Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A13348 | 30019185 | J Physiol Biochem | Cathepsin B inhibition ameliorates the non-alcoholic steatohepatitis through suppressing caspase-1 activation. | 2018 | Details |
| A13353 | 30017991 | Free Radic Biol Med | The role of iron in hepatic inflammation and hepatocellular carcinoma. | 2018 | Details |
| A13376 | 30011790 | Int J Mol Sci | New Aspects of Lipotoxicity in Nonalcoholic Steatohepatitis. | 2018 | Details |
| A13382 | 30009361 | Folia Morphol (Warsz) | The differential effects of high-fat and high- -fructose diets on the liver of male albino rat and the proposed underlying mechanisms. | 2018 | Details |
| A13411 | 29991872 | World J Gastroenterol | Apoptosis and non-alcoholic fatty liver diseases. | 2018 | Details |
| A13416 | 29989845 | Metab Syndr Relat Disord | Association Between Serum CK-18 Levels and the Degree of Liver Damage in Fructose-Induced Metabolic Syndrome. | 2018 | Details |
| A13453 | 29964161 | Pharmacol Res | Human-based systems: Mechanistic NASH modelling just around the corner? | 2018 | Details |
| A13479 | 29956204 | Adv Exp Med Biol | Pathogenesis of NASH: How Metabolic Complications of Overnutrition Favour Lipotoxicity and Pro-Inflammatory Fatty Liver Disease. | 2018 | Details |
| A13515 | 29936596 | Cell Mol Life Sci | Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease. | 2018 | Details |
| A13541 | 29923211 | Andrologia | Beneficial effect of apple vinegar on reproductive parameters in male rat model of nonalcoholic fatty liver disease. | 2018 | Details |
| A13581 | 29896915 | Cancer Sci | Role of caveolin-1 in hepatocellular carcinoma arising from non-alcoholic fatty liver disease. | 2018 | Details |
| A13614 | 29874807 | Med Sci (Basel) | The Role of the Gut Microbiome in Nonalcoholic Fatty Liver Disease. | 2018 | Details |
| A13629 | 29864471 | Toxicol In Vitro | Treatment of cigarette smoke extract and condensate differentially potentiates palmitic acid-induced lipotoxicity and steatohepatitis in vitro. | 2018 | Details |
| A13638 | 29860102 | J Nutr Biochem | Disruption of tumor necrosis factor alpha receptor 1 signaling accelerates NAFLD progression in mice upon a high-fat diet. | 2018 | Details |
| A13658 | 29852394 | Biomed Pharmacother | Naringin attenuates liver damage in streptozotocin-induced diabetic rats. | 2018 | Details |
| A13692 | 29803928 | Biomed Pharmacother | Protective effects of cichoric acid on H2O2-induced oxidative injury in hepatocytes and larval zebrafish models. | 2018 | Details |
| A13708 | 29798686 | Syst Biol Reprod Med | Effects of saturated palmitic acid and omega-3 polyunsaturated fatty acids on Sertoli cell apoptosis. | 2018 | Details |
| A13715 | 29795111 | Cell Death Dis | Carnitine palmitoyltransferase gene upregulation by linoleic acid induces CD4+ T cell apoptosis promoting HCC development. | 2018 | Details |
| A13738 | 29783682 | Diseases | Heat Shock Gene Inactivation and Protein Aggregation with Links to Chronic Diseases. | 2018 | Details |
| A13766 | 29766802 | Curr Drug Targets | Endoplasmic Reticulum Stress Related Molecular Mechanisms in Nonalcoholic Fatty Liver Disease (NAFLD). | 2018 | Details |
| A13819 | 29743560 | Cell Death Differ | Caspases in metabolic disease and their therapeutic potential. | 2018 | Details |
| A13843 | 29729191 | Hepatology | Caspase Recruitment Domain Protein 6 Protects Against Hepatic Steatosis and Insulin Resistance by Suppressing Apoptosis Signal-Regulating Kinase 1. | 2018 | Details |
| A13879 | 29713125 | World J Gastroenterol | Beneficial effects of naringenin in liver diseases: Molecular mechanisms. | 2018 | Details |
| A13886 | 29709653 | Life Sci | Oleic acid protects saturated fatty acid mediated lipotoxicity in hepatocytes and rat of non-alcoholic steatohepatitis. | 2018 | Details |
| A13900 | 29702590 | Int J Mol Sci | Insulin-Like Growth Factor (IGF) System in Liver Diseases. | 2018 | Details |
| A13914 | 29696816 | J Dig Dis | Deletion of Smad4 reduces hepatic inflammation and fibrogenesis during nonalcoholic steatohepatitis progression. | 2018 | Details |
| A13925 | 29686469 | World J Gastroenterol | Evaluation of safety for hepatectomy in a novel mouse model with nonalcoholic-steatohepatitis. | 2018 | Details |
