pathophysiological importance of bile cholesterol reabsorption: hepatic NPC1L1-exacerbated steatosis and decreasing VLDL-TG secretion in mice fed a high-fat diet. | 2019 | Details |
| A09074 | 31883514 | BMC Gastroenterol | Validity of biopsy-based drug effects in a diet-induced obese mouse model of biopsy-confirmed NASH. | 2019 | Details |
| A09078 | 31882889 | Sci Rep | Hepatic Mitochondrial Oxidative Metabolism and Lipogenesis Synergistically Adapt to Mediate Healthy Embryonic-to-Neonatal Transition in Chicken. | 2019 | Details |
| A09096 | 31877771 | Cells | Anti-NASH Drug Development Hitches a Lift on PPAR Agonism. | 2019 | Details |
| A09109 | 31870746 | Ann Hepatol | Peroxisomal footprint in the pathogenesis of nonalcoholic steatohepatitis. | 2019 | Details |
| A09129 | 31864032 | Environ Int | Transcriptome responses in blood reveal distinct biological pathways associated with arsenic exposure through drinking water in rural settings of Punjab, Pakistan. | 2019 | Details |
| A09148 | 31858105 | J Nutr | Niacin Ameliorates Hepatic Steatosis by Inhibiting De Novo Lipogenesis Via a GPR109A-Mediated PKC-ERK1/2-AMPK Signaling Pathway in C57BL/6 Mice Fed a High-Fat Diet. | 2020 | Details |
| A09151 | 31857195 | J Hepatol | ARRB1 inhibits non-alcoholic steatohepatitis progression by promoting GDF15 maturation. | 2019 | Details |
| A09156 | 31853615 | Naunyn Schmiedebergs Arch Pharmacol | Adelmidrol protects against non-alcoholic steatohepatitis in mice. | 2019 | Details |
| A09196 | 31839747 | Int J Med Sci | PPAR δ inhibition protects against palmitic acid-LPS induced lipidosis and injury in cultured hepatocyte L02 cell. | 2019 | Details |
| A09212 | 31834842 | J Med Food | Effects of Eriobotrya japonica Water Extract on Alcoholic and Nonalcoholic Fatty Liver Impairment. | 2019 | Details |
| A09222 | 31832001 | World J Gastroenterol | LB100 ameliorates nonalcoholic fatty liver disease via the AMPK/Sirt1 pathway. | 2019 | Details |
| A09224 | 31831621 | J Biol Chem | Disruption of hepatic small heterodimer partner induces dissociation of steatosis and inflammation in experimental nonalcoholic steatohepatitis. | 2019 | Details |
| A09253 | 31817227 | Nutrients | Fermented Korean Red Ginseng Extract Enriched in Rd and Rg3 Protects against Non-Alcoholic Fatty Liver Disease through Regulation of mTORC1. | 2019 | Details |
| A09256 | 31816064 | Hum Mol Genet | Fenofibrate rapidly decreases hepatic lipid and glycogen storage in neonatal mice with glycogen storage disease type Ia. | 2020 | Details |
| A09361 | 31777896 | Food Funct | Attenuation of metabolic syndrome in the ob/ob mouse model by resistant starch intervention is dose dependent. | 2019 | Details |
| A09367 | 31776016 | Environ Res | Adolescent exposure to environmental level of PCBs (Aroclor 1254) induces non-alcoholic fatty liver disease in male mice. | 2019 | Details |
| A09376 | 31770672 | Mol Ther Nucleic Acids | Long Noncoding RNA lnc-HC Regulates PPARγ-Mediated Hepatic Lipid Metabolism through miR-130b-3p. | 2019 | Details |
| A09381 | 31769484 | Clin Sci (Lond) | Dapagliflozin not only improves hepatic injury and pancreatic endoplasmic reticulum stress, but also induces hepatic gluconeogenic enzymes expression in obese rats. | 2019 | Details |
| A09399 | 31760308 | J Nutr Biochem | Probiotic culture supernatant improves metabolic function through FGF21-adiponectin pathway in mice. | 2019 | Details |
| A09401 | 31759197 | J Nutr Biochem | Mitigation of nonalcoholic fatty liver disease in high-fat-fed mice by the combination of decaffeinated green tea extract and voluntary exercise. | 2019 | Details |
| A09421 | 31756344 | Life Sci | Active vitamin D supplementation alleviates initiation and progression of nonalcoholic fatty liver disease by repressing the p53 pathway. | 2019 | Details |
| A09475 | 31730885 | Toxicol Lett | In vitro and in vivo approaches for identifying the role of aryl hydrocarbon receptor in the development of nonalcoholic fatty liver disease. | 2019 | Details |
| A09531 | 31706011 | Pharmacol Res | Combinational applicaton of silybin and tangeretin attenuates the progression of non-alcoholic steatohepatitis (NASH) in mice via modulating lipid metabolism. | 2019 | Details |
