Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A08502 | 32083947 | Can J Physiol Pharmacol | Combined treatments with metformin and phosphodiesterase inhibitors alleviate nonalcoholic fatty liver disease in high-fat diet fed rats: a comparative study. | 2020 | Details |
| A08505 | 32083445 | Horm Mol Biol Clin Investig | Hepatoprotective effects of Shilajit on high fat-diet induced non-alcoholic fatty liver disease (NAFLD) in rats. | 2020 | Details |
| A08510 | 32081727 | Mitochondrion | Mitochondrial dysfunction: An emerging link in the pathophysiology of polycystic ovary syndrome. | 2020 | Details |
| A08513 | 32077785 | Metab Syndr Relat Disord | Role of Heparin-Binding Epidermal Growth Factor-Like Growth Factor in Oxidative Stress-Associated Metabolic Diseases. | 2020 | Details |
| A08525 | 32074961 | Nutrients | Dietary Platycodon grandiflorus Attenuates Hepatic Insulin Resistance and Oxidative Stress in High-Fat-Diet Induced Non-Alcoholic Fatty Liver Disease. | 2020 | Details |
| A08548 | 32065376 | Adv Ther | Silymarin as Supportive Treatment in Liver Diseases: A Narrative Review. | 2020 | Details |
| A08555 | 32062620 | J Toxicol Sci | Taurine attenuates hepatic steatosis in a genetic model of fatty liver disease. | 2020 | Details |
| A08574 | 32054943 | Sci Rep | Bergamot Polyphenols Improve Dyslipidemia and Pathophysiological Features in a Mouse Model of Non-Alcoholic Fatty Liver Disease. | 2020 | Details |
| A08577 | 32054379 | J Recept Signal Transduct Res | Inevitable role of TGF-β1 in progression of nonalcoholic fatty liver disease. | 2020 | Details |
| A08593 | 32046101 | Int J Mol Sci | Adaptation of Mitochondrial Substrate Flux in a Mouse Model of Nonalcoholic Fatty Liver Disease. | 2020 | Details |
| A08617 | 32040876 | Lipids | Gut microbial fatty acid metabolites (KetoA and KetoC) affect the progression of nonalcoholic steatohepatitis and reverse cholesterol transport metabolism in mouse model. | 2020 | Details |
| A08657 | 32030821 | J Gastroenterol Hepatol | Aging exacerbates high-fat diet-induced steatohepatitis through alteration in hepatic lipid metabolism in mice. | 2020 | Details |
| A08672 | 32026851 | Med Sci Monit | The Effects of RKI-1447 in a Mouse Model of Nonalcoholic Fatty Liver Disease Induced by a High-Fat Diet and in HepG2 Human Hepatocellular Carcinoma Cells Treated with Oleic Acid. | 2020 | Details |
| A08683 | 32023702 | Zhonghua Gan Zang Bing Za Zhi | [Effect of metformin on mitochondrial pathway of apoptosis and oxidative stress in cell model of nonalcoholic fatty liver disease]. | 2020 | Details |
| A08684 | 32023549 | Aging (Albany NY) | Targeting of miR-96-5p by catalpol ameliorates oxidative stress and hepatic steatosis in LDLr-/- mice via p66shc/cytochrome C cascade. | 2020 | Details |
| A08705 | 32017151 | J Food Biochem | Curcuma longa and Trigonella foenum graecum-enriched nutrient mixture from germinated Macrotyloma uniflorum and Vigna radiate ameliorate nonalcoholic fatty liver diseases in rats. | 2020 | Details |
| A08706 | 32017057 | Eur J Clin Invest | Systemic redox imbalance in patients with nonalcoholic fatty liver disease. | 2020 | Details |
| A08732 | 32007822 | J Nutr Biochem | Effects of (-)-epicatechin on the time course of the expression of perilipins in a diet-induced model of nonalcoholic steatohepatitis. | 2019 | Details |
| A08733 | 32007744 | Prostaglandins Leukot Essent Fatty Acids | Iron-induced derangement in hepatic Δ-5 and Δ-6 desaturation capacity and fatty acid profile leading to steatosis: Impact on extrahepatic tissues and prevention by antioxidant-rich extra virgin olive oil. | 2020 | Details |
| A08752 | 32000955 | J Am Coll Cardiol | Mechanisms of Cardiorenal Effects of Sodium-Glucose Cotransporter 2 Inhibitors: JACC State-of-the-Art Review. | 2020 | Details |
