Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A00266 | 35160329 | J Clin Med | Influence of Body Mass Index, Cancer Type and Treatment on Long-Term Metabolic and Liver Outcomes in Childhood Cancer Survivors. | 2022 | Details |
| A00311 | 35142615 | Diagn Interv Radiol | Proton density fat fraction: magnetic resonance imaging applications beyond the liver. | 2022 | Details |
| A00347 | 35126317 | Front Endocrinol (Lausanne) | Prevalence and Trends in Low Bone Density, Osteopenia and Osteoporosis in U.S. Adults With Non-Alcoholic Fatty Liver Disease, 2005-2014. | 2022 | Details |
| A00669 | 35008925 | Int J Mol Sci | Non-Alcoholic Steatohepatitis (NASH) and Organokines: What Is Now and What Will Be in the Future. | 2022 | Details |
| A00687 | 35003513 | Oxid Med Cell Longev | TNF-Like Ligand 1 Aberrance Aggravates Nonalcoholic Steatohepatitis via M1 Macrophage Polarization. | 2021 | Details |
| A00738 | 34983596 | Chin Med | Traditional Chinese medicine Lingguizhugan decoction ameliorate HFD-induced hepatic-lipid deposition in mice by inhibiting STING-mediated inflammation in macrophages. | 2022 | Details |
| A00805 | 34959901 | Nutrients | Role and Treatment of Insulin Resistance in Patients with Chronic Kidney Disease: A Review. | 2021 | Details |
| A01034 | 34895322 | Stem Cell Res Ther | Bone marrow derived-mesenchymal stem cell improves diabetes-associated fatty liver via mitochondria transformation in mice. | 2021 | Details |
| A01283 | 34803490 | Int J Biol Sci | SOCS2 Suppresses Inflammation and Apoptosis during NASH Progression through Limiting NF-κB Activation in Macrophages. | 2021 | Details |
| A01519 | 34710938 | Z Gastroenterol | Non-alcoholic fatty liver disease (NAFLD) is associated with an increased incidence of osteoporosis and bone fractures. | 2021 | Details |
| A01543 | 34704005 | JHEP Rep | PI3Kγ promotes obesity-associated hepatocellular carcinoma by regulating metabolism and inflammation. | 2021 | Details |
| A01681 | 34656648 | Metabolism | CC chemokine ligand 3 deficiency ameliorates diet-induced steatohepatitis by regulating liver macrophage recruitment and M1/M2 status in mice. | 2021 | Details |
| A01806 | 34608587 | Hepatol Int | Hepatic fibrosis is associated with an increased rate of decline in bone mineral density in men with nonalcoholic fatty liver disease. | 2021 | Details |
| A01881 | 34574647 | Int J Environ Res Public Health | Bone Mineral Density in Congenital Generalized Lipodystrophy: The Role of Bone Marrow Tissue, Adipokines, and Insulin Resistance. | 2021 | Details |
| A01936 | 34558838 | Hepatol Commun | Dietary Risks for Liver Mortality in NAFLD: Global Burden of Disease Data. | 2021 | Details |
| A01939 | 34558828 | Hepatol Commun | PRO-C3, a Serological Marker of Fibrosis, During Childhood and Correlations With Fibrosis in Pediatric NAFLD. | 2021 | Details |
| A02039 | 34523053 | Inflammation | Hepatic Macrophages Express Melanoma Differentiation-Associated Gene 5 in Nonalcoholic Steatohepatitis. | 2021 | Details |
| A02300 | 34431493 | J Clin Endocrinol Metab | LLF580, an FGF21 Analog, Reduces Triglycerides and Hepatic Fat in Obese Adults With Modest Hypertriglyceridemia. | 2022 | Details |
| A02318 | 34421825 | Front Endocrinol (Lausanne) | Decreased Sclerostin Secretion in Humans and Mice With Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A02385 | 34394332 | PPAR Res | Computational Analysis of Gly482Ser Single-Nucleotide Polymorphism in PPARGC1A Gene Associated with CAD, NAFLD, T2DM, Obesity, Hypertension, and Metabolic Diseases. | 2021 | Details |
