Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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oxidative stress3585 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A07274 | 32558346 | Liver Int | Oxidative stress is associated with suspected non-alcoholic fatty liver disease and all-cause mortality in the general population. | 2020 | Details |
| A07282 | 32556446 | Eur J Nutr | S-allylmercaptocysteine improves nonalcoholic steatohepatitis by enhancing AHR/NRF2-mediated drug metabolising enzymes and reducing NF-κB/IκBα and NLRP3/6-mediated inflammation. | 2020 | Details |
| A07299 | 32550751 | World J Gastroenterol | Post-transplant diabetes mellitus and preexisting liver disease - a bidirectional relationship affecting treatment and management. | 2020 | Details |
| A07306 | 32546444 | Dig Liver Dis | Increased risk of acute liver failure by pain killer drugs in NAFLD: Focus on nuclear receptors and their coactivators. | 2020 | Details |
| A07336 | 32531941 | Nutrients | Poor Adherence to Mediterranean Diet and Serum Lipopolysaccharide are Associated with Oxidative Stress in Patients with Non-Alcoholic Fatty Liver Disease. | 2020 | Details |
| A07340 | 32531370 | Int J Biol Macromol | The protective effects of walnut green husk polysaccharide on liver injury, vascular endothelial dysfunction and disorder of gut microbiota in high fructose-induced mice. | 2020 | Details |
| A07348 | 32529694 | Mol Nutr Food Res | Resveratrol Alleviates Endoplasmic Reticulum Stress-Associated Hepatic Steatosis and Injury in Mice Challenged with Tunicamycin. | 2020 | Details |
| A07355 | 32526850 | Molecules | The Potential Therapeutic Value of Medicinal Plants in the Management of Metabolic Disorders. | 2020 | Details |
| A07356 | 32526845 | Int J Mol Sci | N-Acetylcysteine Reduced Ischemia and Reperfusion Damage Associated with Steatohepatitis in Mice. | 2020 | Details |
| A07362 | 32526241 | Eur J Pharmacol | Berbamine induced AMPK activation regulates mTOR/SREBP-1c axis and Nrf2/ARE pathway to allay lipid accumulation and oxidative stress in steatotic HepG2 cells. | 2020 | Details |
| A07371 | 32523319 | World J Gastroenterol | Association between non-alcoholic fatty liver disease and obstructive sleep apnea. | 2020 | Details |
| A07385 | 32518275 | Sci Rep | The PPAR α/γ Agonist Saroglitazar Improves Insulin Resistance and Steatohepatitis in a Diet Induced Animal Model of Nonalcoholic Fatty Liver Disease. | 2020 | Details |
| A07409 | 32512191 | Biochim Biophys Acta Mol Basis Dis | Extracellular vesicles derived from fat-laden hepatocytes undergoing chemical hypoxia promote a pro-fibrotic phenotype in hepatic stellate cells. | 2020 | Details |
| A07420 | 32507446 | Complement Ther Med | A pilot study of the effect of curcumin on epigenetic changes and DNA damage among patients with non-alcoholic fatty liver disease: A randomized, double-blind, placebo-controlled, clinical trial. | 2020 | Details |
| A07421 | 32507439 | Complement Ther Med | Effects of garlic powder supplementation on insulin resistance, oxidative stress, and body composition in patients with non-alcoholic fatty liver disease: A randomized controlled clinical trial. | 2020 | Details |
| A07423 | 32506513 | J Gastroenterol Hepatol | Use of metabolic syndrome severity to assess treatment with vitamin E and pioglitazone for non-alcoholic steatohepatitis. | 2020 | Details |
| A07473 | 32482167 | BMC Complement Med Ther | Genistein and exercise modulated lipid peroxidation and improved steatohepatitis in ovariectomized rats. | 2020 | Details |
| A07476 | 32481552 | Nutrients | Oxidative Stress Management in Chronic Liver Diseases and Hepatocellular Carcinoma. | 2020 | Details |
