Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Insulin9623 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A52323 | 28661066 | NMR Biomed | Sexual dimorphism in hepatic lipids is associated with the evolution of metabolic status in mice. | 2017 | Details |
| A52327 | 28545035 | Oncotarget | Novel PPARα agonist MHY553 alleviates hepatic steatosis by increasing fatty acid oxidation and decreasing inflammation during aging. | 2017 | Details |
| A52330 | 28490483 | FASEB J | The ratio of dihomo-γ-linolenic acid to deoxycholic acid species is a potential biomarker for the metabolic abnormalities in obesity. | 2017 | Details |
| A52331 | 28486481 | PLoS One | Temporal changes in sphingolipids and systemic insulin sensitivity during the transition from gestation to lactation. | 2017 | Details |
| A52332 | 28474500 | Immun Inflamm Dis | Vitamin D3 supplementation of a high fat high sugar diet ameliorates prediabetic phenotype in female LDLR-/- and LDLR+/+ mice. | 2017 | Details |
| A52333 | 28458462 | Clin Pediatr Endocrinol | Partial lipodystrophy in patients who have undergone hematopoietic stem cell transplantation during childhood: an institutional cross-sectional survey. | 2017 | Details |
| A52334 | 28431322 | J Nutr Biochem | Xanthohumol and 8-prenylnaringenin ameliorate diabetic-related metabolic dysfunctions in mice. | 2017 | Details |
| A52339 | 28400405 | J Endocrinol | Nutritional approaches for managing obesity-associated metabolic diseases. | 2017 | Details |
| A52340 | 28398943 | Med Sci Sports Exerc | Cardiorespiratory Fitness and Risk of Fatty Liver: The Young Finns Study. | 2017 | Details |
| A52343 | 28379591 | Eur Rev Med Pharmacol Sci | Fatty liver and drugs: the two sides of the same coin. | 2017 | Details |
| A52344 | 28378930 | Hepatology | Hepatic FXR/SHP axis modulates systemic glucose and fatty acid homeostasis in aged mice. | 2017 | Details |
| A52345 | 28375880 | Curr Opin Clin Nutr Metab Care | AMP-activated protein kinase, fatty acid metabolism, and insulin sensitivity. | 2017 | Details |
| A52350 | 28267248 | Mol Nutr Food Res | Lycopene and tomato powder supplementation similarly inhibit high-fat diet induced obesity, inflammatory response, and associated metabolic disorders. | 2017 | Details |
| A52353 | 28246016 | Gastroenterology | Gut-Specific Delivery of T-Helper 17 Cells Reduces Obesity and Insulin Resistance in Mice. | 2017 | Details |
| A52354 | 28239649 | JCI Insight | Switching harmful visceral fat to beneficial energy combustion improves metabolic dysfunctions. | 2017 | Details |
| A52356 | 28223503 | Proc Natl Acad Sci U S A | Mitochondrial energy deficiency leads to hyperproliferation of skeletal muscle mitochondria and enhanced insulin sensitivity. | 2017 | Details |
| A52357 | 28222147 | PLoS One | The desert gerbil Psammomys obesus as a model for metformin-sensitive nutritional type 2 diabetes to protect hepatocellular metabolic damage: Impact of mitochondrial redox state. | 2017 | Details |
| A52358 | 28214879 | J Nutrigenet Nutrigenomics | Thiamine Deprivation Produces a Liver ATP Deficit and Metabolic and Genomic Effects in Mice: Findings Are Parallel to Those of Biotin Deficiency and Have Implications for Energy Disorders. | 2017 | Details |
| A52359 | 28213130 | Biochem Biophys Res Commun | Dipeptidyl peptidase-4 impairs insulin signaling and promotes lipid accumulation in hepatocytes. | 2017 | Details |