| A02427 | 34374436 | J Pathol | The loss of histone deacetylase 4 in macrophages exacerbates hepatic and adipose tissue inflammation in male but not in female mice with diet-induced non-alcoholic steatohepatitis. | 2021 | Details |
| A02537 | 34336366 | Liver Res | Adoptive transfer of Pfkfb3-disrupted hematopoietic cells to wild-type mice exacerbates diet-induced hepatic steatosis and inflammation. | 2020 | Details |
| A02637 | 34300021 | Int J Environ Res Public Health | The Impact of Nordic Walking on Bone Properties in Postmenopausal Women with Pre-Diabetes and Non-Alcohol Fatty Liver Disease. | 2021 | Details |
| A02644 | 34298870 | Int J Mol Sci | Liver Injury and the Macrophage Issue: Molecular and Mechanistic Facts and Their Clinical Relevance. | 2021 | Details |
| A02707 | 34277457 | Front Oncol | Hepcidin Downregulation Correlates With Disease Aggressiveness And Immune Infiltration in Liver Cancers. | 2021 | Details |
| A02727 | 34271043 | Int J Biol Macromol | Structural characterization of two novel polysaccharides from Gastrodia elata and their effects on Akkermansia muciniphila. | 2021 | Details |
| A02969 | 34179315 | Genes Dis | Bone morphogenetic protein 4 (BMP4) promotes hepatic glycogen accumulation and reduces glucose level in hepatocytes through mTORC2 signaling pathway. | 2020 | Details |
| A03019 | 34161185 | Autophagy | Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective. | 2021 | Details |
| A03131 | 34118476 | Mol Metab | Exercise of high intensity ameliorates hepatic inflammation and the progression of NASH. | 2021 | Details |
| A03231 | 34078528 | BMB Rep | Porphyromonas gingivalis exacerbates the progression of fatty liver disease via CD36-PPARγ pathway. | 2021 | Details |
| A03302 | 34052187 | Biochem Pharmacol | Upregulation of miR-96-5p by bone marrow mesenchymal stem cells and their exosomes alleviate non-alcoholic steatohepatitis: Emphasis on caspase-2 signaling inhibition. | 2021 | Details |
| A03392 | 34019202 | Mol Cell Biochem | New insights into BMP9 signaling in liver diseases. | 2021 | Details |
| A03395 | 34017133 | Nat Med | XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis. | 2021 | Details |
| A03620 | 33928009 | Clin Nephrol Case Stud | Severe type-B lactic acidosis in a patient with bilateral renal Burkitt's lymphoma. | 2021 | Details |
| A03655 | 33918456 | Int J Mol Sci | Relationship between NAFLD and Periodontal Disease from the View of Clinical and Basic Research, and Immunological Response. | 2021 | Details |
| A03751 | 33878156 | J Clin Endocrinol Metab | NAFLD and Liver Fibrosis Are Not Associated With Reduced Femoral Bone Mineral Density in the General US Population. | 2021 | Details |
| A03775 | 33868162 | Front Endocrinol (Lausanne) | Association Between 10-Year Fracture Probability and Nonalcoholic Fatty Liver Disease With or Without Sarcopenia in Korean Men: A Nationwide Population-Based Cross-Sectional Study. | 2021 | Details |
| A03888 | 33832643 | Maturitas | Postmenopausal osteoporosis coexisting with other metabolic diseases: Treatment considerations. | 2021 | Details |
| A03937 | 33812253 | Int Immunopharmacol | BMP9 promotes methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis in non-obese mice by enhancing NF-κB dependent macrophage polarization. | 2021 | Details |
