Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Fructose1035 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A26838 | 19679262 | J Nutr Biochem | Dietary fructose and intestinal barrier: potential risk factor in the pathogenesis of nonalcoholic fatty liver disease. | 2009 | Details |
| A26859 | 19637282 | Hepatology | Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice. | 2009 | Details |
| A26863 | 19626358 | Eur J Nutr | Comparison of free fructose and glucose to sucrose in the ability to cause fatty liver. | 2009 | Details |
| A27044 | 19282820 | Obesity (Silver Spring) | Diabetes of the liver: the link between nonalcoholic fatty liver disease and HFCS-55. | 2009 | Details |
| A27054 | 19254570 | Cell Metab | The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance. | 2009 | Details |
| A27276 | 18772365 | Am J Physiol Gastrointest Liver Physiol | Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent. | 2008 | Details |
| A27325 | 18641190 | J Nutr | Nonalcoholic fatty liver disease in humans is associated with increased plasma endotoxin and plasminogen activator inhibitor 1 concentrations and with fructose intake. | 2008 | Details |
| A27433 | 18395289 | J Hepatol | Antibiotics protect against fructose-induced hepatic lipid accumulation in mice: role of endotoxin. | 2008 | Details |
| A27434 | 18395287 | J Hepatol | Fructose consumption as a risk factor for non-alcoholic fatty liver disease. | 2008 | Details |
| A27466 | 18333122 | HPB (Oxford) | Hepato-pancreato-biliary fat: the good, the bad and the ugly. | 2007 | Details |
| A27679 | 17684197 | Am J Clin Nutr | Comparative review of diets for the metabolic syndrome: implications for nonalcoholic fatty liver disease. | 2007 | Details |
| A27839 | 17296492 | J Nutr Biochem | Nonalcoholic fatty liver disease: predisposing factors and the role of nutrition. | 2007 | Details |
| A28123 | 16366738 | Altern Med Rev | Adverse effects of dietary fructose. | 2005 | Details |
| A28279 | 15824194 | Hypertension | Fructose-induced fatty liver disease: hepatic effects of blood pressure and plasma triglyceride reduction. | 2005 | Details |
| A28755 | 35058729 | J Ginseng Res | Oral administration of Jinan Red Ginseng and licorice extract mixtures ameliorates nonalcoholic steatohepatitis by modulating lipogenesis. | 2021 | Details |
| A29074 | 34619076 | Cell Metab | "Sweet death": Fructose as a metabolic toxin that targets the gut-liver axis. | 2021 | Details |
| A29264 | 34341511 | Acta Pharmacol Sin | Histone deacetylase inhibitor givinostat attenuates nonalcoholic steatohepatitis and liver fibrosis. | 2021 | Details |
| A29344 | 34221869 | Acta Pharm Sin B | LIX1-like protein promotes liver cancer progression via miR-21-3p-mediated inhibition of fructose-1,6-bisphosphatase. | 2021 | Details |
| A29509 | 33965587 | Cell Mol Gastroenterol Hepatol | Combined ASBT Inhibitor and FGF15 Treatment Improves Therapeutic Efficacy in Experimental Nonalcoholic Steatohepatitis. | 2021 | Details |
| A29606 | 33808404 | Biomedicines | Dulaglutide Alone and in Combination with Empagliflozin Attenuate Inflammatory Pathways and Microbiome Dysbiosis in a Non-Diabetic Mouse Model of NASH. | 2021 | Details |
| A29858 | 33383845 | Antioxidants (Basel) | Genistein Modulated Lipid Metabolism, Hepatic PPARγ, and Adiponectin Expression in Bilateral Ovariectomized Rats with Nonalcoholic Steatohepatitis (NASH). | 2020 | Details |
| A30134 | 32923834 | Hepatol Commun | The Selective Peroxisome Proliferator-Activated Receptor Gamma Modulator CHS-131 Improves Liver Histopathology and Metabolism in a Mouse Model of Obesity and Nonalcoholic Steatohepatitis. | 2020 | Details |
| A30204 | 32821335 | World J Hepatol | Anti-inflammatory and anti-oxidant effects of aloe vera in rats with non-alcoholic steatohepatitis. | 2020 | Details |
| A30722 | 31909359 | Hepatol Commun | Farnesoid X Receptor Agonism, Acetyl-Coenzyme A Carboxylase Inhibition, and Back Translation of Clinically Observed Endpoints of De Novo Lipogenesis in a Murine NASH Model. | 2019 | Details |