| A08754 | 32000567 | Adipocyte | Transplantation of brown adipose tissue up-regulates miR-99a to ameliorate liver metabolic disorders in diabetic mice by targeting NOX4. | 2020 | Details |
| A08791 | 31982488 | Pharmacol Res | Hypericin attenuates nonalcoholic fatty liver disease and abnormal lipid metabolism via the PKA-mediated AMPK signaling pathway in vitro and in vivo. | 2020 | Details |
| A08821 | 31978521 | J Ethnopharmacol | Phenols fragment of Veronica ciliata Fisch. ameliorate free radical-induced nonalcoholic fatty liver disease by mediating PI3K/Akt signaling pathway. | 2020 | Details |
| A08826 | 31975365 | Histol Histopathol | Cathepsin-B dependent autophagy ameliorates steatoheaptitis in chronic exercise rats. | 2020 | Details |
| A08837 | 31969822 | Front Pharmacol | Microarray Expression Profiling and Raman Spectroscopy Reveal Anti-Fatty Liver Action of Berberine in a Diet-Induced Larval Zebrafish Model. | 2020 | Details |
| A08863 | 31959521 | Ann Hepatol | NRF-2 and nonalcoholic fatty liver disease. | 2020 | Details |
| A08868 | 31956867 | Food Funct | High fat diet incorporated with meat proteins changes biomarkers of lipid metabolism, antioxidant activities, and the serum metabolomic profile in Glrx1-/- mice. | 2020 | Details |
| A08871 | 31955626 | Endocr Res | Therapeutic Effects of SGLT2 Inhibitor Ipragliflozin and Metformin on NASH in Type 2 Diabetic Mice. | 2020 | Details |
| A08886 | 31952573 | Adv Clin Chem | Organokines in disease. | 2019 | Details |
| A08892 | 31950587 | J Dig Dis | Effects and therapeutic mechanism of Yinzhihuang on steatohepatitis in rats induced by a high-fat, high-cholesterol diet. | 2020 | Details |
| A08894 | 31949886 | Oxid Med Cell Longev | Peroxiredoxin 6 Is a Key Antioxidant Enzyme in Modulating the Link between Glycemic and Lipogenic Metabolism. | 2019 | Details |
| A08895 | 31949882 | Oxid Med Cell Longev | Renalase Attenuates Mouse Fatty Liver Ischemia/Reperfusion Injury through Mitigating Oxidative Stress and Mitochondrial Damage via Activating SIRT1. | 2019 | Details |
| A08898 | 31949129 | Cell Death Dis | Targeting alkaline ceramidase 3 alleviates the severity of nonalcoholic steatohepatitis by reducing oxidative stress. | 2020 | Details |
| A08901 | 31947953 | J Clin Med | Randomised Clinical Trial: Calorie Restriction Regimen with Tomato Juice Supplementation Ameliorates Oxidative Stress and Preserves a Proper Immune Surveillance Modulating Mitochondrial Bioenergetics of T-Lymphocytes in Obese Children Affected by Non-Alcoholic Fatty Liver Disease (NAFLD). | 2020 | Details |
| A08903 | 31944077 | Pak J Biol Sci | Effect of <i>Rosa canina</i> Distilled Water on Tamoxifen-treated Male Wistar Rats. | 2020 | Details |
| A08908 | 31941974 | Sci Rep | Polycystin 2 is increased in disease to protect against stress-induced cell death. | 2020 | Details |
| A08913 | 31941015 | Int J Mol Sci | Sarcopenic Obesity, Insulin Resistance, and Their Implications in Cardiovascular and Metabolic Consequences. | 2020 | Details |
| A08951 | 31928222 | Am J Physiol Gastrointest Liver Physiol | Nanoformulated SOD1 ameliorates the combined NASH and alcohol-associated liver disease partly via regulating CYP2E1 expression in adipose tissue and liver. | 2020 | Details |
| A08972 | 31920355 | Diabetes Metab Syndr Obes | Salidroside-Mitigated Inflammatory Injury of Hepatocytes with Non-Alcoholic Fatty Liver Disease via Inhibition TRPM2 Ion Channel Activation. | 2019 | Details |
| A08980 | 31916388 | Mol Nutr Food Res | Differentiated Hepatic Response to Fructose Intake during Adolescence Reveals the Increased Susceptibility to Non-Alcoholic Fatty Liver Disease of Maternal High-Fat Diet Male Rat Offspring. | 2020 | Details |
