Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A00044 | 35246007 | Bioengineered | Quantitative proteomics analysis based on tandem mass tag labeling coupled with labeling coupled with liquid chromatography-tandem mass spectrometry discovers the effect of silibinin on non-alcoholic fatty liver disease in mice. | 2022 | Details |
| A00054 | 35241921 | J Inflamm Res | Reduction of Hepatic Steatosis, Oxidative Stress, Inflammation, Ballooning and Insulin Resistance After Therapy with Safranal in NAFLD Animal Model: A New Approach. | 2022 | Details |
| A00147 | 35208513 | Medicina (Kaunas) | Evaluation of Dose-Dependent Obesity and Diabetes-Related Complications of Water Chestnut (Fruit of Trapa japonica) Extracts in Type II Obese Diabetic Mice Induced by 45% Kcal High-Fat Diet. | 2022 | Details |
| A00183 | 35195377 | Minerva Endocrinol (Torino) | Inflammation is associated with impairment of oxidative status, carbohydrate and lipid metabolism in type 2 diabetes complicated by non-alcoholic fatty liver disease. | 2022 | Details |
| A00205 | 35187676 | J Food Biochem | Chitosan oligosaccharide attenuates hepatic steatosis in HepG2 cells via the activation of AMP-activated protein kinase. | 2022 | Details |
| A00560 | 35046824 | Front Pharmacol | Limonin Alleviates Non-alcoholic Fatty Liver Disease by Reducing Lipid Accumulation, Suppressing Inflammation and Oxidative Stress. | 2022 | Details |
| A00566 | 35045633 | Zhonghua Gan Zang Bing Za Zhi | [Role and mechanism of miRNA-181a in nonalcoholic fatty liver disease]. | 2021 | Details |
| A00706 | 34994824 | Naunyn Schmiedebergs Arch Pharmacol | The crucial role of oxidative stress in non-alcoholic fatty liver disease-induced male reproductive toxicity: the ameliorative effects of Iranian indigenous probiotics. | 2022 | Details |
| A00879 | 34943221 | Biology (Basel) | Beta vulgaris L. (Beetroot) Methanolic Extract Prevents Hepatic Steatosis and Liver Damage in T2DM Rats by Hypoglycemic, Insulin-Sensitizing, Antioxidant Effects, and Upregulation of PPARα. | 2021 | Details |
| A00971 | 34915054 | J Hepatol | A structurally engineered fatty acid, icosabutate, suppresses liver inflammation and fibrosis in NASH. | 2021 | Details |
| A01018 | 34902008 | Am J Clin Nutr | Adiposity, metabolomic biomarkers, and risk of nonalcoholic fatty liver disease: a case-cohort study. | 2022 | Details |
| A01067 | 34881510 | Pediatr Obes | The effects of Mediterranean diet on hepatic steatosis, oxidative stress, and inflammation in adolescents with non-alcoholic fatty liver disease: A randomized controlled trial. | 2021 | Details |
| A01082 | 34874519 | Chin J Integr Med | Lycium barbarum Polysaccharides Promotes Mitochondrial Biogenesis and Energy Balance in a NAFLD Cell Model. | 2021 | Details |
| A01096 | 34870139 | Metabol Open | Protective effects of cerium oxide nanoparticles in non-alcoholic fatty liver disease (NAFLD) and carbon tetrachloride-induced liver damage in rats: Study on intestine and liver. | 2021 | Details |
| A01379 | 34768813 | Int J Mol Sci | The Ameliorative Effects of Saikosaponin in Thioacetamide-Induced Liver Injury and Non-Alcoholic Fatty Liver Disease in Mice. | 2021 | Details |
| A01411 | 34757160 | Toxicology | The combined impact of decabromodiphenyl ether and high fat exposure on non-alcoholic fatty liver disease in vivo and in vitro. | 2021 | Details |
| A01484 | 34729306 | Acta Pharm Sin B | 3D disorganization and rearrangement of genome provide insights into pathogenesis of NAFLD by integrated Hi-C, Nanopore, and RNA sequencing. | 2021 | Details |
| A01587 | 34684533 | Nutrients | Supplementation with a Specific Combination of Metabolic Cofactors Ameliorates Non-Alcoholic Fatty Liver Disease, Hepatic Fibrosis, and Insulin Resistance in Mice. | 2021 | Details |
| A01594 | 34684335 | Nutrients | Pathway Preferential Estrogens Prevent Hepatosteatosis Due to Ovariectomy and High-Fat Diets. | 2021 | Details |
