Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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insulin resistance7794 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A52162 | 30551378 | Biomed Pharmacother | A novel recombinant peptide INSR-IgG4Fc (Yiminsu) restores insulin sensitivity in experimental insulin resistance models. | 2018 | Details |
| A52170 | 30464235 | Int J Obes (Lond) | Very low calorie diets are associated with transient ventricular impairment before reversal of diastolic dysfunction in obesity. | 2018 | Details |
| A52172 | 30429322 | Proc Natl Acad Sci U S A | Obesity-associated exosomal miRNAs modulate glucose and lipid metabolism in mice. | 2018 | Details |
| A52173 | 30425250 | Nat Commun | Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN. | 2018 | Details |
| A52174 | 30423963 | Nutrients | Ursolic Acid Attenuates Hepatic Steatosis, Fibrosis, and Insulin Resistance by Modulating the Circadian Rhythm Pathway in Diet-Induced Obese Mice. | 2018 | Details |
| A52178 | 30379219 | Clinics (Sao Paulo) | α-Linolenic acid prevents hepatic steatosis and improves glucose tolerance in mice fed a high-fat diet. | 2018 | Details |
| A52181 | 30353455 | Eat Weight Disord | Ghrelin forms in the modulation of energy balance and metabolism. | 2018 | Details |
| A52182 | 30346829 | FASEB J | Normalizing adiponectin levels in obese pregnant mice prevents adverse metabolic outcomes in offspring. | 2018 | Details |
| A52188 | 30307158 | J Mol Endocrinol | The mitochondrial unfolded protein response and mitohormesis: a perspective on metabolic diseases | 2018 | Details |
| A52190 | 30296183 | Curr Med Res Opin | Monogenic forms of lipodystrophic syndromes: diagnosis, detection, and practical management considerations from clinical cases. | 2018 | Details |
| A52192 | 30246767 | Infez Med | No effect of MTP polymorphisms on PNPLA3 in HCV-correlated steatosis. | 2018 | Details |
| A52195 | 30213825 | Diabetes | CETP Inhibition Improves HDL Function but Leads to Fatty Liver and Insulin Resistance in CETP-Expressing Transgenic Mice on a High-Fat Diet. | 2018 | Details |
| A52196 | 30212233 | Chronobiol Int | Timing of food intake is more potent than habitual voluntary exercise to prevent diet-induced obesity in mice. | 2018 | Details |
| A52198 | 30201971 | Nat Commun | ER-associated ubiquitin ligase HRD1 programs liver metabolism by targeting multiple metabolic enzymes. | 2018 | Details |
| A52200 | 30159588 | Diabetologia | Relation of plasma ceramides to visceral adiposity, insulin resistance and the development of type 2 diabetes mellitus: the Dallas Heart Study. | 2018 | Details |
| A52208 | 30109419 | Eur J Nutr | Metabolic alterations associated with maternal undernutrition during the first half of gestation lead to a diabetogenic state in the rat. | 2018 | Details |
| A52210 | 30085057 | Endocrinology | Mouse Embryonic Fibroblasts Protect ob/ob Mice From Obesity and Metabolic Complications. | 2018 | Details |
| A52213 | 30049588 | Nutr Res | The interplay of canonical and noncanonical Wnt signaling in metabolic syndrome. | 2018 | Details |
| A52214 | 30040479 | Am J Physiol Endocrinol Metab | Differential contribution of chronic binge alcohol and antiretroviral therapy to metabolic dysregulation in SIV-infected male macaques. | 2018 | Details |
| A52215 | 30032428 | Diabetologia | A novel dual PPAR-γ agonist/sEH inhibitor treats diabetic complications in a rat model of type 2 diabetes. | 2018 | Details |
| A52218 | 29998913 | J Atheroscler Thromb | Pathophysiology of Diabetic Dyslipidemia. | 2018 | Details |
| A52219 | 29980484 | Mol Metab | FGF21 regulates insulin sensitivity following long-term chronic stress. | 2018 | Details |
| A52222 | 29942089 | Nat Med | Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health. | 2018 | Details |
| A52227 | 29908753 | Dig Liver Dis | Abdominal obesity and insulin resistance after an episode of acute pancreatitis. | 2018 | Details |
| A52228 | 29908359 | Clin Gastroenterol Hepatol | Statin Therapy Does Not Reduce Liver Fat Scores in Patients Receiving Antiretroviral Therapy for HIV Infection. | 2018 | Details |
| A52233 | 29895033 | Front Horm Res | Metabolic Syndrome in Hypopituitarism. | 2018 | Details |
