Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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lipogenesis1889 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A00006 | 35256934 | Acta Pharm Sin B | Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma. | 2021 | Details |
| A00030 | 35250593 | Front Pharmacol | Combined Use of Bicyclol and Berberine Alleviates Mouse Nonalcoholic Fatty Liver Disease. | 2022 | Details |
| A00056 | 35240344 | Cell Mol Gastroenterol Hepatol | Activation of Liver mTORC1 Protects Against NASH via Dual Regulation of VLDL-TAG Secretion and De Novo Lipogenesis. | 2022 | Details |
| A00101 | 35219732 | Eur J Pharmacol | mTOR as an eligible molecular target for possible pharmacological treatment of nonalcoholic steatohepatitis. | 2022 | Details |
| A00103 | 35218234 | Hepatology | Dual roles of B lymphocytes in murine models of diet-induced non-alcoholic fatty liver disease. | 2022 | Details |
| A00110 | 35217259 | J Pharm Biomed Anal | CE with Cu2+ ions and 2-hydroxypropyl-β-cyclodextrin additives for the investigation of amino acids composition of the culture medium in a cellular model of non-alcoholic fatty liver disease. | 2022 | Details |
| A00188 | 35192934 | Mol Ther | Dysregulated m6A modification promotes lipogenesis and development of non-alcoholic fatty liver disease and hepatocellular carcinoma. | 2022 | Details |
| A00205 | 35187676 | J Food Biochem | Chitosan oligosaccharide attenuates hepatic steatosis in HepG2 cells via the activation of AMP-activated protein kinase. | 2022 | Details |
| A00256 | 35163881 | Molecules | The Anti-Adiposity Mechanisms of Ampelopsin and Vine Tea Extract in High Fat Diet and Alcohol-Induced Fatty Liver Mouse Models. | 2022 | Details |
| A00261 | 35162967 | Int J Mol Sci | Quercetin Reduces Lipid Accumulation in a Cell Model of NAFLD by Inhibiting De Novo Fatty Acid Synthesis through the Acetyl-CoA Carboxylase 1/AMPK/PP2A Axis. | 2022 | Details |
| A00303 | 35144334 | Endocrinol Metab (Seoul) | Dulaglutide Ameliorates Palmitic Acid-Induced Hepatic Steatosis by Activating FAM3A Signaling Pathway. | 2022 | Details |
| A00318 | 35140289 | Sci Rep | Exendin-4 alleviates steatosis in an in vitro cell model by lowering FABP1 and FOXA1 expression via the Wnt/-catenin signaling pathway. | 2022 | Details |
| A00331 | 35133139 | Environ Sci Technol | 3-tert-Butyl-4-hydroxyanisole Impairs Hepatic Lipid Metabolism in Male Mice Fed with a High-Fat Diet. | 2022 | Details |
| A00344 | 35126846 | World J Hepatol | Stearoyl-CoA desaturase 1: A potential target for non-alcoholic fatty liver disease?-perspective on emerging experimental evidence. | 2022 | Details |
| A00350 | 35124887 | Mol Nutr Food Res | ChREBP-driven DNL and PNPLA3 Expression Induced by Liquid Fructose are Essential in the Production of Fatty Liver and Hypertriglyceridemia in a High-Fat Diet-Fed Rat Model. | 2022 | Details |
| A00352 | 35124446 | J Pharm Biomed Anal | Targeted metabolomics profiles serum fatty acids by HFD induced non-alcoholic fatty liver in mice based on GC-MS. | 2022 | Details |
| A00386 | 35107741 | Mol Biol Rep | Alternate-day fasting alleviates high fat diet induced non-alcoholic fatty liver disease through controlling PPARα/Fgf21 signaling. | 2022 | Details |
| A00400 | 35100965 | Mol Med | Synergistic effects of ISL1 and KDM6B on non-alcoholic fatty liver disease through the regulation of SNAI1. | 2022 | Details |
| A00519 | 35054478 | Life (Basel) | Deep Sea Water-Dissolved Organic Matter Intake Improves Hyperlipidemia and Inhibits Thrombus Formation and Vascular Inflammation in High-Fat Diet Hamsters. | 2022 | Details |
