Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Peroxisome proliferator-activated receptor alpha114 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A00006 | 35256934 | Acta Pharm Sin B | Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma. | 2021 | Details |
| A00547 | 35051553 | Mol Cell Endocrinol | Pdcd4 promotes lipid deposition by attenuating PPARα-mediated fatty acid oxidation in hepatocytes. | 2022 | Details |
| A00595 | 35035496 | Evid Based Complement Alternat Med | Lanzhang Granules Ameliorate Nonalcoholic Fatty Liver Disease by Regulating the PPARα Signaling Pathway. | 2022 | Details |
| A00623 | 35024308 | Acta Pharm Sin B | Proteomics and metabolic phenotyping define principal roles for the aryl hydrocarbon receptor in mouse liver. | 2021 | Details |
| A00725 | 34988225 | Biomed Res Int | Target Deconvolution of Fenofibrate in Nonalcoholic Fatty Liver Disease Using Bioinformatics Analysis. | 2021 | Details |
| A01024 | 34900534 | Acta Pharm Sin B | Integrative lipidomic and transcriptomic study unravels the therapeutic effects of saikosaponins A and D on non-alcoholic fatty liver disease. | 2021 | Details |
| A01186 | 34836021 | Nutrients | Euphausia pacifica (North Pacific Krill): Review of Chemical Features and Potential Benefits of 8-HEPE against Metabolic Syndrome, Dyslipidemia, NAFLD, and Atherosclerosis. | 2021 | Details |
| A01775 | 34621326 | Evid Based Complement Alternat Med | A Novel Identified Peptide Hormone "Metabolitin" Attenuates Lipid Absorption in the Small Intestine of Diabetic Mice with Nonalcoholic Fatty Liver Disease by Regulating Neurotensin and AMPK Signaling Pathway. | 2021 | Details |
| A02310 | 34425199 | Int J Biochem Cell Biol | Sulfated glucuronomannan hexasaccharide G6S1 enhanced lipolysis and lipophagy via PPARα pathway. | 2021 | Details |
| A02443 | 34370218 | Clin J Gastroenterol | Efficacy of elafibranor in patients with liver abnormalities especially non-alcoholic steatohepatitis: a systematic review and meta-analysis. | 2021 | Details |
| A02757 | 34257694 | Evid Based Complement Alternat Med | Alleviative Effect of Ruellia tuberosa L. on Insulin Resistance and Abnormal Lipid Accumulation in TNF-α-Treated FL83B Mouse Hepatocytes. | 2021 | Details |
| A02937 | 34191493 | Anal Chem | Exploring the Changes of Peroxisomal Polarity in the Liver of Mice with Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A03020 | 34161164 | J Med Food | Protective Role of Dietary Capsanthin in a Mouse Model of Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A03551 | 33960342 | Food Funct | Functional milk fat enriched in conjugated linoleic acid prevented liver lipid accumulation induced by a high-fat diet in male rats. | 2021 | Details |
| A03605 | 33934381 | Hepatology | Hepatic Small Ubiquitin-Related Modifier (SUMO)-Specific Protease 2 Controls Systemic Metabolism Through SUMOylation-Dependent Regulation of Liver-Adipose Tissue Crosstalk. | 2021 | Details |
| A04045 | 33777674 | Acta Pharm Sin B | S-Allylmercaptocysteine improves alcoholic liver disease partly through a direct modulation of insulin receptor signaling. | 2020 | Details |
| A04128 | 33746742 | Front Pharmacol | Liraglutide Alleviates Hepatic Steatosis and Liver Injury in T2MD Rats via a GLP-1R Dependent AMPK Pathway. | 2021 | Details |
| A04989 | 33422644 | Mol Metab | Neonatal overfeeding during lactation rapidly and permanently misaligns the hepatic circadian rhythm and programmes adult NAFLD. | 2021 | Details |
| A05052 | 33392801 | Curr Atheroscler Rep | Selective Peroxisome Proliferator-Activated Receptor Alpha Modulators (SPPARMα) in the Metabolic Syndrome: Is Pemafibrate Light at the End of the Tunnel? | 2021 | Details |