| A08983 | 31915635 | Prev Nutr Food Sci | Beneficial Effects of Low-Calorie-Carbohydrate/High-Agar Diet on Cardiometabolic Disorders Associated with Non-Alcoholic Fatty Liver Disease in Obese Rats. | 2019 | Details |
| A09002 | 31908001 | FASEB J | An energy restriction-based weight loss intervention is able to reverse the effects of obesity on the expression of liver tumor-promoting genes. | 2019 | Details |
| A09011 | 31905026 | Am J Physiol Gastrointest Liver Physiol | Addition of trans fat and alcohol has divergent effects on atherogenic diet-induced liver injury in rodent models of steatohepatitis. | 2020 | Details |
| A09019 | 31902937 | Biol Pharm Bull | Repeated Administration of Kupffer Cells-Targeting Nanoantioxidant Ameliorates Liver Fibrosis in an Experimental Mouse Model. | 2020 | Details |
| A09037 | 31894585 | J Food Biochem | Royal jelly attenuates nonalcoholic fatty liver disease by inhibiting oxidative stress and regulating the expression of circadian genes in ovariectomized rats. | 2020 | Details |
| A09050 | 31889412 | IUBMB Life | Inhibiting miR-27a and miR-142-5p attenuate nonalcoholic fatty liver disease by regulating Nrf2 signaling pathway. | 2019 | Details |
| A09070 | 31885103 | Fundam Clin Pharmacol | Comparative effectiveness of phosphodiesterase 3, 4, and 5 inhibitors in amelioration of high-fat diet-induced nonalcoholic fatty liver in rats. | 2020 | Details |
| A09076 | 31883408 | Liver Int | Farnesoid X receptor activation induces the degradation of hepatotoxic 1-deoxysphingolipids in non-alcoholic fatty liver disease. | 2020 | Details |
| A09078 | 31882889 | Sci Rep | Hepatic Mitochondrial Oxidative Metabolism and Lipogenesis Synergistically Adapt to Mediate Healthy Embryonic-to-Neonatal Transition in Chicken. | 2019 | Details |
| A09097 | 31877680 | Int J Mol Sci | Mechanistic Insight of Na/K-ATPase Signaling and HO-1 into Models of Obesity and Nonalcoholic Steatohepatitis. | 2019 | Details |
| A09099 | 31877356 | Free Radic Biol Med | The impaired redox balance in peroxisomes of catalase knockout mice accelerates nonalcoholic fatty liver disease through endoplasmic reticulum stress. | 2019 | Details |
| A09101 | 31876010 | Microcirculation | Pyridoxamine improves metabolic and microcirculatory complications associated with nonalcoholic fatty liver disease. | 2020 | Details |
| A09119 | 31867441 | Hepatoma Res | Molecular links between non-alcoholic fatty liver disease and hepatocellular carcinoma. | 2019 | Details |
| A09156 | 31853615 | Naunyn Schmiedebergs Arch Pharmacol | Adelmidrol protects against non-alcoholic steatohepatitis in mice. | 2019 | Details |
| A09166 | 31850710 | Clin Lab | MiR-218-XOR-ROS Pathway Regulates the Progression of Nonalcoholic Steatohepatitis. | 2019 | Details |
| A09190 | 31841744 | Nutr Res | An energy-restricted high-protein diet supplemented with β-cryptoxanthin alleviated oxidative stress and inflammation in nonalcoholic fatty liver disease: a randomized controlled trial. | 2019 | Details |
| A09191 | 31841118 | Aging (Albany NY) | Effects of XIAP on high fat diet-induced hepatic steatosis: a mechanism involving NLRP3 inflammasome and oxidative stress. | 2019 | Details |
| A09203 | 31837337 | Life Sci | Prefrontal cortex inflammation and liver pathologies accompany cognitive and motor deficits following Western diet consumption in non-obese female mice. | 2019 | Details |
| A09210 | 31835339 | Metabolites | Acupuncture on ST36, CV4 and KI1 Suppresses the Progression of Methionine- and Choline-Deficient Diet-Induced Nonalcoholic Fatty Liver Disease in Mice. | 2019 | Details |
| A09212 | 31834842 | J Med Food | Effects of Eriobotrya japonica Water Extract on Alcoholic and Nonalcoholic Fatty Liver Impairment. | 2019 | Details |