| A30723 | 31909358 | Hepatol Commun | Ablation of Hmgb1 in Intestinal Epithelial Cells Causes Intestinal Lipid Accumulation and Reduces NASH in Mice. | 2019 | Details |
| A30847 | 31680767 | Korean J Physiol Pharmacol | Efficacy of evogliptin and cenicriviroc against nonalcoholic steatohepatitis in mice: a comparative study. | 2019 | Details |
| A30905 | 31585800 | Mol Ther | MicroRNA 223 3p Negatively Regulates the NLRP3 Inflammasome in Acute and Chronic Liver Injury. | 2019 | Details |
| A30947 | 31497744 | Hepatol Commun | Characterization of Cellular Sources and Circulating Levels of Extracellular Vesicles in a Dietary Murine Model of Nonalcoholic Steatohepatitis. | 2019 | Details |
| A31100 | 31227742 | Sci Rep | Combined obeticholic acid and elafibranor treatment promotes additive liver histological improvements in a diet-induced ob/ob mouse model of biopsy-confirmed NASH. | 2019 | Details |
| A31722 | 29983886 | Oncotarget | Oral administration of fructose exacerbates liver fibrosis and hepatocarcinogenesis via increased intestinal permeability in a rat steatohepatitis model. | 2018 | Details |
| A32016 | 29316085 | Hepatol Res | Deletion of endoplasmic reticulum stress-responsive co-chaperone p58IPK protects mice from diet-induced steatohepatitis. | 2018 | Details |
| A32097 | 29196931 | Calcif Tissue Int | Metabolic Syndrome and Bone: Pharmacologically Induced Diabetes has Deleterious Effect on Bone in Growing Obese Rats. | 2017 | Details |
| A32137 | 29124251 | Hepatol Commun | TRAIL Deletion Prevents Liver, but Not Adipose Tissue, Inflammation during Murine Diet-Induced Obesity. | 2017 | Details |
| A32173 | 29057935 | Sci Rep | Gpbar1 agonism promotes a Pgc-1α-dependent browning of white adipose tissue and energy expenditure and reverses diet-induced steatohepatitis in mice. | 2017 | Details |
| A32297 | 28768902 | JCI Insight | Mixed-lineage kinase 3 pharmacological inhibition attenuates murine nonalcoholic steatohepatitis. | 2017 | Details |
| A32493 | 28298638 | Sci Rep | pNaKtide Attenuates Steatohepatitis and Atherosclerosis by Blocking Na/K-ATPase/ROS Amplification in C57Bl6 and ApoE Knockout Mice Fed a Western Diet. | 2017 | Details |
| A33165 | 26566303 | J Clin Biochem Nutr | Sodium 4-phenylbutyrate prevents murine dietary steatohepatitis caused by trans-fatty acid plus fructose. | 2015 | Details |
| A33442 | 25978364 | PLoS One | Liver injury and fibrosis induced by dietary challenge in the Ossabaw miniature Swine. | 2015 | Details |
| A33490 | 25888330 | Gastroenterology | Hepatocyte Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 4 Regulates Stress Signaling, Fibrosis, and Insulin Sensitivity During Development of Steatohepatitis in Mice. | 2015 | Details |
| A33515 | 25830098 | Mol Metab | The LXR inverse agonist SR9238 suppresses fibrosis in a model of non-alcoholic steatohepatitis. | 2015 | Details |
| A34881 | 22318941 | Hepatology | Stat3-mediated activation of microRNA-23a suppresses gluconeogenesis in hepatocellular carcinoma by down-regulating glucose-6-phosphatase and peroxisome proliferator-activated receptor gamma, coactivator 1 alpha. | 2012 | Details |
| A35224 | 21376711 | Chem Biol Interact | Cytotoxic molecular mechanisms and cytoprotection by enzymic metabolism or autoxidation for glyceraldehyde, hydroxypyruvate and glycolaldehyde. | 2011 | Details |
| A35460 | 20607689 | Hepatology | High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis. | 2010 | Details |
| A35480 | 20561512 | Chem Biol Interact | Hepatocyte or serum albumin protein carbonylation by oxidized fructose metabolites: Glyceraldehyde or glycolaldehyde as endogenous toxins? | 2010 | Details |
| A35749 | 19776184 | J Nutr | Rats fed fructose-enriched diets have characteristics of nonalcoholic hepatic steatosis. | 2009 | Details |
| A35909 | 19434740 | Hepatology | Nutritional model of steatohepatitis and metabolic syndrome in the Ossabaw miniature swine. | 2009 | Details |
| A36106 | 19000661 | Chem Biol Interact | Fructose and carbonyl metabolites as endogenous toxins. | 2008 | Details |