| A05366 | 33281535 | Food Nutr Res | Bile salt hydrolase-overexpressing Lactobacillus strains can improve hepatic lipid accumulation in vitro in an NAFLD cell model. | 2020 | Details |
| A06127 | 32996649 | FASEB J | N-glycosylation of CREBH improves lipid metabolism and attenuates lipotoxicity in NAFLD by modulating PPARα and SCD-1. | 2020 | Details |
| A06222 | 32963289 | Sci Rep | Maternal exercise conveys protection against NAFLD in the offspring via hepatic metabolic programming. | 2020 | Details |
| A06917 | 32698101 | Growth Horm IGF Res | Growth hormone ameliorates high glucose-induced steatosis on in vitro cultured human HepG2 hepatocytes by inhibiting de novo lipogenesis via ChREBP and FAS suppression. | 2020 | Details |
| A06996 | 32666969 | Food Funct | Ameliorative effects and molecular mechanisms of vine tea on western diet-induced NAFLD. | 2020 | Details |
| A07486 | 32476787 | World J Gastroenterol | Folic acid attenuates high-fat diet-induced steatohepatitis via deacetylase SIRT1-dependent restoration of PPARα. | 2020 | Details |
| A07510 | 32463484 | Hepatology | Protective and Detrimental Roles of p38α Mitogen-Activated Protein Kinase in Different Stages of Nonalcoholic Fatty Liver Disease. | 2020 | Details |
| A07617 | 32419060 | Biochem Genet | Suppression of miR-30a-3p Attenuates Hepatic Steatosis in Non-alcoholic Fatty Liver Disease. | 2020 | Details |
| A08763 | 31993314 | Acta Pharm Sin B | Impact of obese levels on the hepatic expression of nuclear receptors and drug-metabolizing enzymes in adult and offspring mice. | 2019 | Details |
| A08799 | 31981449 | Clin Transl Sci | A 3-week nonalcoholic steatohepatitis mouse model shows elafibranor benefits on hepatic inflammation and cell death. | 2020 | Details |
| A09212 | 31834842 | J Med Food | Effects of Eriobotrya japonica Water Extract on Alcoholic and Nonalcoholic Fatty Liver Impairment. | 2019 | Details |
| A09367 | 31776016 | Environ Res | Adolescent exposure to environmental level of PCBs (Aroclor 1254) induces non-alcoholic fatty liver disease in male mice. | 2019 | Details |
| A09475 | 31730885 | Toxicol Lett | In vitro and in vivo approaches for identifying the role of aryl hydrocarbon receptor in the development of nonalcoholic fatty liver disease. | 2019 | Details |
| A09701 | 31640183 | Nutrients | Water Extract of Curcuma longa L. Ameliorates Non-Alcoholic Fatty Liver Disease. | 2019 | Details |
| A09776 | 31614650 | J Clin Med | Polyphenol-Rich Extracts from Toona sinensis Bark and Fruit Ameliorate Free Fatty Acid-Induced Lipogenesis through AMPK and LC3 Pathways. | 2019 | Details |
| A10082 | 31496048 | Physiol Rep | Dipeptidyl peptidase-4 inhibitors and aerobic exercise synergistically protect against liver injury in ovariectomized rats. | 2019 | Details |
| A10564 | 31289229 | Proc Natl Acad Sci U S A | YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. | 2019 | Details |
| A11900 | 30689650 | PLoS One | Conophylline inhibits high fat diet-induced non-alcoholic fatty liver disease in mice. | 2019 | Details |
| A12051 | 30622377 | World J Gastroenterol | Mismatched effects of receptor interacting protein kinase-3 on hepatic steatosis and inflammation in non-alcoholic fatty liver disease. | 2018 | Details |
| A12486 | 30428868 | Lipids Health Dis | Changes in peroxisome proliferator-activated receptor alpha target gene expression in peripheral blood mononuclear cells associated with non-alcoholic fatty liver disease. | 2018 | Details |
| A12979 | 30198086 | J Sci Food Agric | Dietary salmon milt extracts attenuate hepatosteatosis and liver dysfunction in diet-induced fatty liver model. | 2018 | Details |