| A09213 | 31834465 | Naunyn Schmiedebergs Arch Pharmacol | NLRP3 inhibitor glibenclamide attenuates high-fat diet and streptozotocin-induced non-alcoholic fatty liver disease in rat: studies on oxidative stress, inflammation, DNA damage and insulin signalling pathway. | 2019 | Details |
| A09245 | 31819934 | Food Funct | Acerola polysaccharides ameliorate high-fat diet-induced non-alcoholic fatty liver disease through reduction of lipogenesis and improvement of mitochondrial functions in mice. | 2020 | Details |
| A09255 | 31816412 | Biochim Biophys Acta Mol Cell Biol Lipids | Aquaporin-9 is involved in the lipid-lowering activity of the nutraceutical silybin on hepatocytes through modulation of autophagy and lipid droplets composition. | 2019 | Details |
| A09258 | 31815116 | Front Cell Dev Biol | Corrigendum: NFκB/Orai1 Facilitates Endoplasmic Reticulum Stress by Oxidative Stress in the Pathogenesis of Non-alcoholic Fatty Liver Disease. | 2019 | Details |
| A09259 | 31814783 | Hepat Med | A Review Of Current And Upcoming Treatment Modalities In Non-Alcoholic Fatty Liver Disease And Non-Alcoholic Steatohepatitis. | 2019 | Details |
| A09263 | 31813265 | Antioxid Redox Signal | Redox Regulation via Glutaredoxin-1 and Protein S-Glutathionylation. | 2020 | Details |
| A09268 | 31810868 | Clin Res Hepatol Gastroenterol | Active vitamin D impedes the progression of non-alcoholic fatty liver disease by inhibiting cell senescence in a rat model. | 2019 | Details |
| A09273 | 31809303 | J Chin Med Assoc | CircularRNA as novel biomarkers in liver diseases. | 2020 | Details |
| A09285 | 31805752 | Molecules | Effects of Propolis Extract and Propolis-Derived Compounds on Obesity and Diabetes: Knowledge from Cellular and Animal Models. | 2019 | Details |
| A09292 | 31803542 | PeerJ | Polyphenol-rich Trapa quadrispinosa pericarp extract ameliorates high-fat diet induced non-alcoholic fatty liver disease by regulating lipid metabolism and insulin resistance in mice. | 2019 | Details |
| A09306 | 31797544 | Mol Nutr Food Res | Vitamin D Deficiency Induces Insulin Resistance and Re-Supplementation Attenuates Hepatic Glucose Output via the PI3K-AKT-FOXO1 Mediated Pathway. | 2020 | Details |
| A09313 | 31795130 | Nutrients | Lotus Seedpod Extracts Reduced Lipid Accumulation and Lipotoxicity in Hepatocytes. | 2019 | Details |
| A09324 | 31790829 | Free Radic Biol Med | Lycopene prevents the progression of lipotoxicity-induced nonalcoholic steatohepatitis by decreasing oxidative stress in mice. | 2019 | Details |
| A09346 | 31783479 | Int J Mol Sci | Cerium Oxide Nanoparticles Protect against Oxidant Injury and Interfere with Oxidative Mediated Kinase Signaling in Human-Derived Hepatocytes. | 2019 | Details |
| A09349 | 31782258 | Physiol Rep | SGLT2 inhibitor ipragliflozin alone and combined with pioglitazone prevents progression of nonalcoholic steatohepatitis in a type 2 diabetes rodent model. | 2019 | Details |
| A09367 | 31776016 | Environ Res | Adolescent exposure to environmental level of PCBs (Aroclor 1254) induces non-alcoholic fatty liver disease in male mice. | 2019 | Details |
| A09369 | 31775341 | Int J Mol Sci | Impact of Glucoraphanin-Mediated Activation of Nrf2 on Non-Alcoholic Fatty Liver Disease with a Focus on Mitochondrial Dysfunction. | 2019 | Details |
| A09375 | 31771244 | Nutrients | Fat and Sugar-A Dangerous Duet. A Comparative Review on Metabolic Remodeling in Rodent Models of Nonalcoholic Fatty Liver Disease. | 2019 | Details |
| A09381 | 31769484 | Clin Sci (Lond) | Dapagliflozin not only improves hepatic injury and pancreatic endoplasmic reticulum stress, but also induces hepatic gluconeogenic enzymes expression in obese rats. | 2019 | Details |