| A00538 | 35052685 | Biomedicines | Fatty Acid Synthase Inhibitor Platensimycin Intervenes the Development of Nonalcoholic Fatty Liver Disease in a Mouse Model. | 2021 | Details |
| A00540 | 35052597 | Antioxidants (Basel) | Gallic Acid Improves Diabetic Steatosis by Downregulating MicroRNA-34a-5p through Targeting NFE2L2 Expression in High-Fat Diet-Fed db/db Mice. | 2021 | Details |
| A00589 | 35038311 | Eur J Endocrinol | Metformin maintains intrahepatic triglyceride content through increased hepatic de novo lipogenesis. | 2022 | Details |
| A00614 | 35028615 | Cell Rep Med | Pharmacodynamic effects of direct AMP kinase activation in humans with insulin resistance and non-alcoholic fatty liver disease: A phase 1b study. | 2021 | Details |
| A00624 | 35024184 | J Adv Res | Hyperoside attenuates non-alcoholic fatty liver disease in rats via cholesterol metabolism and bile acid metabolism. | 2021 | Details |
| A00662 | 35011585 | Cells | Cynanchum atratum Alleviates Non-Alcoholic Fatty Liver by Balancing Lipogenesis and Fatty Acid Oxidation in a High-Fat, High-Fructose Diet Mice Model. | 2021 | Details |
| A00679 | 35005107 | Genes Dis | Critical roles of FTO-mediated mRNA m6A demethylation in regulating adipogenesis and lipid metabolism: Implications in lipid metabolic disorders. | 2021 | Details |
| A00693 | 35001345 | J Physiol Biochem | Vaspin attenuates steatosis-induced fibrosis via GRP78 receptor by targeting AMPK signaling pathway. | 2022 | Details |
| A00753 | 34979169 | Toxicology | Elemicin exposure induced aberrant lipid metabolism via modulation of gut microbiota in mice. | 2022 | Details |
| A00769 | 34974159 | Mol Metab | CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing. | 2021 | Details |
| A00871 | 34944021 | Cells | IL-19 Contributes to the Development of Nonalcoholic Steatohepatitis by Altering Lipid Metabolism. | 2021 | Details |
| A00873 | 34943942 | Cells | MXD3 Promotes Obesity and the Androgen Receptor Signaling Pathway in Gender-Disparity Hepatocarcinogenesis. | 2021 | Details |
| A00881 | 34943104 | Antioxidants (Basel) | The Synbiotic Combination of Akkermansia muciniphila and Quercetin Ameliorates Early Obesity and NAFLD through Gut Microbiota Reshaping and Bile Acid Metabolism Modulation. | 2021 | Details |
| A00928 | 34927251 | Eur J Clin Invest | De novo lipogenesis in non-alcoholic fatty liver disease: Quantification with stable isotope tracers. | 2022 | Details |
| A00929 | 34927020 | iScience | Liver sphingomyelin synthase 1 deficiency causes steatosis, steatohepatitis, fibrosis, and tumorigenesis: An effect of glucosylceramide accumulation. | 2021 | Details |
| A00952 | 34921174 | Sci Rep | Elevated serum S14 levels are associated with more severe liver steatosis by ultrasonography. | 2021 | Details |
| A00980 | 34911556 | BMC Biol | Enhanced hepatic respiratory capacity and altered lipid metabolism support metabolic homeostasis during short-term hypoxic stress. | 2021 | Details |
| A00991 | 34907907 | J Clin Invest | Dietary sugar restriction reduces hepatic de novo lipogenesis in adolescent boys with fatty liver disease. | 2021 | Details |
| A00992 | 34907906 | J Clin Invest | Dietary sugar restriction reduces hepatic de novo lipogenesis in boys with fatty liver disease. | 2021 | Details |
| A01006 | 34904613 | Food Funct | Steatosis induced by nonylphenol in HepG2 cells and the intervention effect of curcumin. | 2022 | Details |
| A01016 | 34902629 | Cell Mol Gastroenterol Hepatol | Escherichia fergusonii Promotes Nonobese Nonalcoholic Fatty Liver Disease by Interfering With Host Hepatic Lipid Metabolism Through Its Own msRNA 23487. | 2021 | Details |
