Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Stearoyl-CoA desaturase219 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A00174 | 35198905 | iScience | Deletion of RNF186 expression suppresses diet-induced hepatic steatosis by regulating insulin activity. | 2022 | Details |
| A00344 | 35126846 | World J Hepatol | Stearoyl-CoA desaturase 1: A potential target for non-alcoholic fatty liver disease?-perspective on emerging experimental evidence. | 2022 | Details |
| A00356 | 35122619 | J Physiol Biochem | Blockage of NDUFB9-SCD1 pathway inhibits adipogenesis : Blockage of NDUFB9-SCD1 pathway inhibits adipogenesis. | 2022 | Details |
| A00538 | 35052685 | Biomedicines | Fatty Acid Synthase Inhibitor Platensimycin Intervenes the Development of Nonalcoholic Fatty Liver Disease in a Mouse Model. | 2021 | Details |
| A00658 | 35013040 | J Oleo Sci | Pink Lotus Essential Oil and Alleviates on Free Fatty Acid Induced Steatosis in HepG2 Cells via PI3K/Akt and NF-κB Pathways. | 2022 | Details |
| A01411 | 34757160 | Toxicology | The combined impact of decabromodiphenyl ether and high fat exposure on non-alcoholic fatty liver disease in vivo and in vitro. | 2021 | Details |
| A01652 | 34667947 | JHEP Rep | New targets for NAFLD. | 2021 | Details |
| A01775 | 34621326 | Evid Based Complement Alternat Med | A Novel Identified Peptide Hormone "Metabolitin" Attenuates Lipid Absorption in the Small Intestine of Diabetic Mice with Nonalcoholic Fatty Liver Disease by Regulating Neurotensin and AMPK Signaling Pathway. | 2021 | Details |
| A01778 | 34621052 | Nat Med | Aramchol in patients with nonalcoholic steatohepatitis: a randomized, double-blind, placebo-controlled phase 2b trial. | 2021 | Details |
| A02244 | 34447968 | J Anim Sci Technol | Effect of ciglitazone on adipogenic transdifferentiation of bovine skeletal muscle satellite cells. | 2021 | Details |
| A02256 | 34445549 | Int J Mol Sci | Kaempferol and Kaempferide Attenuate Oleic Acid-Induced Lipid Accumulation and Oxidative Stress in HepG2 Cells. | 2021 | Details |
| A02309 | 34426119 | Int Immunopharmacol | Rotundic acid ameliorates non-alcoholic steatohepatitis via SREBP-1c/ SCD1 signaling pathway and modulating gut microbiota. | 2021 | Details |
| A02993 | 34171462 | Biochim Biophys Acta Gene Regul Mech | Polymorphisms rs55710213 and rs56334587 regulate SCD1 expression by modulating HNF4A binding. | 2021 | Details |
| A03200 | 34092291 | Chin J Nat Med | Silybin alleviates hepatic lipid accumulation in methionine-choline deficient diet-induced nonalcoholic fatty liver disease in mice via peroxisome proliferator-activated receptor α. | 2021 | Details |
| A03245 | 34073834 | Int J Mol Sci | P2Y2R Deficiency Ameliorates Hepatic Steatosis by Reducing Lipogenesis and Enhancing Fatty Acid β-Oxidation through AMPK and PGC-1α Induction in High-Fat Diet-Fed Mice. | 2021 | Details |
| A03394 | 34017254 | Front Pharmacol | Geniposide and Chlorogenic Acid Combination Improves Non-Alcoholic Fatty Liver Disease Involving the Potent Suppression of Elevated Hepatic SCD-1. | 2021 | Details |
| A04366 | 33647280 | Gastroenterology | Squalene Epoxidase Induces Nonalcoholic Steatohepatitis Via Binding to Carbonic Anhydrase III and is a Therapeutic Target. | 2021 | Details |
| A04546 | 33583577 | Clin Ther | Therapy for Nonalcoholic Fatty Liver Disease: Current Options and Future Directions. | 2021 | Details |
| A04870 | 33474802 | Pharmacol Res Perspect | Dexmedetomidine ameliorates high-fat diet-induced nonalcoholic fatty liver disease by targeting SCD1 in obesity mice. | 2021 | Details |