| A03963 | 33807573 | Int J Mol Sci | An Overview of the Molecular Mechanisms Contributing to Musculoskeletal Disorders in Chronic Liver Disease: Osteoporosis, Sarcopenia, and Osteoporotic Sarcopenia. | 2021 | Details |
| A04136 | 33745573 | Clin Nutr ESPEN | A significant association of non-obese non-alcoholic fatty liver disease with osteosarcopenic obesity in females 50 years and older. | 2021 | Details |
| A04267 | 33684566 | Biochim Biophys Acta Mol Cell Biol Lipids | GDF11 rapidly increases lipid accumulation in liver cancer cells through ALK5-dependent signaling. | 2021 | Details |
| A04300 | 33672787 | Int J Mol Sci | Absence of Adiponutrin (PNPLA3) and Monoacylglycerol Lipase Synergistically Increases Weight Gain and Aggravates Steatohepatitis in Mice. | 2021 | Details |
| A04343 | 33657443 | Contemp Clin Trials | The FALCON program: Two phase 2b randomized, double-blind, placebo-controlled studies to assess the efficacy and safety of pegbelfermin in the treatment of patients with nonalcoholic steatohepatitis and bridging fibrosis or compensated cirrhosis. | 2021 | Details |
| A04474 | 33603666 | Front Pharmacol | The Role of Bone Morphogenetic Protein 9 in Nonalcoholic Fatty Liver Disease in Mice. | 2021 | Details |
| A04515 | 33591626 | J Cell Mol Med | Mesenchymal stromal cells protect hepatocytes from lipotoxicity through alleviation of endoplasmic reticulum stress by restoring SERCA activity. | 2021 | Details |
| A04578 | 33574817 | Front Immunol | Epigenetic Regulation of Kupffer Cell Function in Health and Disease. | 2021 | Details |
| A04676 | 33545191 | J Pediatr | Hepatic Steatosis is Negatively Associated with Bone Mineral Density in Children. | 2021 | Details |
| A04712 | 33531899 | Int J Endocrinol | Osteocalcin Alleviates Nonalcoholic Fatty Liver Disease in Mice through GPRC6A. | 2021 | Details |
| A04722 | 33528915 | Obesity (Silver Spring) | Association Between Liver Fat and Bone Density is Confounded by General and Visceral Adiposity in a Community-Based Cohort. | 2021 | Details |
| A04899 | 33460628 | Biochem Pharmacol | Prenatal dexamethasone exposure induces nonalcoholic fatty liver disease in male rat offspring via the miR-122/YY1/ACE2-MAS1 pathway. | 2021 | Details |
| A04983 | 33426540 | J Cell Immunol | Maternal Diet Alters Trained Immunity in the Pathogenesis of Pediatric NAFLD. | 2020 | Details |
| A05059 | 33391181 | Front Endocrinol (Lausanne) | Identification of the Biomarkers and Pathological Process of Heterotopic Ossification: Weighted Gene Co-Expression Network Analysis. | 2020 | Details |
| A05081 | 33384662 | Front Endocrinol (Lausanne) | Chronic Inflammation in Non-Alcoholic Steatohepatitis: Molecular Mechanisms and Therapeutic Strategies. | 2020 | Details |
| A05167 | 33347986 | Free Radic Biol Med | STING-dependent induction of lipid peroxidation mediates intestinal ischemia-reperfusion injury. | 2020 | Details |
| A05342 | 33294831 | JHEP Rep | Macrophage-derived thrombospondin 1 promotes obesity-associated non-alcoholic fatty liver disease. | 2020 | Details |
| A05399 | 33270924 | J Bone Miner Res | Osteocalcin and Non-Alcoholic Fatty Liver Disease: Lessons From Two Population-Based Cohorts and Animal Models. | 2020 | Details |
| A05472 | 33246954 | Sci Adv | CRISPR-mediated BMP9 ablation promotes liver steatosis via the down-regulation of PPARα expression. | 2020 | Details |
| A05551 | 33208891 | Cell Death Differ | RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in macrophages. | 2020 | Details |
