Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Fructose1035 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A00006 | 35256934 | Acta Pharm Sin B | Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma. | 2021 | Details |
| A00024 | 35251356 | EFSA J | Tolerable upper intake level for dietary sugars. | 2022 | Details |
| A00051 | 35242578 | Mol Genet Metab Rep | Expression signature of the Leigh syndrome French-Canadian type. | 2022 | Details |
| A00141 | 35212227 | J Agric Food Chem | Targeted Lipidomics Reveal the Effects of Different Phospholipids on the Phospholipid Profiles of Hepatic Mitochondria and Endoplasmic Reticulum in High-Fat/High-Fructose-Diet-Induced Nonalcoholic Fatty Liver Disease Mice. | 2022 | Details |
| A00305 | 35143711 | Clin Transl Sci | Hepatoprotective effects of semaglutide, lanifibranor and dietary intervention in the GAN diet-induced obese and biopsy-confirmed mouse model of NASH. | 2022 | Details |
| A00338 | 35129307 | Liver Int | Anti-CD47 antibody treatment attenuates liver inflammation and fibrosis in experimental non-alcoholic steatohepatitis models. | 2022 | Details |
| A00344 | 35126846 | World J Hepatol | Stearoyl-CoA desaturase 1: A potential target for non-alcoholic fatty liver disease?-perspective on emerging experimental evidence. | 2022 | Details |
| A00350 | 35124887 | Mol Nutr Food Res | ChREBP-driven DNL and PNPLA3 Expression Induced by Liquid Fructose are Essential in the Production of Fatty Liver and Hypertriglyceridemia in a High-Fat Diet-Fed Rat Model. | 2022 | Details |
| A00429 | 35087411 | Front Pharmacol | Aurantio-Obtusin Attenuates Non-Alcoholic Fatty Liver Disease Through AMPK-Mediated Autophagy and Fatty Acid Oxidation Pathways. | 2022 | Details |
| A00505 | 35058605 | Eur J Clin Nutr | Effects of a low free sugar diet on the management of nonalcoholic fatty liver disease: a randomized clinical trial. | 2022 | Details |
| A00548 | 35050189 | Metabolites | The Role of Fructose as a Cardiovascular Risk Factor: An Update. | 2022 | Details |
| A00562 | 35046474 | Sci Rep | Hepatic galectin-3 is associated with lipid droplet area in non-alcoholic steatohepatitis in a new swine model. | 2022 | Details |
| A00592 | 35036886 | JHEP Rep | Vasoconstrictor antagonism improves functional and structural vascular alterations and liver damage in rats with early NAFLD. | 2021 | Details |
| A00612 | 35029027 | J Cell Mol Med | Alterations of nitric oxide homeostasis as trigger of intestinal barrier dysfunction in non-alcoholic fatty liver disease. | 2022 | Details |
| A00615 | 35028346 | Data Brief | Dataset for liver metabolomic profile of highland barley Monascus purpureus went extract-treated golden hamsters with nonalcoholic fatty liver disease. | 2021 | Details |
| A00638 | 35018944 | Food Funct | Ginsenoside CK ameliorates hepatic lipid accumulation via activating the LKB1/AMPK pathway in vitro and in vivo. | 2022 | Details |
| A00647 | 35015019 | Food Funct | Preventive effects of black soybean polyphenols on non-alcoholic fatty liver disease in three different mouse models. | 2022 | Details |
| A00662 | 35011585 | Cells | Cynanchum atratum Alleviates Non-Alcoholic Fatty Liver by Balancing Lipogenesis and Fatty Acid Oxidation in a High-Fat, High-Fructose Diet Mice Model. | 2021 | Details |
| A00663 | 35010976 | Nutrients | Metabolic-Associated Fatty Liver Disease (MAFLD), Diabetes, and Cardiovascular Disease: Associations with Fructose Metabolism and Gut Microbiota. | 2021 | Details |
| A00669 | 35008925 | Int J Mol Sci | Non-Alcoholic Steatohepatitis (NASH) and Organokines: What Is Now and What Will Be in the Future. | 2022 | Details |
