Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A00006 | 35256934 | Acta Pharm Sin B | Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma. | 2021 | Details |
| A00100 | 35220131 | Phytomedicine | 2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside ameliorates NAFLD via attenuating hepatic steatosis through inhibiting mitochondrial dysfunction dependent on SIRT5. | 2022 | Details |
| A00141 | 35212227 | J Agric Food Chem | Targeted Lipidomics Reveal the Effects of Different Phospholipids on the Phospholipid Profiles of Hepatic Mitochondria and Endoplasmic Reticulum in High-Fat/High-Fructose-Diet-Induced Nonalcoholic Fatty Liver Disease Mice. | 2022 | Details |
| A00217 | 35181350 | Diabetes Res Clin Pract | Metabolic Changes Induced by Dapagliflozin, an SGLT2 Inhibitor, in Japanese Patients with Type 2 Diabetes Treated by Oral Anti-diabetic Agents: A Randomized, Clinical Trial. | 2022 | Details |
| A00260 | 35162992 | Int J Mol Sci | Emerging Insights on the Diverse Roles of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in Chronic Liver Diseases: Cholesterol Metabolism and Beyond. | 2022 | Details |
| A00342 | 35127372 | Acta Pharm Sin B | The cGAS-STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy. | 2021 | Details |
| A00343 | 35127371 | Acta Pharm Sin B | Therapeutic regulation of autophagy in hepatic metabolism. | 2021 | Details |
| A00458 | 35074921 | Proc Natl Acad Sci U S A | Myeloid cell TBK1 restricts inflammatory responses. | 2022 | Details |
| A00464 | 35070304 | Mol Clin Oncol | Serine palmitoyltransferase long chain subunit 3 is associated with hepatocellular carcinoma in patients with NAFLD. | 2021 | Details |
| A00728 | 34986838 | Cancer Cell Int | STK25 enhances hepatocellular carcinoma progression through the STRN/AMPK/ACC1 pathway. | 2022 | Details |
| A00832 | 34954499 | Redox Biol | Inhibition of GCN2 alleviates hepatic steatosis and oxidative stress in obese mice: Involvement of NRF2 regulation. | 2021 | Details |
| A01134 | 34859513 | Phytother Res | Scutellarin ameliorates hepatic lipid accumulation by enhancing autophagy and suppressing IRE1α/XBP1 pathway. | 2021 | Details |
| A01198 | 34830360 | Int J Mol Sci | Time-Dependent Changes in Hepatic Sphingolipid Accumulation and PI3K/Akt/mTOR Signaling Pathway in a Rat Model of NAFLD. | 2021 | Details |
| A01279 | 34803916 | Front Endocrinol (Lausanne) | Sestrin2 as a Potential Target for Regulating Metabolic-Related Diseases. | 2021 | Details |
| A01444 | 34743657 | Adipocyte | Association of cell death mechanisms and fibrosis in visceral white adipose tissue with pathological alterations in the liver of morbidly obese patients with NAFLD. | 2021 | Details |
| A01446 | 34742934 | Arch Biochem Biophys | The probiotic effects of AB23A on high-fat-diet-induced non-alcoholic fatty liver disease in mice may be associated with suppressing the serum levels of lipopolysaccharides and branched-chain amino acids. | 2021 | Details |
| A01555 | 34695228 | Eur J Clin Invest | Adipose tissue insulin resistance and lipidome alterations as the characterizing factors of non-alcoholic steatohepatitis. | 2021 | Details |
| A01608 | 34680557 | Biomedicines | Combined Metabolic Activators Decrease Liver Steatosis by Activating Mitochondrial Metabolism in Hamsters Fed with a High-Fat Diet. | 2021 | Details |
| A01794 | 34614409 | Cell Metab | DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing. | 2021 | Details |
