Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
stats1
stats2
stats3
stats4
Search for:
Branched-chain amino acids71 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A00291 | 35150905 | Mol Metab | ITCH E3 ubiquitin ligase downregulation compromises hepatic degradation of branched-chain amino acids. | 2022 | Details |
| A01446 | 34742934 | Arch Biochem Biophys | The probiotic effects of AB23A on high-fat-diet-induced non-alcoholic fatty liver disease in mice may be associated with suppressing the serum levels of lipopolysaccharides and branched-chain amino acids. | 2021 | Details |
| A02295 | 34433228 | Hepatology | Up-regulation of thioesterase superfamily member 2 in skeletal muscle promotes hepatic steatosis and insulin resistance in mice. | 2021 | Details |
| A02414 | 34382495 | Ann Med | Effects of PPM1K rs1440581 and rs7678928 on serum branched-chain amino acid levels and risk of cardiovascular disease. | 2021 | Details |
| A02703 | 34277974 | Endocrinol Diabetes Metab | Impact of lifestyle Intervention on branched-chain amino acid catabolism and insulin sensitivity in adolescents with obesity. | 2021 | Details |
| A02960 | 34183740 | Sci Rep | Circulating branch chain amino acids and improvement in liver fat content in response to exercise interventions in NAFLD. | 2021 | Details |
| A03604 | 33935282 | Int J Obes (Lond) | The effect of physical activity level and exercise training on the association between plasma branched-chain amino acids and intrahepatic lipid content in participants with obesity. | 2021 | Details |
| A05068 | 33388736 | Orv Hetil | Sarcopenia - 2021: Pathophysiology, diagnosis, therapy | 2021 | Details |
| A05523 | 33219609 | Liver Int | Serum aromatic and branched-chain amino acids associated with NASH demonstrate divergent associations with serum lipids. | 2020 | Details |
| A05764 | 33127939 | Sci Rep | Supplementation of branched-chain amino acids decreases fat accumulation in the liver through intestinal microbiota-mediated production of acetic acid. | 2020 | Details |
| A05971 | 33058486 | Pediatr Obes | A branched-chain amino acid-based metabolic score can predict liver fat in children and adolescents with severe obesity. | 2020 | Details |
| A06490 | 32857176 | Eur J Nutr | Dietary intake of specific amino acids and liver status in subjects with nonalcoholic fatty liver disease: fatty liver in obesity (FLiO) study. | 2020 | Details |
| A06810 | 32738185 | Mol Nutr Food Res | The Gut Microbiota and Its Metabolites, Novel Targets for Treating and Preventing Non-Alcoholic Fatty Liver Disease. | 2020 | Details |
| A06812 | 32738061 | Hepatology | Prenatal Exposure to Perfluoroalkyl Substances Associated With Increased Susceptibility to Liver Injury in Children. | 2020 | Details |
| A07067 | 32634278 | J Intern Med | Liver mitochondrial DNA damage and genetic variability of Cytochrome b - a key component of the respirasome - drive the severity of fatty liver disease. | 2020 | Details |
| A09339 | 31785600 | Biomed Chromatogr | Simultaneous determination of thirteen substances related to NAFLD in mouse brain tissue using 3-aminobutyric acid as internal standard by HPLC-FLD. | 2020 | Details |
| A09358 | 31779730 | Br J Nutr | Dietary protein insufficiency: an important consideration in fatty liver disease? | 2019 | Details |
| A09432 | 31752378 | Nutrients | Role of Probiotics in Non-alcoholic Fatty Liver Disease: Does Gut Microbiota Matter? | 2019 | Details |
| A11384 | 30917546 | Nutrients | Non-Alcoholic Fatty Liver Disease and Risk of Incident Type 2 Diabetes: Role of Circulating Branched-Chain Amino Acids. | 2019 | Details |
| A11681 | 30791794 | Expert Rev Gastroenterol Hepatol | Sarcopenia and chronic liver diseases. | 2018 | Details |
| A14499 | 29380062 | J Gastroenterol | The profiling of plasma free amino acids and the relationship between serum albumin and plasma-branched chain amino acids in chronic liver disease: a single-center retrospective study. | 2018 | Details |
| A15236 | 29030588 | Sci Rep | Impaired branched-chain amino acid metabolism may underlie the nonalcoholic fatty liver disease-like pathology of neonatal testosterone-treated female rats. | 2017 | Details |