| A04984 | 33425805 | Can J Gastroenterol Hepatol | Diospyros kaki and Citrus unshiu Mixture Improves Disorders of Lipid Metabolism in Nonalcoholic Fatty Liver Disease. | 2020 | Details |
| A05187 | 33343352 | Front Pharmacol | Hepatoprotective Effect and Molecular Mechanisms of Hengshun Aromatic Vinegar on Non-Alcoholic Fatty Liver Disease. | 2020 | Details |
| A05360 | 33282902 | Front Nutr | Maternal High-Fat Diet Leads to Non-alcoholic Fatty Liver Disease Through Upregulating Hepatic SCD1 Expression in Neonate Rats. | 2020 | Details |
| A05595 | 33195520 | Front Vet Sci | Lipid Accumulation and Injury in Primary Calf Hepatocytes Challenged With Different Long-Chain Fatty Acids. | 2020 | Details |
| A05623 | 33185911 | Hepatology | Neutral Ceramidase Mediates Nonalcoholic Steatohepatitis by Regulating Monounsaturated Fatty Acids and Gut IgA+ B Cells. | 2021 | Details |
| A05744 | 33134908 | JHEP Rep | Hepatic miR-192-3p reactivation alleviates steatosis by targeting glucocorticoid receptor. | 2020 | Details |
| A05952 | 33064664 | Endocr Connect | The hepatic lipidome and HNF4α and SHBG expression in human liver. | 2020 | Details |
| A06004 | 33040080 | Cell Death Dis | USP7 mediates pathological hepatic de novo lipogenesis through promoting stabilization and transcription of ZNF638. | 2020 | Details |
| A06019 | 33037652 | J Food Sci | Coniferaldehyde ameliorates the lipid and glucose metabolism in palmitic acid-induced HepG2 cells via the LKB1/AMPK signaling pathway. | 2020 | Details |
| A06127 | 32996649 | FASEB J | N-glycosylation of CREBH improves lipid metabolism and attenuates lipotoxicity in NAFLD by modulating PPARα and SCD-1. | 2020 | Details |
| A06162 | 32982112 | World J Gastroenterol | Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis via AMPK and mTOR regulation. | 2020 | Details |
| A06565 | 32824277 | Int J Mol Sci | Lactobacillus Strains Alleviated Hyperlipidemia and Liver Steatosis in Aging Rats via Activation of AMPK. | 2020 | Details |
| A07166 | 32594969 | J Dev Orig Health Dis | Post-weaning exposure to high-sucrose diet induces early non-alcoholic fatty liver disease onset and progression in male mice: role of dysfunctional white adipose tissue. | 2020 | Details |
| A07314 | 32542253 | Food Funct | S-petasin inhibits lipid accumulation in oleic acid-induced HepG2 cells through activation of the AMPK signaling pathway. | 2020 | Details |
| A07362 | 32526241 | Eur J Pharmacol | Berbamine induced AMPK activation regulates mTOR/SREBP-1c axis and Nrf2/ARE pathway to allay lipid accumulation and oxidative stress in steatotic HepG2 cells. | 2020 | Details |
| A07381 | 32519629 | J Dev Orig Health Dis | Hepatic lipid metabolism in adult rats using early weaning models: sex-related differences. | 2020 | Details |
| A07881 | 32324591 | Aging (Albany NY) | Inhibition of stearoyl-coenzyme A desaturase 1 ameliorates hepatic steatosis by inducing AMPK-mediated lipophagy. | 2020 | Details |
| A07997 | 32284043 | Lipids Health Dis | Orotic acid-treated hepatocellular carcinoma cells resist steatosis by modification of fatty acid metabolism. | 2020 | Details |
| A08038 | 32272865 | Adipocyte | MiR-455 targeting SOCS3 improve liver lipid disorders in diabetic mice. | 2020 | Details |
| A08138 | 32231762 | World J Hepatol | High omega arachidonic acid/docosahexaenoic acid ratio induces mitochondrial dysfunction and altered lipid metabolism in human hepatoma cells. | 2020 | Details |