| A05553 | 33208241 | Med Hypotheses | Treatment of nonalcoholic fatty liver disease with an anti-osteoporotic medication: A hypothesis on drug repurposing. | 2020 | Details |
| A05771 | 33126224 | Aging (Albany NY) | GDF11 induces mild hepatic fibrosis independent of metabolic health. | 2020 | Details |
| A05937 | 33070506 | J Prev Med Public Health | Relationship Between Non-alcoholic Fatty Liver Disease and Decreased Bone Mineral Density: A Retrospective Cohort Study in Korea. | 2020 | Details |
| A06047 | 33029058 | J Clin Exp Hepatol | Hepatocellular Carcinoma Screening and Nonalcoholic Fatty Liver Disease: How is it Different? | 2020 | Details |
| A06122 | 32998095 | Diabetes Metab Syndr | Pathophysiological mechanisms underlying MAFLD. | 2020 | Details |
| A06125 | 32997872 | Mol Nutr Food Res | CREBH: A Complex Array of Regulatory Mechanisms in Nutritional Signaling, Metabolic Inflammation, and Metabolic Disease. | 2020 | Details |
| A06137 | 32992234 | Adv Biol Regul | The roles of osteocalcin in lipid metabolism in adipose tissue and liver. | 2020 | Details |
| A06151 | 32986864 | Hepatology | Osteopontin Takes Center Stage in Chronic Liver Disease. | 2021 | Details |
| A06218 | 32964054 | J Diabetes Res | Association between Thyroid Function and Nonalcoholic Fatty Liver Disease in Euthyroid Type 2 Diabetes Patients. | 2020 | Details |
| A06288 | 32940183 | Curr HIV Res | Association between Nonalcoholic Fatty Liver Disease and Bone Mineral Density in HIV-Infected Patients Receiving Long-term TDF-Based Antiretroviral Therapy. | 2021 | Details |
| A06343 | 32922061 | Clin Exp Gastroenterol | Changes in Function and Dynamics in Hepatic and Splenic Macrophages in Non-Alcoholic Fatty Liver Disease. | 2020 | Details |
| A06415 | 32888418 | Immunity | Osteopontin Expression Identifies a Subset of Recruited Macrophages Distinct from Kupffer Cells in the Fatty Liver. | 2020 | Details |
| A06474 | 32865911 | Crit Rev Oncog | Role of the Gut Microbiome in Nonalcoholic Fatty Liver Disease Progression. | 2020 | Details |
| A06478 | 32863955 | Theranostics | Fibrinogen-like protein 2 aggravates nonalcoholic steatohepatitis via interaction with TLR4, eliciting inflammation in macrophages and inducing hepatic lipid metabolism disorder. | 2020 | Details |
| A06578 | 32821721 | J Lipid Atheroscler | Ceramides: Nutrient Signals that Drive Hepatosteatosis. | 2019 | Details |
| A06611 | 32809824 | J Med Chem | Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting. | 2020 | Details |
| A06613 | 32808114 | J Physiol Biochem | Potential roles of bone morphogenetic protein-9 in glucose and lipid homeostasis. | 2020 | Details |
| A06633 | 32800550 | Biochem Biophys Res Commun | Metformin, resveratrol, and exendin-4 inhibit high phosphate-induced vascular calcification via AMPK-RANKL signaling. | 2020 | Details |
| A06755 | 32759166 | BMJ Open Diabetes Res Care | Association between non-alcoholic fatty liver disease-associated hepatic fibrosis and bone mineral density in postmenopausal women with type 2 diabetes or impaired glucose regulation. | 2020 | Details |
| A06825 | 32733906 | Front Med (Lausanne) | Selective Thyroid Hormone Receptor-Beta (TRβ) Agonists: New Perspectives for the Treatment of Metabolic and Neurodegenerative Disorders. | 2020 | Details |
| A06829 | 32731709 | Wiad Lek | Features of some anthropometric indices and indices of insulin resistance in patients with non-alcoholic steatohepatitis on the background of obesity and osteoarthritis. | 2020 | Details |