| A00687 | 35003513 | Oxid Med Cell Longev | TNF-Like Ligand 1 Aberrance Aggravates Nonalcoholic Steatohepatitis via M1 Macrophage Polarization. | 2021 | Details |
| A00706 | 34994824 | Naunyn Schmiedebergs Arch Pharmacol | The crucial role of oxidative stress in non-alcoholic fatty liver disease-induced male reproductive toxicity: the ameliorative effects of Iranian indigenous probiotics. | 2022 | Details |
| A00709 | 34993389 | Curr Dev Nutr | Considerations When Choosing High-Fat, High-Fructose, and High-Cholesterol Diets to Induce Experimental Nonalcoholic Fatty Liver Disease in Laboratory Animal Models. | 2021 | Details |
| A00780 | 34969770 | Anticancer Res | Development of Non-alcoholic Steatohepatitis and Nodular Regenerative Hyperplasia in C57BL/6J Mice Fed a Fructose-containing Western Diet. | 2022 | Details |
| A00797 | 34964117 | Compr Physiol | Bile Acids, Gut Microbiome and the Road to Fatty Liver Disease. | 2021 | Details |
| A00807 | 34959755 | Nutrients | The Effects of Butyrate on Induced Metabolic-Associated Fatty Liver Disease in Precision-Cut Liver Slices. | 2021 | Details |
| A00808 | 34959747 | Nutrients | High-Fructose, High-Fat Diet Alters Muscle Composition and Fuel Utilization in a Juvenile Iberian Pig Model of Non-Alcoholic Fatty Liver Disease. | 2021 | Details |
| A00846 | 34950107 | Front Endocrinol (Lausanne) | Analysis of N6-Methyladenosine Methylation Modification in Fructose-Induced Non-Alcoholic Fatty Liver Disease. | 2021 | Details |
| A00908 | 34933425 | Zhonghua Gan Zang Bing Za Zhi | [Intestinal flora polymorphisms with different lesional stages in an animal model of MAFLD]. | 2021 | Details |
| A00943 | 34923087 | J Ethnopharmacol | Highland barley Monascus purpureus Went extract ameliorates high-fat, high-fructose, high-cholesterol diet induced nonalcoholic fatty liver disease by regulating lipid metabolism in golden hamsters. | 2021 | Details |
| A00951 | 34921208 | Sci Rep | Dual role of neutrophils in modulating liver injury and fibrosis during development and resolution of diet-induced murine steatohepatitis. | 2021 | Details |
| A01015 | 34903499 | Dig Liver Dis | Colonic inflammation accelerates the progression of liver disease: A protective role of dipotassium glycyrrhizate. | 2021 | Details |
| A01022 | 34900816 | J Diabetes Metab Disord | The effects of high fructose fruits and honey on the serum level of metabolic factors and nonalcoholic fatty liver disease. | 2021 | Details |
| A01106 | 34867414 | Front Pharmacol | The Contribution of Dietary Fructose to Non-alcoholic Fatty Liver Disease. | 2021 | Details |
| A01178 | 34838723 | Clin Gastroenterol Hepatol | Systematic Review and Meta-analysis: The Role of Diet in the Development of Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A01218 | 34825156 | JHEP Rep | Bile acids contribute to the development of non-alcoholic steatohepatitis in mice. | 2021 | Details |
| A01260 | 34811578 | Handb Exp Pharmacol | NAFLD and NASH: The Metabolically Diseased Liver. | 2021 | Details |
| A01303 | 34795650 | Front Microbiol | Dextran Sulfate Sodium Salt-Induced Colitis Aggravates Gut Microbiota Dysbiosis and Liver Injury in Mice With Non-alcoholic Steatohepatitis. | 2021 | Details |
| A01308 | 34794234 | Biomed Pharmacother | Saroglitazar and Hepano treatment offers protection against high fat high fructose diet induced obesity, insulin resistance and steatosis by modulating various class of hepatic and circulating lipids. | 2021 | Details |
| A01343 | 34781143 | Biomed Pharmacother | Carminic acid mitigates fructose-triggered hepatic steatosis by inhibition of oxidative stress and inflammatory reaction. | 2021 | Details |