| A01815 | 34606548 | Food Funct | Sesamol supplementation alleviates nonalcoholic steatohepatitis and atherosclerosis in high-fat, high carbohydrate and high-cholesterol diet-fed rats. | 2021 | Details |
| A01992 | 34536498 | Life Sci | Intermittent hypoxia aggravates non-alcoholic fatty liver disease via RIPK3-dependent necroptosis-modulated Nrf2/NFκB signaling pathway. | 2021 | Details |
| A01995 | 34535985 | Hepatol Commun | Genome-Wide Association Study of NAFLD Using Electronic Health Records. | 2021 | Details |
| A02236 | 34449924 | Hepatology | S-adenosylmethionine inhibits la ribonucleoprotein domain family member 1 in murine liver and human liver cancer cells. | 2021 | Details |
| A02441 | 34371126 | J Nutr Biochem | Dietary citrate acutely induces insulin resistance and markers of liver inflammation in mice. | 2021 | Details |
| A02472 | 34360667 | Int J Mol Sci | Hepatic LKB1 Reduces the Progression of Non-Alcoholic Fatty Liver Disease via Genomic Androgen Receptor Signaling. | 2021 | Details |
| A02615 | 34308859 | Nan Fang Yi Ke Da Xue Xue Bao | [Exendin-4 promotes autophagy to relieve lipid deposition in a NAFLD cell model by activating AKT/mTOR signaling pathway]. | 2021 | Details |
| A02689 | 34281337 | J Agric Food Chem | γ-Linolenic Acid Prevents Lipid Metabolism Disorder in Palmitic Acid-Treated Alpha Mouse Liver-12 Cells by Balancing Autophagy and Apoptosis via the LKB1-AMPK-mTOR Pathway. | 2021 | Details |
| A02818 | 34231324 | Physiol Rep | Crosstalk between beta-adrenergic and insulin signaling mediates mechanistic target of rapamycin hyperactivation in liver of high-fat diet-fed male mice. | 2021 | Details |
| A03019 | 34161185 | Autophagy | Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective. | 2021 | Details |
| A03206 | 34090052 | Biomed Pharmacother | Probiotic-prebiotic-synbiotic modulation of (YAP1, LATS1 and NF2 mRNAs/miR-1205/lncRNA SRD5A3-AS1) panel in NASH animal model. | 2021 | Details |
| A03300 | 34054524 | Front Pharmacol | Informing Pharmacokinetic Models With Physiological Data: Oral Population Modeling of L-Serine in Humans. | 2021 | Details |
| A03353 | 34031390 | Nat Commun | PPDPF alleviates hepatic steatosis through inhibition of mTOR signaling. | 2021 | Details |
| A03508 | 33977946 | Food Funct | DHA-enriched phosphatidylserine ameliorates non-alcoholic fatty liver disease and intestinal dysbacteriosis in mice induced by a high-fat diet. | 2021 | Details |
| A03558 | 33955510 | Mol Med Rep | Parthenolide plays a protective role in the liver of mice with metabolic dysfunction‑associated fatty liver disease through the activation of the HIPPO pathway. | 2021 | Details |
| A03725 | 33891332 | FASEB J | Silencing of STE20-type kinase MST3 in mice with antisense oligonucleotide treatment ameliorates diet-induced nonalcoholic fatty liver disease. | 2021 | Details |
| A03756 | 33875327 | Trends Endocrinol Metab | RIPK1 targeting protects against obesity and atherosclerosis. | 2021 | Details |
| A03926 | 33815655 | Oxid Med Cell Longev | Effect of Different Exercise Intensities on Hepatocyte Apoptosis in HFD-Induced NAFLD in Rats: The Possible Role of Endoplasmic Reticulum Stress through the Regulation of the IRE1/JNK and eIF2α/CHOP Signal Pathways. | 2021 | Details |
| A04000 | 33794741 | Autophagy | The ménage à trois of autophagy, lipid droplets and liver disease. | 2021 | Details |
| A04245 | 33691757 | Diabetol Metab Syndr | Beneficial effect of omarigliptin on diabetic patients with non-alcoholic fatty liver disease/non-alcoholic steatohepatitis. | 2021 | Details |