| A37399 | 15770222 | Eur J Clin Nutr | Effects of oligofructose on glucose and lipid metabolism in patients with nonalcoholic steatohepatitis: results of a pilot study. | 2005 | Details |
| A38211 | 11890207 | Crit Rev Clin Lab Sci | Mechanisms of liver injury relevant to pediatric hepatology. | 2002 | Details |
| A40637 | 2996484 | Biochem Genet | Fructose bisphosphatase isozymes of the mouse. I. Inheritance. | 1985 | Details |
| A42230 | 35158374 | Diabetes Care | Fructose Intake From Fruit Juice and Sugar-Sweetened Beverages Is Associated With Higher Intrahepatic Lipid Content: The Maastricht Study. | 2022 | Details |
| A42242 | 35118020 | J Lipid Atheroscler | Metabolism and Health Impacts of Dietary Sugars. | 2022 | Details |
| A42317 | 34887111 | Clin Investig Arterioscler | Bempedoic acid as a PPARα activator: new perspectives for hepatic steatosis treatment in a female rat experimental model. | 2021 | Details |
| A42359 | 34767670 | Biofactors | Vitamin D3 enhances the effects of omega-3 oils against metabolic dysfunction-associated fatty liver disease in rat. | 2021 | Details |
| A42452 | 34503598 | J Dev Orig Health Dis | Metabolic programming in offspring of mice fed fructose during pregnancy and lactation. | 2021 | Details |
| A42573 | 34134003 | Clin Nutr | Fructose intake is not associated to the risk of hepatic fibrosis in patients with Non-Alcoholic Fatty Liver Disease (NAFLD). | 2021 | Details |
| A42588 | 34101669 | Am J Gastroenterol | "Sickeningly Sweet"…. High-Fructose Corn Syrup-Caveat Emptor! | 2021 | Details |
| A42627 | 33980244 | BMC Complement Med Ther | Correction to: Hepatoprotective effect of silymarin on fructose induced nonalcoholic fatty liver disease in male albino wistar rats. | 2021 | Details |
| A42745 | 33595107 | J Physiol | Sex-specific metabolic changes induced by high fructose corn syrup during adolescence: novel evidence from metabolomic and microbiome analyses in mice. | 2021 | Details |
| A42770 | 33525643 | Nutrients | The Marine Microalga, Tisochrysis lutea, Protects against Metabolic Disorders Associated with Metabolic Syndrome and Obesity. | 2021 | Details |
| A42799 | 33445170 | J Clin Invest | Apobec1 complementation factor overexpression promotes hepatic steatosis, fibrosis, and hepatocellular cancer. | 2021 | Details |
| A42865 | 33257823 | Nat Rev Endocrinol | Metabolic liver disease - what's in a name? | 2021 | Details |
| A42956 | 32970909 | Liver Int | Liver adenomatosis and NAFLD developed in the context of hereditary fructose intolerance. | 2020 | Details |
| A42986 | 32887949 | Nat Rev Endocrinol | Role of fructose in NASH defined. | 2020 | Details |
| A43066 | 32646248 | Expert Opin Drug Discov | What is on the horizon for type 2 diabetes pharmacotherapy? - An overview of the antidiabetic drug development pipeline. | 2020 | Details |
| A43091 | 32591859 | Cell Mol Life Sci | KHK inhibition for the treatment of hereditary fructose intolerance and nonalcoholic fatty liver disease: a double-edged sword. | 2020 | Details |
| A43160 | 32403898 | Clin Exp Pediatr | Early menarche and its consequence in Korean female: reducing fructose intake could be one solution. | 2020 | Details |
| A43174 | 32373709 | Int J Cardiol Heart Vasc | Can cysteinyl cathepsin activity control diet-induced NAFLD? | 2020 | Details |
| A43200 | 32318746 | J Mol Med (Berl) | Fructose metabolism by the guts cuts liver fat. | 2020 | Details |
| A43277 | 32086945 | Hepatology | Elevated Fructose and Uric Acid Through Aldose Reductase Contribute to Experimental and Human Alcoholic Liver Disease. | 2020 | Details |
| A43460 | 31663469 | Curr Med Chem | Effects of Pterostilbene on Diabetes, Liver Steatosis and Serum Lipids. | 2021 | Details |
| A43616 | 31282740 | Am J Physiol Endocrinol Metab | Copper deficiency can change the microbiome of swine. | 2019 | Details |
| A43617 | 31282739 | Am J Physiol Endocrinol Metab | Reply to Letter to the Editor: "Copper deficiency can change the microbiome of swine". | 2019 | Details |
