Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Betaine123 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A00271 | 35159219 | Cells | S-Adenosylmethionine: From the Discovery of Its Inhibition of Tumorigenesis to Its Use as a Therapeutic Agent. | 2022 | Details |
| A01227 | 34822395 | Metabolites | Aqueous Metabolite Trends for the Progression of Nonalcoholic Fatty Liver Disease in Female Bariatric Surgery Patients by Targeted 1H-NMR Metabolomics. | 2021 | Details |
| A01443 | 34743980 | Eur J Pharmacol | Preventive and therapeutic role of betaine in liver disease: A review on molecular mechanisms. | 2021 | Details |
| A01525 | 34708066 | Front Nutr | Integrated Transcriptomic and Translatomic Inquiry of the Role of Betaine on Lipid Metabolic Dysregulation Induced by a High-Fat Diet. | 2021 | Details |
| A01587 | 34684533 | Nutrients | Supplementation with a Specific Combination of Metabolic Cofactors Ameliorates Non-Alcoholic Fatty Liver Disease, Hepatic Fibrosis, and Insulin Resistance in Mice. | 2021 | Details |
| A01608 | 34680557 | Biomedicines | Combined Metabolic Activators Decrease Liver Steatosis by Activating Mitochondrial Metabolism in Hamsters Fed with a High-Fat Diet. | 2021 | Details |
| A02223 | 34454176 | Biochem Biophys Res Commun | Translatome analysis reveals the regulatory role of betaine in high fat diet (HFD)-induced hepatic steatosis. | 2021 | Details |
| A03391 | 34019353 | Vopr Pitan | [Specialized products for dietary correction of the diet of patients with non-alcoholic steatohepatitis]. | 2021 | Details |
| A03918 | 33818349 | Nutr Res Rev | Effects of betaine on non-alcoholic liver disease. | 2021 | Details |
| A05753 | 33132631 | World J Gastroenterol | Role of betaine in liver disease-worth revisiting or has the die been cast? | 2020 | Details |
| A06375 | 32908189 | Sci Rep | 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dysregulates hepatic one carbon metabolism during the progression of steatosis to steatohepatitis with fibrosis in mice. | 2020 | Details |
| A06614 | 32808060 | Eur J Nutr | Betaine prevented high-fat diet-induced NAFLD by regulating the FGF10/AMPK signaling pathway in ApoE-/- mice. | 2020 | Details |
| A06660 | 32791310 | Diabetes Metab | Trimethylamine N-oxide levels are associated with NASH in obese subjects with type 2 diabetes. | 2020 | Details |
| A06681 | 32782033 | Microsc Microanal | Effect of Betaine Supplementation on Liver Tissue and Ultrastructural Changes in Methionine-Choline-Deficient Diet-Induced NAFLD. | 2020 | Details |
| A06792 | 32744096 | Am J Physiol Endocrinol Metab | Neurodegeneration in juvenile Iberian pigs with diet-induced nonalcoholic fatty liver disease. | 2020 | Details |
| A08075 | 32257815 | Mol Genet Metab Rep | Mtrr hypomorphic mutation alters liver morphology, metabolism and fuel storage in mice. | 2020 | Details |
| A08417 | 32119738 | J Nutr | One-Carbon Metabolism in Fatty Liver Disease and Fibrosis: One-Carbon to Rule Them All. | 2020 | Details |
| A08451 | 32105727 | Gastroenterology | TMAVA, a Metabolite of Intestinal Microbes, Is Increased in Plasma From Patients With Liver Steatosis, Inhibits γ-Butyrobetaine Hydroxylase, and Exacerbates Fatty Liver in Mice. | 2020 | Details |
| A09179 | 31846961 | Lifestyle Genom | One-Carbon Metabolism and Nonalcoholic Fatty Liver Disease: The Crosstalk between Nutrients, Microbiota, and Genetics. | 2019 | Details |
| A09448 | 31744629 | Environ Int | Perfluoroalkyl substances and severity of nonalcoholic fatty liver in Children: An untargeted metabolomics approach. | 2019 | Details |
| A10323 | 31388096 | Int J Obes (Lond) | Circulating microbiota-derived metabolites: a "liquid biopsy? | 2019 | Details |
| A11897 | 30689995 | Eur J Pharmacol | Betaine modulates oxidative stress, inflammation, apoptosis, autophagy, and Akt/mTOR signaling in methionine-choline deficiency-induced fatty liver disease. | 2019 | Details |
| A11898 | 30689994 | Eur J Pharmacol | Evaluating the therapeutic potential of one-carbon donors in nonalcoholic fatty liver disease. | 2019 | Details |