| A13956 | 29672926 | J Gastroenterol Hepatol | Insights into the etiology-associated gene regulatory networks in hepatocellular carcinoma from The Cancer Genome Atlas. | 2018 | Details |
| A14090 | 29593815 | Arch Med Sci | Preventive effects of total saponins of Panax japonicus on fatty liver fibrosis in mice. | 2016 | Details |
| A14105 | 29580823 | Mol Cell Endocrinol | GW0742 (PPAR-beta agonist) attenuates hepatic endoplasmic reticulum stress by improving hepatic energy metabolism in high-fat diet fed mice. | 2018 | Details |
| A14122 | 29574534 | J Gastroenterol | To die or not to die: death signaling in nonalcoholic fatty liver disease. | 2018 | Details |
| A14156 | 29560693 | Acta Gastroenterol Belg | Apoptosis and Disease Severity is Associated with Insulin Resistance in Non-alcoholic Fatty Liver Disease. | 2018 | Details |
| A14172 | 29552625 | Cell Mol Gastroenterol Hepatol | Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2). | 2017 | Details |
| A14206 | 29526820 | Biochim Biophys Acta Mol Basis Dis | Benzbromarone aggravates hepatic steatosis in obese individuals. | 2018 | Details |
| A14243 | 29507903 | Hepatol Commun | Insulin signaling as a potential natural killer cell checkpoint in fatty liver disease. | 2018 | Details |
| A14278 | 29486327 | Biochim Biophys Acta Mol Cell Biol Lipids | FTO promotes SREBP1c maturation and enhances CIDEC transcription during lipid accumulation in HepG2 cells. | 2018 | Details |
| A14279 | 29486218 | Toxicology | Cadmium exposure exacerbates hyperlipidemia in cholesterol-overloaded hepatocytes via autophagy dysregulation. | 2018 | Details |
| A14330 | 29463133 | Arch Physiol Biochem | Effects of combined therapy with resveratrol, continuous and interval exercises on apoptosis, oxidative stress, and inflammatory biomarkers in the liver of old rats with non-alcoholic fatty liver disease. | 2018 | Details |
| A14339 | 29457838 | Hepatology | Bax inhibitor-1 protects from nonalcoholic steatohepatitis by limiting inositol-requiring enzyme 1 alpha signaling in mice. | 2018 | Details |
| A14400 | 29427492 | Liver Int | Future therapy for non-alcoholic fatty liver disease. | 2018 | Details |
| A14403 | 29427339 | Cancer Sci | Stearate-to-palmitate ratio modulates endoplasmic reticulum stress and cell apoptosis in non-B non-C hepatoma cells. | 2018 | Details |
| A14444 | 29404514 | Hepatol Commun | Serine/threonine protein kinase 25 antisense oligonucleotide treatment reverses glucose intolerance, insulin resistance, and nonalcoholic fatty liver disease in mice. | 2017 | Details |
| A14516 | 29373070 | J Med Food | Lipolysis-Stimulating Peptide from Soybean Protects Against High Fat Diet-Induced Apoptosis in Skeletal Muscles. | 2018 | Details |
| A14519 | 29371918 | Oncotarget | Long-term administration of tacrolimus and everolimus prevents high cholesterol-high fructose-induced steatosis in C57BL/6J mice by inhibiting de-novo lipogenesis. | 2017 | Details |
| A14524 | 29367738 | Cell Death Dis | Differential effects of reticulophagy and mitophagy on nonalcoholic fatty liver disease. | 2018 | Details |
| A14543 | 29360762 | Mar Drugs | Protective Effect of Meretrix meretrix Oligopeptides on High-Fat-Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice. | 2018 | Details |
| A14575 | 29345253 | Acta Pharmacol Sin | 3-Acetyl-oleanolic acid ameliorates non-alcoholic fatty liver disease in high fat diet-treated rats by activating AMPK-related pathways. | 2018 | Details |
| A14611 | 29324774 | PLoS One | Activated carbon N-acetylcysteine microcapsule protects against nonalcoholic fatty liver disease in young rats via activating telomerase and inhibiting apoptosis. | 2018 | Details |
| A14635 | 29314568 | Liver Int | Genetic determinants of hepatic steatosis and serum cytokeratin-18 fragment levels in Taiwanese children. | 2018 | Details |
| A14662 | 29299797 | Ecotoxicology | Transcriptome assembly and expression profiling of the molecular responses to cadmium toxicity in cerebral ganglia of wolf spider Pardosa pseudoannulata (Araneae: Lycosidae). | 2018 | Details |