| A01608 | 34680557 | Biomedicines | Combined Metabolic Activators Decrease Liver Steatosis by Activating Mitochondrial Metabolism in Hamsters Fed with a High-Fat Diet. | 2021 | Details |
| A01616 | 34679651 | Antioxidants (Basel) | Association of Urinary and Dietary Selenium and of Serum Selenium Species with Serum Alanine Aminotransferase in a Healthy Italian Population. | 2021 | Details |
| A01676 | 34658353 | Nan Fang Yi Ke Da Xue Xue Bao | [Quantitative analysis of differential proteins in liver tissues of patients with non-alcoholic steatohepatitis using iTRAQ technology]. | 2021 | Details |
| A01680 | 34656650 | J Hepatol | Hepatocyte glutathione S-transferase mu 2 prevents non-alcoholic steatohepatitis by suppressing ASK1 signaling. | 2021 | Details |
| A01698 | 34651285 | J Physiol Biochem | Astaxanthin attenuates hepatic steatosis in high-fat diet-fed rats by suppressing microRNA-21 via transactivation of nuclear factor erythroid 2-related factor 2. | 2021 | Details |
| A01777 | 34621168 | Front Pharmacol | Study on the Hepatoprotection of Schisandra chinensis Caulis Polysaccharides in Nonalcoholic Fatty Liver Disease in Rats Based on Metabolomics. | 2021 | Details |
| A01861 | 34585409 | J Food Biochem | Crataegus aronia prevents high-fat diet-induced hepatic steatosis in rats by activating AMPK-induced suppression of SREBP1 and activation of PPARα. | 2021 | Details |
| A01882 | 34574082 | Foods | AGL9: A Novel Hepatoprotective Peptide from the Larvae of Edible Insects Alleviates Obesity-Induced Hepatic Inflammation by Regulating AMPK/Nrf2 Signaling. | 2021 | Details |
| A01907 | 34565410 | Malar J | Transcriptome-based analysis of blood samples reveals elevation of DNA damage response, neutrophil degranulation, cancer and neurodegenerative pathways in Plasmodium falciparum patients. | 2021 | Details |
| A01973 | 34546515 | Obes Surg | Changes in Total Homocysteine and Glutathione Levels After Laparoscopic Sleeve Gastrectomy in Children with Metabolic-Associated Fatty Liver Disease. | 2021 | Details |
| A02100 | 34508238 | Nat Rev Gastroenterol Hepatol | Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests. | 2021 | Details |
| A02240 | 34449316 | Biomed Pharmacother | Jiuzhuan Huangjing Pills relieve mitochondrial dysfunction and attenuate high-fat diet-induced metabolic dysfunction-associated fatty liver disease. | 2021 | Details |
| A02285 | 34437407 | Toxins (Basel) | Microcystin Toxicokinetics, Molecular Toxicology, and Pathophysiology in Preclinical Rodent Models and Humans. | 2021 | Details |
| A02312 | 34423525 | Int J Clin Pract | Omega 3-rich Camelina sativa oil in the context of a weight loss program improves glucose homeostasis, inflammation and oxidative stress in patients with NAFLD: A randomised placebo-controlled clinical trial. | 2021 | Details |
| A02426 | 34374658 | J Physiol Pharmacol | Hesperidin, a novel candidate for the successful treatment of high fat diet plus ethanol-induced fatty liver disease in mice. | 2021 | Details |
| A02521 | 34342168 | Physiol Rep | Hormonal regulation of glycine decarboxylase and its relationship to oxidative stress. | 2021 | Details |
| A02562 | 34328087 | Biomed Pharmacother | Supplementation of cumin seed powder prevents oxidative stress, hyperlipidemia and non-alcoholic fatty liver in high fat diet fed rats. | 2021 | Details |
| A02625 | 34305077 | Exp Anim | AP39 ameliorates high fat diet-induced liver injury in young rats via alleviation of oxidative stress and mitochondrial impairment. | 2021 | Details |
| A02689 | 34281337 | J Agric Food Chem | γ-Linolenic Acid Prevents Lipid Metabolism Disorder in Palmitic Acid-Treated Alpha Mouse Liver-12 Cells by Balancing Autophagy and Apoptosis via the LKB1-AMPK-mTOR Pathway. | 2021 | Details |
| A02765 | 34252441 | Eur J Pharmacol | Ferroptosis as a new therapeutic opportunity for nonviral liver disease. | 2021 | Details |