| A01368 | 34773257 | Hepatology | A GLP-1/GLP-2 receptor dual agonist to treat NASH: Targeting the gut-liver axis and microbiome. | 2021 | Details |
| A01374 | 34769488 | Int J Mol Sci | The Roles of Carbohydrate Response Element Binding Protein in the Relationship between Carbohydrate Intake and Diseases. | 2021 | Details |
| A01383 | 34765514 | J Tradit Complement Med | Genistein and exercise treatment reduced NASH related HDAC3, IL-13 and MMP-12 expressions in ovariectomized rats fed with high fat high fructose diet. | 2021 | Details |
| A01403 | 34758930 | Arch Pediatr | The role of nutrition in non-alcoholic fatty liver disease treatment in obese children. | 2021 | Details |
| A01413 | 34757046 | Mol Metab | Pleiotropic actions of IP6K1 mediate hepatic metabolic dysfunction to promote nonalcoholic fatty liver disease and steatohepatitis. | 2021 | Details |
| A01426 | 34752964 | Clin Gastroenterol Hepatol | Sugar-Sweetened Beverage, Diet Soda, and Nonalcoholic Fatty Liver Disease Over 6 Years: The Framingham Heart Study. | 2021 | Details |
| A01574 | 34688661 | J Biol Chem | A retinoic acid receptor β2 agonist attenuates transcriptome and metabolome changes underlying nonalcohol-associated fatty liver disease. | 2021 | Details |
| A01587 | 34684533 | Nutrients | Supplementation with a Specific Combination of Metabolic Cofactors Ameliorates Non-Alcoholic Fatty Liver Disease, Hepatic Fibrosis, and Insulin Resistance in Mice. | 2021 | Details |
| A01592 | 34684371 | Nutrients | Advanced Glycation End-Products in Common Non-Infectious Liver Diseases: Systematic Review and Meta-Analysis. | 2021 | Details |
| A01702 | 34650394 | Food Nutr Res | Chronic liquid fructose supplementation does not cause liver tumorigenesis but elicits clear sex differences in the metabolic response in Sprague-Dawley rats. | 2021 | Details |
| A01783 | 34619074 | Cell Metab | Molecular aspects of fructose metabolism and metabolic disease. | 2021 | Details |
| A01788 | 34617537 | Food Funct | Kombuchas from green and black teas reduce oxidative stress, liver steatosis and inflammation, and improve glucose metabolism in Wistar rats fed a high-fat high-fructose diet. | 2021 | Details |
| A01847 | 34591699 | J Med Food | Artichoke Extract Directly Suppresses Inflammation and Apoptosis in Hepatocytes During the Development of Non-Alcoholic Fatty Liver Disease. | 2021 | Details |
| A01877 | 34576091 | Int J Mol Sci | Establishment of an Adult Medaka Fatty Liver Model by Administration of a Gubra-Amylin-Nonalcoholic Steatohepatitis Diet Containing High Levels of Palmitic Acid and Fructose. | 2021 | Details |
| A01884 | 34573421 | Genes (Basel) | The Mitochondrial Trigger in an Animal Model of Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A01918 | 34563519 | J Lipid Res | Inhibition of chylomicron assembly leads to dissociation of hepatic steatosis from inflammation and fibrosis. | 2021 | Details |
| A01991 | 34536973 | FEBS Lett | Transcription factor SOX2 contributes to nonalcoholic fatty liver disease development by regulating the expression of the fatty acid transporter CD36. | 2021 | Details |
| A02094 | 34508810 | Pharmacol Res | GADD45β stabilized by direct interaction with HSP72 ameliorates insulin resistance and lipid accumulation. | 2021 | Details |
| A02127 | 34497333 | Sci Rep | Toll-like receptor 1 as a possible target in non-alcoholic fatty liver disease. | 2021 | Details |
| A02149 | 34486129 | Alcohol Clin Exp Res | Multiparametric magnetic resonance imaging/magnetic resonance elastography assesses progression and regression of steatosis, inflammation, and fibrosis in alcohol-associated liver disease. | 2021 | Details |