| A15311 | 28971838 | Am J Physiol Gastrointest Liver Physiol | Hyperglucagonemia correlates with plasma levels of non-branched-chain amino acids in patients with liver disease independent of type 2 diabetes. | 2017 | Details |
| A15949 | 28640216 | Nutrients | A Branched-Chain Amino Acid-Related Metabolic Signature Characterizes Obese Adolescents with Non-Alcoholic Fatty Liver Disease. | 2017 | Details |
| A16452 | 28378853 | Eur J Clin Nutr | Serum metabolomic profiling highlights pathways associated with liver fat content in a general population sample. | 2017 | Details |
| A16608 | 28285648 | Metabolism | Branched-chain amino acids alleviate hepatic steatosis and liver injury in choline-deficient high-fat diet induced NASH mice. | 2017 | Details |
| A16745 | 28212548 | Oncotarget | Branched-chain amino acids prevent hepatic fibrosis and development of hepatocellular carcinoma in a non-alcoholic steatohepatitis mouse model. | 2017 | Details |
| A17372 | 27821715 | Physiol Rep | A novel diet-induced murine model of steatohepatitis with fibrosis for screening and evaluation of drug candidates for nonalcoholic steatohepatitis. | 2016 | Details |
| A17468 | 27775848 | Hepatology | Metabolic profiling of fatty liver in young and middle-aged adults: Cross-sectional and prospective analyses of the Young Finns Study. | 2016 | Details |
| A19113 | 26755885 | World J Gastroenterol | Chemoprevention of obesity-related liver carcinogenesis by using pharmaceutical and nutraceutical agents. | 2016 | Details |
| A20259 | 26058864 | Am J Physiol Endocrinol Metab | Cross-talk between branched-chain amino acids and hepatic mitochondria is compromised in nonalcoholic fatty liver disease. | 2015 | Details |
| A20295 | 26041952 | J Clin Exp Hepatol | Reprint of: Nutrition in the Management of Cirrhosis and its Neurological Complications. | 2015 | Details |
| A20543 | 25904096 | J Gastroenterol | Pancrelipase with branched-chain amino acids for preventing nonalcoholic fatty liver disease after pancreaticoduodenectomy. | 2015 | Details |
| A20753 | 25755550 | J Clin Exp Hepatol | Nutrition in the management of cirrhosis and its neurological complications. | 2013 | Details |
| A21441 | 25316683 | JPEN J Parenter Enteral Nutr | Branched-Chain Amino Acid-Rich Supplements Containing Microelements Have Antioxidant Effects on Nonalcoholic Steatohepatitis in Mice. | 2014 | Details |
| A21497 | 25274101 | Br J Nutr | Non-alcoholic fatty liver disease: need for a balanced nutritional source. | 2014 | Details |
| A23344 | 23855271 | Appl Physiol Nutr Metab | Branched-chain amino acids alleviate nonalcoholic steatohepatitis in rats. | 2013 | Details |
| A23745 | 23514731 | Diabetes Care | Circulating lysophosphatidylcholines are markers of a metabolically benign nonalcoholic fatty liver. | 2013 | Details |
| A23875 | 23410526 | Biochim Biophys Acta | Prevention and reversal of hepatic steatosis with a high-protein diet in mice. | 2013 | Details |
| A24131 | 23197979 | Gastroenterol Res Pract | Nutrition therapy for liver diseases based on the status of nutritional intake. | 2012 | Details |
| A24460 | 22876026 | World J Gastroenterol | Alanine and aspartate aminotransferase and glutamine-cycling pathway: their roles in pathogenesis of metabolic syndrome. | 2012 | Details |
| A26472 | 20423748 | Metabolism | Plasma metabolomic profile in nonalcoholic fatty liver disease. | 2010 | Details |
| A26704 | 19929783 | Curr Med Chem | Branched-chain amino acids and pigment epithelium-derived factor: novel therapeutic agents for hepatitis c virus-associated insulin resistance. | 2009 | Details |
| A28452 | 14620622 | Dig Liver Dis | Impaired insulin-mediated amino acid plasma disappearance in non-alcoholic fatty liver disease: a feature of insulin resistance. | 2003 | Details |
| A33388 | 26082668 | Hepat Med | Tyrosine levels are associated with insulin resistance in patients with nonalcoholic fatty liver disease. | 2015 | Details |
| A34334 | 26201790 | Hepatol Int | The influence of pioglitazone on the plasma amino acid profile in patients with nonalcoholic steatohepatitis (NASH). | 2012 | Details |