| A01054 | 34886991 | J Comp Pathol | Role of Plin5 Deficiency in Progression of Non-Alcoholic Fatty Liver Disease Induced by a High-Fat Diet in Mice. | 2021 | Details |
| A01056 | 34884968 | Int J Mol Sci | Neochlorogenic Acid Attenuates Hepatic Lipid Accumulation and Inflammation via Regulating miR-34a In Vitro. | 2021 | Details |
| A01059 | 34884755 | Int J Mol Sci | Role of ANGPTL8 in NAFLD Improvement after Bariatric Surgery in Experimental and Human Obesity. | 2021 | Details |
| A01097 | 34870138 | Metabol Open | Metabolic causes and consequences of nonalcoholic fatty liver disease (NAFLD). | 2021 | Details |
| A01099 | 34869587 | Front Mol Biosci | Therapeutic Targeting of Nonalcoholic Fatty Liver Disease by Downregulating SREBP-1C Expression via AMPK-KLF10 Axis. | 2021 | Details |
| A01106 | 34867414 | Front Pharmacol | The Contribution of Dietary Fructose to Non-alcoholic Fatty Liver Disease. | 2021 | Details |
| A01108 | 34867358 | Front Pharmacol | (+)-Dehydrovomifoliol Alleviates Oleic Acid-Induced Lipid Accumulation in HepG2 Cells via the PPARα-FGF21 Pathway. | 2021 | Details |
| A01154 | 34850865 | Dis Model Mech | Concerted regulation of non-alcoholic fatty liver disease progression by microRNAs in apolipoprotein E-deficient mice. | 2021 | Details |
| A01179 | 34838715 | Mol Metab | A novel role of CRTC2 in promoting nonalcoholic fatty liver disease. | 2021 | Details |
| A01246 | 34815180 | Trends Mol Med | Linking liver metabolic and vascular disease via bile acid signaling. | 2021 | Details |
| A01316 | 34789275 | J Nanobiotechnology | A nanodrug system overexpressed circRNA_0001805 alleviates nonalcoholic fatty liver disease via miR-106a-5p/miR-320a and ABCA1/CPT1 axis. | 2021 | Details |
| A01329 | 34786236 | Cureus | Non-alcoholic Fatty Liver Disease and Carbohydrate Restricted Diets: A Case Report and Literature Review. | 2021 | Details |
| A01374 | 34769488 | Int J Mol Sci | The Roles of Carbohydrate Response Element Binding Protein in the Relationship between Carbohydrate Intake and Diseases. | 2021 | Details |
| A01378 | 34768942 | Int J Mol Sci | In a Prediabetic Model, Empagliflozin Improves Hepatic Lipid Metabolism Independently of Obesity and before Onset of Hyperglycemia. | 2021 | Details |
| A01385 | 34765085 | Oxid Med Cell Longev | Target Sestrin2 to Rescue the Damaged Organ: Mechanistic Insight into Its Function. | 2021 | Details |
| A01422 | 34754150 | World J Gastroenterol | Acetyl-CoA carboxylase inhibitors in non-alcoholic steatohepatitis: Is there a benefit? | 2021 | Details |
| A01492 | 34726148 | Proc Nutr Soc | Dysregulation of hepatic metabolism with obesity: factors influencing glucose and lipid metabolism. | 2021 | Details |
| A01498 | 34722615 | Front Nutr | Role of the Aryl Hydrocarbon Receptor and Gut Microbiota-Derived Metabolites Indole-3-Acetic Acid in Sulforaphane Alleviates Hepatic Steatosis in Mice. | 2021 | Details |
| A01520 | 34710482 | J Hepatol | Distinct contributions of metabolic dysfunction and genetic risk factors in the pathogenesis of non-alcoholic fatty liver disease. | 2021 | Details |
| A01593 | 34684339 | Nutrients | Ethanol Extract of Liriope platyphylla Root Attenuates Non-Alcoholic Fatty Liver Disease in High-Fat Diet-Induced Obese Mice via Regulation of Lipogenesis and Lipid Uptake. | 2021 | Details |
| A01609 | 34680522 | Biomedicines | Lipid Disorders in NAFLD and Chronic Kidney Disease. | 2021 | Details |
| A01685 | 34654875 | Acta Pharmacol Sin | Sulforaphane ameliorates non-alcoholic fatty liver disease in mice by promoting FGF21/FGFR1 signaling pathway. | 2021 | Details |