| A52360 | 28194444 | JCI Insight | Adipocyte JAK2 mediates growth hormone-induced hepatic insulin resistance. | 2017 | Details |
| A52365 | 28153881 | Arterioscler Thromb Vasc Biol | Prevention of Diet-Induced Metabolic Dysregulation, Inflammation, and Atherosclerosis in Ldlr-/- Mice by Treatment With the ATP-Citrate Lyase Inhibitor Bempedoic Acid. | 2017 | Details |
| A52367 | 28110829 | Prostaglandins Leukot Essent Fatty Acids | Lipidomic analysis reveals significant lipogenesis and accumulation of lipotoxic components in ob/ob mouse organs. | 2017 | Details |
| A52368 | 28100772 | J Biol Chem | De Novo Sphingolipid Biosynthesis Is Required for Adipocyte Survival and Metabolic Homeostasis. | 2017 | Details |
| A52370 | 28086952 | J Med Case Rep | Glucagon-like peptide-1 analogues - an efficient therapeutic option for the severe insulin resistance of lipodystrophic syndromes: two case reports. | 2017 | Details |
| A52371 | 28080913 | J Zoo Wildl Med | LIVER ULTRASONOGRAPHY IN DOLPHINS: USE OF ULTRASONOGRAPHY TO ESTABLISH A TECHNIQUE FOR HEPATOBILIARY IMAGING AND TO EVALUATE METABOLIC DISEASE-ASSOCIATED LIVER CHANGES IN BOTTLENOSE DOLPHINS (TURSIOPS TRUNCATUS). | 2016 | Details |
| A52373 | 28052632 | Liver Int | Impact of hepatitis C virus therapy on metabolism and public health. | 2017 | Details |
| A52374 | 28049662 | Am J Clin Nutr | Gut permeability is related to body weight, fatty liver disease, and insulin resistance in obese individuals undergoing weight reduction. | 2016 | Details |
| A52376 | 27925195 | J Cell Physiol | Palmitoleic Acid Improves Metabolic Functions in Fatty Liver by PPARα-Dependent AMPK Activation. | 2017 | Details |
| A52377 | 27921045 | Visc Med | Clinical Scenario of the Metabolic Syndrome. | 2016 | Details |
| A52380 | 27884961 | J Lipid Res | Therapeutic silencing of fat-specific protein 27 improves glycemic control in mouse models of obesity and insulin resistance. | 2016 | Details |
| A52383 | 27832862 | Metabolism | Time-restricted feeding improves insulin resistance and hepatic steatosis in a mouse model of postmenopausal obesity. | 2016 | Details |
| A52385 | 27813205 | Genes Cells | Dietary fructose-induced hepatocellular carcinoma development manifested in mice lacking apoptosis inhibitor of macrophage (AIM). | 2016 | Details |
| A52386 | 27588438 | J Clin Endocrinol Metab | VLDL Triglyceride Kinetics in Lean, Overweight, and Obese Men and Women. | 2016 | Details |
| A52387 | 27799461 | J Endocrinol | Hepatocyte-specific, PPARγ-regulated mechanisms to promote steatosis in adult mice. | 2016 | Details |
| A52388 | 27796312 | Sci Rep | Ubc13 haploinsufficiency protects against age-related insulin resistance and high-fat diet-induced obesity. | 2016 | Details |
| A52391 | 27766312 | JCI Insight | Insulin resistance uncoupled from dyslipidemia due to C-terminal PIK3R1 mutations. | 2016 | Details |
| A52396 | 29489091 | Cesk Fysiol | Metabolically healthy obese individuals -- mechanisms and clinical relevance. | 2016 | Details |
| A52397 | 27659144 | Trends Endocrinol Metab | Perilipin 2 and Age-Related Metabolic Diseases: A New Perspective. | 2016 | Details |
| A52399 | 27629946 | Intern Med | A Comparison of the Abdominal Fat Distribution and Coronary Risk Markers in Body Mass Index-matched Subjects with and without Fatty Liver. | 2016 | Details |
| A52400 | 27628219 | Biol Reprod | Low Body Mass Index in Endometriosis Is Promoted by Hepatic Metabolic Gene Dysregulation in Mice. | 2016 | Details |