| A12531 | 30408316 | Mol Nutr Food Res | Mild Methylenetetrahydrofolate Reductase Deficiency Alters Inflammatory and Lipid Pathways in Liver. | 2018 | Details |
| A14569 | 29350612 | Microsc Microanal | The Effects of Betaine on the Nuclear Fractal Dimension, Chromatin Texture, and Proliferative Activity in Hepatocytes in Mouse Model of Nonalcoholic Fatty Liver Disease. | 2018 | Details |
| A14597 | 29331496 | J Nutr Biochem | Maternal betaine supplementation attenuates glucocorticoid-induced hepatic lipid accumulation through epigenetic modification in adult offspring rats. | 2017 | Details |
| A15041 | 29121861 | BMC Genomics | Transcriptomics, metabolomics and histology indicate that high-carbohydrate diet negatively affects the liver health of blunt snout bream (Megalobrama amblycephala). | 2017 | Details |
| A16129 | 28549240 | J Nutr Biochem | Dietary salecan reverts partially the metabolic gene expressions and NMR-based metabolomic profiles from high-fat-diet-induced obese rats. | 2017 | Details |
| A16335 | 28452429 | Obesity (Silver Spring) | Metabolomic profiling distinction of human nonalcoholic fatty liver disease progression from a common rat model. | 2017 | Details |
| A16949 | 28077733 | J Nutr | Identification of Potential Plasma Biomarkers for Nonalcoholic Fatty Liver Disease by Integrating Transcriptomics and Proteomics in Laying Hens. | 2017 | Details |
| A17233 | 27896396 | Anal Bioanal Chem | Metabolic profiling of ob/ob mouse fatty liver using HR-MAS 1H-NMR combined with gene expression analysis reveals alterations in betaine metabolism and the transsulfuration pathway. | 2016 | Details |
| A17762 | 27614103 | Liver Int | Nonalcoholic steatohepatitis is associated with a state of betaine-insufficiency. | 2016 | Details |
| A17889 | 27494683 | Int Immunopharmacol | High-fat diet plus carbon tetrachloride-induced liver fibrosis is alleviated by betaine treatment in rats. | 2016 | Details |
| A18955 | 26850693 | Biochim Biophys Acta | Betaine chemistry, roles, and potential use in liver disease. | 2016 | Details |
| A18963 | 26846427 | Lipids Health Dis | Tetradecylthiopropionic acid induces hepatic mitochondrial dysfunction and steatosis, accompanied by increased plasma homocysteine in mice. | 2016 | Details |
| A19125 | 26743949 | Sci Rep | Associations of gut-flora-dependent metabolite trimethylamine-N-oxide, betaine and choline with non-alcoholic fatty liver disease in adults. | 2016 | Details |
| A19390 | 26593707 | Eur J Pharmacol | Betaine prevented fructose-induced NAFLD by regulating LXRα/PPARα pathway and alleviating ER stress in rats. | 2015 | Details |
| A19827 | 26322888 | PLoS One | Dysregulated Hepatic Methionine Metabolism Drives Homocysteine Elevation in Diet-Induced Nonalcoholic Fatty Liver Disease. | 2015 | Details |
| A20225 | 26078098 | J Physiol Biochem | FTO-dependent function of N6-methyladenosine is involved in the hepatoprotective effects of betaine on adolescent mice. | 2015 | Details |
| A20788 | 25733650 | Am J Clin Nutr | High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice. | 2015 | Details |
| A21482 | 25290169 | Exp Mol Pathol | Mallory-Denk Body (MDB) formation modulates Ufmylation expression epigenetically in alcoholic hepatitis (AH) and non-alcoholic steatohepatitis (NASH). | 2014 | Details |
| A21765 | 25061561 | Mol Metab | Methyl-donor supplementation in obese mice prevents the progression of NAFLD, activates AMPK and decreases acyl-carnitine levels. | 2014 | Details |
| A22570 | 24456734 | J Nutr Biochem | Betaine attenuates hepatic steatosis by reducing methylation of the MTTP promoter and elevating genomic methylation in mice fed a high-fat diet. | 2013 | Details |
| A23041 | 24084163 | Mol Genet Metab | Transcriptomic and epigenetic changes in early liver steatosis associated to obesity: effect of dietary methyl donor supplementation. | 2013 | Details |
| A23338 | 23861108 | Dig Dis Sci | Betaine protects against high-fat-diet-induced liver injury by inhibition of high-mobility group box 1 and Toll-like receptor 4 expression in rats. | 2013 | Details |