| A42858 | 33277657 | J Clin Endocrinol Metab | Elevated Circulating Glutamate Is Associated With Subclinical Atherosclerosis Independently of Established Risk Markers: A Cross-Sectional Study. | 2021 | Details |
| A43074 | 32624568 | Exp Mol Med | Exercise training modulates the gut microbiota profile and impairs inflammatory signaling pathways in obese children. | 2020 | Details |
| A43246 | 32184272 | Diabetes | Branched-Chain Amino Acids Exacerbate Obesity-Related Hepatic Glucose and Lipid Metabolic Disorders via Attenuating Akt2 Signaling. | 2020 | Details |
| A44532 | 28323986 | J Clin Endocrinol Metab | Chronic Intranasal Insulin Does Not Affect Hepatic Lipids but Lowers Circulating BCAAs in Healthy Male Subjects. | 2017 | Details |
| A44808 | 27252163 | Physiology (Bethesda) | Linking Gut Microbiota and Inflammation to Obesity and Insulin Resistance. | 2016 | Details |
| A45301 | 25287814 | J Nutr Biochem | High-protein diets prevent steatosis and induce hepatic accumulation of monomethyl branched-chain fatty acids. | 2014 | Details |
| A47021 | 29368944 | Am J Physiol Gastrointest Liver Physiol | A specific amino acid formula prevents alcoholic liver disease in rodents. | 2018 | Details |
| A47355 | 12940921 | Aliment Pharmacol Ther | Review article: Nutritional therapy in alcoholic liver disease. | 2003 | Details |
| A47403 | 9164258 | J Nutr | Nutritional factors required for alcoholic liver disease in rats. | 1997 | Details |
| A48948 | 23467319 | Case Rep Gastroenterol | Rapid recovery from acute liver failure secondary to pancreatoduodenectomy-related non-alcoholic steatohepatitis. | 2013 | Details |
| A48964 | 23027617 | Carcinogenesis | Preventive effects of branched-chain amino acid supplementation on the spontaneous development of hepatic preneoplastic lesions in C57BL/KsJ-db/db obese mice. | 2012 | Details |
| A49054 | 19906067 | Cancer Sci | Dietary supplementation with branched-chain amino acids suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db mice. | 2009 | Details |
| A49292 | 35797133 | JCI Insight | Altered branched-chain α-keto acid metabolism is a feature of NAFLD in individuals with severe obesity. | 2022 | Details |
| A49478 | 35740464 | Biomedicines | The Emerging Role of Branched-Chain Amino Acids in Liver Diseases. | 2022 | Details |
| A50164 | 35495903 | Front Nutr | Amino Acid and Fatty Acid Metabolism Disorders Trigger Oxidative Stress and Inflammatory Response in Excessive Dietary Valine-Induced NAFLD of Laying Hens. | 2022 | Details |
| A50248 | 35457142 | Int J Mol Sci | Role of Branched-Chain Amino Acid Metabolism in Type 2 Diabetes, Obesity, Cardiovascular Disease and Non-Alcoholic Fatty Liver Disease. | 2022 | Details |
| A50395 | 35406066 | Nutrients | Amino Acid-Related Metabolic Signature in Obese Children and Adolescents. | 2022 | Details |
| A50503 | 35360107 | Front Cell Infect Microbiol | Porphyromonas gingivalis Induces Increases in Branched-Chain Amino Acid Levels and Exacerbates Liver Injury Through livh/livk. | 2022 | Details |
| A51157 | 35447117 | J Biol Chem | Calpain-mediated proteolytic production of free amino acids in vascular endothelial cells augments obesity-induced hepatic steatosis. | 2022 | Details |
| A51395 | 35830259 | FASEB J | Intervention with isoleucine or valine corrects hyperinsulinemia and reduces intrahepatic diacylglycerols, liver steatosis, and inflammation in Ldlr-/-.Leiden mice with manifest obesity-associated NASH. | 2022 | Details |
| A51925 | 33176135 | Cell Rep | Muscle-Liver Trafficking of BCAA-Derived Nitrogen Underlies Obesity-Related Glycine Depletion. | 2020 | Details |
| A51948 | 32985578 | Sci Rep | Interaction between MyD88, TIRAP and IL1RL1 against Helicobacter pylori infection. | 2020 | Details |
| A52131 | 30920846 | Am J Physiol Gastrointest Liver Physiol | Intestinal serine protease inhibition increases FGF21 and improves metabolism in obese mice. | 2019 | Details |
| A52653 | 24130792 | PLoS One | Diagnosing fatty liver disease: a comparative evaluation of metabolic markers, phenotypes, genotypes and established biomarkers. | 2013 | Details |
| A52760 | 22351884 | Pediatrics | Toward a unifying hypothesis of metabolic syndrome. | 2012 | Details |