| A07481 | 32477116 | Front Pharmacol | Herbal Medicine in the Treatment of Non-Alcoholic Fatty Liver Diseases-Efficacy, Action Mechanism, and Clinical Application. | 2020 | Details |
| A07493 | 32475638 | Biochem Biophys Res Commun | Fucoxanthin inhibits hepatic oxidative stress, inflammation, and fibrosis in diet-induced nonalcoholic steatohepatitis model mice. | 2020 | Details |
| A07510 | 32463484 | Hepatology | Protective and Detrimental Roles of p38α Mitogen-Activated Protein Kinase in Different Stages of Nonalcoholic Fatty Liver Disease. | 2020 | Details |
| A07521 | 32460191 | Biomed Pharmacother | Sodium acetate-mediated inhibition of histone deacetylase alleviates hepatic lipid dysregulation and its accompanied injury in streptozotocin-nicotinamide-induced diabetic rats. | 2020 | Details |
| A07548 | 32446270 | Br J Pharmacol | Astaxanthin attenuates hepatic damage and mitochondrial dysfunction in non-alcoholic fatty liver disease by up-regulating the FGF21/PGC-1α pathway. | 2020 | Details |
| A07551 | 32445755 | Toxicol Appl Pharmacol | PBPK modeling of impact of nonalcoholic fatty liver disease on toxicokinetics of perchloroethylene in mice. | 2020 | Details |
| A07559 | 32443660 | Nutrients | Gallic Acid Inhibits Lipid Accumulation via AMPK Pathway and Suppresses Apoptosis and Macrophage-Mediated Inflammation in Hepatocytes. | 2020 | Details |
| A07566 | 32440840 | J Nephrol | Therapeutic implications of shared mechanisms in non-alcoholic fatty liver disease and chronic kidney disease. | 2020 | Details |
| A07578 | 32437790 | Life Sci | Ginsenoside Rg1 protects against d-galactose induced fatty liver disease in a mouse model via FOXO1 transcriptional factor. | 2020 | Details |
| A07602 | 32428560 | Biochim Biophys Acta Mol Basis Dis | Mitochondrial dysfunction in metabolic syndrome. | 2020 | Details |
| A07631 | 32414691 | J Pharmacol Sci | Capsaicinoid nonivamide improves nonalcoholic fatty liver disease in rats fed a high-fat diet. | 2020 | Details |
| A07643 | 32410680 | Lipids Health Dis | Hepatic steatosis induced in C57BL/6 mice by a non-ß oxidizable fatty acid analogue is associated with reduced plasma kynurenine metabolites and a modified hepatic NAD+/NADH ratio. | 2020 | Details |
| A07651 | 32408667 | Int J Environ Res Public Health | The Bisphenol A Induced Oxidative Stress in Non-Alcoholic Fatty Liver Disease Male Patients: A Clinical Strategy to Antagonize the Progression of the Disease. | 2020 | Details |
| A07667 | 32403305 | Antioxidants (Basel) | The Hepatoprotective Effect of Taurisolo, a Nutraceutical Enriched in Resveratrol and Polyphenols, Involves Activation of Mitochondrial Metabolism in Mice Liver. | 2020 | Details |
| A07685 | 32390839 | Front Pharmacol | Hepatoprotective and Anti-Oxidative Effects of Total Flavonoids From Qu Zhi Qiao (Fruit of Citrus Paradisi cv.Changshanhuyou) on Nonalcoholic Steatohepatitis In Vivo and In Vitro Through Nrf2-ARE Signaling Pathway. | 2020 | Details |
| A07689 | 32390455 | Antioxid Redox Signal | Intestinal Dysbiosis and Development of Cardiometabolic Disorders in Childhood Cancer Survivors: A Critical Review. | 2020 | Details |
| A07696 | 32388251 | J Nutr Biochem | Olanzapine-induced liver injury in mice: aggravation by high-fat diet and protection with sulforaphane. | 2020 | Details |
| A07698 | 32387861 | Biomed Pharmacother | 2,3,5,4'-tetrahydroxystilbence-2-O-β-D-glucoside attenuates hepatic steatosis via IKKβ/NF-κB and Keap1-Nrf2 pathways in larval zebrafish. | 2020 | Details |
| A07709 | 32382414 | Biomed Rep | Diet induces hepatocyte protection in fatty liver disease via modulation of PTEN signaling. | 2020 | Details |
| A07725 | 32375340 | Int J Mol Sci | Coenzyme Q10 Supplementation Improves Adipokine Levels and Alleviates Inflammation and Lipid Peroxidation in Conditions of Metabolic Syndrome: A Meta-Analysis of Randomized Controlled Trials. | 2020 | Details |