| A01689 | 34653601 | J Nutr Biochem | Copper (Cu) induced changes of lipid metabolism through oxidative stress-mediated autophagy and Nrf2/PPARγ pathways. | 2021 | Details |
| A01712 | 34646529 | Food Sci Nutr | Sargassum fusiforme polysaccharide attenuates high-sugar-induced lipid accumulation in HepG2 cells and Drosophila melanogaster larvae. | 2021 | Details |
| A01722 | 34639029 | Int J Mol Sci | Inhibition of Atherosclerosis and Liver Steatosis by Agmatine in Western Diet-Fed apoE-Knockout Mice Is Associated with Decrease in Hepatic De Novo Lipogenesis and Reduction in Plasma Triglyceride/High-Density Lipoprotein Cholesterol Ratio. | 2021 | Details |
| A01731 | 34634561 | Biomed Pharmacother | Jaboticaba (Myrciaria jaboticaba) powder consumption improves the metabolic profile and regulates gut microbiome composition in high-fat diet-fed mice. | 2021 | Details |
| A01732 | 34634521 | Mol Metab | STE20-type kinase TAOK3 regulates hepatic lipid partitioning. | 2021 | Details |
| A01762 | 34626855 | Mol Metab | The hepatocyte IKK:NF-κB axis promotes liver steatosis by stimulating de novo lipogenesis and cholesterol synthesis. | 2021 | Details |
| A01763 | 34626841 | Cell Mol Gastroenterol Hepatol | Defective Lipid Droplet-Lysosome Interaction Causes Fatty Liver Disease as Evidenced by Human Mutations in TMEM199 and CCDC115. | 2021 | Details |
| A01775 | 34621326 | Evid Based Complement Alternat Med | A Novel Identified Peptide Hormone "Metabolitin" Attenuates Lipid Absorption in the Small Intestine of Diabetic Mice with Nonalcoholic Fatty Liver Disease by Regulating Neurotensin and AMPK Signaling Pathway. | 2021 | Details |
| A01780 | 34620653 | BMJ Open | Effects of an isoenergetic low Glycaemic Index (GI) diet on liver fat accumulation and gut microbiota composition in patients with non-alcoholic fatty liver disease (NAFLD): a study protocol of an efficacy mechanism evaluation. | 2021 | Details |
| A01783 | 34619074 | Cell Metab | Molecular aspects of fructose metabolism and metabolic disease. | 2021 | Details |
| A01800 | 34610720 | Diabetes Metab J | Rho-Kinase as a Therapeutic Target for Nonalcoholic Fatty Liver Diseases. | 2021 | Details |
| A01808 | 34607257 | Biochem Biophys Res Commun | The alleviating effect of sphingosine kinases 2 inhibitor K145 on nonalcoholic fatty liver. | 2021 | Details |
| A01810 | 34607007 | Fish Shellfish Immunol | Polysaccharide extract from pomelo fruitlet ameliorates diet-induced nonalcoholic fatty liver disease in hybrid grouper (Epinephelus lanceolatus♂ × Epinephelus fuscoguttatus♀). | 2021 | Details |
| A01834 | 34600974 | J Hepatol | TTC39B destabilizes retinoblastoma protein promoting hepatic lipogenesis in a sex-specific fashion. | 2021 | Details |
| A01844 | 34592488 | Phytomedicine | Activation of AMPK by triptolide alleviates nonalcoholic fatty liver disease by improving hepatic lipid metabolism, inflammation and fibrosis. | 2021 | Details |
| A01872 | 34578867 | Nutrients | Amelioration of Hepatic Steatosis in Mice through Bacteroides uniformis CBA7346-Mediated Regulation of High-Fat Diet-Induced Insulin Resistance and Lipogenesis. | 2021 | Details |
| A01873 | 34578828 | Nutrients | Coffee Restores Expression of lncRNAs Involved in Steatosis and Fibrosis in a Mouse Model of NAFLD. | 2021 | Details |
| A01875 | 34576229 | Int J Mol Sci | Methyl Brevifolincarboxylate Attenuates Free Fatty Acid-Induced Lipid Metabolism and Inflammation in Hepatocytes through AMPK/NF-κB Signaling Pathway. | 2021 | Details |
| A01893 | 34571189 | J Nutr Biochem | Grape pomace reduces the severity of non-alcoholic hepatic steatosis and the development of steatohepatitis by improving insulin sensitivity and reducing ectopic fat deposition in mice. | 2021 | Details |