| A04246 | 33691721 | Nutr Metab (Lond) | Integrative proteomic and lipidomic analysis of Kaili Sour Soup-mediated attenuation of high-fat diet-induced nonalcoholic fatty liver disease in a rat model. | 2021 | Details |
| A04362 | 33647823 | Int Immunopharmacol | The SGLT2 inhibitor empagliflozin negatively regulates IL-17/IL-23 axis-mediated inflammatory responses in T2DM with NAFLD via the AMPK/mTOR/autophagy pathway. | 2021 | Details |
| A04394 | 33636349 | Pharmacol Res | Current innovations in nutraceuticals and functional foods for intervention of non-alcoholic fatty liver disease. | 2021 | Details |
| A04438 | 33616081 | JCI Insight | Differential role of MLKL in alcohol-associated and non-alcohol-associated fatty liver diseases in mice and humans. | 2021 | Details |
| A04440 | 33615993 | Gut Microbes | Modulation of the PI3K/Akt/mTOR signaling pathway by probiotics as a fruitful target for orchestrating the immune response. | 2022 | Details |
| A04442 | 33615471 | J Cell Physiol | A new activator of esterase D decreases blood cholesterol level through ESD/JAB1/ABCA1 pathway. | 2020 | Details |
| A04470 | 33603909 | Maedica (Bucur) | Red Blood Cell Dysfunction in Non-Alcoholic Fatty Liver Disease: Marker and Mediator of Molecular Mechanisms. | 2020 | Details |
| A04591 | 33571540 | Metabolism | The S100 calcium-binding protein A11 promotes hepatic steatosis through RAGE-mediated AKT-mTOR signaling. | 2021 | Details |
| A04659 | 33549441 | Nutr Metab Cardiovasc Dis | Analysis of steatosis biomarkers and inflammatory profile after adding on PCSK9 inhibitor treatment in familial hypercholesterolemia subjects with nonalcoholic fatty liver disease: A single lipid center real-world experience. | 2020 | Details |
| A04690 | 33541129 | Exp Biol Med (Maywood) | Effect of vitamin D3 supplementation on hepatic lipid dysregulation associated with autophagy regulatory AMPK/Akt-mTOR signaling in type 2 diabetic mice. | 2021 | Details |
| A04745 | 33516698 | Life Sci | Prolyl endopeptidase disruption reduces hepatic inflammation and oxidative stress in methionine-choline-deficient diet-induced steatohepatitis. | 2021 | Details |
| A05011 | 33411880 | Food Funct | Berbamine induced activation of the SIRT1/LKB1/AMPK signaling axis attenuates the development of hepatic steatosis in high-fat diet-induced NAFLD rats. | 2021 | Details |
| A05133 | 33361348 | Gut | RIPK3 acts as a lipid metabolism regulator contributing to inflammation and carcinogenesis in non-alcoholic fatty liver disease. | 2020 | Details |
| A05234 | 33328987 | Front Pharmacol | Da-Chai-Hu Decoction Ameliorates High Fat Diet-Induced Nonalcoholic Fatty Liver Disease Through Remodeling the Gut Microbiota and Modulating the Serum Metabolism. | 2020 | Details |
| A05332 | 33299856 | Biomed Res Int | GCN2 Deficiency Enhances Protective Effects of Exercise on Hepatic Steatosis. | 2020 | Details |
| A05348 | 33291552 | Children (Basel) | Glutamate-Serine-Glycine Index: A Novel Potential Biomarker in Pediatric Non-Alcoholic Fatty Liver Disease. | 2020 | Details |
| A05419 | 33266488 | Int J Mol Sci | Interplay between Oxidative Stress and Metabolic Derangements in Non-Alcoholic Fatty Liver Disease: The Role of Selenoprotein P. | 2020 | Details |
| A05421 | 33264665 | J Nutr Biochem | Hepatic metabolic adaptation and adipose tissue expansion are altered in mice with steatohepatitis induced by high-fat high sucrose diet. | 2020 | Details |
| A05479 | 33242590 | Biochim Biophys Acta Mol Basis Dis | Regulation of autophagy by bile acids and in cholestasis - CholestoPHAGY or CholeSTOPagy. | 2020 | Details |