| A52401 | 27615511 | Immunobiology | Association of the I148M/PNPLA3 (rs738409) polymorphism with premature coronary artery disease, fatty liver, and insulin resistance in type 2 diabetic patients and healthy controls. The GEA study. | 2016 | Details |
| A52402 | 30452850 | J Med Pract Manage | Ketogenic Weight Loss: The Lowering of Insulin Levels Is the Sleeping Giant in Patient Care. | 2016 | Details |
| A52403 | 27568222 | EBioMedicine | Transgenic Adipose-specific Expression of the Nuclear Receptor RORα Drives a Striking Shift in Fat Distribution and Impairs Glycemic Control. | 2016 | Details |
| A52404 | 27552247 | Endocrinology | Nonnuclear Estrogen Receptor Activation Improves Hepatic Steatosis in Female Mice. | 2016 | Details |
| A52407 | 27533883 | Environ Toxicol | Exposure to an environmentally relevant mixture of organochlorine compounds and polychlorinated biphenyls Promotes hepatic steatosis in male Ob/Ob mice. | 2016 | Details |
| A52408 | 27519883 | Cardiovasc Diabetol | High levels of serum vitamin D are associated with a decreased risk of metabolic diseases in both men and women, but an increased risk for coronary artery calcification in Korean men. | 2016 | Details |
| A52412 | 27382035 | Am J Physiol Endocrinol Metab | Targeting ceramide metabolism in obesity. | 2016 | Details |
| A52421 | 27302175 | Exp Biol Med (Maywood) | Regulation of lipid deposition in farm animals: Parallels between agriculture and human physiology. | 2016 | Details |
| A52423 | 27257602 | Mol Metab | Raptor/mTORC1 loss in adipocytes causes progressive lipodystrophy and fatty liver disease. | 2016 | Details |
| A52426 | 27228955 | Sci Rep | Relationship of Serum Trimethylamine N-Oxide (TMAO) Levels with early Atherosclerosis in Humans. | 2016 | Details |
| A52432 | 27185751 | Hypertension | Adipocyte (Pro)Renin-Receptor Deficiency Induces Lipodystrophy, Liver Steatosis and Increases Blood Pressure in Male Mice. | 2016 | Details |
| A52436 | 27138913 | Diabetologia | Neuronal human BACE1 knockin induces systemic diabetes in mice. | 2016 | Details |
| A52437 | 27126637 | Hum Mol Genet | Early hypermethylation of hepatic Igfbp2 results in its reduced expression preceding fatty liver in mice. | 2016 | Details |
| A52442 | 27094951 | Sci Rep | Hypoxia-inducible factor prolyl hydroxylase 1 (PHD1) deficiency promotes hepatic steatosis and liver-specific insulin resistance in mice. | 2016 | Details |
| A52446 | 27060421 | Am J Obstet Gynecol | High-fructose diet in pregnancy leads to fetal programming of hypertension, insulin resistance, and obesity in adult offspring. | 2016 | Details |
| A52448 | 27033445 | Physiol Rep | Similar degrees of obesity induced by diet or aging cause strikingly different immunologic and metabolic outcomes. | 2016 | Details |
| A52451 | 27016890 | Diabetes Metab | Osteoprotegerin levels are associated with liver fat and liver markers in dysmetabolic adults. | 2016 | Details |
| A52454 | 26976583 | Proc Natl Acad Sci U S A | Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats. | 2016 | Details |
| A52455 | 26964726 | Obes Res Clin Pract | Predictive value of serum dihomo-γ-linolenic acid level and estimated Δ-5 desaturase activity in patients with hepatic steatosis. | 2016 | Details |
| A52458 | 26921251 | Oncotarget | Chronic Trypanosoma cruzi infection potentiates adipose tissue macrophage polarization toward an anti-inflammatory M2 phenotype and contributes to diabetes progression in a diet-induced obesity model. | 2016 | Details |