| A08149 | 32228319 | Am J Physiol Endocrinol Metab | Downregulated microRNA-130b-5p prevents lipid accumulation and insulin resistance in a murine model of nonalcoholic fatty liver disease. | 2020 | Details |
| A08330 | 32150756 | Hepatology | N6 -Methyladenosine Reader Protein YT521-B Homology Domain-Containing 2 Suppresses Liver Steatosis by Regulation of mRNA Stability of Lipogenic Genes. | 2020 | Details |
| A08425 | 32116145 | RNA Biol | GR-mediated FTO transactivation induces lipid accumulation in hepatocytes via demethylation of m6A on lipogenic mRNAs. | 2020 | Details |
| A08555 | 32062620 | J Toxicol Sci | Taurine attenuates hepatic steatosis in a genetic model of fatty liver disease. | 2020 | Details |
| A08606 | 32043636 | FASEB J | REDD1 deficiency protects against nonalcoholic hepatic steatosis induced by high-fat diet. | 2020 | Details |
| A08640 | 32035613 | Biochem Biophys Res Commun | MicroRNA-103 represses hepatic de novo lipogenesis and alleviates NAFLD via targeting FASN and SCD1. | 2020 | Details |
| A09189 | 31842467 | Int J Mol Sci | Resveratrol Treatment Enhances the Cellular Response to Leptin by Increasing OBRb Content in Palmitate-Induced Steatotic HepG2 Cells. | 2019 | Details |
| A09202 | 31838050 | Chem Biol Interact | Stearoyl-CoA desaturase and tumorigenesis. | 2019 | Details |
| A09222 | 31832001 | World J Gastroenterol | LB100 ameliorates nonalcoholic fatty liver disease via the AMPK/Sirt1 pathway. | 2019 | Details |
| A09510 | 31715523 | J Nutr Biochem | Interactive effects of maternal and weaning high linoleic acid intake on hepatic lipid metabolism, oxylipins profile and hepatic steatosis in offspring. | 2019 | Details |
| A09587 | 31685793 | Nutr Diabetes | Energy restriction in obese women suggest linear reduction of hepatic fat content and time-dependent metabolic improvements. | 2019 | Details |
| A09739 | 31630534 | Am J Physiol Gastrointest Liver Physiol | Comparison of murine steatohepatitis models identifies a dietary intervention with robust fibrosis, ductular reaction, and rapid progression to cirrhosis and cancer. | 2019 | Details |
| A09776 | 31614650 | J Clin Med | Polyphenol-Rich Extracts from Toona sinensis Bark and Fruit Ameliorate Free Fatty Acid-Induced Lipogenesis through AMPK and LC3 Pathways. | 2019 | Details |
| A09788 | 31610126 | J Agric Food Chem | Reduction of Hepatic Lipogenesis by Loliolide and Pinoresinol from Lysimachia vulgaris via Degrading Liver X Receptors. | 2019 | Details |
| A09807 | 31602953 | Zhongguo Zhong Yao Za Zhi | [Mechanism of Calculus Bovis Sativus in inhibiting hepatocyte lipid deposition based on serum pharmacology]. | 2019 | Details |
| A10144 | 31470288 | Nutr Res | Gnotobiotic mice inoculated with Firmicutes, but not Bacteroidetes, deteriorate nonalcoholic fatty liver disease severity by modulating hepatic lipid metabolism. | 2019 | Details |
| A10212 | 31430456 | Eur J Pharmacol | Pinolenic acid ameliorates oleic acid-induced lipogenesis and oxidative stress via AMPK/SIRT1 signaling pathway in HepG2 cells. | 2019 | Details |
| A10523 | 31301418 | Life Sci | (5R)-5-hydroxytriptolide ameliorates liver lipid accumulation by suppressing lipid synthesis and promoting lipid oxidation in mice. | 2019 | Details |
| A10586 | 31280138 | Phytomedicine | Anti-hepatic steatosis activity of Sicyos angulatus extract in high-fat diet-fed mice and chemical profiling study using UHPLC-qTOF-MS/MS spectrometry. | 2019 | Details |