| A05551 | 33208891 | Cell Death Differ | RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in macrophages. | 2020 | Details |
| A05565 | 33204683 | Biomed Res Int | Research on the Mechanism of Qushi Huayu Decoction in the Intervention of Nonalcoholic Fatty Liver Disease Based on Network Pharmacology and Molecular Docking Technology. | 2020 | Details |
| A05606 | 33191205 | Exp Cell Res | CKIP-1 augments autophagy in steatotic hepatocytes by inhibiting Akt/mTOR signal pathway. | 2020 | Details |
| A05697 | 33152322 | Cell Metab | TANK-Binding Kinase 1 Regulates the Localization of Acyl-CoA Synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation. | 2020 | Details |
| A05963 | 33060460 | Curr Opin Clin Nutr Metab Care | Protein and amino acids in nonalcoholic fatty liver disease. | 2021 | Details |
| A05983 | 33052067 | Am J Physiol Cell Physiol | Inositol-requiring enzyme 1α links palmitate-induced mTOR activation and lipotoxicity in hepatocytes. | 2020 | Details |
| A05984 | 33051603 | Nat Rev Gastroenterol Hepatol | Maladaptive regeneration - the reawakening of developmental pathways in NASH and fibrosis. | 2020 | Details |
| A06019 | 33037652 | J Food Sci | Coniferaldehyde ameliorates the lipid and glucose metabolism in palmitic acid-induced HepG2 cells via the LKB1/AMPK signaling pathway. | 2020 | Details |
| A06048 | 33028928 | Sci Rep | The effects of fructose and metabolic inhibition on hepatocellular carcinoma. | 2020 | Details |
| A06117 | 32998777 | Lipids Health Dis | Signaling and other functions of lipids in autophagy: a review. | 2020 | Details |
| A06162 | 32982112 | World J Gastroenterol | Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis via AMPK and mTOR regulation. | 2020 | Details |
| A06357 | 32916992 | Molecules | LRRK2 Regulates CPT1A to Promote β-Oxidation in HepG2 Cells. | 2020 | Details |
| A06382 | 32905826 | Toxicology | Dual TBK1/IKKε inhibitor amlexanox mitigates palmitic acid-induced hepatotoxicity and lipoapoptosis in vitro. | 2020 | Details |
| A06397 | 32893589 | Zhongguo Zhong Yao Za Zhi | [Effect and mechanism of Bidens pilosa decoction on non-alcoholic fatty liver induced by high fat and high glucose in mice]. | 2020 | Details |
| A06426 | 32884949 | J Immunol Res | Kangtaizhi Granule Alleviated Nonalcoholic Fatty Liver Disease in High-Fat Diet-Fed Rats and HepG2 Cells via AMPK/mTOR Signaling Pathway. | 2020 | Details |
| A06442 | 32880077 | Hepatol Int | The role of neutrophils in innate immunity-driven nonalcoholic steatohepatitis: lessons learned and future promise. | 2020 | Details |
| A06516 | 32846589 | Food Res Int | Monascus purpureus-fermented common buckwheat protects against dyslipidemia and non-alcoholic fatty liver disease through the regulation of liver metabolome and intestinal microbiome. | 2020 | Details |
| A06552 | 32827918 | Int Immunopharmacol | Bavachinin inhibits cholesterol synthesis enzyme FDFT1 expression via AKT/mTOR/SREBP-2 pathway. | 2020 | Details |
| A06577 | 32821738 | J Lipid Atheroscler | Hepatic Expression of the Serine Palmitoyltransferase Subunit Sptlc2 Reduces Lipid Droplets in the Liver by Activating VLDL Secretion. | 2020 | Details |
| A06586 | 32819566 | Biochem Biophys Res Commun | Genetic ablation of Fas-activated serine/threonine kinase ameliorates obesity-related hepatic glucose and lipid metabolic disorders via sirtuin-1 signaling. | 2020 | Details |
| A06589 | 32818435 | Cell Metab | Triose Kinase Controls the Lipogenic Potential of Fructose and Dietary Tolerance. | 2020 | Details |
