Repositioning Candidate Details
| Candidate ID: | R1044 |
| Source ID: | DB06546 |
| Source Type: | investigational |
| Compound Type: | biotech |
| Compound Name: | Atibuclimab |
| Synonyms: | Atibuclimab |
| Molecular Formula: | -- |
| SMILES: | -- |
| DrugBank Description: | Atibuclimab (IC14) is a chimeric CD14 antibody investigated for the treatment of patients with severe sepsis. |
| CAS Number: | 2417175-94-9 |
| Molecular Weight: | |
| DrugBank Indication: | Investigated for use/treatment in sepsis and septicemia and pneumonia. |
| DrugBank Pharmacology: | -- |
| DrugBank MoA: | Atibuclimab (IC14) is a chimeric CD14 antibody investigated for the treatment of patients with severe sepsis. It acts as a pattern recognition receptor for bacterial cell wall components in gram-positive and negative bacteria. CD14 antibody action stimulates a pro-inflammatory cytokine cascade often associated with inflammation in sepsis. Atibuclimab neutralization of this antibody results in the inhibition of TNF-a, IL-6 and IL-10, dampening systemic inflammatory responses. Atibuclimab also delays the release of sTNFR(1) and IL-1ra. |
| Targets: | Monocyte differentiation antigen CD14 |
| Inclusion Criteria: | Therapeutic strategy associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs | |
|---|---|---|---|---|---|
| S05 | Anti-inflammatory | inflammatory | Bile acid; TNF-a inhibitor; Dual PPAR-α and -δ agonists; Toll-Like Receptor; (TLR)-4 antagonist; Caspase inhibitor; ASK-1 inhibitor | Ursodeoxycholic Acid; Pentoxifylline; Elafibranor; JKB-121; Emricasan; Selonsertib; | Details |
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I01 | 552 | Pneumonia | A lung disease that involves lung parenchyma or alveolar inflammation and abnormal alveolar filling with fluid (consolidation and exudation). It results from a variety of causes including infection with bacteria, viruses, fungi or parasites, and chemical or physical injury to the lungs. It is accompanied by fever, chills, cough, and difficulty in breathing. http://en.wikipedia.org/wiki/Pneumonia | disease of anatomical entity/respiratory system disease/ lower respiratory tract disease/lung disease | Details |