| A13215 | 30079055 | Front Microbiol | Genetically Obese Human Gut Microbiota Induces Liver Steatosis in Germ-Free Mice Fed on Normal Diet. | 2018 | Details |
| A13715 | 29795111 | Cell Death Dis | Carnitine palmitoyltransferase gene upregulation by linoleic acid induces CD4+ T cell apoptosis promoting HCC development. | 2018 | Details |
| A14210 | 29525610 | Nutr Res | Arctigenin protects against steatosis in WRL68 hepatocytes through activation of phosphoinositide 3-kinase/protein kinase B and AMP-activated protein kinase pathways. | 2018 | Details |
| A14518 | 29371998 | Toxicol Res | Protective Effect of Isoliquiritigenin against Ethanol-Induced Hepatic Steatosis by Regulating the SIRT1-AMPK Pathway. | 2018 | Details |
| A15293 | 28982243 | J Agric Food Chem | Solanum nigrum Polyphenol Extracts Inhibit Hepatic Inflammation, Oxidative Stress, and Lipogenesis in High-Fat-Diet-Treated Mice. | 2017 | Details |
| A15417 | 28923496 | Gastroenterology | Deficiency of the Mitochondrial NAD Kinase Causes Stress-Induced Hepatic Steatosis in Mice. | 2017 | Details |
| A16087 | 28577437 | Int Immunopharmacol | Rutin exhibits hepatoprotective effects in a mouse model of non-alcoholic fatty liver disease by reducing hepatic lipid levels and mitigating lipid-induced oxidative injuries. | 2017 | Details |
| A16131 | 28546081 | Pharmacol Ther | Targeting nuclear receptors for the treatment of fatty liver disease. | 2017 | Details |
| A16361 | 28437865 | Hepatology | A novel role of astrocyte elevated gene-1 (AEG-1) in regulating nonalcoholic steatohepatitis (NASH). | 2017 | Details |
| A16762 | 28195199 | Sci Rep | Pemafibrate, a novel selective peroxisome proliferator-activated receptor alpha modulator, improves the pathogenesis in a rodent model of nonalcoholic steatohepatitis. | 2017 | Details |
| A18174 | 27308945 | Stem Cells Dev | Modeling Nonalcoholic Fatty Liver Disease with Human Pluripotent Stem Cell-Derived Immature Hepatocyte-Like Cells Reveals Activation of PLIN2 and Confirms Regulatory Functions of Peroxisome Proliferator-Activated Receptor Alpha. | 2016 | Details |
| A18423 | 27145114 | Mol Nutr Food Res | Biochanin A improves hepatic steatosis and insulin resistance by regulating the hepatic lipid and glucose metabolic pathways in diet-induced obese mice. | 2016 | Details |
| A18577 | 27051590 | BBA Clin | Diabetic and dyslipidaemic morbidly obese exhibit more liver alterations compared with healthy morbidly obese. | 2016 | Details |
| A18972 | 26842974 | J Chin Med Assoc | Lipid-lowering, hepatoprotective, and atheroprotective effects of the mixture Hong-Qu and gypenosides in hyperlipidemia with NAFLD rats. | 2016 | Details |
| A19043 | 26806698 | J Pharm Pharmacol | Wild ginseng cambial meristematic cells ameliorate hepatic steatosis and mitochondrial dysfunction in high-fat diet-fed mice. | 2016 | Details |
| A20041 | 26194065 | Cytokine | PPARα/γ agonists and antagonists differently affect hepatic lipid metabolism, oxidative stress and inflammatory cytokine production in steatohepatitic rats. | 2015 | Details |
| A20293 | 26042596 | PLoS One | Association of adiponectin gene polymorphism with nonalcoholic fatty liver disease in Taiwanese patients with type 2 diabetes. | 2015 | Details |
| A20389 | 25998209 | Hepatology | Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice. | 2015 | Details |
| A20643 | 25837920 | J Pharmacol Sci | Effect of oleoylethanolamide on diet-induced nonalcoholic fatty liver in rats. | 2014 | Details |
| A21444 | 25312970 | J Mol Endocrinol | Aberrant miR199a-5p/caveolin1/PPARα axis in hepatic steatosis. | 2014 | Details |
