Repositioning Candidate Details
| Candidate ID: | R1067 |
| Source ID: | DB06641 |
| Source Type: | investigational |
| Compound Type: | small molecule |
| Compound Name: | Perifosine |
| Synonyms: | Perifosine |
| Molecular Formula: | C25H52NO4P |
| SMILES: | CCCCCCCCCCCCCCCCCCOP([O-])(=O)OC1CC[N+](C)(C)CC1 |
| Structure: |
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| DrugBank Description: | Perifosine is a novel alkylphospholipid with antiproliferative properties attributed to protein kinase B inhibition. |
| CAS Number: | 157716-52-4 |
| Molecular Weight: | 461.668 |
| DrugBank Indication: | Investigated for use/treatment in solid tumors, multiple myeloma, leukemia (unspecified), lung cancer, and brain cancer. |
| DrugBank Pharmacology: | -- |
| DrugBank MoA: | Targeting cellular membranes, perifosine modulates membrane permeability, membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth. This agent also inhibits the anti-apoptotic mitogen-activated protein kinase (MAPK) pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing apoptosis. |
| Targets: | RAC-alpha serine/threonine-protein kinase; Mitogen-activated protein kinase 1; Protein kinase C alpha type |
| Inclusion Criteria: | Therapeutic strategy associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs | |
|---|---|---|---|---|---|
| S02 | Enhance lipid metabolism | triglyceride-lowering; lipid tolerance; lipid metabolism | 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) inhibitor; Decreases intestinal cholesterol absorption; FXR agonist; ACC inhibitor; FAS inhibitor; DGAT2 inhibitor; SCD-1 inhibitor | Atorvastatin; Ezetimibe; Obeticholic Acid; GS-9674; GS-0976; TVB-2640; IONIS-DGAT2rx; Aramchol; | Details |
| S13 | Anti-apoptosis | hepatocyte apoptosis; hepatic autophagy; apoptosis | Pan-caspase inhibitor | Emricasan | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
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| Diseases ID | DO ID | Disease Name | Definition | Class |
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