| A07726 | 32375182 | Horm Metab Res | Liraglutide Ameliorates Lipotoxicity-Induced Oxidative Stress by Activating the NRF2 Pathway in HepG2 Cells. | 2020 | Details |
| A07735 | 32371503 | BMJ Open Gastroenterol | SIRT1-dependent mechanisms and effects of resveratrol for amelioration of muscle wasting in NASH mice. | 2020 | Details |
| A07738 | 32369900 | J Clin Med | Inhibition of Protein-tyrosine Phosphatase PTP1B and LMPTP Promotes Palmitate/Oleate-challenged HepG2 Cell Survival by Reducing Lipoapoptosis, Improving Mitochondrial Dynamics and Mitigating Oxidative and Endoplasmic Reticulum Stress. | 2020 | Details |
| A07745 | 32366854 | Sci Rep | Novel Combinatorial Regimen of Garcinol and Curcuminoids for Non-alcoholic Steatohepatitis (NASH) in Mice. | 2020 | Details |
| A07748 | 32365632 | Cells | L-Selectin/CD62L is a Key Driver of Non-Alcoholic Steatohepatitis in Mice and Men. | 2020 | Details |
| A07787 | 32354880 | In Vivo | Pathophysiological Changes During Ischemia-reperfusion Injury in Rodent Hepatic Steatosis. | 2021 | Details |
| A07826 | 32343398 | Br J Pharmacol | Cyanidin-3-O-glucoside improves non-alcoholic fatty liver disease by promoting PINK1-mediated mitophagy in mice. | 2020 | Details |
| A07860 | 32331364 | Cells | The Emerging Role of MicroRNAs in NAFLD: Highlight of MicroRNA-29a in Modulating Oxidative Stress, Inflammation, and Beyond. | 2020 | Details |
| A07861 | 32331258 | Nutrients | Lemon Balm and Its Constituent, Rosmarinic Acid, Alleviate Liver Damage in an Animal Model of Nonalcoholic Steatohepatitis. | 2020 | Details |
| A07862 | 32330605 | J Hepatol | TGF-β1-driven reduction of cytoglobin leads to oxidative DNA damage in stellate cells during non-alcoholic steatohepatitis. | 2020 | Details |
| A07865 | 32330379 | Cell Physiol Biochem | Genistein and 17β-Estradiol Protect Hepatocytes from Fatty Degeneration by Mechanisms Involving Mitochondria, Inflammasome and Kinases Activation. | 2020 | Details |
| A07901 | 32317079 | BMB Rep | GPx7 ameliorates non-alcoholic steatohepatitis by regulating oxidative stress. | 2020 | Details |
| A07906 | 32315893 | Nutr Res | Siphonaxanthin, a carotenoid from green algae Codium cylindricum, protects Ob/Ob mice fed on a high-fat diet against lipotoxicity by ameliorating somatic stresses and restoring anti-oxidative capacity. | 2020 | Details |
| A07907 | 32315005 | Food Funct | Alleviating effects of noni fruit polysaccharide on hepatic oxidative stress and inflammation in rats under a high-fat diet and its possible mechanisms. | 2020 | Details |
| A07917 | 32311490 | Free Radic Biol Med | Targeting DUSP7 signaling alleviates hepatic steatosis, inflammation and oxidative stress in high fat diet (HFD)-fed mice via suppression of TAK1. | 2020 | Details |
| A07922 | 32308060 | Free Radic Res | Emerging connections between oxidative stress, defective proteolysis, and metabolic diseases. | 2020 | Details |
| A07938 | 32304952 | Environ Pollut | Exposure to 2,3,3',4,4',5-hexachlorobiphenyl promotes nonalcoholic fatty liver disease development in C57BL/6 mice. | 2020 | Details |
| A07939 | 32304762 | Life Sci | ApoE deficiency promotes non-alcoholic fatty liver disease in mice via impeding AMPK/mTOR mediated autophagy. | 2020 | Details |
| A07943 | 32303170 | Curr Pharm Des | Hepatoprotective Effects of Resveratrol in Non-Alcoholic Fatty Live Disease. | 2021 | Details |
| A07973 | 32293113 | J Cell Mol Med | Geniposide alleviates non-alcohol fatty liver disease via regulating Nrf2/AMPK/mTOR signalling pathways. | 2020 | Details |
| A07995 | 32284169 | Biochem Biophys Res Commun | Effect of methionine/choline-deficient diet and high-fat diet-induced steatohepatitis on mitochondrial homeostasis in mice. | 2020 | Details |
