Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Fructose1035 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A18690 | 26997538 | Metabolism | Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease. | 2016 | Details |
| A18746 | 26973390 | World J Gastroenterol | Resveratrol and fenofibrate ameliorate fructose-induced nonalcoholic steatohepatitis by modulation of genes expression. | 2016 | Details |
| A18828 | 26915720 | Gen Physiol Biophys | Hepatoprotective potential of zingerone against nonalcoholic fatty liver disease in rats fed with fructose-enriched diet. | 2016 | Details |
| A18875 | 26890135 | Cell Death Dis | Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease. | 2016 | Details |
| A18915 | 26871756 | Can J Physiol Pharmacol | The ergogenic supplement β-hydroxy-β-methylbutyrate (HMB) attenuates insulin resistance through suppressing GLUT-2 in rat liver. | 2015 | Details |
| A18922 | 26869391 | Life Sci | Fructose consumption induces hypomethylation of hepatic mitochondrial DNA in rats. | 2016 | Details |
| A18939 | 26858714 | Front Microbiol | Ethanol Production by Selected Intestinal Microorganisms and Lactic Acid Bacteria Growing under Different Nutritional Conditions. | 2016 | Details |
| A18945 | 26856717 | Dig Dis Sci | Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease. | 2016 | Details |
| A19001 | 26825546 | Eur J Pharmacol | Effects of combined PPAR-γ and PPAR-α agonist therapy on fructose induced NASH in rats: Modulation of gene expression. | 2016 | Details |
| A19024 | 26814015 | Am J Physiol Endocrinol Metab | Lipotoxicity in steatohepatitis occurs despite an increase in tricarboxylic acid cycle activity. | 2016 | Details |
| A19045 | 26805874 | Nutrients | Docosahexaenoic Acid Ameliorates Fructose-Induced Hepatic Steatosis Involving ER Stress Response in Primary Mouse Hepatocytes. | 2016 | Details |
| A19103 | 26764184 | Gastroenterology | Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles From Hepatocytes. | 2016 | Details |
| A19143 | 26730275 | World J Hepatol | Management of non-alcoholic fatty liver disease in 2015. | 2015 | Details |
| A19190 | 28332698 | Mol Med | Induction of steatohepatitis (NASH) with insulin resistance in wildtype B6 mice by a western-type diet containing soybean oil and cholesterol. | 2017 | Details |
| A19256 | 26670487 | Am J Physiol Endocrinol Metab | Metabolic phenotype and adipose and liver features in a high-fat Western diet-induced mouse model of obesity-linked NAFLD. | 2015 | Details |
| A19271 | 26663351 | Hepatology | Diet, weight loss, and liver health in nonalcoholic fatty liver disease: Pathophysiology, evidence, and practice. | 2016 | Details |
| A19383 | 26597784 | Biochim Biophys Acta | Vitamin A deficiency suppresses high fructose-induced triglyceride synthesis and elevates resolvin D1 levels. | 2015 | Details |
| A19385 | 26597602 | J Diabetes Complications | Chronic fructose intake accelerates non-alcoholic fatty liver disease in the presence of essential hypertension. | 2015 | Details |
| A19390 | 26593707 | Eur J Pharmacol | Betaine prevented fructose-induced NAFLD by regulating LXRα/PPARα pathway and alleviating ER stress in rats. | 2015 | Details |
| A19408 | 26586275 | Prog Cardiovasc Dis | The Evidence for Saturated Fat and for Sugar Related to Coronary Heart Disease. | 2015 | Details |
| A19412 | 26583036 | Nutr Metab (Lond) | Comparative study of the modulation of fructose/sucrose-induced hepatic steatosis by mixed lipid formulations varying in unsaturated fatty acid content. | 2015 | Details |
| A19462 | 26556368 | Nutrients | Nutritional Modulation of Non-Alcoholic Fatty Liver Disease and Insulin Resistance. | 2015 | Details |
| A19495 | 26523205 | World J Hepatol | Dietary approach in the treatment of nonalcoholic fatty liver disease. | 2015 | Details |
| A19572 | 26476631 | Eur J Nutr | A possible link between hepatic mitochondrial dysfunction and diet-induced insulin resistance. | 2016 | Details |
| A19587 | 26472223 | Am J Physiol Gastrointest Liver Physiol | Hepatocyte X-box binding protein 1 deficiency increases liver injury in mice fed a high-fat/sugar diet. | 2015 | Details |
| A19655 | 26435020 | Bratisl Lek Listy | Petroselinum crispum extract attenuates hepatic steatosis in rats fed with fructose enriched diet. | 2015 | Details |