| A21673 | 25130427 | Hepatology | Genetic ablation of solute carrier family 7a3a leads to hepatic steatosis in zebrafish during fasting. | 2014 | Details |
| A21758 | 25066281 | Liver Int | Blockade of interleukin 6 signalling ameliorates systemic insulin resistance through upregulation of glucose uptake in skeletal muscle and improves hepatic steatosis in high-fat diet fed mice. | 2014 | Details |
| A21857 | 24995693 | Hepatology | The transrepressive activity of peroxisome proliferator-activated receptor alpha is necessary and sufficient to prevent liver fibrosis in mice. | 2014 | Details |
| A21920 | 24966582 | World J Gastroenterol | Pathogenesis and significance of hepatitis C virus steatosis: an update on survival strategy of a successful pathogen. | 2014 | Details |
| A23532 | 23703580 | Hepatology | Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. | 2013 | Details |
| A23627 | 23618531 | J Nutr Biochem | Polychlorinated biphenyl 153 is a diet-dependent obesogen that worsens nonalcoholic fatty liver disease in male C57BL6/J mice. | 2013 | Details |
| A23641 | 23603006 | Food Chem Toxicol | Amelioration by chicory seed extract of diabetes- and oleic acid-induced non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) via modulation of PPARα and SREBP-1. | 2013 | Details |
| A24356 | 22973438 | PLoS One | Hepatic lipid accumulation alters global histone h3 lysine 9 and 4 trimethylation in the peroxisome proliferator-activated receptor alpha network. | 2012 | Details |
| A24455 | 22876924 | Curr Med Chem | Adiponectin: key player in the adipose tissue-liver crosstalk. | 2012 | Details |
| A25444 | 21835806 | J Gerontol A Biol Sci Med Sci | Aging is associated with a shift of fatty metabolism toward lipogenesis. | 2011 | Details |
| A25772 | 21475632 | Int J Gen Med | The effects of diet-induced obesity on hepatocyte insulin signaling pathways and induction of non-alcoholic liver damage. | 2011 | Details |
| A26543 | 20236931 | J Biol Chem | Thyroid hormone regulates hepatic expression of fibroblast growth factor 21 in a PPARalpha-dependent manner. | 2010 | Details |
| A26560 | 20204774 | Adv Exp Med Biol | Fenofibrate, a peroxisome proliferator-activated receptor alpha agonist, improves hepatic microcirculatory patency and oxygen availability in a high-fat-diet-induced fatty liver in mice. | 2010 | Details |
| A26745 | 19847649 | Dig Dis Sci | The effects of a fat- and sugar-enriched diet and chronic stress on nonalcoholic fatty liver disease in male Wistar rats. | 2009 | Details |
| A27227 | 18949388 | Int J Mol Med | The significance of differences in fatty acid metabolism between obese and non-obese patients with non-alcoholic fatty liver disease. | 2008 | Details |
| A27390 | 18488193 | Arch Toxicol | Drug metabolizing enzyme induction pathways in experimental non-alcoholic steatohepatitis. | 2008 | Details |
| A27421 | 18417155 | Life Sci | The establishment of a novel non-alcoholic steatohepatitis model accompanied with obesity and insulin resistance in mice. | 2008 | Details |
| A27511 | 18220286 | Hepatology | Low circulating levels of dehydroepiandrosterone in histologically advanced nonalcoholic fatty liver disease. | 2008 | Details |
| A27635 | 17868330 | J Gastroenterol Hepatol | Activation of peroxisome proliferator-activated receptor alpha by dietary fish oil attenuates steatosis, but does not prevent experimental steatohepatitis because of hepatic lipoperoxide accumulation. | 2007 | Details |
| A27937 | 16949573 | Exp Mol Pathol | Transcriptional networks in a rat model for nonalcoholic fatty liver disease: a microarray analysis. | 2006 | Details |