| A10712 | 31226399 | Free Radic Biol Med | Berberine attenuates nonalcoholic hepatic steatosis through the AMPK-SREBP-1c-SCD1 pathway. | 2019 | Details |
| A10748 | 31212314 | J Nutr | Dietary β-Cryptoxanthin Inhibits High-Refined Carbohydrate Diet-Induced Fatty Liver via Differential Protective Mechanisms Depending on Carotenoid Cleavage Enzymes in Male Mice. | 2019 | Details |
| A10893 | 31136997 | Top Antivir Med | Fatty liver disease in persons with HIV infection. | 2019 | Details |
| A11007 | 31083413 | Int J Mol Sci | Arazyme Suppresses Hepatic Steatosis and Steatohepatitis in Diet-Induced Non-Alcoholic Fatty Liver Disease-Like Mouse Model. | 2019 | Details |
| A11191 | 31004931 | Environ Toxicol Pharmacol | Mono-2-ethylhexyl phthalate induces the expression of genes involved in fatty acid synthesis in HepG2 cells. | 2019 | Details |
| A11246 | 30975380 | Prostaglandins Leukot Essent Fatty Acids | Fish oil protects the liver from parenteral nutrition-induced injury via GPR120-mediated PPARγ signaling. | 2019 | Details |
| A11512 | 30864855 | J Med Food | Fermented Cordyceps militaris Extract Ameliorates Hepatosteatosis via Activation of Fatty Acid Oxidation. | 2019 | Details |
| A11959 | 30668392 | Phytomedicine | Yangonin protects against non-alcoholic fatty liver disease through farnesoid X receptor. | 2018 | Details |
| A12054 | 30621686 | Lipids Health Dis | Crocin ameliorates hepatic steatosis through activation of AMPK signaling in db/db mice. | 2019 | Details |
| A12165 | 30576936 | Biomed Pharmacother | Sodium tanshinone IIA sulfonate ameliorates hepatic steatosis by inhibiting lipogenesis and inflammation. | 2018 | Details |
| A12201 | 30564000 | J Clin Exp Hepatol | Genetic and Epigenetic Culprits in the Pathogenesis of Nonalcoholic Fatty Liver Disease. | 2018 | Details |
| A12351 | 30489192 | J Med Food | Hovenia dulcis Extract Attenuates High-Fat Diet-Induced Hepatic Lipid Accumulation and Hypertriglyceridemia in C57BL/6 Mice. | 2018 | Details |
| A12517 | 30411763 | Food Funct | Hepatoprotective mechanism of freshwater clam extract alleviates non-alcoholic fatty liver disease: elucidated in vitro and in vivo models. | 2018 | Details |
| A12615 | 30363699 | PPAR Res | Effects of Pioglitazone on Nonalcoholic Fatty Liver Disease in the Absence of Constitutive Androstane Receptor Expression. | 2018 | Details |
| A12693 | 30324559 | Cell Biochem Biophys | Melatonin Modulates lipid Metabolism in HepG2 Cells Cultured in High Concentrations of Oleic Acid: AMPK Pathway Activation may Play an Important Role. | 2018 | Details |
| A12714 | 30317781 | Zhonghua Gan Zang Bing Za Zhi | [Research progress of stearoyl-CoA desaturase-1 on obesity and non-alcoholic fatty liver disease Abstract]. | 2018 | Details |
| A12811 | 30273090 | J Med Food | Aqueous Extract of Humulus japonicus Attenuates Hyperlipidemia and Fatty Liver in Obese Mice. | 2018 | Details |
| A13067 | 30154382 | Int J Mol Sci | Flavonones from Penthorum chinense Ameliorate Hepatic Steatosis by Activating the SIRT1/AMPK Pathway in HepG2 Cells. | 2018 | Details |
| A13785 | 29759071 | Lipids Health Dis | Metformin attenuates triglyceride accumulation in HepG2 cells through decreasing stearyl-coenzyme A desaturase 1 expression. | 2018 | Details |
| A13814 | 29743929 | Nutr Metab (Lond) | Neonatal overfeeding induced glucocorticoid overexposure accelerates hepatic lipogenesis in male rats. | 2018 | Details |
| A13897 | 29704577 | Food Chem Toxicol | Food-drug interaction: Anabolic steroids aggravate hepatic lipotoxicity and nonalcoholic fatty liver disease induced by trans fatty acids. | 2018 | Details |