| A07996 | 32284046 | Lipids Health Dis | Mutual interaction between endoplasmic reticulum and mitochondria in nonalcoholic fatty liver disease. | 2020 | Details |
| A08002 | 32283070 | Chem Biol Interact | Role of epidermal growth factor receptor in liver injury and lipid metabolism: Emerging new roles for an old receptor. | 2020 | Details |
| A08041 | 32272794 | Animals (Basel) | Identification of Crucial Genetic Factors, Such as PPARγ, that Regulate the Pathogenesis of Fatty Liver Disease in Dairy Cows Is Imperative for the Sustainable Development of Dairy Industry. | 2020 | Details |
| A08059 | 32265720 | Front Pharmacol | The Impacts of Herbal Medicines and Natural Products on Regulating the Hepatic Lipid Metabolism. | 2020 | Details |
| A08077 | 32256346 | Front Pharmacol | Hepatoprotective Effect of Cranberry Nutraceutical Extract in Non-alcoholic Fatty Liver Model in Rats: Impact on Insulin Resistance and Nrf-2 Expression. | 2020 | Details |
| A08084 | 32253274 | J Am Soc Nephrol | Fructose Production and Metabolism in the Kidney. | 2020 | Details |
| A08098 | 32245940 | Med Sci Monit | Ganoderma Lucidum Polysaccharides Ameliorates Hepatic Steatosis and Oxidative Stress in db/db Mice via Targeting Nuclear Factor E2 (Erythroid-Derived 2)-Related Factor-2/Heme Oxygenase-1 (HO-1) Pathway. | 2020 | Details |
| A08101 | 32245586 | Chin J Nat Med | Selenium-enriched Bifidobacterium longum protected alcohol and high fat diet induced hepatic injury in mice. | 2020 | Details |
| A08104 | 32245205 | Int J Mol Sci | Combined Treatment with Sodium-Glucose Cotransporter-2 Inhibitor (Canagliflozin) and Dipeptidyl Peptidase-4 Inhibitor (Teneligliptin) Alleviates NASH Progression in A Non-Diabetic Rat Model of Steatohepatitis. | 2020 | Details |
| A08116 | 32240928 | Phytomedicine | Phytotherapy using blueberry leaf polyphenols to alleviate non-alcoholic fatty liver disease through improving mitochondrial function and oxidative defense. | 2020 | Details |
| A08119 | 32240652 | Biochem Pharmacol | Pyrvinium pamoate attenuates non-alcoholic steatohepatitis: Insight on hedgehog/Gli and Wnt/β-catenin signaling crosstalk. | 2020 | Details |
| A08138 | 32231762 | World J Hepatol | High omega arachidonic acid/docosahexaenoic acid ratio induces mitochondrial dysfunction and altered lipid metabolism in human hepatoma cells. | 2020 | Details |
| A08158 | 32223569 | Arch Physiol Biochem | Crosstalk between kidney and liver in non-alcoholic fatty liver disease: mechanisms and therapeutic approaches. | 2020 | Details |
| A08169 | 32220030 | J Biochem Mol Toxicol | Chrysin ameliorates hepatic steatosis induced by a diet deficient in methionine and choline by inducing the secretion of hepatocyte nuclear factor 4α-dependent very low-density lipoprotein. | 2020 | Details |
| A08174 | 32218179 | Biomolecules | A Sweet Connection? Fructose's Role in Hepatocellular Carcinoma. | 2020 | Details |
| A08181 | 32217100 | Biochem Pharmacol | Modulation of SIRT1-mediated signaling cascades in the liver contributes to the amelioration of nonalcoholic steatohepatitis in high fat fed middle-aged LDL receptor knockout mice by dihydromyricetin. | 2020 | Details |
| A08188 | 32213662 | Aging (Albany NY) | Role of mitochondrial quality control in the pathogenesis of nonalcoholic fatty liver disease. | 2020 | Details |
| A08195 | 32210914 | Front Endocrinol (Lausanne) | The Atypical Cannabinoid Abn-CBD Reduces Inflammation and Protects Liver, Pancreas, and Adipose Tissue in a Mouse Model of Prediabetes and Non-alcoholic Fatty Liver Disease. | 2020 | Details |
| A08197 | 32209476 | Cell Rep | OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation. | 2020 | Details |
| A08264 | 32181656 | J Agric Food Chem | Ginsenoside Rg2 Ameliorates High-Fat Diet-Induced Metabolic Disease through SIRT1. | 2020 | Details |