| A52234 | 29886355 | Atherosclerosis | Ferritin, metabolic syndrome and its components: A systematic review and meta-analysis. | 2018 | Details |
| A52239 | 29812971 | FASEB J | Epigenetic programming at the Mogat1 locus may link neonatal overnutrition with long-term hepatic steatosis and insulin resistance. | 2018 | Details |
| A52241 | 29789270 | Mol Metab | Surplus fat rapidly increases fat oxidation and insulin resistance in lipodystrophic mice. | 2018 | Details |
| A52243 | 29768198 | Cell Rep | Myocardin-Related Transcription Factor A Promotes Recruitment of ITGA5+ Profibrotic Progenitors during Obesity-Induced Adipose Tissue Fibrosis. | 2018 | Details |
| A52246 | 29730627 | BMJ Open | Short-term abstinence from alcohol and changes in cardiovascular risk factors, liver function tests and cancer-related growth factors: a prospective observational study. | 2018 | Details |
| A52248 | 29689264 | Gastroenterology | Disruption of Epithelial HDAC3 in Intestine Prevents Diet-Induced Obesity in Mice. | 2018 | Details |
| A52252 | 29681858 | Front Pharmacol | Aqueous Extract of Black Maca Prevents Metabolism Disorder via Regulating the Glycolysis/Gluconeogenesis-TCA Cycle and PPARα Signaling Activation in Golden Hamsters Fed a High-Fat, High-Fructose Diet. | 2018 | Details |
| A52254 | 29659785 | Endocrinology | Glucocorticoid-Induced Metabolic Disturbances Are Exacerbated in Obese Male Mice. | 2018 | Details |
| A52259 | 29596053 | Horm Mol Biol Clin Investig | The "adipose tissue expandability" hypothesis: a potential mechanism for insulin resistance in obese youth. | 2018 | Details |
| A52267 | 29477938 | Curr Opin Genet Dev | Genetic syndromes of severe insulin resistance. | 2018 | Details |
| A52269 | 29453696 | Heart Fail Rev | Interrelationship between diabetes mellitus and heart failure: the role of peroxisome proliferator-activated receptors in left ventricle performance. | 2018 | Details |
| A52272 | 29419749 | Int J Mol Sci | Deficiency of Invariant Natural Killer T Cells Does Not Protect Against Obesity but Exacerbates Atherosclerosis in Ldlr-/- Mice. | 2018 | Details |
| A52273 | 29406938 | Prim Care | Metabolic Syndrome: Systems Thinking in Heart Disease. | 2018 | Details |
| A52275 | 29402742 | Bioorg Med Chem Lett | Novel SIRT1 activator MHY2233 improves glucose tolerance and reduces hepatic lipid accumulation in db/db mice. | 2018 | Details |
| A52276 | 29398618 | Mol Metab | A role for long-chain acyl-CoA synthetase-4 (ACSL4) in diet-induced phospholipid remodeling and obesity-associated adipocyte dysfunction. | 2018 | Details |
| A52287 | 29115530 | Mol Med Rep | Curcumin suppresses Notch‑1 signaling: Improvements in fatty liver and insulin resistance in rats. | 2017 | Details |
| A52289 | 29074588 | Arterioscler Thromb Vasc Biol | GLP-1 Elicits an Intrinsic Gut-Liver Metabolic Signal to Ameliorate Diet-Induced VLDL Overproduction and Insulin Resistance. | 2017 | Details |
| A52291 | 30581334 | J Med Biochem | The Monitoring of Protein Markers of Inflammation and Serum Lipid Concentration in Obese Subjects with Metabolic Syndrome. | 2017 | Details |
| A52292 | 29055921 | Ann Hepatol | Hepatitis C and Its Metabolic Complications in Kidney Disease. | 2018 | Details |
| A52299 | 28940824 | Liver Int | Clinical implications of controlled attenuation parameter in a health check-up cohort. | 2017 | Details |
| A52304 | 28867797 | Nutrients | Flavonoid-Rich Extract of Paulownia fortunei Flowers Attenuates Diet-Induced Hyperlipidemia, Hepatic Steatosis and Insulin Resistance in Obesity Mice by AMPK Pathway. | 2017 | Details |
| A52305 | 28839198 | Sci Rep | The effect of the TM6SF2 E167K variant on liver steatosis and fibrosis in patients with chronic hepatitis C: a meta-analysis. | 2017 | Details |
| A52307 | 28823009 | J Gastroenterol | Proton pump inhibitors as risk factor for metabolic syndrome and hepatic steatosis in coeliac disease patients on gluten-free diet. | 2017 | Details |
| A52308 | 28811612 | Sci Rep | Coenzyme Q10 Improves Lipid Metabolism and Ameliorates Obesity by Regulating CaMKII-Mediated PDE4 Inhibition. | 2017 | Details |