| A02184 | 34470675 | Br J Nutr | Diet containing dehulled adlay ameliorates hepatic steatosis, inflammation and insulin resistance in rats with non-alcoholic fatty liver disease. | 2021 | Details |
| A02243 | 34448436 | J Histochem Cytochem | Independent of Calorie Intake, Short-term Alternate-day Fasting Alleviates NASH, With Modulation of Markers of Lipogenesis, Autophagy, Apoptosis, and Inflammation in Rats. | 2021 | Details |
| A02265 | 34443333 | Molecules | Phenolics-Rich Extracts of Dietary Plants as Regulators of Fructose Uptake in Caco-2 Cells via GLUT5 Involvement. | 2021 | Details |
| A02315 | 34422323 | J Clin Transl Sci | Excess dietary fructose does not alter gut microbiota or permeability in humans: A pilot randomized controlled study. | 2021 | Details |
| A02342 | 34410623 | Hum Cell | Human umbilical cord-derived mesenchymal stem cell-exosomal miR-627-5p ameliorates non-alcoholic fatty liver disease by repressing FTO expression. | 2021 | Details |
| A02345 | 34409309 | STAR Protoc | A luminescence-based protocol for assessing fructose metabolism via quantification of ketohexokinase enzymatic activity in mouse or human hepatocytes. | 2021 | Details |
| A02455 | 34365685 | FASEB J | Melatonin induces Nrf2-HO-1 reprogramming and corrections in hepatic core clock oscillations in Non-alcoholic fatty liver disease. | 2021 | Details |
| A02476 | 34359974 | Cells | Diet-Induced Models of Non-Alcoholic Fatty Liver Disease: Food for Thought on Sugar, Fat, and Cholesterol. | 2021 | Details |
| A02479 | 34359438 | Foods | Comparison of Egg Yolk and Soybean Phospholipids on Hepatic Fatty Acid Profile and Liver Protection in Rats Fed a High-Fructose Diet. | 2021 | Details |
| A02537 | 34336366 | Liver Res | Adoptive transfer of Pfkfb3-disrupted hematopoietic cells to wild-type mice exacerbates diet-induced hepatic steatosis and inflammation. | 2020 | Details |
| A02550 | 34331779 | Hepatology | Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates Diet-Induced Metabolic Syndrome, Steatohepatitis, and Hepatic Fibrosis. | 2021 | Details |
| A02575 | 34326012 | J Genet Genomics | Fructose and fructose kinase in cancer and other pathologies. | 2021 | Details |
| A02582 | 34323067 | J Agric Food Chem | Regulation on Citrate Influx and Metabolism through Inhibiting SLC13A5 and ACLY: A Novel Mechanism Mediating the Therapeutic Effects of Curcumin on NAFLD. | 2021 | Details |
| A02583 | 34322898 | Hepatology | Guanine Nucleotide-Binding Protein G(i) Subunit Alpha 2 Exacerbates NASH Progression by Regulating Peroxiredoxin 1-Related Inflammation and Lipophagy. | 2021 | Details |
| A02594 | 34321089 | Stem Cell Res Ther | Addressing the liver progenitor cell response and hepatic oxidative stress in experimental non-alcoholic fatty liver disease/non-alcoholic steatohepatitis using amniotic epithelial cells. | 2021 | Details |
| A02696 | 34279787 | Arch Pharm Res | Aldose Reductase: a cause and a potential target for the treatment of diabetic complications. | 2021 | Details |
| A02739 | 34264552 | Vopr Pitan | [Pathogenetic mechanisms for the development of hematological disorders in induced fatty liver disease in Wistar rats and assessment of the regulatory effects of carnosine and α-lipoic acid]. | 2021 | Details |
| A02758 | 34257427 | Nat Rev Gastroenterol Hepatol | Dietary carbohydrates and fats in nonalcoholic fatty liver disease. | 2021 | Details |
| A02878 | 34208774 | Int J Mol Sci | Atorvastatin Modulates Bile Acid Homeostasis in Mice with Diet-Induced Nonalcoholic Steatohepatitis. | 2021 | Details |