| A01909 | 34565074 | Rev Cardiovasc Med | Pathophysiological mechanisms and clinical evidence of relationship between Nonalcoholic fatty liver disease (NAFLD) and cardiovascular disease. | 2021 | Details |
| A01918 | 34563519 | J Lipid Res | Inhibition of chylomicron assembly leads to dissociation of hepatic steatosis from inflammation and fibrosis. | 2021 | Details |
| A01997 | 34535562 | J Pharmacol Exp Ther | Selective Acetyl-CoA Carboxylase 1 Inhibitor Improves Hepatic Steatosis and Hepatic Fibrosis in a Preclinical Nonalcoholic Steatohepatitis Model. | 2021 | Details |
| A02031 | 34525916 | Curr Med Chem | Beneficial Effects of Dietary Polyphenols in the Prevention and Treatment of NAFLD: Cell-Signaling Pathways Underlying Health Effects. | 2022 | Details |
| A02037 | 34524028 | J Med Food | Black Mulberry Extract Elicits Hepatoprotective Effects in Nonalcoholic Fatty Liver Disease Models by Inhibition of Histone Acetylation. | 2021 | Details |
| A02067 | 34512784 | Evid Based Complement Alternat Med | Cinnamic Acid Ameliorates Nonalcoholic Fatty Liver Disease by Suppressing Hepatic Lipogenesis and Promoting Fatty Acid Oxidation. | 2021 | Details |
| A02083 | 34511037 | Bioengineered | Long non-coding RNA AC012668 suppresses non-alcoholic fatty liver disease by competing for microRNA miR-380-5p with lipoprotein-related protein LRP2. | 2021 | Details |
| A02133 | 34494384 | Hepatol Commun | Direct AMPK Activation Corrects NASH in Rodents Through Metabolic Effects and Direct Action on Inflammation and Fibrogenesis. | 2021 | Details |
| A02153 | 34484560 | Oxid Med Cell Longev | Dietary Valine Ameliorated Gut Health and Accelerated the Development of Nonalcoholic Fatty Liver Disease of Laying Hens. | 2021 | Details |
| A02182 | 34470993 | J Toxicol Sci | Resveratrol reverses the programmed high-susceptibility to non-alcoholic fatty liver disease by targeting the hepatic SIRT1-SREBP1c pathway in prenatal ethanol-exposed rat offspring. | 2021 | Details |
| A02186 | 34469716 | Cell Rep | Myricetin supplementation decreases hepatic lipid synthesis and inflammation by modulating gut microbiota. | 2021 | Details |
| A02194 | 34465857 | Int J Obes (Lond) | Obese mice weight loss role on nonalcoholic fatty liver disease and endoplasmic reticulum stress treated by a GLP-1 receptor agonist. | 2021 | Details |
| A02243 | 34448436 | J Histochem Cytochem | Independent of Calorie Intake, Short-term Alternate-day Fasting Alleviates NASH, With Modulation of Markers of Lipogenesis, Autophagy, Apoptosis, and Inflammation in Rats. | 2021 | Details |
| A02249 | 34446693 | Cell Death Dis | Circ_0057558 promotes nonalcoholic fatty liver disease by regulating ROCK1/AMPK signaling through targeting miR-206. | 2021 | Details |
| A02251 | 34446271 | Clin Ther | Emerging and Established Therapeutic Approaches for Nonalcoholic Fatty Liver Disease. | 2021 | Details |
| A02256 | 34445549 | Int J Mol Sci | Kaempferol and Kaempferide Attenuate Oleic Acid-Induced Lipid Accumulation and Oxidative Stress in HepG2 Cells. | 2021 | Details |
| A02288 | 34435375 | Hepatology | A conventional immune regulator mitochondrial antiviral signaling protein blocks hepatic steatosis by maintaining mitochondrial homeostasis. | 2021 | Details |
| A02302 | 34430140 | Cureus | Rapid Onset of Weight Gain and Liver Dysfunction Successfully Treated With Nutrition and Exercise. | 2021 | Details |
| A02352 | 34406209 | Braz J Med Biol Res | α,β-Amyrin prevents steatosis and insulin resistance in a high-fat diet-induced mouse model of NAFLD via the AMPK-mTORC1-SREBP1 signaling mechanism. | 2021 | Details |