| A19658 | 26432021 | Trends Mol Med | Emerging Liver-Kidney Interactions in Nonalcoholic Fatty Liver Disease. | 2015 | Details |
| A19698 | 26405708 | J Gastrointestin Liver Dis | Hype or Reality: Should Patients with Metabolic Syndrome-related NAFLD be on the Hunter-Gatherer (Paleo) Diet to Decrease Morbidity? | 2015 | Details |
| A19903 | 26273656 | Biomed Res Int | Fructose-Drinking Water Induced Nonalcoholic Fatty Liver Disease and Ultrastructural Alteration of Hepatocyte Mitochondria in Male Wistar Rat. | 2015 | Details |
| A19922 | 26264689 | Proc Nutr Soc | Dietary carbohydrate and control of hepatic gene expression: mechanistic links from ATP and phosphate ester homeostasis to the carbohydrate-response element-binding protein. | 2015 | Details |
| A19950 | 26246323 | J Nutr | Citrulline and Nonessential Amino Acids Prevent Fructose-Induced Nonalcoholic Fatty Liver Disease in Rats. | 2015 | Details |
| A19952 | 26244072 | Nutr Res Pract | Characteristics of nonalcoholic fatty liver disease induced in wistar rats following four different diets. | 2015 | Details |
| A19994 | 26216400 | J Proteome Res | Effects of Dietary Different Doses of Copper and High Fructose Feeding on Rat Fecal Metabolome. | 2015 | Details |
| A20007 | 26211668 | Endocr J | A case of insulinoma with non-alcoholic fatty liver disease: Roles of hyperphagia and hyperinsulinemia in pathogenesis of the disease. | 2015 | Details |
| A20015 | 26203597 | Curr Opin Clin Nutr Metab Care | Fructose and liver function--is this behind nonalcoholic liver disease? | 2015 | Details |
| A20083 | 26168700 | J Nutr Biochem | Diets rich in fructose, fat or fructose and fat alter intestinal barrier function and lead to the development of nonalcoholic fatty liver disease over time. | 2015 | Details |
| A20118 | 26143342 | Dig Dis Sci | Lactobacillus paracasei Induces M2-Dominant Kupffer Cell Polarization in a Mouse Model of Nonalcoholic Steatohepatitis. | 2015 | Details |
| A20186 | 26098879 | PLoS One | Fructose Mediated Non-Alcoholic Fatty Liver Is Attenuated by HO-1-SIRT1 Module in Murine Hepatocytes and Mice Fed a High Fructose Diet. | 2015 | Details |
| A20192 | 26090514 | ScientificWorldJournal | Histologic and Metabolic Derangement in High-Fat, High-Fructose, and Combination Diet Animal Models. | 2015 | Details |
| A20195 | 26090419 | Biomed Res Int | Individual CLA Isomers, c9t11 and t10c12, Prevent Excess Liver Glycogen Storage and Inhibit Lipogenic Genes Expression Induced by High-Fructose Diet in Rats. | 2015 | Details |
| A20245 | 26064924 | Biomed Res Int | Nonalcoholic Steatohepatitis: A Search for Factual Animal Models. | 2015 | Details |
| A20313 | 26033743 | J Nutr Biochem | Nutrigenomics analysis reveals that copper deficiency and dietary sucrose up-regulate inflammation, fibrosis and lipogenic pathways in a mature rat model of nonalcoholic fatty liver disease. | 2015 | Details |
| A20319 | 26031413 | Hepatol Res | Emodin ameliorates hepatic steatosis through endoplasmic reticulum-stress sterol regulatory element-binding protein 1c pathway in liquid fructose-feeding rats. | 2015 | Details |
| A20358 | 26017539 | PLoS One | Mouse models of diet-induced nonalcoholic steatohepatitis reproduce the heterogeneity of the human disease. | 2015 | Details |
| A20364 | 26015548 | Diabetes | Growth Hormone Inhibits Hepatic De Novo Lipogenesis in Adult Mice. | 2015 | Details |
| A20372 | 26005677 | Hepatobiliary Surg Nutr | Carbohydrate intake and nonalcoholic fatty liver disease: fructose as a weapon of mass destruction. | 2015 | Details |
| A20383 | 26000287 | Biomed Res Int | Inhibitory effects of eucalyptus and banaba leaf extracts on nonalcoholic steatohepatitis induced by a high-fructose/high-glucose diet in rats. | 2015 | Details |
| A20400 | 25992705 | Proc Nutr Soc | Relevance of liver fat to the impact of dietary extrinsic sugars on lipid metabolism. | 2015 | Details |
| A20478 | 25935852 | Clin Nutr | Investigating the effects of an oral fructose challenge on hepatic ATP reserves in healthy volunteers: A (31)P MRS study. | 2015 | Details |
| A20535 | 25905791 | Food Funct | Differences and similarities in hepatic lipogenesis, gluconeogenesis and oxidative imbalance in mice fed diets rich in fructose or sucrose. | 2015 | Details |