| A52313 | 28778179 | Orphanet J Rare Dis | Is age a risk factor for liver disease and metabolic alterations in ataxia Telangiectasia patients? | 2017 | Details |
| A52316 | 28743670 | J Ethnopharmacol | Xuefu Zhuyu decoction ameliorates obesity, hepatic steatosis, neuroinflammation, amyloid deposition and cognition impairment in metabolically stressed APPswe/PS1dE9 mice. | 2017 | Details |
| A52317 | 28739173 | Biochim Biophys Acta Mol Basis Dis | Lipid droplet proteins and metabolic diseases. | 2017 | Details |
| A52319 | 28711626 | Gastroenterology | Influence of Metabolic Risk Factors on Risk of Hepatocellular Carcinoma and Liver-Related Death in Men With Chronic Hepatitis B: A Large Cohort Study. | 2017 | Details |
| A52322 | 28672736 | Horm Mol Biol Clin Investig | Innate immunity orchestrates adipose tissue homeostasis. | 2017 | Details |
| A52323 | 28661066 | NMR Biomed | Sexual dimorphism in hepatic lipids is associated with the evolution of metabolic status in mice. | 2017 | Details |
| A52327 | 28545035 | Oncotarget | Novel PPARα agonist MHY553 alleviates hepatic steatosis by increasing fatty acid oxidation and decreasing inflammation during aging. | 2017 | Details |
| A52330 | 28490483 | FASEB J | The ratio of dihomo-γ-linolenic acid to deoxycholic acid species is a potential biomarker for the metabolic abnormalities in obesity. | 2017 | Details |
| A52331 | 28486481 | PLoS One | Temporal changes in sphingolipids and systemic insulin sensitivity during the transition from gestation to lactation. | 2017 | Details |
| A52332 | 28474500 | Immun Inflamm Dis | Vitamin D3 supplementation of a high fat high sugar diet ameliorates prediabetic phenotype in female LDLR-/- and LDLR+/+ mice. | 2017 | Details |
| A52333 | 28458462 | Clin Pediatr Endocrinol | Partial lipodystrophy in patients who have undergone hematopoietic stem cell transplantation during childhood: an institutional cross-sectional survey. | 2017 | Details |
| A52334 | 28431322 | J Nutr Biochem | Xanthohumol and 8-prenylnaringenin ameliorate diabetic-related metabolic dysfunctions in mice. | 2017 | Details |
| A52339 | 28400405 | J Endocrinol | Nutritional approaches for managing obesity-associated metabolic diseases. | 2017 | Details |
| A52343 | 28379591 | Eur Rev Med Pharmacol Sci | Fatty liver and drugs: the two sides of the same coin. | 2017 | Details |
| A52345 | 28375880 | Curr Opin Clin Nutr Metab Care | AMP-activated protein kinase, fatty acid metabolism, and insulin sensitivity. | 2017 | Details |
| A52353 | 28246016 | Gastroenterology | Gut-Specific Delivery of T-Helper 17 Cells Reduces Obesity and Insulin Resistance in Mice. | 2017 | Details |
| A52354 | 28239649 | JCI Insight | Switching harmful visceral fat to beneficial energy combustion improves metabolic dysfunctions. | 2017 | Details |
| A52356 | 28223503 | Proc Natl Acad Sci U S A | Mitochondrial energy deficiency leads to hyperproliferation of skeletal muscle mitochondria and enhanced insulin sensitivity. | 2017 | Details |
| A52357 | 28222147 | PLoS One | The desert gerbil Psammomys obesus as a model for metformin-sensitive nutritional type 2 diabetes to protect hepatocellular metabolic damage: Impact of mitochondrial redox state. | 2017 | Details |
| A52359 | 28213130 | Biochem Biophys Res Commun | Dipeptidyl peptidase-4 impairs insulin signaling and promotes lipid accumulation in hepatocytes. | 2017 | Details |
| A52360 | 28194444 | JCI Insight | Adipocyte JAK2 mediates growth hormone-induced hepatic insulin resistance. | 2017 | Details |
| A52367 | 28110829 | Prostaglandins Leukot Essent Fatty Acids | Lipidomic analysis reveals significant lipogenesis and accumulation of lipotoxic components in ob/ob mouse organs. | 2017 | Details |
| A52368 | 28100772 | J Biol Chem | De Novo Sphingolipid Biosynthesis Is Required for Adipocyte Survival and Metabolic Homeostasis. | 2017 | Details |
| A52370 | 28086952 | J Med Case Rep | Glucagon-like peptide-1 analogues - an efficient therapeutic option for the severe insulin resistance of lipodystrophic syndromes: two case reports. | 2017 | Details |
| A52373 | 28052632 | Liver Int | Impact of hepatitis C virus therapy on metabolism and public health. | 2017 | Details |
