Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Acetyl-CoA carboxylase 154 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A00261 | 35162967 | Int J Mol Sci | Quercetin Reduces Lipid Accumulation in a Cell Model of NAFLD by Inhibiting De Novo Fatty Acid Synthesis through the Acetyl-CoA Carboxylase 1/AMPK/PP2A Axis. | 2022 | Details |
| A00748 | 34981123 | Biosci Rep | Tandem mass tag-based proteomics analysis of type 2 diabetes mellitus with non-alcoholic fatty liver disease in mice treated with acupuncture. | 2022 | Details |
| A00982 | 34910548 | Sci Transl Med | A small molecule targeting ALOX12-ACC1 ameliorates nonalcoholic steatohepatitis in mice and macaques. | 2021 | Details |
| A00983 | 34910546 | Sci Transl Med | Multiple omics study identifies an interspecies conserved driver for nonalcoholic steatohepatitis. | 2021 | Details |
| A01997 | 34535562 | J Pharmacol Exp Ther | Selective Acetyl-CoA Carboxylase 1 Inhibitor Improves Hepatic Steatosis and Hepatic Fibrosis in a Preclinical Nonalcoholic Steatohepatitis Model. | 2021 | Details |
| A03197 | 34093169 | Front Pharmacol | Dapagliflozin Alleviates Hepatic Steatosis by Restoring Autophagy via the AMPK-mTOR Pathway. | 2021 | Details |
| A03474 | 33990765 | Acta Pharmacol Sin | Blueberry-derived exosomes-like nanoparticles ameliorate nonalcoholic fatty liver disease by attenuating mitochondrial oxidative stress. | 2021 | Details |
| A03693 | 33900847 | Am J Physiol Endocrinol Metab | High uric acid induces liver fat accumulation via ROS/JNK/AP-1 signaling. | 2021 | Details |
| A05426 | 33260679 | Nutrients | The Dietary Replacement of Soybean Oil by Canola Oil Does Not Prevent Liver Fatty Acid Accumulation and Liver Inflammation in Mice. | 2020 | Details |
| A07015 | 32657010 | Obesity (Silver Spring) | Hepatocyte Notch Signaling Deregulation Related to Lipid Metabolism in Women with Obesity and Nonalcoholic Fatty Liver. | 2020 | Details |
| A07142 | 32604760 | Nutrients | Selenoneine Ameliorates Hepatocellular Injury and Hepatic Steatosis in a Mouse Model of NAFLD. | 2020 | Details |
| A08330 | 32150756 | Hepatology | N6 -Methyladenosine Reader Protein YT521-B Homology Domain-Containing 2 Suppresses Liver Steatosis by Regulation of mRNA Stability of Lipogenic Genes. | 2020 | Details |
| A08764 | 31993306 | Acta Pharm Sin B | Cytochrome P450 endoplasmic reticulum-associated degradation (ERAD): therapeutic and pathophysiological implications. | 2019 | Details |
| A08772 | 31990961 | PLoS One | Acetyl-CoA carboxylase 1 and 2 inhibition ameliorates steatosis and hepatic fibrosis in a MC4R knockout murine model of nonalcoholic steatohepatitis. | 2020 | Details |
| A09367 | 31776016 | Environ Res | Adolescent exposure to environmental level of PCBs (Aroclor 1254) induces non-alcoholic fatty liver disease in male mice. | 2019 | Details |
| A09554 | 31695954 | Food Sci Biotechnol | Dansameum regulates hepatic lipogenesis and inflammation in vitro and in vivo. | 2019 | Details |
| A09807 | 31602953 | Zhongguo Zhong Yao Za Zhi | [Mechanism of Calculus Bovis Sativus in inhibiting hepatocyte lipid deposition based on serum pharmacology]. | 2019 | Details |
| A09941 | 31551937 | Front Endocrinol (Lausanne) | Non-alcoholic Fatty Liver Disease Induced by Perinatal Exposure to Bisphenol a Is Associated With Activated mTOR and TLR4/NF-κB Signaling Pathways in Offspring Rats. | 2019 | Details |
| A10099 | 31484323 | Nutrients | Indole-3-Acetic Acid Alleviates Nonalcoholic Fatty Liver Disease in Mice via Attenuation of Hepatic Lipogenesis, and Oxidative and Inflammatory Stress. | 2019 | Details |
| A10174 | 31454158 | Mol Nutr Food Res | Tomatidine Reduces Palmitate-Induced Lipid Accumulation by Activating AMPK via Vitamin D Receptor-Mediated Signaling in Human HepG2 Hepatocytes. | 2019 | Details |
| A10748 | 31212314 | J Nutr | Dietary β-Cryptoxanthin Inhibits High-Refined Carbohydrate Diet-Induced Fatty Liver via Differential Protective Mechanisms Depending on Carotenoid Cleavage Enzymes in Male Mice. | 2019 | Details |
| A11007 | 31083413 | Int J Mol Sci | Arazyme Suppresses Hepatic Steatosis and Steatohepatitis in Diet-Induced Non-Alcoholic Fatty Liver Disease-Like Mouse Model. | 2019 | Details |
| A11190 | 31005808 | Phytomedicine | Amelioration of nonalcoholic fatty liver disease by swertiamarin in fructose-fed mice. | 2018 | Details |
| A11617 | 30818824 | Nutrients | A Pathophysiological Model of Non-Alcoholic Fatty Liver Disease Using Precision-Cut Liver Slices. | 2019 | Details |
| A11959 | 30668392 | Phytomedicine | Yangonin protects against non-alcoholic fatty liver disease through farnesoid X receptor. | 2018 | Details |
| A12878 | 30244972 | Cell Metab | Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma. | 2018 | Details |
| A13814 | 29743929 | Nutr Metab (Lond) | Neonatal overfeeding induced glucocorticoid overexposure accelerates hepatic lipogenesis in male rats. | 2018 | Details |