| A20579 | 25875119 | Nutrients | A green algae mixture of Scenedesmus and Schroederiella attenuates obesity-linked metabolic syndrome in rats. | 2015 | Details |
| A20620 | 25848481 | World J Hepatol | Role of diet on non-alcoholic fatty liver disease: An updated narrative review. | 2015 | Details |
| A20654 | 25829790 | Pharmacognosy Res | Psidium guajava Linn. leaf extract affects hepatic glucose transporter-2 to attenuate early onset of insulin resistance consequent to high fructose intake: An experimental study. | 2015 | Details |
| A20746 | 25759243 | Toxicol Appl Pharmacol | Oligofructose protects against arsenic-induced liver injury in a model of environment/obesity interaction. | 2015 | Details |
| A20779 | 25740151 | Biol Rev Camb Philos Soc | De novo lipogenesis in the liver in health and disease: more than just a shunting yard for glucose. | 2015 | Details |
| A20787 | 25736031 | Clin Nutr | Effect of specific amino acids on hepatic lipid metabolism in fructose-induced non-alcoholic fatty liver disease. | 2015 | Details |
| A20852 | 25684943 | World J Gastroenterol | In vitro identification of nonalcoholic fatty liver disease-related protein hnRNPM. | 2015 | Details |
| A20910 | 25648511 | Mar Drugs | Seaweed supplements normalise metabolic, cardiovascular and liver responses in high-carbohydrate, high-fat fed rats. | 2015 | Details |
| A20926 | 25637246 | Mol Genet Metab | Aldolase-B knockout in mice phenocopies hereditary fructose intolerance in humans. | 2015 | Details |
| A20936 | 25632182 | World J Gastroenterol | Novel insights into the mechanisms whereby isoflavones protect against fatty liver disease. | 2015 | Details |
| A20985 | 25602171 | Antioxid Redox Signal | Reactive oxygen species-induced TXNIP drives fructose-mediated hepatic inflammation and lipid accumulation through NLRP3 inflammasome activation. | 2015 | Details |
| A21011 | 25577467 | J Nutr Biochem | Saturated fat and cholesterol are critical to inducing murine metabolic syndrome with robust nonalcoholic steatohepatitis. | 2014 | Details |
| A21014 | 25576095 | J Nutr Biochem | Maternal taurine supplementation attenuates maternal fructose-induced metabolic and inflammatory dysregulation and partially reverses adverse metabolic programming in offspring. | 2014 | Details |
| A21083 | 25544875 | World J Hepatol | Involvement of the TAGE-RAGE system in non-alcoholic steatohepatitis: Novel treatment strategies. | 2014 | Details |
| A21111 | 25533006 | Nutrients | Simple sugar intake and hepatocellular carcinoma: epidemiological and mechanistic insight. | 2014 | Details |
| A21158 | 25514388 | Nutrients | The role of dietary sugars and de novo lipogenesis in non-alcoholic fatty liver disease. | 2014 | Details |
| A21214 | 25476828 | Life Sci | Chronic intermittent hypobaric hypoxia ameliorates endoplasmic reticulum stress mediated liver damage induced by fructose in rats. | 2014 | Details |
| A21259 | 25450719 | J Hepatol | Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine. | 2014 | Details |
| A21269 | 25445398 | J Hepatol | TRAIL receptor deletion in mice suppresses the inflammation of nutrient excess. | 2014 | Details |
| A21282 | 28664097 | Integr Med Res | Practical approaches to the nutritional management of nonalcoholic fatty liver disease. | 2014 | Details |
| A21288 | 25430922 | Pharm Biol | A novel animal model of metabolic syndrome with non-alcoholic fatty liver disease and skin inflammation. | 2014 | Details |
| A21312 | 25413450 | Metab Brain Dis | Low-grade chronic inflammation induces behavioral stereotypy in rats. | 2014 | Details |
| A21388 | 25353664 | Nutrients | Non-alcoholic fatty liver disease in children: focus on nutritional interventions. | 2014 | Details |
| A21425 | 25328713 | Int J Hepatol | Fructose induced endotoxemia in pediatric nonalcoholic Fatty liver disease. | 2014 | Details |
| A21589 | 25203709 | Zhonghua Gan Zang Bing Za Zhi | [Development and evaluation of a high-fat/high-fructose diet-induced nonalcoholic steatohepatitis mouse model]. | 2014 | Details |
| A21698 | 25111123 | Nutrients | Dietary fructose reduction improves markers of cardiovascular disease risk in Hispanic-American adolescents with NAFLD. | 2014 | Details |