| A02789 | 34239698 | World J Hepatol | Glutathione-S-transferases genes-promising predictors of hepatic dysfunction. | 2021 | Details |
| A02882 | 34206460 | Int J Mol Sci | Clozapine Worsens Glucose Intolerance, Nonalcoholic Fatty Liver Disease, Kidney Damage, and Retinal Injury and Increases Renal Reactive Oxygen Species Production and Chromium Loss in Obese Mice. | 2021 | Details |
| A02888 | 34204849 | Antioxidants (Basel) | Neonatal Vitamin C and Cysteine Deficiencies Program Adult Hepatic Glutathione and Specific Activities of Glucokinase, Phosphofructokinase, and Acetyl-CoA Carboxylase in Guinea Pigs' Livers. | 2021 | Details |
| A02910 | 34200615 | Nutrients | Lipoic Acid Exacerbates Oxidative Stress and Lipid Accumulation in the Liver of Wistar Rats Fed a Hypercaloric Choline-Deficient Diet. | 2021 | Details |
| A02919 | 34199098 | Int J Mol Sci | Western Diet Decreases the Liver Mitochondrial Oxidative Flux of Succinate: Insight from a Murine NAFLD Model. | 2021 | Details |
| A02979 | 34176275 | Nutr Hosp | Temporal effect of fructose supplementation at different concentrations on hepatic metabolism of Wistar rats. | 2021 | Details |
| A03033 | 34156590 | Dig Dis Sci | A Decreased Response to Resistin in Mononuclear Leukocytes Contributes to Oxidative Stress in Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A03058 | 34151243 | JHEP Rep | Aramchol downregulates stearoyl CoA-desaturase 1 in hepatic stellate cells to attenuate cellular fibrogenesis. | 2021 | Details |
| A03071 | 34142329 | Fish Physiol Biochem | Metabolism and antioxidation regulation of total flavanones from Sedum sarmentosum Bunge against high-fat diet-induced fatty liver disease in Nile tilapia (Oreochromis niloticus). | 2021 | Details |
| A03076 | 34139927 | Pharm Biol | Tocopheryl quinone improves non-alcoholic steatohepatitis (NASH) associated dysmetabolism of glucose and lipids by upregulating the expression of glucagon-like peptide 1 (GLP-1) via restoring the balance of intestinal flora in rats. | 2021 | Details |
| A03087 | 34136174 | Food Sci Nutr | Synergistic effects of black ginseng and aged garlic extracts for the amelioration of nonalcoholic fatty liver disease (NAFLD) in mice. | 2021 | Details |
| A03088 | 34136163 | Food Sci Nutr | Effects of several tea extracts on nonalcoholic fatty liver disease in mice fed with a high-fat diet. | 2021 | Details |
| A03158 | 34107585 | Zhonghua Gan Zang Bing Za Zhi | [Protective effect of baicalein on high fat-induced hepatocytes oxidative damage]. | 2021 | Details |
| A03256 | 34069176 | Life (Basel) | Kaempferol-3-O-Glucuronide Ameliorates Non-Alcoholic Steatohepatitis in High-Cholesterol-Diet-Induced Larval Zebrafish and HepG2 Cell Models via Regulating Oxidation Stress. | 2021 | Details |
| A03267 | 34065270 | Nutrients | Comparison of the Improvement Effect of Deep Ocean Water with Different Mineral Composition on the High Fat Diet-Induced Blood Lipid and Nonalcoholic Fatty Liver Disease in a Mouse Model. | 2021 | Details |
| A03298 | 34055494 | PeerJ | Liver proteome alterations in psychologically distressed rats and a nootropic drug. | 2021 | Details |
| A03375 | 34025683 | Front Immunol | Nutrigenetic Interactions Might Modulate the Antioxidant and Anti-Inflammatory Status in Mastiha-Supplemented Patients With NAFLD. | 2021 | Details |
| A03377 | 34025131 | J Ginseng Res | Effect of Korean Red Ginseng on metabolic syndrome. | 2020 | Details |
| A03507 | 33977953 | Food Funct | Hesperetin ameliorates hepatic oxidative stress and inflammation via the PI3K/AKT-Nrf2-ARE pathway in oleic acid-induced HepG2 cells and a rat model of high-fat diet-induced NAFLD. | 2021 | Details |
| A03533 | 33965728 | Biomed Pharmacother | Açaí (Euterpe oleracea Martius) supplementation improves oxidative stress biomarkers in liver tissue of dams fed a high-fat diet and increases antioxidant enzymes' gene expression in offspring. | 2021 | Details |