| A14663 | 29299759 | Hepatol Int | Translating scientific discovery: the need for preclinical models of nonalcoholic steatohepatitis. | 2018 | Details |
| A14679 | 29290620 | Mol Metab | Pharmacological stimulation of p53 with low-dose doxorubicin ameliorates diet-induced nonalcoholic steatosis and steatohepatitis. | 2017 | Details |
| A14718 | 29273476 | J Hepatol | Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice. | 2017 | Details |
| A14751 | 29255346 | Drug Des Devel Ther | Hepatoprotective effect of calculus bovis sativus on nonalcoholic fatty liver disease in mice by inhibiting oxidative stress and apoptosis of hepatocytes. | 2017 | Details |
| A14754 | 29254185 | Oncotarget | Hepatoprotective potential of isoquercitrin against type 2 diabetes-induced hepatic injury in rats. | 2017 | Details |
| A14771 | 29247356 | J Gastroenterol | Current and future pharmacological therapies for NAFLD/NASH. | 2017 | Details |
| A14794 | 29228666 | Oncotarget | Granulocyte colony stimulating factor treatment in non-alcoholic fatty liver disease: beyond marrow cell mobilization. | 2017 | Details |
| A14796 | 29227477 | Nat Med | The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis. | 2017 | Details |
| A14820 | 29220698 | Redox Biol | Synergistic interaction of fatty acids and oxysterols impairs mitochondrial function and limits liver adaptation during nafld progression. | 2017 | Details |
| A14833 | 29214510 | J Cell Commun Signal | Myeloid deficiency of CCN3 exacerbates liver injury in a mouse model of nonalcoholic fatty liver disease. | 2017 | Details |
| A14904 | 29181663 | Bull Exp Biol Med | Gene TNF Polymorphism -308G>A (rs1800629) and Its Relationship with the Efficiency of Ursodeoxycholic Acid Therapy in Patients with Nonalcoholic Stetohepatitis. | 2017 | Details |
| A14912 | 29175671 | J Nutr Biochem | Dietary omega-3 and omega-6 polyunsaturated fatty acids modulate hepatic pathology. | 2017 | Details |
| A14933 | 29167318 | Clin Sci (Lond) | TRAIL reduces impaired glucose tolerance and NAFLD in the high-fat diet fed mouse. | 2018 | Details |
| A14951 | 29158819 | Theranostics | Pro-Inflammatory CXCR3 Impairs Mitochondrial Function in Experimental Non-Alcoholic Steatohepatitis. | 2017 | Details |
| A14956 | 29158052 | Life Sci | Baicalin attenuates non-alcoholic steatohepatitis by suppressing key regulators of lipid metabolism, inflammation and fibrosis in mice. | 2017 | Details |
| A14961 | 29154966 | J Hepatol | Determinants of fibrosis progression and regression in NASH. | 2017 | Details |
| A14963 | 29154964 | J Hepatol | Lipotoxicity and the gut-liver axis in NASH pathogenesis. | 2017 | Details |
| A15008 | 29128061 | Clin Liver Dis | The Genetics of Pediatric Nonalcoholic Fatty Liver Disease. | 2017 | Details |
| A15042 | 29121675 | PLoS One | Astaxanthin prevents ischemia-reperfusion injury of the steatotic liver in mice. | 2017 | Details |
| A15066 | 29112771 | Clin Exp Pharmacol Physiol | Role of mitochondria and mitochondria-targeted agents in non-alcoholic fatty liver disease. | 2017 | Details |
| A15076 | 29107687 | Biochem Biophys Res Commun | MiR-150 deficiency ameliorated hepatosteatosis and insulin resistance in nonalcoholic fatty liver disease via targeting CASP8 and FADD-like apoptosis regulator. | 2017 | Details |
| A15079 | 29106945 | Metabolism | Activation of the STING-IRF3 pathway promotes hepatocyte inflammation, apoptosis and induces metabolic disorders in nonalcoholic fatty liver disease. | 2017 | Details |
| A15117 | 29086016 | J Gastroenterol | Activation of apoptosis inhibitor of macrophage is a sensitive diagnostic marker for NASH-associated hepatocellular carcinoma. | 2017 | Details |
| A15137 | 29079763 | Sci Rep | Impact of intracellular glyceraldehyde-derived advanced glycation end-products on human hepatocyte cell death. | 2017 | Details |
| A15153 | 29072704 | Cell Death Dis | Inhibition of Caspase-8 does not protect from alcohol-induced liver apoptosis but alleviates alcoholic hepatic steatosis in mice. | 2017 | Details |
| A15155 | 29071867 | Zhongguo Zhong Yao Za Zhi | [Effects of three Wenyang Jianpi Tang on cell proliferation and apoptosis of nonalcoholic fatty liver cells]. | 2017 | Details |
