Repositioning Candidate Details
| Candidate ID: | R1280 |
| Source ID: | DB09279 |
| Source Type: | investigational |
| Compound Type: | small molecule |
| Compound Name: | Fimasartan |
| Synonyms: | Fimasartan |
| Molecular Formula: | C27H31N7OS |
| SMILES: | CCCCC1=NC(C)=C(CC(=S)N(C)C)C(=O)N1CC1=CC=C(C=C1)C1=C(C=CC=C1)C1=NN=NN1 |
| Structure: |
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| DrugBank Description: | Fimasartan is an angiotensin II receptor antagonist (ARB) drug employed in the treatment of both hypertension and heart failure. It has been found to be safe when administered with hydrochlorothiazide (a diuretic) in clinical trials. Fimasartan was initially approved September 9th, 2010 in South Korea and is marketed under the brand name _Kanarb_ by Boryung Pharmaceuticals. |
| CAS Number: | 247257-48-3 |
| Molecular Weight: | 501.65 |
| DrugBank Indication: | Used for the treatment of hypertension and heart failure . |
| DrugBank Pharmacology: | Fimasartan is a selective angiotensin receptor 1 (AR1) inhibitor . It acts to lower blood pressure by inhibiting vasoconstriction |
| DrugBank MoA: | Angiotensin II activates AR1 leading to vasoconstriction and increased noradrenaline release which further increases vasoconstriction via action at α1-adrenergic receptors . It also stimulates secretion of aldosterone which acts to increase sodium and water reabsorption in the renal tubules . Fimasartan bind to and antagonizes AR1 preventing vasoconstriction and reducing aldosterone secretion to increase natriuresis leading to a reduction in blood volume. Together these effects produce an anti-hypertensive effect. |
| Targets: | Type-1 angiotensin II receptor antagonist |
| Inclusion Criteria: | Therapeutic strategy associated |
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I12 | 10763 | Hypertension | An artery disease characterized by chronic elevated blood pressure in the arteries. https://en.wikipedia.org/wiki/Hypertension, https://www.ncbi.nlm.nih.gov/pubmed/24352797 | disease of anatomical entity/ cardiovascular system disease/vascular disease/ artery disease | Details |