| A03540 | 33962692 | Microbiome | Iron status influences non-alcoholic fatty liver disease in obesity through the gut microbiome. | 2021 | Details |
| A03558 | 33955510 | Mol Med Rep | Parthenolide plays a protective role in the liver of mice with metabolic dysfunction‑associated fatty liver disease through the activation of the HIPPO pathway. | 2021 | Details |
| A03562 | 33953586 | Diabetes Metab Syndr Obes | Astragaloside IV Alleviates Liver Inflammation, Oxidative Stress and Apoptosis to Protect Against Experimental Non-Alcoholic Fatty Liver Disease. | 2021 | Details |
| A03660 | 33917360 | Antioxidants (Basel) | Lingonberry Improves Non-Alcoholic Fatty Liver Disease by Reducing Hepatic Lipid Accumulation, Oxidative Stress and Inflammatory Response. | 2021 | Details |
| A03702 | 33898958 | JHEP Rep | Weight-loss-independent benefits of exercise on liver steatosis and stiffness in Japanese men with NAFLD. | 2021 | Details |
| A03815 | 33859314 | Sci Rep | Extra virgin olive oil improved body weight and insulin sensitivity in high fat diet-induced obese LDLr-/-.Leiden mice without attenuation of steatohepatitis. | 2021 | Details |
| A03906 | 33824122 | Pak J Pharm Sci | Antioxidant characteristics and hepatoprotective effects of a formula derived from Maydis stigma, Nelumbo nucifera and Taraxacum officinale against carbon tetrachloride-induced hepatic damage in rats. | 2020 | Details |
| A03912 | 33822104 | J Pharm Pharmacol | Eugenol modulates insulin sensitivity by upregulating insulin receptor substrate-2 in non-alcoholic fatty liver disease in rats. | 2021 | Details |
| A03960 | 33807699 | J Clin Med | The Role of the Transsulfuration Pathway in Non-Alcoholic Fatty Liver Disease. | 2021 | Details |
| A03999 | 33794784 | BMC Gastroenterol | A randomised placebo controlled trial of VSL#3® probiotic on biomarkers of cardiovascular risk and liver injury in non-alcoholic fatty liver disease. | 2021 | Details |
| A04020 | 33787249 | J Agric Food Chem | Malvidin-3-O-Glucoside from Blueberry Ameliorates Nonalcoholic Fatty Liver Disease by Regulating Transcription Factor EB-Mediated Lysosomal Function and Activating the Nrf2/ARE Signaling Pathway. | 2021 | Details |
| A04028 | 33785007 | BMC Complement Med Ther | Hepatoprotective effect of silymarin on fructose induced nonalcoholic fatty liver disease in male albino wistar rats. | 2021 | Details |
| A04160 | 33733575 | Biofactors | Quercetin prevents cadmium chloride-induced hepatic steatosis and fibrosis by downregulating the transcription of miR-21. | 2021 | Details |
| A04214 | 33711421 | J Nutr Biochem | Dietary cocoa ameliorates non-alcoholic fatty liver disease and increases markers of antioxidant response and mitochondrial biogenesis in high fat-fed mice. | 2021 | Details |
| A04310 | 33670839 | Antioxidants (Basel) | Changes in Glutathione Content in Liver Diseases: An Update. | 2021 | Details |
| A04370 | 33643422 | Evid Based Complement Alternat Med | Gegen Qinlian Decoction Ameliorates Nonalcoholic Fatty Liver Disease in Rats via Oxidative Stress, Inflammation, and the NLRP3 Signal Axis. | 2021 | Details |
| A04518 | 33590347 | J Nat Med | Dehydroabietic acid improves nonalcoholic fatty liver disease through activating the Keap1/Nrf2-ARE signaling pathway to reduce ferroptosis. | 2021 | Details |
| A04826 | 33492571 | Mol Biol Rep | Association of xenobiotic-metabolizing enzymes (GSTM1 and GSTT 1), and pro-inflammatory cytokines (TNF-α and IL-6) genetic polymorphisms with non-alcoholic fatty liver disease. | 2021 | Details |
| A04903 | 33458794 | Metabolomics | Untargeted metabolomics as a diagnostic tool in NAFLD: discrimination of steatosis, steatohepatitis and cirrhosis. | 2021 | Details |