| A02891 | 34204343 | Metabolites | Fructose Causes Liver Damage, Polyploidy, and Dysplasia in the Setting of Short Telomeres and p53 Loss. | 2021 | Details |
| A02895 | 34203484 | Int J Mol Sci | Fructose and the Liver. | 2021 | Details |
| A02915 | 34199317 | Int J Mol Sci | Empagliflozin Improves Metabolic and Hepatic Outcomes in a Non-Diabetic Obese Biopsy-Proven Mouse Model of Advanced NASH. | 2021 | Details |
| A02927 | 34195217 | Front Nutr | Grape Polyphenols Attenuate Diet-Induced Obesity and Hepatic Steatosis in Mice in Association With Reduced Butyrate and Increased Markers of Intestinal Carbohydrate Oxidation. | 2021 | Details |
| A02973 | 34177920 | Front Immunol | Prebiotic Inulin and Sodium Butyrate Attenuate Obesity-Induced Intestinal Barrier Dysfunction by Induction of Antimicrobial Peptides. | 2021 | Details |
| A02979 | 34176275 | Nutr Hosp | Temporal effect of fructose supplementation at different concentrations on hepatic metabolism of Wistar rats. | 2021 | Details |
| A03103 | 34130208 | Nutr Res | A rise in Proteobacteria is an indicator of gut-liver axis-mediated nonalcoholic fatty liver disease in high-fructose-fed adult mice. | 2021 | Details |
| A03177 | 34099584 | J Physiol Pharmacol | Acute responses of hepatic fat content to consuming fat, glucose and fructose alone and in combination in non-obese non-diabetic individuals with non-alcoholic fatty liver disease. | 2021 | Details |
| A03180 | 34098145 | Mol Metab | Early induction of hepatic deiodinase type 1 inhibits hepatosteatosis during NAFLD progression. | 2021 | Details |
| A03253 | 34069635 | Nutrients | Exploratory Data Analysis of Cell and Mitochondrial High-Fat, High-Sugar Toxicity on Human HepG2 Cells. | 2021 | Details |
| A03265 | 34065444 | Nutrients | Gut Microbiota Induced by Pterostilbene and Resveratrol in High-Fat-High-Fructose Fed Rats: Putative Role in Steatohepatitis Onset. | 2021 | Details |
| A03396 | 34017059 | Exp Mol Med | The interaction between the gut microbiota and dietary carbohydrates in nonalcoholic fatty liver disease. | 2021 | Details |
| A03418 | 34007294 | Evid Based Complement Alternat Med | Mechanism of Huo-Xue-Qu-Yu Formula in Treating Nonalcoholic Hepatic Steatosis by Regulating Lipid Metabolism and Oxidative Stress in Rats. | 2021 | Details |
| A03419 | 34007127 | World J Gastroenterol | Non-alcoholic fatty liver and chronic kidney disease: Retrospect, introspect, and prospect. | 2021 | Details |
| A03420 | 34006994 | Eur J Clin Nutr | Non-alcoholic fatty liver disease in obese children and adolescents: a role for nutrition? | 2021 | Details |
| A03517 | 33973269 | Hepatology | A Systematic Review of Animal Models of NAFLD Finds High-Fat, High-Fructose Diets Most Closely Resemble Human NAFLD. | 2021 | Details |
| A03520 | 33972568 | Sci Rep | Allopurinol ameliorates high fructose diet induced hepatic steatosis in diabetic rats through modulation of lipid metabolism, inflammation, and ER stress pathway. | 2021 | Details |
| A03614 | 33930596 | Mol Metab | Hepatocyte miR-34a is a key regulator in the development and progression of non-alcoholic fatty liver disease. | 2021 | Details |
| A03622 | 33926132 | Metabolites | Dietary Macronutrient Composition Differentially Modulates the Remodeling of Mitochondrial Oxidative Metabolism during NAFLD. | 2021 | Details |
| A03628 | 33925122 | Curr Issues Mol Biol | Effect of Bombyx mori on the Liver Protection of Non-Alcoholic Fatty Liver Disease Based on In Vitro and In Vivo Models. | 2021 | Details |
| A03635 | 33923525 | Nutrients | The Role of Fructose in Non-Alcoholic Steatohepatitis: Old Relationship and New Insights. | 2021 | Details |