| A06831 | 32731119 | Cytokine | Osteocalcin and osteoprotegerin levels and their relationship with adipokines and proinflammatory cytokines in children with nonalcoholic fatty liver disease. | 2020 | Details |
| A06927 | 32695965 | JHEP Rep | Imaging and immunometabolic phenotyping uncover changes in the hepatic immune response in the early phases of NAFLD. | 2020 | Details |
| A06928 | 32695733 | Can J Gastroenterol Hepatol | Verification of the Nutritional and Dietary Factors Associated with Skeletal Muscle Index in Japanese Patients with Nonalcoholic Fatty Liver Disease. | 2020 | Details |
| A06933 | 32694734 | Nat Metab | Bone morphogenetic protein 8B promotes the progression of non-alcoholic steatohepatitis. | 2020 | Details |
| A07179 | 32592194 | Hepatology | iRhom2 Promotes Hepatic Steatosis by Activating MAP3K7-Dependent Pathway. | 2021 | Details |
| A07266 | 32561790 | Sci Rep | The Role of Bone Morphogenetic Protein Signaling in Non-Alcoholic Fatty Liver Disease. | 2020 | Details |
| A07337 | 32531862 | Oral Dis | Bromelain reduces the non-alcoholic fatty liver disease and periodontal damages caused by ligature-induced periodontitis. | 2020 | Details |
| A07466 | 32484830 | PLoS One | Bone marrow fat change in pediatric patients with non-alcoholic fatty liver disease. | 2020 | Details |
| A07469 | 32483408 | EXCLI J | Artificial sweeteners are related to non-alcoholic fatty liver disease: Microbiota dysbiosis as a novel potential mechanism. | 2020 | Details |
| A07498 | 32472585 | J Pathol | Sex-opposed inflammatory effects of 27-hydroxycholesterol are mediated via differences in estrogen signaling. | 2020 | Details |
| A07612 | 32422858 | Nutrients | A Diet Rich in Saturated Fat and Cholesterol Aggravates the Effect of Bacterial Lipopolysaccharide on Alveolar Bone Loss in a Rabbit Model of Periodontal Disease. | 2020 | Details |
| A07731 | 32373213 | Theranostics | PTPROt aggravates inflammation by enhancing NF-κB activation in liver macrophages during nonalcoholic steatohepatitis. | 2020 | Details |
| A07769 | 32360434 | J Hepatol | Differential effects of selective- and pan-PPAR agonists on experimental steatohepatitis and hepatic macrophages☆. | 2020 | Details |
| A07771 | 32360132 | Dig Liver Dis | Mitochondrial DNA from hepatocytes induces upregulation of interleukin-33 expression of macrophages in nonalcoholic steatohepatitis. | 2020 | Details |
| A07952 | 32301540 | FASEB J | Smurf1 aggravates non-alcoholic fatty liver disease by stabilizing SREBP-1c in an E3 activity-independent manner. | 2020 | Details |
| A08203 | 32207258 | Endocrinol Metab (Seoul) | Impact of Skeletal Muscle Mass on Metabolic Health. | 2020 | Details |
| A08288 | 32168769 | Int J Mol Sci | Antidiabetic Therapy in the Treatment of Nonalcoholic Steatohepatitis. | 2020 | Details |
| A08463 | 32101831 | Intern Med | Association of Bone Metabolism with Fatty Liver Disease in the Elderly in Japan: A Community-based Study. | 2020 | Details |
| A08552 | 32063885 | Front Endocrinol (Lausanne) | Bone Turnover Markers and Probable Advanced Nonalcoholic Fatty Liver Disease in Middle-Aged and Elderly Men and Postmenopausal Women With Type 2 Diabetes. | 2020 | Details |
| A08580 | 32053033 | Expert Opin Ther Targets | Emerging therapeutic targets for NASH: key innovations at the preclinical level. | 2020 | Details |