| A28006 | 16762007 | Liver Int | Fenofibrate, a peroxisome proliferator-activated receptor alpha agonist, reduces hepatic steatosis and lipid peroxidation in fatty liver Shionogi mice with hereditary fatty liver. | 2006 | Details |
| A28033 | 16649140 | Cell Mol Life Sci | Regulation of fat metabolism in the liver: link to non-alcoholic hepatic steatosis and impact of physical exercise. | 2006 | Details |
| A28039 | 16624332 | Life Sci | High-fat emulsion-induced rat model of nonalcoholic steatohepatitis. | 2006 | Details |
| A30482 | 32373294 | Iran J Basic Med Sci | Allantoin improves methionine-choline deficient diet-induced nonalcoholic steatohepatitis in mice through involvement in endoplasmic reticulum stress and hepatocytes apoptosis-related genes expressions. | 2019 | Details |
| A30599 | 32140659 | Hepatol Commun | Pirfenidone Is an Agonistic Ligand for PPARα and Improves NASH by Activation of SIRT1/LKB1/pAMPK. | 2020 | Details |
| A32608 | 28003852 | Evid Based Complement Alternat Med | Shugan Xiaozhi Decoction Attenuates Nonalcoholic Steatohepatitis by Enhancing PPARα and L-FABP Expressions in High-Fat-Fed Rats. | 2016 | Details |
| A32923 | 27083546 | Poult Sci | Expression and methylation of microsomal triglyceride transfer protein and acetyl-CoA carboxylase are associated with fatty liver syndrome in chicken. | 2016 | Details |
| A36145 | 18941143 | J Lipid Res | The nuclear receptor CAR (NR1I3) regulates serum triglyceride levels under conditions of metabolic stress. | 2008 | Details |
| A36270 | 18571789 | Hepatology | Tranilast, an antifibrogenic agent, ameliorates a dietary rat model of nonalcoholic steatohepatitis. | 2008 | Details |
| A37187 | 16297361 | J Investig Med | Peroxisome proliferator-activated receptor alpha L162V polymorphism in nonalcoholic steatohepatitis and genotype 1 hepatitis C virus-related liver steatosis. | 2005 | Details |
| A37414 | 15727690 | Zhonghua Gan Zang Bing Za Zhi | [Effect of Endotoxin on the expression of peroxisome proliferator-activated receptor alpha in the development of nonalcoholic steatohepatitis in rats]. | 2005 | Details |
| A42675 | 33824670 | J Res Med Sci | The effect of trans-palmitoleic acid on cell viability and sirtuin 1 gene expression in hepatocytes and the activity of peroxisome-proliferator-activated receptor-alpha. | 2020 | Details |
| A42710 | 33681679 | Hepatol Commun | Fatty Acid Desaturase 1 Influences Hepatic Lipid Homeostasis by Modulating the PPARα-FGF21 Axis. | 2020 | Details |
| A42732 | 33612688 | Intern Med | Potential Effect of a Selective Peroxisome Proliferator-activated Receptor Alpha Modulator on Metabolic Dysfunction-associated Fatty Liver Disease. | 2021 | Details |
| A45582 | 23787705 | Hepatology | Nuclear control of inflammation and fibrosis in nonalcoholic steatohepatitis: therapeutic potential of dual peroxisome proliferator-activated receptor alpha/delta agonism. | 2013 | Details |
| A46283 | 19783528 | J Lipid Res | A subset of dysregulated metabolic and survival genes is associated with severity of hepatic steatosis in obese Zucker rats. | 2009 | Details |
| A46682 | 16557554 | Hepatology | COX-2 induction in mice with experimental nutritional steatohepatitis: Role as pro-inflammatory mediator. | 2006 | Details |
| A46776 | 15670659 | Alcohol | Role of fatty liver, dietary fatty acid supplements, and obesity in the progression of alcoholic liver disease: introduction and summary of the symposium. | 2004 | Details |
| A46790 | 15519275 | Hepatol Res | Lack of peroxisome proliferator-activated receptor alpha in mice enhances methionine and choline deficient diet-induced steatohepatitis. | 2004 | Details |
| A46891 | 11296696 | Semin Liver Dis | Peroxisomal beta-oxidation and steatohepatitis. | 2001 | Details |