| A52461 | 26893932 | Clin Hypertens | Change in fatty liver status and 5-year risk of incident metabolic syndrome: a retrospective cohort study. | 2015 | Details |
| A52462 | 26865583 | Eur J Endocrinol | EJE PRIZE 2015: How does insulin resistance arise, and how does it cause disease? Human genetic lessons. | 2016 | Details |
| A52463 | 26838266 | Nat Commun | PKR is not obligatory for high-fat diet-induced obesity and its associated metabolic and inflammatory complications. | 2016 | Details |
| A52465 | 26777475 | Nutr Metab Cardiovasc Dis | Subclinical atherosclerosis is associated with Epicardial Fat Thickness and hepatic steatosis in the general population. | 2015 | Details |
| A52469 | 26652506 | Expert Rev Clin Pharmacol | Fatty liver in adults receiving antiepileptic medications: relationship to the metabolic risks. | 2016 | Details |
| A52472 | 26608809 | Exp Gerontol | The presence of the ovary prevents hepatic mitochondrial oxidative stress in young and aged female mice through glutathione peroxidase 1. | 2015 | Details |
| A52473 | 26608096 | J Physiol | The roles of c-Jun NH2-terminal kinases (JNKs) in obesity and insulin resistance. | 2015 | Details |
| A52474 | 26603189 | Cell Metab | Fetuin B Is a Secreted Hepatocyte Factor Linking Steatosis to Impaired Glucose Metabolism. | 2015 | Details |
| A52476 | 26562264 | Endocrinology | Androgen Deficiency Exacerbates High-Fat Diet-Induced Metabolic Alterations in Male Mice. | 2015 | Details |
| A52480 | 26491440 | Int J Endocrinol | Sex Hormones and Their Receptors Regulate Liver Energy Homeostasis. | 2015 | Details |
| A52485 | 26467487 | Rev Chil Pediatr | [Hyperuricaemia and metabolic syndrome in obese children and adolescents]. | 2015 | Details |
| A52486 | 26464614 | Int J Clin Exp Pathol | Lipid droplet-associated proteins in alcoholic liver disease: a potential linkage with hepatocellular damage. | 2015 | Details |
| A52489 | 26439088 | J Clin Endocrinol Metab | The Genetic Variant I148M in PNPLA3 Is Associated With Increased Hepatic Retinyl-Palmitate Storage in Humans. | 2015 | Details |
| A52490 | 26423886 | J Nutr Biochem | Berry intake changes hepatic gene expression and DNA methylation patterns associated with high-fat diet. | 2015 | Details |
| A52492 | 26414730 | Curr Med Res Opin | Why focus on uric acid? | 2015 | Details |
| A52494 | 26382148 | J Vis Exp | Determination of Fatty Acid Oxidation and Lipogenesis in Mouse Primary Hepatocytes. | 2015 | Details |
| A52495 | 26376619 | Crit Rev Clin Lab Sci | Sugar consumption, metabolic disease and obesity: The state of the controversy. | 2015 | Details |
| A52497 | 26344102 | Cell Metab | Celastrol Protects against Obesity and Metabolic Dysfunction through Activation of a HSF1-PGC1α Transcriptional Axis. | 2015 | Details |
| A52498 | 26337697 | Obes Surg | Changes in Bile Acid Profile After Laparoscopic Sleeve Gastrectomy are Associated with Improvements in Metabolic Profile and Fatty Liver Disease. | 2016 | Details |
| A52499 | 26336158 | J Mol Endocrinol | Truncation of POC1A associated with short stature and extreme insulin resistance. | 2015 | Details |
| A52505 | 26256894 | Ann Hepatol | Fatty liver and abdominal fat relationships with high C-reactive protein in adults without coronary heart disease. | 2016 | Details |