| A13946 | 29675558 | Eur J Nutr | Dietary polyunsaturated fatty acids mediate the inverse association of stearoyl-CoA desaturase activity with the risk of fatty liver in dyslipidaemic individuals. | 2018 | Details |
| A14020 | 29631603 | Lipids Health Dis | Heat shock protein 70 promotes lipogenesis in HepG2 cells. | 2018 | Details |
| A14063 | 29604329 | Mol Cell Endocrinol | MiR-451a attenuates free fatty acids-mediated hepatocyte steatosis by targeting the thyroid hormone responsive spot 14 gene. | 2018 | Details |
| A14172 | 29552625 | Cell Mol Gastroenterol Hepatol | Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2). | 2017 | Details |
| A14187 | 29542003 | J Nat Med | Scutellaria baicalensis regulates FFA metabolism to ameliorate NAFLD through the AMPK-mediated SREBP signaling pathway. | 2018 | Details |
| A14211 | 29524401 | Biochem Biophys Res Commun | Ablation of prolactin receptor increases hepatic triglyceride accumulation. | 2018 | Details |
| A14404 | 29426937 | Nat Commun | Ultraconserved element uc.372 drives hepatic lipid accumulation by suppressing miR-195/miR4668 maturation. | 2018 | Details |
| A14519 | 29371918 | Oncotarget | Long-term administration of tacrolimus and everolimus prevents high cholesterol-high fructose-induced steatosis in C57BL/6J mice by inhibiting de-novo lipogenesis. | 2017 | Details |
| A14678 | 29290651 | World J Gastroenterol | miR-192-5p regulates lipid synthesis in non-alcoholic fatty liver disease through SCD-1. | 2017 | Details |
| A14950 | 29159325 | Hepatol Commun | Role of Aramchol in steatohepatitis and fibrosis in mice. | 2017 | Details |
| A14957 | 29156529 | Biomed Pharmacother | Alpinetin improved high fat diet-induced non-alcoholic fatty liver disease (NAFLD) through improving oxidative stress, inflammatory response and lipid metabolism. | 2017 | Details |
| A14975 | 29149647 | J Nutr Biochem | Dietary fish oil differentially ameliorates high-fructose diet-induced hepatic steatosis and hyperlipidemia in mice depending on time of feeding. | 2017 | Details |
| A15091 | 29101357 | Sci Rep | MicroRNA-27a regulates hepatic lipid metabolism and alleviates NAFLD via repressing FAS and SCD1. | 2017 | Details |
| A15513 | 28867301 | Cell Metab | Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases. | 2017 | Details |
| A15514 | 28867186 | Biochem Biophys Res Commun | Dietary β-conglycinin prevents acute ethanol-induced fatty liver in mice. | 2017 | Details |
| A15647 | 28790196 | Sci Signal | TRIF-dependent Toll-like receptor signaling suppresses Scd1 transcription in hepatocytes and prevents diet-induced hepatic steatosis. | 2017 | Details |
| A15893 | 28667176 | J Mol Endocrinol | miR-212-5p suppresses lipid accumulation by targeting FAS and SCD1. | 2017 | Details |
| A16169 | 28526925 | Eur J Nutr | Polyphenolic extract attenuates fatty acid-induced steatosis and oxidative stress in hepatic and endothelial cells. | 2017 | Details |
| A16661 | 28257781 | Food Chem Toxicol | Diet high in fructose promotes liver steatosis and hepatocyte apoptosis in C57BL/6J female mice: Role of disturbed lipid homeostasis and increased oxidative stress. | 2017 | Details |
| A16825 | 28146130 | Nutrients | Effects of Natural Products on Fructose-Induced Nonalcoholic Fatty Liver Disease (NAFLD). | 2017 | Details |
| A17078 | 28003715 | J Clin Exp Hepatol | High-Fructose Intake Impairs the Hepatic Hypolipidemic Effects of a High-Fat Fish-Oil Diet in C57BL/6 Mice. | 2016 | Details |