Repositioning Candidate Details
| Candidate ID: | R1218 |
| Source ID: | DB09087 |
| Source Type: | approved |
| Compound Type: | small molecule |
| Compound Name: | Potassium alum |
| Synonyms: | Alum, potassium; Aluminium potassium bis(sulphate); Aluminium potassium sulfate; Aluminum potassium alum; Aluminum potassium disulfate; Aluminum potassium sulfate; Aluminum potassium sulfate anhydrous; Burnt potassium alum; Potash alum; Potassium aluminium sulfate; Potassium aluminum disulfate |
| Molecular Formula: | AlKO8S2 |
| SMILES: | [Al+3].[K+].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O |
| Structure: |
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| DrugBank Description: | Potassium alum is considered by the FDA as a generally recognized as safe (GRAS) substance. It is an inorganic salt, also called potassium aluminum sulfate with a formula of AlK(SO4)2 that is predominantly produced in the dodecahydrate form (AlK(SO4)2 * 12H2O). Potassium alum is formed by large, transparent crystals that are used in different products like food or drugs as a buffer, neutralizing or forming agent. |
| CAS Number: | 10043-67-1 |
| Molecular Weight: | 258.205 |
| DrugBank Indication: | Potassium alum is considered safe by the FDA and its use is in homepathic or OTC products. Due to its presence in several different drugs, the main indications for the use of potassium alum are: -Constipation -Cosmetic or drug astringent, helping the shrinkage of tissues and the dry of secretions -Oral health care drug -Part of formulation in cleansing products, skin-care products, mosturizers, face powders and deodorants -Antiperspirant -Antifungal |
| DrugBank Pharmacology: | The presence of potassium alum reduces swollen mucous membranes that result from inflammation of the nasal, gastrointestinal and urinary passages as well as in the presence of excessive secretions. The induction of the coagulation cascade will also stop bleeding. |
| DrugBank MoA: | The main functions of potassium alum in drugs are as an astringent, antiseptic or adjuvant agent. The astringent action is performed by the induction of coagulation in the superficial tissue layers until the formation of a crust. The formation of alum ions neutralize the charges on plasma proteins, causing the blood to coagulate. Similar effect is observed in disinfectants where these ions react with the free organic acid and thiol groups of proteins on microbes and free proteins, resulting in protein precipitation. This action will generate the contraction of the tissue and dry up secretions. Its adjuvant properties are mainly used in the production of vaccines where the presence of this chemical enhances the immune response. |
| Targets: | -- |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
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