Therapeutic Target Details
| Target ID: | T23 |
| Target Name: | Type-1 angiotensin II receptor |
| Synonyms: | AGTR1A; AGTR1B; Angiotensin II type-1 receptor; AT1; AT1AR; AT1BR; AT2R1; AT2R1B; Angiotensin Receptor; AGTR1 |
| GENE: | AGTR1 |
| Action: | antagonist |
| Class: | GPCR |
| UniProtKB ID: | P30556 |
| Entry Name: | AGTR1_HUMAN |
| Related Drugs: | Losartan; Telmisartan |
| Mechanism: | Treatment with angiotensin II type I receptor blocker attenuated the progression of hepatic steatosis, activation of hepatic stellate cells, expression of transforming growth factor beta 1, and liver fibrosis in the rat methione-choline-deficient diet model of nonalcoholic steatohepatitis. |
| Reference (PMIDs): | 17518368 |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| D209 | Losartan | Chemical drug | DB00678 | AGTR1 antagonist&binder | Anti-fibrosis | Under clinical trials | Details |
| D360 | Telmisartan | Chemical drug | DB00966 | PPARG partial agonist | Improve insulin resistance | Under clinical trials | Details |
| D541 | Olmesartan | Chemical drug | DB00275 | -- | -- | Under clinical trials | Details |
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| R0064 | DB00177 | approved; investigational | small molecule | Valsartan | Therapeutic strategy associated | Details |
| R0283 | DB00796 | approved | small molecule | Candesartan cilexetil | Target associated | Details |
| R0320 | DB00876 | approved | small molecule | Eprosartan | Target associated | Details |
| R0377 | DB01029 | approved; investigational | small molecule | Irbesartan | Target associated | Details |
| R0497 | DB01342 | experimental | small molecule | Forasartan | Target associated | Details |
| R0498 | DB01347 | experimental | small molecule | Saprisartan | Target associated | Details |
| R0500 | DB01349 | experimental | small molecule | Tasosartan | Target associated | Details |
| R0858 | DB05739 | investigational | biotech | CYT006-AngQb | Therapeutic strategy associated | Details |
| R1161 | DB08822 | approved; investigational | small molecule | Azilsartan medoxomil | Target associated | Details |
| R1280 | DB09279 | investigational | small molecule | Fimasartan | Therapeutic strategy associated | Details |
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| B000042 | CHEMBL1014 | Small molecule | CANDESARTAN CILEXETIL | 610.67 | C33H34N6O6 | ACID | Details |
| B000049 | CHEMBL1016 | Small molecule | CANDESARTAN | 440.46 | C24H20N6O3 | ACID | Details |
| B000055 | CHEMBL1017 | Small molecule | TELMISARTAN | 514.63 | C33H30N4O2 | ACID | Details |
| B000077 | CHEMBL10247 | Small molecule | THIORPHAN | 253.32 | C12H15NO3S | ACID | Details |
| B000185 | CHEMBL1069 | Small molecule | VALSARTAN | 435.53 | C24H29N5O3 | ACID | Details |
| B000239 | CHEMBL1076601 | Protein | -- | 1097.28 | C59H72N10O11 | None | Details |
| B000240 | CHEMBL1076602 | Protein | -- | 1101.2 | C54H67F3N12O10 | None | Details |
| B000241 | CHEMBL1076603 | Protein | -- | 1154.34 | C60H75N13O11 | None | Details |
| B000242 | CHEMBL1076604 | Protein | -- | 1158.25 | C55H70F3N15O10 | None | Details |
| B000243 | CHEMBL1076605 | Protein | -- | 1090.3 | C56H75N13O10 | None | Details |
| Article ID | PMID | Source | Title |
|---|