| A06843 | 32726654 | Eur J Pharmacol | Neuregulin 4 alleviates hepatic steatosis via activating AMPK/mTOR-mediated autophagy in aged mice fed a high fat diet. | 2020 | Details |
| A06877 | 32712601 | Aging (Albany NY) | Decreased autophagy and fuel switching occur in a senescent hepatic cell model system. | 2020 | Details |
| A06914 | 32699106 | BMJ Open Diabetes Res Care | Hepatic fat is a stronger correlate of key clinical and molecular abnormalities than visceral and abdominal subcutaneous fat in youth. | 2020 | Details |
| A06955 | 32687428 | Autophagy | Hepatic peroxisomal β-oxidation suppresses lipophagy via RPTOR acetylation and MTOR activation. | 2020 | Details |
| A07170 | 32593899 | Environ Res | Ferroptosis mediated by the interaction between Mfn2 and IREα promotes arsenic-induced nonalcoholic steatohepatitis. | 2020 | Details |
| A07227 | 32574624 | Gastroenterology | IRE1A Stimulates Hepatocyte-Derived Extracellular Vesicles That Promote Inflammation in Mice With Steatohepatitis. | 2020 | Details |
| A07322 | 32538722 | Curr Protein Pept Sci | Gut Barrier Proteins Mediate Liver Regulation by the Effects of Serotonin on the Non-Alcoholic Fatty Liver Disease. | 2020 | Details |
| A07362 | 32526241 | Eur J Pharmacol | Berbamine induced AMPK activation regulates mTOR/SREBP-1c axis and Nrf2/ARE pathway to allay lipid accumulation and oxidative stress in steatotic HepG2 cells. | 2020 | Details |
| A07438 | 32496563 | Endocrinology | LXRα Phosphorylation in Cardiometabolic Disease: Insight From Mouse Models. | 2020 | Details |
| A07621 | 32417256 | Biochim Biophys Acta Mol Cell Res | GSK-3 in liver diseases: Friend or foe? | 2020 | Details |
| A07757 | 32363319 | Hepatol Commun | High Protein Intake Is Associated With Histological Disease Activity in Patients With NAFLD. | 2020 | Details |
| A07791 | 32353589 | Pharmacol Res | 18β-Glycyrrhetinic acid acts through hepatocyte nuclear factor 4 alpha to modulate lipid and carbohydrate metabolism. | 2020 | Details |
| A07840 | 32337855 | Mol Syst Biol | The acute effect of metabolic cofactor supplementation: a potential therapeutic strategy against non-alcoholic fatty liver disease. | 2020 | Details |
| A07920 | 32309365 | Ann Transl Med | Prolyl endopeptidase gene disruption attenuates high fat diet-induced nonalcoholic fatty liver disease in mice by improving hepatic steatosis and inflammation. | 2020 | Details |
| A07939 | 32304762 | Life Sci | ApoE deficiency promotes non-alcoholic fatty liver disease in mice via impeding AMPK/mTOR mediated autophagy. | 2020 | Details |
| A07973 | 32293113 | J Cell Mol Med | Geniposide alleviates non-alcohol fatty liver disease via regulating Nrf2/AMPK/mTOR signalling pathways. | 2020 | Details |
| A08075 | 32257815 | Mol Genet Metab Rep | Mtrr hypomorphic mutation alters liver morphology, metabolism and fuel storage in mice. | 2020 | Details |
| A08110 | 32243868 | Metabolism | Myeloid-specific IRE1alpha deletion reduces tumour development in a diabetic, non-alcoholic steatohepatitis-induced hepatocellular carcinoma mouse model. | 2020 | Details |
| A08139 | 32231442 | Clin Med Insights Endocrinol Diabetes | Dipeptidyl Peptidase-4 at the Interface Between Inflammation and Metabolism. | 2020 | Details |
| A08166 | 32220583 | J Hepatol | MLKL-dependent signaling regulates autophagic flux in a murine model of non-alcohol-associated fatty liver and steatohepatitis. | 2020 | Details |
| A08417 | 32119738 | J Nutr | One-Carbon Metabolism in Fatty Liver Disease and Fibrosis: One-Carbon to Rule Them All. | 2020 | Details |