| A23783 | 23483818 | World J Gastroenterol | From fatty liver to fibrosis: a tale of "second hit". | 2013 | Details |
| A23799 | 23472083 | PLoS One | Hepatic methionine homeostasis is conserved in C57BL/6N mice on high-fat diet despite major changes in hepatic one-carbon metabolism. | 2013 | Details |
| A23984 | 23327974 | J Nutr Sci Vitaminol (Tokyo) | Effects of dietary supplementation with betaine on a nonalcoholic steatohepatitis (NASH) mouse model. | 2012 | Details |
| A24229 | 23075871 | Dig Dis | Clinical spectrum and therapy of non-alcoholic steatohepatitis. | 2012 | Details |
| A24651 | 22648174 | Genes Nutr | Dietary supplementation with methyl donors reduces fatty liver and modifies the fatty acid synthase DNA methylation profile in rats fed an obesogenic diet. | 2012 | Details |
| A24655 | 25755424 | J Clin Exp Hepatol | Management of Non-alcoholic Fatty Liver Disease and Steatohepatitis. | 2012 | Details |
| A25291 | 21990946 | World J Gastroenterol | Betaine and nonalcoholic steatohepatitis: back to the future? | 2011 | Details |
| A25522 | 21745592 | Biochim Biophys Acta | Phosphatidylcholine protects against steatosis in mice but not non-alcoholic steatohepatitis. | 2011 | Details |
| A26526 | 20037278 | Korean J Hepatol | Current status of liver disease in Korea: nonalcoholic fatty liver disease. | 2009 | Details |
| A26564 | 20203061 | Am J Physiol Gastrointest Liver Physiol | Betaine improved adipose tissue function in mice fed a high-fat diet: a mechanism for hepatoprotective effect of betaine in nonalcoholic fatty liver disease. | 2010 | Details |
| A26761 | 19818312 | Clin Liver Dis | Pharmacologic therapy of non-alcoholic steatohepatitis. | 2009 | Details |
| A27165 | 19056644 | J Nutr | Impaired sulfur-amino acid metabolism and oxidative stress in nonalcoholic fatty liver are alleviated by betaine supplementation in rats. | 2008 | Details |
| A27428 | 18336657 | J Gastroenterol Hepatol | Dissection of endoplasmic reticulum stress signaling in alcoholic and non-alcoholic liver injury. | 2008 | Details |
| A27671 | 17702954 | Am J Physiol Gastrointest Liver Physiol | Involvement of AMP-activated protein kinase in beneficial effects of betaine on high-sucrose diet-induced hepatic steatosis. | 2007 | Details |
| A27839 | 17296492 | J Nutr Biochem | Nonalcoholic fatty liver disease: predisposing factors and the role of nutrition. | 2007 | Details |
| A28060 | 16540769 | J Clin Gastroenterol | Therapy of NAFLD: antioxidants and cytoprotective agents. | 2006 | Details |
| A28112 | 16393299 | Aliment Pharmacol Ther | Review article: Drug therapy for non-alcoholic fatty liver disease. | 2006 | Details |
| A28165 | 16231594 | Eur Rev Med Pharmacol Sci | The treatment of NAFLD. | 2006 | Details |
| A28319 | 15696851 | Scand J Gastroenterol Suppl | Non-alcoholic fatty liver disease: a brief review. | 2004 | Details |
| A28339 | 15598336 | Pediatr Transplant | Non-alcoholic steatohepatitis in children. | 2004 | Details |
| A28416 | 15114291 | Ann Hepatol | Treatment of nonalcoholic fatty liver disease. | 2004 | Details |
| A28459 | 14585234 | Curr Treat Options Gastroenterol | Treatment of Nonalcoholic Fatty Liver Disease. | 2003 | Details |
| A28479 | 12739988 | Expert Opin Pharmacother | Current best treatment for non-alcoholic fatty liver disease. | 2003 | Details |
| A28507 | 12406446 | Best Pract Res Clin Gastroenterol | Treatment of non-alcoholic steatohepatitis. | 2002 | Details |
| A28519 | 12296456 | Nutr Rev | Nonalcoholic fatty liver disease: pathogenesis and the role of antioxidants. | 2002 | Details |
| A28520 | 12214335 | Rev Gastroenterol Mex | [Non-alcoholic steatohepatitis]. | 2002 | Details |
| A28525 | 12122975 | Rev Gastroenterol Disord | Nonalcoholic fatty liver disease. | 2002 | Details |
| A31161 | 31120771 | FASEB J | Betaine attenuates pathology by stimulating lipid oxidation in liver and regulating phospholipid metabolism in brain of methionine-choline-deficient rats. | 2019 | Details |