| A52507 | 26252778 | PLoS One | 1H-MRS Measured Ectopic Fat in Liver and Muscle in Danish Lean and Obese Children and Adolescents. | 2015 | Details |
| A52513 | 26171768 | Aging Male | Connections between lower urinary tract symptoms related to benign prostatic enlargement and metabolic syndrome with its components: a systematic review and meta-analysis. | 2015 | Details |
| A52515 | 26152236 | J Agric Food Chem | Dietary (-)-Epigallocatechin-3-gallate Supplementation Counteracts Aging-Associated Skeletal Muscle Insulin Resistance and Fatty Liver in Senescence-Accelerated Mouse. | 2015 | Details |
| A52517 | 26119995 | Int J Obes (Lond) | Leptin-induced mitochondrial fusion mediates hepatic lipid accumulation. | 2015 | Details |
| A52518 | 26112408 | J Biol Chem | Lipid-induced Muscle Insulin Resistance Is Mediated by GGPPS via Modulation of the RhoA/Rho Kinase Signaling Pathway. | 2015 | Details |
| A52519 | 26101431 | Arch Dis Child | Optimal management of polycystic ovary syndrome in adolescence. | 2015 | Details |
| A52522 | 26097021 | Obesity (Silver Spring) | Protection from diet-induced obesity and insulin resistance in mice lacking CCL19-CCR7 signaling. | 2015 | Details |
| A52523 | 26059381 | Nutrition | Conjugated linoleic acid reduces visceral and ectopic lipid accumulation and insulin resistance in chronic severe hypertriacylglycerolemia. | 2015 | Details |
| A52528 | 25972231 | Diabetologia | Oncostatin M is a potential agent for the treatment of obesity and related metabolic disorders: a study in mice. | 2015 | Details |
| A52529 | 25943649 | Eur J Nutr | Fasting for 3 days during the suckling-weaning transient period in male rats induces metabolic abnormalities in the liver and is associated with impaired glucose tolerance in adulthood. | 2015 | Details |
| A52530 | 25941430 | J Clin Exp Hepatol | Study of the effects of cyclooxygenase-2 inhibitor on the promotion of hepatic tumorigenesis in rats fed a high fat diet. | 2015 | Details |
| A52532 | 25916863 | Eur J Nutr | Labrador tea (Rhododendron groenlandicum) attenuates insulin resistance in a diet-induced obesity mouse model. | 2015 | Details |
| A52533 | 25906681 | Biochim Biophys Acta | Fenofibrate insulates diacylglycerol in lipid droplet/ER and preserves insulin signaling transduction in the liver of high fat fed mice. | 2015 | Details |
| A52537 | 25895678 | Cell Physiol Biochem | Mice Lacking Free Fatty Acid Receptor 1 (GPR40/FFAR1) are Protected Against Conjugated Linoleic Acid-Induced Fatty Liver but Develop Inflammation and Insulin Resistance in the Brain. | 2015 | Details |
| A52538 | 25854303 | Endocrine | Short-term administration of GW501516 improves inflammatory state in white adipose tissue and liver damage in high-fructose-fed mice through modulation of the renin-angiotensin system. | 2015 | Details |
| A52541 | 25805830 | FASEB J | Activated Kupffer cells inhibit insulin sensitivity in obese mice. | 2015 | Details |
| A52542 | 25766534 | Cell Physiol Biochem | Increased oxidative stress and mitochondrial dysfunction in zucker diabetic rat liver and brain. | 2015 | Details |
| A52544 | 25749935 | J Physiol Biochem | Gut microbiota: a key player in health and disease. A review focused on obesity. | 2015 | Details |
| A52545 | 25745813 | Gen Comp Endocrinol | Histomorphology of the bottlenose dolphin (Tursiops truncatus) pancreas and association of increasing islet β-cell size with chronic hypercholesterolemia. | 2015 | Details |