| Candidate ID: | R1323 |
| Source ID: | DB10771 |
| Source Type: | approved |
| Compound Type: |
biotech
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| Compound Name: |
Bovine type I collagen
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| Synonyms: |
Collagen Type I, Bovine
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| Molecular Formula: |
--
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| SMILES: |
--
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| DrugBank Description: |
Bovine collagen alpha-1 is a naturally occurring extracellular matrix protein which is found in tendons and other connective tissues. It plays a vital role in cell growth, differentiation, attachment, and migration . Often combined with other ingredients, such as fibroblasts and keratinocytes, it allows for accelerated and effective wound healing , .
Excellagen, a topical gel of bovine type I collagen, is used in the management of wounds including: partial and full- thickness wounds, pressure ulcers, venous ulcers, diabetic ulcers, chronic vascular ulcers, tunneled/undermined wounds, surgical wounds (donor sites/graft, post-Moh’s surgery, post-laser surgery, podiatric, wound dehiscence), trauma wounds (abrasions, lacerations, second-degree burns and skin tears) and draining wounds .
Bovine type I collagen is also used as a health supplement for bones and joints .
Interestingly, bovine type I collagen has been studied as a possible endovascular stent material, and has demonstrated promising results in rabbits .
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| CAS Number: |
9050-08-2
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| Molecular Weight: |
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| DrugBank Indication: |
For the management of wounds including: partial and full- thickness wounds, pressure ulcers, venous ulcers, diabetic ulcers, chronic vascular ulcers, tunneled/undermined wounds, surgical wounds (donor sites/graft, post-Moh’s dermatological surgery, post-laser surgery, podiatric, wound dehiscence), trauma wounds (abrasions, lacerations, second-degree burns and skin tears) and draining wounds .
Gintuit (Allogeneic Cultured Keratinocytes and Fibroblasts in Bovine Collagen) is an allogeneic cellularized scaffold product indicated for topical (non-submerged) application to a surgically created vascular wound bed in the treatment of mucogingival conditions in adults. It uses bovine collagen as a matrix to support the growth of keratinocytes and fibroblasts in wound healing . Other products using bovine type 1 collagen include PriMatrix, Integra, Orcel and Matriderm .
Orcel is a bilayered cellular matrix in which normal human allogeneic skin cells (both epidermal keratinocytes and dermal fibroblasts) are cultured in two separate layers into a Type I bovine collagen sponge, indicated in venous leg ulcers and diabetic foot. Type I bovine collagen acts as a matrix for the growth and proliferation of fibroblasts and keratinocytes, offering structure and support .
In the laboratory, bovine Collagen Type I purified protein standard is used as a control for SDS-PAGE, Western Blot, ELISA, immunoprecipitation, and for other immunological assays .
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| DrugBank Pharmacology: |
Collagen-based ingredients are very important for tissue engineering and regenerative medicine because of its superior human biocompatibility and low immunogenicity .
Bovine Collagen Type I belongs to a family of proteins found particularly in the flesh and connective tissues of mammals (approximately 1/3 of the body's total protein). More than two dozen types of collagen have been discovered; Type I is the most abundant form in the body. This type of collagen is found in scar tissue, tendons, the skin, arterial wall, the cornea, muscles, cartilage, and in certain parts of bones and teeth. Bovine Collagen Type I is ideal for investigators studying in extracellular matrix proteins and osteoporosis .
Type I collagen is the primary organic component of the extracellular matrix in the bone and can play an imperative role in bone tissue engineering. Type I collagen (bovine) is the basis of several laboratory and pharmaceutical products including Collapat II, Healos, Collagraft, and Biostite, among others .
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| DrugBank MoA: |
Collagen is a fibrillar protein that forms the conjunctive and connective tissues in the human body, including the skin, joints, and bones. This molecule is one of the most predominant in many living organisms, owing to its connective role in biological structures .
Collagen as a general substance is the most abundant structural protein in the human body that provides support to numerous tissues such as tendons, skin, and teeth (collagen joined to mineral crystals). All proteins that have a structure based on three helix structured polypeptidic chains . Bovine collagen is used most frequently out of naturally-sourced collagen, due to its biocompatibility with human beings .
When applied to a wound surface, bovine type I collagen absorbs wound fluid and maintains a moist wound environment, which is optimal for healing .
Numerous studies have demonstrated that the use of type I collagen matrices is capable of promoting osteogenic differentiation and mineralization of marrow stromal cells as well as human adipose stem cells. Another study demonstrated that a collagen scaffold (Gingistat) is appropriate for supporting the distribution of cells to form bone tissue .
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| Targets: |
--
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| Inclusion Criteria: |
Indication associated
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