| A04925 | 33446707 | Sci Rep | The potential ameliorative impacts of cerium oxide nanoparticles against fipronil-induced hepatic steatosis. | 2021 | Details |
| A04988 | 33424294 | Saudi J Biol Sci | The protective effect of shrimp cooked in different methods on high-cholesterol- induced fatty liver in rats. | 2020 | Details |
| A04990 | 33422521 | Chem Biol Interact | Phenolic-rich smoothie consumption ameliorates non-alcoholic fatty liver disease in obesity mice by increasing antioxidant response. | 2021 | Details |
| A04997 | 33421258 | J Biochem Mol Toxicol | The protective effects of trelagliptin on high-fat diet-induced nonalcoholic fatty liver disease in mice. | 2021 | Details |
| A05000 | 33419084 | Antioxidants (Basel) | Antioxidant and Anti-Inflammatory Effects of Korean Black Ginseng Extract through ER Stress Pathway. | 2021 | Details |
| A05012 | 33410857 | Food Funct | Aloin protects mice from diet-induced non-alcoholic steatohepatitis via activation of Nrf2/HO-1 signaling. | 2021 | Details |
| A05030 | 33401717 | Int J Mol Sci | Risperidone Exacerbates Glucose Intolerance, Nonalcoholic Fatty Liver Disease, and Renal Impairment in Obese Mice. | 2021 | Details |
| A05131 | 33362385 | World J Gastroenterol | Untargeted metabolomics characteristics of nonobese nonalcoholic fatty liver disease induced by high-temperature-processed feed in Sprague-Dawley rats. | 2020 | Details |
| A05188 | 33342543 | J Hepatol | Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis. | 2020 | Details |
| A05207 | 33339155 | Antioxidants (Basel) | N-Acetyl Cysteine Targets Hepatic Lipid Accumulation to Curb Oxidative Stress and Inflammation in NAFLD: A Comprehensive Analysis of the Literature. | 2020 | Details |
| A05329 | 33300526 | Food Funct | Improvement of the hepatic lipid status in intrauterine growth retarded pigs by resveratrol is related to the inhibition of mitochondrial dysfunction, oxidative stress and inflammation. | 2020 | Details |
| A05338 | 33297922 | CNS Neurol Disord Drug Targets | Liver-Brain Axis in Sporadic Alzheimer's Disease: Role of Ten Signature Genes in a Mouse Model. | 2021 | Details |
| A05348 | 33291552 | Children (Basel) | Glutamate-Serine-Glycine Index: A Novel Potential Biomarker in Pediatric Non-Alcoholic Fatty Liver Disease. | 2020 | Details |
| A05414 | 33268508 | Sci Transl Med | Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome. | 2020 | Details |
| A05457 | 33249742 | Mol Nutr Food Res | Catechin-Rich Green Tea Extract and the Loss-of-TLR4 Signaling Differentially Alter the Hepatic Metabolome in Mice with Nonalcoholic Steatohepatitis. | 2020 | Details |
| A05512 | 33221744 | Aging (Albany NY) | Hsa_circ_0048179 attenuates free fatty acid-induced steatosis via hsa_circ_0048179/miR-188-3p/GPX4 signaling. | 2020 | Details |
| A05577 | 33202166 | J Med Food | Water Extract of Artemisia annua L. Exhibits Hepatoprotective Effects Through Improvement of Lipid Accumulation and Oxidative Stress-Induced Cytotoxicity. | 2020 | Details |
| A05590 | 33197790 | Environ Int | Unravelling the metabolic alterations of liver damage induced by thirdhand smoke. | 2020 | Details |
| A05693 | 33153126 | Nutrients | Inositol and Non-Alcoholic Fatty Liver Disease: A Systematic Review on Deficiencies and Supplementation. | 2020 | Details |
| A05750 | 33132768 | ScientificWorldJournal | Hepatoprotective Effects of a Novel Trihoney against Nonalcoholic Fatty Liver Disease: A Comparative Study with Atorvastatin. | 2020 | Details |
| A05880 | 33090351 | Obes Surg | First Case Report of Fulminant Hepatitis After Laparoscopic Sleeve Gastrectomy Associated with Concomitant Maximal Therapeutic Dose of Acetaminophen Use, Protein Calorie Malnutrition, and Vitamins A and D, Selenium, and Glutathione Deficiencies. | 2020 | Details |
| A05882 | 33090099 | Turk J Gastroenterol | Morphological evaluation of the effects of exercise on high-fat-diet-induced liver damage in rats. | 2020 | Details |