| A32420 | 28487605 | World J Gastroenterol | Changes in human hepatic metabolism in steatosis and cirrhosis. | 2017 | Details |
| A33027 | 26843403 | Environ Sci Technol | Identification of Biochemical Pathways Associated with Lead Tolerance and Detoxification in Chrysopogon zizanioides L. Nash (Vetiver) by Metabolic Profiling. | 2016 | Details |
| A34355 | 23665184 | J Hepatol | Pleiotropic effects of methionine adenosyltransferases deregulation as determinants of liver cancer progression and prognosis. | 2013 | Details |
| A35728 | 19824078 | Hepatology | Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial. | 2009 | Details |
| A36672 | 17483780 | Gastroenterol Clin Biol | [Steatosis, chronic hepatitis virus C infection and homocysteine]. | 2007 | Details |
| A38083 | 12197781 | Altern Med Rev | Nonalcoholic fatty liver disease: relationship to insulin sensitivity and oxidative stress. Treatment approaches using vitamin E, magnesium, and betaine. | 2002 | Details |
| A38186 | 11944630 | Semin Gastrointest Dis | Diabetes mellitus, obesity, and hepatic steatosis. | 2002 | Details |
| A38320 | 11569700 | Am J Gastroenterol | Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study. | 2001 | Details |
| A43389 | 31851339 | J Nutr | Dietary Choline Supplementation Attenuates High-Fat-Diet-Induced Hepatocellular Carcinoma in Mice. | 2020 | Details |
| A44127 | 29651702 | Hepatol Int | Tsumura-Suzuki obese diabetic mice-derived hepatic tumors closely resemble human hepatocellular carcinomas in metabolism-related genes expression and bile acid accumulation. | 2018 | Details |
| A44161 | 29546310 | J Nutr | Corticosterone-Induced Lipogenesis Activation and Lipophagy Inhibition in Chicken Liver Are Alleviated by Maternal Betaine Supplementation. | 2018 | Details |
| A44212 | 29373534 | Nutrients | Betaine Supplementation Enhances Lipid Metabolism and Improves Insulin Resistance in Mice Fed a High-Fat Diet. | 2018 | Details |
| A45464 | 24429813 | Cell Physiol Biochem | Betaine transport in kidney and liver: use of betaine in liver injury. | 2013 | Details |
| A45703 | 23200777 | Toxicol Appl Pharmacol | Liver proteomics in progressive alcoholic steatosis. | 2012 | Details |
| A46015 | 21538633 | NMR Biomed | Ursodeoxycholic acid treatment of hepatic steatosis: a (13)C NMR metabolic study. | 2011 | Details |
| A46016 | 21538430 | Hepatology | Dietary supplementation with methyl donor groups could prevent nonalcoholic fatty liver. | 2011 | Details |
| A46147 | 20724529 | Am J Physiol Gastrointest Liver Physiol | Betaine improves nonalcoholic fatty liver and associated hepatic insulin resistance: a potential mechanism for hepatoprotection by betaine. | 2010 | Details |
| A46410 | 21180527 | Therap Adv Gastroenterol | Treatment options for nonalcoholic Fatty liver disease. | 2008 | Details |
| A46522 | 17979073 | Semin Liver Dis | Endoplasmic reticulum stress and liver injury. | 2007 | Details |
| A46860 | 12408779 | Curr Treat Options Gastroenterol | Therapeutic Options in Nonalcoholic Fatty Liver Disease. | 2002 | Details |
| A46890 | 11296699 | Semin Liver Dis | Treatment of nonalcoholic fatty liver: present and emerging therapies. | 2001 | Details |
| A46908 | 34817678 | Eur J Nutr | Betaine in ameliorating alcohol-induced hepatic steatosis. | 2021 | Details |
| A47117 | 25644346 | J Nutr | L-serine supplementation attenuates alcoholic fatty liver by enhancing homocysteine metabolism in mice and rats. | 2014 | Details |
| A47158 | 24730561 | Alcohol Clin Exp Res | Methylation and gene expression responses to ethanol feeding and betaine supplementation in the cystathionine beta synthase-deficient mouse. | 2014 | Details |
| A47189 | 23707365 | J Hepatol | ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading. | 2013 | Details |
| A47216 | 22532405 | Mol Biosyst | Metabolic profiling of an alcoholic fatty liver in zebrafish (Danio rerio). | 2012 | Details |
| A47241 | 21708146 | Exp Mol Pathol | Betaine feeding prevents the blood alcohol cycle in rats fed alcohol continuously for 1 month using the rat intragastric tube feeding model. | 2011 | Details |