| A15165 | 29065724 | Exp Biol Med (Maywood) | Microcirculatory disturbances and cellular changes during progression of hepatic steatosis to liver tumors. | 2017 | Details |
| A15184 | 29058997 | Annu Rev Pharmacol Toxicol | Nonalcoholic Steatohepatitis (NASH) and Hepatic Fibrosis: Emerging Therapies. | 2017 | Details |
| A15234 | 29031535 | Chem Biol Interact | Baicalin protects AML-12 cells from lipotoxicity via the suppression of ER stress and TXNIP/NLRP3 inflammasome activation. | 2017 | Details |
| A15260 | 29018509 | Oxid Med Cell Longev | circRNA_0046367 Prevents Hepatoxicity of Lipid Peroxidation: An Inhibitory Role against Hepatic Steatosis. | 2017 | Details |
| A15285 | 28987260 | Clin Liver Dis | Treatment Strategies for Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis. | 2017 | Details |
| A15312 | 28971098 | Front Nutr | The Nutraceutic Silybin Counteracts Excess Lipid Accumulation and Ongoing Oxidative Stress in an In Vitro Model of Non-Alcoholic Fatty Liver Disease Progression. | 2017 | Details |
| A15320 | 28968997 | Oncotarget | Dysregulated expression of proteins associated with ER stress, autophagy and apoptosis in tissues from nonalcoholic fatty liver disease. | 2017 | Details |
| A15352 | 28951310 | Gene | Glucose regulated protein 78 is potentially an important player in the development of nonalcoholic steatohepatitis. | 2017 | Details |
| A15395 | 28931802 | Med Sci Monit | Hepatitis C Virus Infection Increases c-Jun N-Terminal Kinase (JNK) Phosphorylation and Accentuates Hepatocyte Lipoapoptosis. | 2017 | Details |
| A15428 | 28918598 | J Bioenerg Biomembr | Triacsin C reduces lipid droplet formation and induces mitochondrial biogenesis in primary rat hepatocytes. | 2017 | Details |
| A15444 | 28904022 | FASEB J | PI3Kγ ablation does not promote diabetes in db/db mice, but improves insulin sensitivity and reduces pancreatic β-cell apoptosis. | 2017 | Details |
| A15459 | 28895929 | Nutrients | Effects of Oral Administration of Silymarin in a Juvenile Murine Model of Non-alcoholic Steatohepatitis. | 2017 | Details |
| A15468 | 28892558 | Hepatology | The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: A randomized, phase 2 trial. | 2017 | Details |
| A15490 | 28878132 | JCI Insight | Therapeutic opportunities for alcoholic steatohepatitis and nonalcoholic steatohepatitis: exploiting similarities and differences in pathogenesis. | 2017 | Details |
| A15494 | 28877220 | PLoS One | Attenuated lipotoxicity and apoptosis is linked to exogenous and endogenous augmenter of liver regeneration by different pathways. | 2017 | Details |
| A15501 | 28874313 | Gastroenterol Hepatol | New therapeutic perspectives in non-alcoholic steatohepatitis. | 2017 | Details |
| A15539 | 28853202 | Liver Int | Ursodeoxycholic acid: Effects on hepatic unfolded protein response, apoptosis and oxidative stress in morbidly obese patients. | 2017 | Details |
| A15545 | 28849786 | Nat Rev Endocrinol | SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology. | 2017 | Details |
| A15595 | 28823369 | Hepatobiliary Pancreat Dis Int | Remote ischemic preconditioning protects liver ischemia-reperfusion injury by regulating eNOS-NO pathway and liver microRNA expressions in fatty liver rats. | 2017 | Details |
| A15643 | 28791501 | J Gastroenterol | Skeletal muscle mass to visceral fat area ratio is an important determinant affecting hepatic conditions of non-alcoholic fatty liver disease. | 2017 | Details |
| A15670 | 28775168 | Cancer Res | JCAD Promotes Progression of Nonalcoholic Steatohepatitis to Liver Cancer by Inhibiting LATS2 Kinase Activity. | 2017 | Details |
| A15678 | 28768719 | FASEB J | The specialized proresolving lipid mediator maresin 1 protects hepatocytes from lipotoxic and hypoxia-induced endoplasmic reticulum stress. | 2017 | Details |
| A15747 | 28730729 | Pediatr Obes | Traffic-related air pollution associations with cytokeratin-18, a marker of hepatocellular apoptosis, in an overweight and obese paediatric population. | 2017 | Details |
| A15810 | 28698650 | Sci Rep | Complementary Role of Fibroblast Growth Factor 21 and Cytokeratin 18 in Monitoring the Different Stages of Nonalcoholic Fatty Liver Disease. | 2017 | Details |