| A09548 | 31697972 | J Hepatol | Insulin sensitizer MSDC-0602K in non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled phase IIb study. | 2019 | Details |
| A09582 | 31687367 | Can J Gastroenterol Hepatol | The Triglyceride and Glucose Index Is a Predictor of Incident Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study. | 2019 | Details |
| A09602 | 31678261 | Food Chem Toxicol | Cigarette smoking differentially regulates inflammatory responses in a mouse model of nonalcoholic steatohepatitis depending on exposure time point. | 2019 | Details |
| A09625 | 31670498 | Panminerva Med | Liver disease and heart failure. | 2019 | Details |
| A09658 | 31656991 | Rev Endocr Metab Disord | Adiponectin and PPAR: a setup for intricate crosstalk between obesity and non-alcoholic fatty liver disease. | 2019 | Details |
| A09662 | 31654717 | Cell Signal | Identification of Nogo-B as a new molecular target of peroxisome proliferator-activated receptor gamma. | 2019 | Details |
| A09670 | 31652636 | Cells | MicroRNA-29a Suppresses CD36 to Ameliorate High Fat Diet-Induced Steatohepatitis and Liver Fibrosis in Mice. | 2019 | Details |
| A09701 | 31640183 | Nutrients | Water Extract of Curcuma longa L. Ameliorates Non-Alcoholic Fatty Liver Disease. | 2019 | Details |
| A09702 | 31639005 | Lipids Health Dis | Therapeutic effect and autophagy regulation of myriocin in nonalcoholic steatohepatitis. | 2019 | Details |
| A09706 | 31638173 | Int J Mol Med | Role and mechanisms of action of microRNA‑21 as regards the regulation of the WNT/β‑catenin signaling pathway in the pathogenesis of non‑alcoholic fatty liver disease. | 2019 | Details |
| A09766 | 31618976 | Int J Mol Sci | The Potential of the FSP1cre-Pparb/d-/- Mouse Model for Studying Juvenile NAFLD. | 2019 | Details |
| A09774 | 31614690 | Int J Mol Sci | Exploration and Development of PPAR Modulators in Health and Disease: An Update of Clinical Evidence. | 2019 | Details |
| A09785 | 31611031 | Clin Res Hepatol Gastroenterol | Characterization of biopsy proven non-alcoholic fatty liver disease in healthy non-obese and lean population of living liver donors: The impact of uric acid. | 2019 | Details |
| A09796 | 31607566 | Dig Liver Dis | L-carnitine supplementation attenuates NAFLD progression and cardiac dysfunction in a mouse model fed with methionine and choline-deficient diet. | 2019 | Details |
| A09808 | 31602526 | J Gastroenterol | Hepatic FATP5 expression is associated with histological progression and loss of hepatic fat in NAFLD patients. | 2019 | Details |
| A09859 | 31589122 | Curr Drug Targets | Natural Aldose Reductase Inhibitor: A Potential Therapeutic Agent for Non-alcoholic Fatty Liver Disease. | 2020 | Details |
| A09881 | 31576092 | World J Gastroenterol | Zinc-α2-glycoprotein 1 attenuates non-alcoholic fatty liver disease by negatively regulating tumour necrosis factor-α. | 2019 | Details |
| A09894 | 31571145 | Arch Pharm Res | Molecular insights into the role of mitochondria in non-alcoholic fatty liver disease. | 2019 | Details |
| A09898 | 31569521 | Molecules | Separation and Lipid Inhibition Effects of a Novel Decapeptide from Chlorella pyenoidose. | 2019 | Details |
| A09934 | 31554528 | Br J Nutr | Randomised trial of chronic supplementation with a nutraceutical mixture in subjects with non-alcoholic fatty liver disease. | 2020 | Details |
| A09942 | 31551930 | Front Endocrinol (Lausanne) | Integrated Analysis of Multiple Microarray Studies to Identify Novel Gene Signatures in Non-alcoholic Fatty Liver Disease. | 2019 | Details |
| A09946 | 31548878 | Cell Biosci | BabaoDan attenuates high-fat diet-induced non-alcoholic fatty liver disease via activation of AMPK signaling. | 2019 | Details |
| A09952 | 31545283 | Biomed Pharmacother | Gypenosides improve the intestinal microbiota of non-alcoholic fatty liver in mice and alleviate its progression. | 2019 | Details |
| A10014 | 31523999 | Expert Opin Investig Drugs | Elafibranor: a potential drug for the treatment of nonalcoholic steatohepatitis (NASH). | 2019 | Details |