| A21714 | 25099548 | Am J Clin Nutr | Higher fructose intake is inversely associated with risk of nonalcoholic fatty liver disease in older Finnish adults. | 2014 | Details |
| A21715 | 25099546 | Am J Clin Nutr | Fructose, high-fructose corn syrup, sucrose, and nonalcoholic fatty liver disease or indexes of liver health: a systematic review and meta-analysis. | 2014 | Details |
| A21792 | 25043405 | Hepatology | Fructose leads to hepatic steatosis in zebrafish that is reversed by mechanistic target of rapamycin (mTOR) inhibition. | 2014 | Details |
| A21817 | 25024607 | World J Gastroenterol | High fat diet feeding results in gender specific steatohepatitis and inflammasome activation. | 2014 | Details |
| A21897 | 24975050 | Basic Clin Pharmacol Toxicol | Effects of antihypertensive and triglyceride-lowering agents on hepatic copper concentrations in rats with fatty liver disease. | 2014 | Details |
| A21909 | 24968200 | Br J Nutr | Beneficial effects of soluble dietary Jerusalem artichoke (Helianthus tuberosus) in the prevention of the onset of type 2 diabetes and non-alcoholic fatty liver disease in high-fructose diet-fed rats. | 2014 | Details |
| A21926 | 24961681 | Pediatr Obes | Oral fructose absorption in obese children with non-alcoholic fatty liver disease. | 2014 | Details |
| A22016 | 24887549 | Int J Biol Macromol | Hypoglycemic and hepatoprotective effects of polysaccharides from Artemisia sphaerocephala Krasch seeds. | 2014 | Details |
| A22021 | 24875360 | Biochem Biophys Res Commun | Activation of farnesoid X receptor (FXR) protects against fructose-induced liver steatosis via inflammatory inhibition and ADRP reduction. | 2014 | Details |
| A22028 | 24868294 | Prz Gastroenterol | Dietary recommendations for patients with nonalcoholic fatty liver disease. | 2014 | Details |
| A22105 | 24816759 | Horm Metab Res | Effect of fructose and 3,5-diiodothyronine (3,5-T(2)) on lipid accumulation and insulin signalling in non-alcoholic fatty liver disease (NAFLD)-like rat primary hepatocytes. | 2014 | Details |
| A22107 | 24816278 | PLoS One | Lactoferrin dampens high-fructose corn syrup-induced hepatic manifestations of the metabolic syndrome in a murine model. | 2014 | Details |
| A22121 | 24799990 | World J Hepatol | Pediatric non-alcoholic fatty liver disease: New insights and future directions. | 2014 | Details |
| A22227 | 24739055 | Clin Exp Pharmacol Physiol | Toll-like receptor-4 signalling in the progression of non-alcoholic fatty liver disease induced by high-fat and high-fructose diet in mice. | 2014 | Details |
| A22257 | 24715054 | Neurol Sci | The association between seizure predisposition and inflammation in a rat model of fatty liver disease. | 2014 | Details |
| A22262 | 24708895 | Br J Nutr | Effect of tryptophan supplementation on diet-induced non-alcoholic fatty liver disease in mice. | 2014 | Details |
| A22342 | 24650559 | Am J Pathol | Development of hepatocellular carcinoma in a murine model of nonalcoholic steatohepatitis induced by use of a high-fat/fructose diet and sedentary lifestyle. | 2014 | Details |
| A22353 | 24645313 | Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi | [Activation of Kupffer cell and related signal pathway proteins in the liver of high fat and high fructose diet induced NAFLD mice]. | 2013 | Details |
| A22389 | 24626737 | Food Funct | A diet formula of Puerariae radix, Lycium barbarum, Crataegus pinnatifida, and Polygonati rhizoma alleviates insulin resistance and hepatic steatosis in CD-1 mice and HepG2 cells. | 2014 | Details |
| A22424 | 24587658 | World J Gastroenterol | Diet high in fructose leads to an overexpression of lipocalin-2 in rat fatty liver. | 2014 | Details |
| A22446 | 24569542 | Eur J Clin Nutr | Effect of fructose on markers of non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of controlled feeding trials. | 2014 | Details |
| A22453 | 24558989 | Nutr Hosp | [Fructose consumption and its health implications; fructose malabsorption and nonalcoholic fatty liver disease]. | 2014 | Details |
| A22461 | 24550584 | Indian J Pharmacol | Combination of vildagliptin and rosiglitazone ameliorates nonalcoholic fatty liver disease in C57BL/6 mice. | 2014 | Details |
| A22490 | 24519932 | J Biol Chem | Glucose transporter 8 (GLUT8) mediates fructose-induced de novo lipogenesis and macrosteatosis. | 2014 | Details |