| A16086 | 28577569 | Lipids Health Dis | Overexpression of apolipoprotein A-I alleviates endoplasmic reticulum stress in hepatocytes. | 2017 | Details |
| A16146 | 28539716 | Pharmacogn Mag | Prevention Mechanism of 2,3,5,4'-Tetrahydroxy-stilbene-2-O-β-D-glucoside on Lipid Accumulation in Steatosis Hepatic L-02 Cell. | 2017 | Details |
| A16524 | 28337300 | Am J Transl Res | Mutation of miR-21 targets endogenous lipoprotein receptor-related protein 6 and nonalcoholic fatty liver disease. | 2017 | Details |
| A17406 | 27801862 | Nutrients | Liver Fatty Acid Composition and Inflammation in Mice Fed with High-Carbohydrate Diet or High-Fat Diet. | 2016 | Details |
| A17492 | 27765368 | Phytomedicine | The chloroform extract of Cyclocarya paliurus attenuates high-fat diet induced non-alcoholic hepatic steatosis in Sprague Dawley rats. | 2016 | Details |
| A17953 | 27456850 | BMC Complement Altern Med | Anti-lipoapoptotic effects of Alisma orientalis extract on non-esterified fatty acid-induced HepG2 cells. | 2016 | Details |
| A18295 | 27234712 | Mol Nutr Food Res | β-Caryophyllene attenuates palmitate-induced lipid accumulation through AMPK signaling by activating CB2 receptor in human HepG2 hepatocytes. | 2016 | Details |
| A21697 | 25111690 | Lab Invest | Uric acid induces fat accumulation via generation of endoplasmic reticulum stress and SREBP-1c activation in hepatocytes. | 2014 | Details |
| A21706 | 25105012 | Cell Biosci | Regulation of fatty acid composition and lipid storage by thyroid hormone in mouse liver. | 2014 | Details |
| A21910 | 24967351 | Biomed Res Int | Enhanced amelioration of high-fat diet-induced fatty liver by docosahexaenoic acid and lysine supplementations. | 2014 | Details |
| A22114 | 24811405 | Appl Microbiol Biotechnol | Preventing non-alcoholic fatty liver disease through Lactobacillus johnsonii BS15 by attenuating inflammation and mitochondrial injury and improving gut environment in obese mice. | 2014 | Details |
| A22723 | 24356885 | Am J Physiol Gastrointest Liver Physiol | Therapeutic role of niacin in the prevention and regression of hepatic steatosis in rat model of nonalcoholic fatty liver disease. | 2013 | Details |
| A22949 | 24185692 | Nat Med | Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin. | 2013 | Details |
| A22981 | 24140006 | Prostaglandins Leukot Essent Fatty Acids | A diet high in α-linolenic acid and monounsaturated fatty acids attenuates hepatic steatosis and alters hepatic phospholipid fatty acid profile in diet-induced obese rats. | 2013 | Details |
| A24078 | 23258548 | Mol Pharmacol | 5-cholesten-3β,25-diol 3-sulfate decreases lipid accumulation in diet-induced nonalcoholic fatty liver disease mouse model. | 2012 | Details |
| A26275 | 20801631 | J Nutr Biochem | An increase in liver PPARγ2 is an initial event to induce fatty liver in response to a diet high in butter: PPARγ2 knockdown improves fatty liver induced by high-saturated fat. | 2010 | Details |
| A26753 | 19832698 | Clin Sci (Lond) | Hypoxia aggravates non-alcoholic steatohepatitis in mice lacking hepatocellular PTEN. | 2009 | Details |
| A33951 | 24793484 | Biochimie | ApoA-I or ABCA1 expression suppresses fatty acid synthesis by reducing 27-hydroxycholesterol levels. | 2014 | Details |
| A36768 | 17300698 | Hepatol Res | Longitudinal analysis of murine steatohepatitis model induced by chronic exposure to high-fat diet. | 2007 | Details |
| A43197 | 32331890 | J Dairy Sci | Sirtuin 3 improves fatty acid metabolism in response to high nonesterified fatty acids in calf hepatocytes by modulating gene expression. | 2020 | Details |
| A44920 | 26790190 | Pharmazie | Nectandrin B, a lignan isolated from nutmeg, inhibits liver X receptor-α-induced hepatic lipogenesis through AMP-activated protein kinase activation. | 2015 | Details |
| A44975 | 26566312 | J Clin Biochem Nutr | Sitagliptin can inhibit the development of hepatic steatosis in high-fructose diet-fed ob/ob mice. | 2015 | Details |
| A45509 | 24223615 | Evid Based Complement Alternat Med | Zerumbone, a Natural Cyclic Sesquiterpene of Zingiber zerumbet Smith, Attenuates Nonalcoholic Fatty Liver Disease in Hamsters Fed on High-Fat Diet. | 2013 | Details |
| A47177 | 24146112 | Arch Toxicol | Protective effects of dioscin against alcohol-induced liver injury. | 2013 | Details |
| A49125 | 16622296 | Endocrine | Modulation of fatty acid metabolism as a potential approach to the treatment of obesity and the metabolic syndrome. | 2006 | Details |
| A52164 | 30520016 | Int J Cancer | Impact of systemic and tumor lipid metabolism on everolimus efficacy in advanced pancreatic neuroendocrine tumors (pNETs). | 2019 | Details |
| A52610 | 24944901 | Mol Metab | Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation. | 2014 | Details |