| A10064 | 31505261 | Biochim Biophys Acta Mol Cell Biol Lipids | Lipid accumulation impairs lysosomal acid lipase activity in hepatocytes: Evidence in NAFLD patients and cell cultures. | 2019 | Details |
| A10073 | 31501836 | Food Funct | High-fat diet induces mouse liver steatosis with a concomitant decline in energy metabolism: attenuation by eicosapentaenoic acid (EPA) or hydroxytyrosol (HT) supplementation and the additive effects upon EPA and HT co-administration. | 2019 | Details |
| A10082 | 31496048 | Physiol Rep | Dipeptidyl peptidase-4 inhibitors and aerobic exercise synergistically protect against liver injury in ovariectomized rats. | 2019 | Details |
| A10090 | 31491949 | Int J Mol Sci | Combined Treatment with L-Carnitine and Nicotinamide Riboside Improves Hepatic Metabolism and Attenuates Obesity and Liver Steatosis. | 2019 | Details |
| A10099 | 31484323 | Nutrients | Indole-3-Acetic Acid Alleviates Nonalcoholic Fatty Liver Disease in Mice via Attenuation of Hepatic Lipogenesis, and Oxidative and Inflammatory Stress. | 2019 | Details |
| A10110 | 31480575 | Biomolecules | Raw Bowl Tea (Tuocha) Polyphenol Prevention of Nonalcoholic Fatty Liver Disease by Regulating Intestinal Function in Mice. | 2019 | Details |
| A10134 | 31472955 | Biochem Biophys Res Commun | Vitexin alleviates non-alcoholic fatty liver disease by activating AMPK in high fat diet fed mice. | 2019 | Details |
| A10184 | 31445117 | Magn Reson Imaging | Evaluation of diffusion kurtosis imaging in stratification of nonalcoholic fatty liver disease and early diagnosis of nonalcoholic steatohepatitis in a rabbit model. | 2019 | Details |
| A10185 | 31445019 | Biochem Pharmacol | M3 muscarinic receptor activation reduces hepatocyte lipid accumulation via CaMKKβ/AMPK pathway. | 2019 | Details |
| A10212 | 31430456 | Eur J Pharmacol | Pinolenic acid ameliorates oleic acid-induced lipogenesis and oxidative stress via AMPK/SIRT1 signaling pathway in HepG2 cells. | 2019 | Details |
| A10214 | 31430204 | Am J Physiol Endocrinol Metab | Hypoxia exacerbates nonalcoholic fatty liver disease via the HIF-2α/PPARα pathway. | 2019 | Details |
| A10227 | 31421115 | Chem Biol Interact | Acanthoic acid modulates lipogenesis in nonalcoholic fatty liver disease via FXR/LXRs-dependent manner. | 2019 | Details |
| A10234 | 31419466 | Mol Cell Endocrinol | Empaglifozin mitigates NAFLD in high-fat-fed mice by alleviating insulin resistance, lipogenesis and ER stress. | 2019 | Details |
| A10237 | 31418509 | Phytother Res | Fiber and phenolic compounds contribution to the hepatoprotective effects of mango diets in rats fed high cholesterol/sodium cholate. | 2019 | Details |
| A10247 | 31413241 | J Oleo Sci | Elaeagnus mollis Oil Attenuates Non-alcoholic Fatty Disease in High-fat Diet Induced Obese Mice via Modifying the Expression of Lipid Metabolismrelated Genes. | 2019 | Details |
| A10304 | 31392349 | Cell Mol Life Sci | Lipophagy mediated carbohydrate-induced changes of lipid metabolism via oxidative stress, endoplasmic reticulum (ER) stress and ChREBP/PPARγ pathways. | 2019 | Details |
| A10309 | 31390852 | Turk J Med Sci | Association between PPARGC1A single nucleotide polymorphisms and increased risk of nonalcoholic fatty liver disease among Iranian patients with type 2 diabetes mellitus | 2019 | Details |
| A10321 | 31388624 | Hepatol Commun | Genetic Polymorphisms Implicated in Nonalcoholic Liver Disease or Selected Other Disorders Have No Influence on Drug-Induced Liver Injury. | 2019 | Details |
| A10323 | 31388096 | Int J Obes (Lond) | Circulating microbiota-derived metabolites: a "liquid biopsy? | 2019 | Details |
| A10337 | 31384535 | Acta Pharm Sin B | Silibinin ameliorates hepatic lipid accumulation and oxidative stress in mice with non-alcoholic steatohepatitis by regulating CFLAR-JNK pathway. | 2019 | Details |
| A10367 | 31372694 | Naunyn Schmiedebergs Arch Pharmacol | Chrysin ameliorates nonalcoholic fatty liver disease in rats. | 2019 | Details |
| A10383 | 31361543 | Am J Physiol Endocrinol Metab | eNOS deletion impairs mitochondrial quality control and exacerbates Western diet-induced NASH. | 2019 | Details |