| A52374 | 28049662 | Am J Clin Nutr | Gut permeability is related to body weight, fatty liver disease, and insulin resistance in obese individuals undergoing weight reduction. | 2016 | Details |
| A52377 | 27921045 | Visc Med | Clinical Scenario of the Metabolic Syndrome. | 2016 | Details |
| A52380 | 27884961 | J Lipid Res | Therapeutic silencing of fat-specific protein 27 improves glycemic control in mouse models of obesity and insulin resistance. | 2016 | Details |
| A52383 | 27832862 | Metabolism | Time-restricted feeding improves insulin resistance and hepatic steatosis in a mouse model of postmenopausal obesity. | 2016 | Details |
| A52385 | 27813205 | Genes Cells | Dietary fructose-induced hepatocellular carcinoma development manifested in mice lacking apoptosis inhibitor of macrophage (AIM). | 2016 | Details |
| A52388 | 27796312 | Sci Rep | Ubc13 haploinsufficiency protects against age-related insulin resistance and high-fat diet-induced obesity. | 2016 | Details |
| A52391 | 27766312 | JCI Insight | Insulin resistance uncoupled from dyslipidemia due to C-terminal PIK3R1 mutations. | 2016 | Details |
| A52396 | 29489091 | Cesk Fysiol | Metabolically healthy obese individuals -- mechanisms and clinical relevance. | 2016 | Details |
| A52397 | 27659144 | Trends Endocrinol Metab | Perilipin 2 and Age-Related Metabolic Diseases: A New Perspective. | 2016 | Details |
| A52399 | 27629946 | Intern Med | A Comparison of the Abdominal Fat Distribution and Coronary Risk Markers in Body Mass Index-matched Subjects with and without Fatty Liver. | 2016 | Details |
| A52401 | 27615511 | Immunobiology | Association of the I148M/PNPLA3 (rs738409) polymorphism with premature coronary artery disease, fatty liver, and insulin resistance in type 2 diabetic patients and healthy controls. The GEA study. | 2016 | Details |
| A52403 | 27568222 | EBioMedicine | Transgenic Adipose-specific Expression of the Nuclear Receptor RORα Drives a Striking Shift in Fat Distribution and Impairs Glycemic Control. | 2016 | Details |
| A52404 | 27552247 | Endocrinology | Nonnuclear Estrogen Receptor Activation Improves Hepatic Steatosis in Female Mice. | 2016 | Details |
| A52408 | 27519883 | Cardiovasc Diabetol | High levels of serum vitamin D are associated with a decreased risk of metabolic diseases in both men and women, but an increased risk for coronary artery calcification in Korean men. | 2016 | Details |
| A52412 | 27382035 | Am J Physiol Endocrinol Metab | Targeting ceramide metabolism in obesity. | 2016 | Details |
| A52421 | 27302175 | Exp Biol Med (Maywood) | Regulation of lipid deposition in farm animals: Parallels between agriculture and human physiology. | 2016 | Details |
| A52426 | 27228955 | Sci Rep | Relationship of Serum Trimethylamine N-Oxide (TMAO) Levels with early Atherosclerosis in Humans. | 2016 | Details |
| A52437 | 27126637 | Hum Mol Genet | Early hypermethylation of hepatic Igfbp2 results in its reduced expression preceding fatty liver in mice. | 2016 | Details |
| A52442 | 27094951 | Sci Rep | Hypoxia-inducible factor prolyl hydroxylase 1 (PHD1) deficiency promotes hepatic steatosis and liver-specific insulin resistance in mice. | 2016 | Details |
| A52446 | 27060421 | Am J Obstet Gynecol | High-fructose diet in pregnancy leads to fetal programming of hypertension, insulin resistance, and obesity in adult offspring. | 2016 | Details |
| A52448 | 27033445 | Physiol Rep | Similar degrees of obesity induced by diet or aging cause strikingly different immunologic and metabolic outcomes. | 2016 | Details |
| A52451 | 27016890 | Diabetes Metab | Osteoprotegerin levels are associated with liver fat and liver markers in dysmetabolic adults. | 2016 | Details |
| A52454 | 26976583 | Proc Natl Acad Sci U S A | Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats. | 2016 | Details |
| A52455 | 26964726 | Obes Res Clin Pract | Predictive value of serum dihomo-γ-linolenic acid level and estimated Δ-5 desaturase activity in patients with hepatic steatosis. | 2016 | Details |
| A52458 | 26921251 | Oncotarget | Chronic Trypanosoma cruzi infection potentiates adipose tissue macrophage polarization toward an anti-inflammatory M2 phenotype and contributes to diabetes progression in a diet-induced obesity model. | 2016 | Details |