| A43620 | 31273795 | Hepatology | Fructose Promotion of Intestinal and Liver Injury: A Sugar by Any Other Name That Isn't So Sweet. | 2019 | Details |
| A43636 | 31240235 | Hypoxia (Auckl) | Role of pseudohypoxia in the pathogenesis of type 2 diabetes. | 2019 | Details |
| A43684 | 31104878 | Clin Nutr | Reply-Letter to the Editor-Is liver steatosis diagnostic of non-alcoholic fatty liver disease in patients with hereditary fructose intolerance? | 2019 | Details |
| A43704 | 31078304 | Clin Nutr | Is liver steatosis diagnostic of non-alcoholic fatty liver disease in patients with hereditary fructose intolerance? | 2019 | Details |
| A43719 | 31030166 | J Nutr Biochem | High-fructose drinks affect microRNAs expression differently in lean and obese mice. | 2019 | Details |
| A43840 | 30734689 | Endocr Metab Immune Disord Drug Targets | Silibinin Ameliorates Fructose-induced Lipid Accumulation and Activates Autophagy in HepG2 Cells. | 2019 | Details |
| A43873 | 30629464 | FASEB J | Maternal prebiotic supplementation reduces fatty liver development in offspring through altered microbial and metabolomic profiles in rats. | 2019 | Details |
| A43938 | 30408104 | PLoS One | Effects of fructose-containing sweeteners on fructose intestinal, hepatic, and oral bioavailability in dual-catheterized rats. | 2018 | Details |
| A44059 | 30014902 | Redox Biol | Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1/Nrf2 pathway. | 2018 | Details |
| A44155 | 29558206 | Am J Physiol Endocrinol Metab | Dose-dependent quantitative effects of acute fructose administration on hepatic de novo lipogenesis in healthy humans. | 2018 | Details |
| A44197 | 29452087 | Gastroenterology | PNPLA3: A Determinant of Response to Low-Fructose Diet in Nonalcoholic Fatty Liver Disease. | 2018 | Details |
| A44275 | 29175287 | J Hepatol | Energy drinks and adolescents - A hepatic health hazard? | 2017 | Details |
| A44320 | 29035477 | J Calif Dent Assoc | Fructose and Nonalcoholic Fatty Liver Disease | 2016 | Details |
| A44415 | 28690178 | J Hepatol | Fructose, uric acid, and zonal differences in NASH. | 2017 | Details |
| A44416 | 28690177 | J Hepatol | Reply to: "Fructose, uric acid and zonal differences in NASH". | 2017 | Details |
| A44438 | 28628040 | J Clin Invest | Lipogenic transcription factor ChREBP mediates fructose-induced metabolic adaptations to prevent hepatotoxicity. | 2017 | Details |
| A44462 | 28548281 | J Intern Med | Adverse effects of fructose on cardiometabolic risk factors and hepatic lipid metabolism in subjects with abdominal obesity. | 2017 | Details |
| A44582 | 28096127 | Adv Nutr | Formation of Fructose-Mediated Advanced Glycation End Products and Their Roles in Metabolic and Inflammatory Diseases. | 2017 | Details |
| A44910 | 26858005 | Alcohol Clin Exp Res | Chronic Alcohol Consumption Causes Liver Injury in High-Fructose-Fed Male Mice Through Enhanced Hepatic Inflammatory Response. | 2016 | Details |
| A44975 | 26566312 | J Clin Biochem Nutr | Sitagliptin can inhibit the development of hepatic steatosis in high-fructose diet-fed ob/ob mice. | 2015 | Details |
| A45174 | 25813056 | Am J Physiol Gastrointest Liver Physiol | Kupffer cell depletion protects against the steatosis, but not the liver damage, induced by marginal-copper, high-fructose diet in male rats. | 2015 | Details |
| A45236 | 25564814 | J Pediatr Gastroenterol Nutr | Authors' response. | 2015 | Details |
| A45238 | 25564811 | J Pediatr Gastroenterol Nutr | Overstated associations between fructose and nonalcoholic fatty liver disease. | 2015 | Details |
| A45313 | 25222975 | Zhonghua Gan Zang Bing Za Zhi | [Fructose as a risk factor nonalcoholic fatty liver disease]. | 2014 | Details |
| A45364 | 24985013 | Nutrition | Fructose content in popular beverages made with and without high-fructose corn syrup. | 2014 | Details |
| A45484 | 24370846 | Curr Opin Lipidol | Fructose vs. glucose and metabolism: do the metabolic differences matter? | 2014 | Details |
| A45524 | 24143116 | Diabetes Metab Syndr Obes | Hepatic function and the cardiometabolic syndrome. | 2013 | Details |