| A09394 | 31761566 | Cell Metab | Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis. | 2019 | Details |
| A09415 | 31757735 | Presse Med | [Pharmacological treatment of NASH]. | 2019 | Details |
| A09421 | 31756344 | Life Sci | Active vitamin D supplementation alleviates initiation and progression of nonalcoholic fatty liver disease by repressing the p53 pathway. | 2019 | Details |
| A09449 | 31744059 | Mar Drugs | Chitosan Oligosaccharide Attenuates Nonalcoholic Fatty Liver Disease Induced by High Fat Diet through Reducing Lipid Accumulation, Inflammation and Oxidative Stress in C57BL/6 Mice. | 2019 | Details |
| A09453 | 31742325 | Clin Sci (Lond) | Processes exacerbating apoptosis in non-alcoholic steatohepatitis. | 2019 | Details |
| A09460 | 31737175 | Oxid Med Cell Longev | Evaluation of the Effect Derived from Silybin with Vitamin D and Vitamin E Administration on Clinical, Metabolic, Endothelial Dysfunction, Oxidative Stress Parameters, and Serological Worsening Markers in Nonalcoholic Fatty Liver Disease Patients. | 2019 | Details |
| A09503 | 31717842 | Nutrients | Efficacy and Mechanism of Polymerized Anthocyanin from Grape-Skin Extract on High-Fat-Diet-Induced Nonalcoholic Fatty Liver Disease. | 2019 | Details |
| A09507 | 31717358 | Nutrients | Reduced Oxidative Stress and Enhanced FGF21 Formation in Livers of Endurance-Exercised Rats with Diet-Induced NASH. | 2019 | Details |
| A09528 | 31706905 | J Clin Lipidol | Niacin for treatment of nonalcoholic fatty liver disease (NAFLD): novel use for an old drug? | 2019 | Details |
| A09530 | 31706246 | Environ Toxicol Pharmacol | Microcystin exposure worsens nonalcoholic fatty liver disease associated ectopic glomerular toxicity via NOX-2-MIR21 axis. | 2019 | Details |
| A09531 | 31706011 | Pharmacol Res | Combinational applicaton of silybin and tangeretin attenuates the progression of non-alcoholic steatohepatitis (NASH) in mice via modulating lipid metabolism. | 2019 | Details |
| A09534 | 31705800 | Hepatology | Interleukin-22 Ameliorates Neutrophil-Driven Nonalcoholic Steatohepatitis Through Multiple Targets. | 2020 | Details |
| A09536 | 31705397 | J Endocrinol Invest | L-Carnitine counteracts in vitro fructose-induced hepatic steatosis through targeting oxidative stress markers. | 2019 | Details |
| A09557 | 31695251 | J Clin Exp Hepatol | Molecular and Pathological Events Involved in the Pathogenesis of Diabetes-Associated Nonalcoholic Fatty Liver Disease. | 2018 | Details |
| A09567 | 31692530 | Pediatric Health Med Ther | Pediatric non-alcoholic fatty liver disease: current perspectives on diagnosis and management. | 2019 | Details |
| A09576 | 31689883 | Foods | Agaricus brasiliensis KA21 May Prevent Diet-Induced Nash Through Its Antioxidant, Anti-Inflammatory, and Anti-Fibrotic Activities in the Liver. | 2019 | Details |
| A09589 | 31684925 | BMC Complement Altern Med | The potential of antioxidant-rich Maoberry (Antidesma bunius) extract on fat metabolism in liver tissues of rats fed a high-fat diet. | 2019 | Details |
| A09596 | 31682309 | J Dig Dis | Development of new drugs for the treatment of nonalcoholic steatohepatitis. | 2019 | Details |
| A09597 | 31680967 | Front Pharmacol | Chinese Herbal Formula (CHF03) Attenuates Non-Alcoholic Fatty Liver Disease (NAFLD) Through Inhibiting Lipogenesis and Anti-Oxidation Mechanisms. | 2019 | Details |
| A09627 | 31670060 | Pharmacol Rep | Hepatoprotective potential of 7,8-Dihydroxyflavone against alcohol and high-fat diet induced liver toxicity via attenuation of oxido-nitrosative stress and NF-κB activation. | 2019 | Details |
| A09628 | 31669275 | Int J Biol Macromol | Codonopsis lanceolata polysaccharide CLPS alleviates high fat/high sucrose diet-induced insulin resistance via anti-oxidative stress. | 2019 | Details |