| A08275 | 32171848 | Chem Biol Interact | Sphingolipids and the link between alcohol and cancer. | 2020 | Details |
| A08283 | 32169759 | Biomed Pharmacother | Gegen Qinlian Decoction abates nonalcoholic steatohepatitis associated liver injuries via anti-oxidative stress and anti-inflammatory response involved inhibition of toll-like receptor 4 signaling pathways. | 2020 | Details |
| A08307 | 32158345 | Malays J Med Sci | Anti-Hypolipidemic and Anti-Oxidative Effects of Hydroalcoholic Extract of Origanum majorana on the Hepatosteatosis Induced with High-Fat Diet in Rats. | 2020 | Details |
| A08308 | 32158249 | Clin Exp Gastroenterol | Effect of Ginger Powder Supplementation in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial. | 2020 | Details |
| A08312 | 32156524 | Free Radic Biol Med | Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease. | 2020 | Details |
| A08328 | 32151552 | Surg Obes Relat Dis | Management of nonalcoholic fatty liver disease and the role of bariatric surgery: a brief review for surgeons. | 2020 | Details |
| A08363 | 32143527 | Nutrients | The Effects of Endoplasmic-Reticulum-Resident Selenoproteins in a Nonalcoholic Fatty Liver Disease Pig Model Induced by a High-Fat Diet. | 2020 | Details |
| A08376 | 32138593 | Prion | The role of cellular prion protein in lipid metabolism in the liver. | 2020 | Details |
| A08399 | 32124935 | Int J Mol Med | CYP4A11 is involved in the development of nonalcoholic fatty liver disease via ROS‑induced lipid peroxidation and inflammation. | 2020 | Details |
| A08401 | 32124686 | Curr Med Chem | The Effect of CB1 Antagonism on Hepatic Oxidative/Nitrosative Stress and Inflammation in Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A08423 | 32116684 | Front Pharmacol | Corilagin Alleviates Nonalcoholic Fatty Liver Disease in High-Fat Diet-Induced C57BL/6 Mice by Ameliorating Oxidative Stress and Restoring Autophagic Flux. | 2020 | Details |
| A08424 | 32116659 | Front Pharmacol | Five Constituents in Psoralea corylifolia L. Attenuate Palmitic Acid-Induced Hepatocyte Injury via Inhibiting the Protein Kinase C-α/Nicotinamide-Adenine Dinucleotide Phosphate Oxidase Pathway. | 2020 | Details |
| A08428 | 32115688 | Int J Cancer | Defects in long-chain 3-hydroxy acyl-CoA dehydrogenase lead to hepatocellular carcinoma: A novel etiology of hepatocellular carcinoma. | 2020 | Details |
| A08450 | 32105829 | Free Radic Biol Med | 17β-estradiol ameliorates lipotoxicity-induced hepatic mitochondrial oxidative stress and insulin resistance. | 2020 | Details |
| A08461 | 32102936 | Sci Transl Med | Liver macrophages inhibit the endogenous antioxidant response in obesity-associated insulin resistance. | 2020 | Details |
| A08468 | 32099613 | Gastroenterol Hepatol Bed Bench | Effects of high fat medium conditions on cellular gene expression profile: a network analysis approach. | 2019 | Details |
| A08476 | 32095444 | Clin Nutr Res | Effects of Quercetin Supplementation on Hematological Parameters in Non-Alcoholic Fatty Liver Disease: a Randomized, Double-Blind, Placebo-Controlled Pilot Study. | 2020 | Details |
| A08482 | 32092735 | Biomed Res | Placental extract ameliorates liver fibrosis in a methionine- and choline-deficient diet-induced mouse model of non-alcoholic steatohepatitis. | 2020 | Details |
| A08483 | 32092316 | Clin Chim Acta | Bnip3 in mitophagy: Novel insights and potential therapeutic target for diseases of secondary mitochondrial dysfunction. | 2020 | Details |
| A08497 | 32086249 | Biol Open | Long-term sucrose solution consumption causes metabolic alterations and affects hepatic oxidative stress in Wistar rats. | 2020 | Details |
| A08501 | 32084378 | Cell Metab | Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly. | 2020 | Details |