| A10392 | 31357780 | Zhonghua Gan Zang Bing Za Zhi | [A new attempt with lipoprotein lipase agonists in the treatment of nonalcoholic steatohepatitis]. | 2019 | Details |
| A10523 | 31301418 | Life Sci | (5R)-5-hydroxytriptolide ameliorates liver lipid accumulation by suppressing lipid synthesis and promoting lipid oxidation in mice. | 2019 | Details |
| A10544 | 31293521 | Front Endocrinol (Lausanne) | The Nuclear Receptor-Co-repressor Complex in Control of Liver Metabolism and Disease. | 2019 | Details |
| A10545 | 31293441 | Front Physiol | The Influence of Different Fat Sources on Steatohepatitis and Fibrosis Development in the Western Diet Mouse Model of Non-alcoholic Steatohepatitis (NASH). | 2019 | Details |
| A10555 | 31292134 | Diabetes | Osteoprotegerin Promotes Liver Steatosis by Targeting the ERK-PPAR-γ-CD36 Pathway. | 2019 | Details |
| A10565 | 31288993 | Mol Metab | GDF10 blocks hepatic PPARγ activation to protect against diet-induced liver injury. | 2019 | Details |
| A10586 | 31280138 | Phytomedicine | Anti-hepatic steatosis activity of Sicyos angulatus extract in high-fat diet-fed mice and chemical profiling study using UHPLC-qTOF-MS/MS spectrometry. | 2019 | Details |
| A10597 | 31275587 | BMJ Open Gastroenterol | Non-alcoholic fatty liver disease with obesity as an independent predictor for incident gastric and colorectal cancer: a population-based longitudinal study. | 2019 | Details |
| A10614 | 31271251 | Mol Nutr Food Res | Diet Consisting of Balanced Yogurt, Fruit, and Vegetables Modifies the Gut Microbiota and Protects Mice against Nonalcoholic Fatty Liver Disease. | 2019 | Details |
| A10624 | 31266632 | Biochem Biophys Res Commun | Expression of Vsig4 attenuates macrophage-mediated hepatic inflammation and fibrosis in high fat diet (HFD)-induced mice. | 2019 | Details |
| A10659 | 31250564 | Physiol Rep | AdipoRon prevents myostatin-induced upregulation of fatty acid synthesis and downregulation of insulin activity in a mouse hepatocyte line. | 2019 | Details |
| A10667 | 31245168 | Liver Res | Hepatic lipid homeostasis by peroxisome proliferator-activated receptor gamma 2. | 2018 | Details |
| A10725 | 31220177 | PLoS One | Anti-obesity effects of Spirulina platensis protein hydrolysate by modulating brain-liver axis in high-fat diet fed mice. | 2019 | Details |
| A10734 | 31216433 | J Ethnopharmacol | Exploring the protective effect of ShengMai-Yin and Ganmaidazao decoction combination against type 2 diabetes mellitus with nonalcoholic fatty liver disease by network pharmacology and validation in KKAy mice. | 2019 | Details |
| A10739 | 31214287 | Nutr Res Pract | Free fatty acid-induced histone acetyltransferase activity accelerates lipid accumulation in HepG2 cells. | 2019 | Details |
| A10749 | 31211621 | Am J Physiol Endocrinol Metab | Mouse trefoil factor 3 ameliorated high-fat-diet-induced hepatic steatosis via increasing peroxisome proliferator-activated receptor-α-mediated fatty acid oxidation. | 2019 | Details |
| A10755 | 31208414 | Cardiovasc Diabetol | New dual peroxisome proliferator activated receptor agonist-Saroglitazar in diabetic dyslipidemia and non-alcoholic fatty liver disease: integrated analysis of the real world evidence. | 2019 | Details |
| A10792 | 31191323 | Front Pharmacol | Role of Myeloid-Epithelial-Reproductive Tyrosine Kinase and Macrophage Polarization in the Progression of Atherosclerotic Lesions Associated With Nonalcoholic Fatty Liver Disease. | 2019 | Details |
| A10813 | 31176759 | Mol Cell Endocrinol | Adiponectin is required for pioglitazone-induced improvements in hepatic steatosis in mice fed a high-fat diet. | 2019 | Details |
| A10819 | 31173696 | Appl Physiol Nutr Metab | Resveratrol protects against nonalcoholic fatty liver disease by improving lipid metabolism and redox homeostasis via the PPARα pathway. | 2019 | Details |
| A10864 | 32953568 | J Tradit Complement Med | Calcium supplementation shows a hepatoprotective effect against high-fat diet by regulating oxidative-induced inflammatory response and lipogenesis activity in male rats. | 2019 | Details |